31May

Much awaited result of Trastuzumab + trimodality treatment for HER2+ esophageal adenocarcinoma brought disappointment with its failure in reaching the primary end point

Trastuzumab with trimodality treatment for esophageal adenocarcinoma with HER2 overexpression: NRG Oncology/RTOG 1010


Abstract No : 4500

Abstract Type : Oral Abstract Session

Indication : Esophageal Carcinoma

Intervention : Trastuzumab

Company : Roche

Technology : Immune Checkpoint Inhibitors (ICI)


Results:

571 patients were entered for assessment of HER2 expression, 203 HER2+ patients randomized. The median follow-up for alive patients is 5.0 years. The estimated 2, 3, and 4-year DFS (95% CI) for the CXRT +trastuzumab arm were 41.8% (31.8%, 51.7%), 34.3% (24.7%, 43.9%), and 33.1% (23.6%, 42.7%), respectively, and for the CXRT arm were 40.0% (30.0%, 49.9%), 33.4% (23.8%, 43.0%), and 30.1% (20.7%, 39.4%), respectively; log-rank p = 0.85. The median DFS time is 19.6 months (13.5-26.2) for the CXRT +trastuzumab arm compared to 14.2 months (10.5-23.0) for the CXRT arm. The hazard ratio (95% CI) comparing the DFS of CXRT+trastuzumab arm to the CXRT arm was 0.97 (0.69, 1.36). The median OS time was 38.5 months (26.2-70.4) for the CXRT+trastuzumab arm compared to 38.9 months (29.0- 64.5) for the CXRT arm, hazard ratio (95% CI): 1.01 (0.69, 1.47). There was no statistically significant increase in treatment-related toxicities with the addition of trastuzumab including no increase in cardiac events


Conclusion:

The addition of trastuzumab to trimodality treatment did not improve DFS for patients with HER2 overexpressing esophageal adenocarcinoma.


Commentary:

Trastuzumab with trimodality treatment for esophageal adenocarcinoma with HER2 overexpression did not increases disease-free survival (DFS) which was the primary endpoint and also pathologic complete response or overall survival which was the secondary endpoint in trial


Refer to Esophageal Cancer Market report for detailed Insights.