ProCAID: A randomized double-blind phase II clinical trial of capivasertib (C) in combination with docetaxel and prednisolone chemotherapy (DP) in metastatic castrationresistant prostate cancer (mCRPC).
Abstract Number : 5520
Abstract Type : Poster Discussion Session
Indication : Metastatic Castration Resistant Prostate Cancer
Intervention : Capivasertib (C) plus docetaxel and prednisolone (DP)
Company : Cancer Research UK, Pharmaceutical/Biotech Company
Technology : Small Molecule
150 patients were randomised to 01/2019. Median follow up 16.77 months (IQR 12.0-26.5). PFS and OS by ITT and B status, are shown in the table (NR, not reached; CI confidence interval). Grade 3–4 adverse events (AE) were equally common between arms (62.2%). The most common AEs were diarrhoea, fatigue and nausea.
Adding C to DP did not extend PFS. The OS secondary endpoint was significantly increased. PFS and OS results were consistent irrespective of PI3K/AKT/PTEN pathway activation status.
Adding capivasertib to docetaxel and prednisolone chemotherapy did not extend PFS in mCRPC patients. However, the OS secondary endpoint was significantly increased.
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