Indirect comparison of TAK-788 vs real-world data outcomes in refractory non-small cell lung cancer (NSCLC) with EGFR exon 20 insertions
Abstract No : 9580
Abstract Type : Poster Session
Indication : NSCLC with EGFR exon 20 insertions
Intervention : TAK-788
Company : Millennium Pharmaceuticals, Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited.
Technology : Small molecule
Results:
A total of 99 pts were included, n=28 TAK-788 and n=71 RWD; mean age 62/65 y; male 25%/46%; Asian 18%/10%; former smoker 39%/45%; brain metastases 43%/34%. In the RWD, there was no consistent regimen for second-line treatment (including 29.6% immuno-oncologic agents, 25.4% EGFR TKI, 10% docetaxel). Baseline characteristics were comparable after weighting. PFS and ORR showed statistically significant improvements with TAK-788 vs RWD (Table). Specifically, after weighting, median PFS for TAK-788 vs RWD is 7.3 vs 3.5 mo, and ORR is 43% vs 13%.
Conclusion:
Despite a more heavily pretreated pt population, the efficacy of TAK-788 in pts with refractory NSCLC with EGFR exon 20 insertions appears better than other second-line treatment options used in the real-world setting.
Commentary:
Among pretreated patients with NSCLC with EGFR exon 20 insertions, mobocertinib (TAK-788) demonstrated prolonged PFS and higher ORR compared with other second line treatment options used in real world setting
Refer to Non Small Cell Lung Cancer Market report for detailed Insights.
