Agios Pharmaceuticals

View All

cholangiocarcinoma
What is Cholangiocarcinoma (CCA)?

Cholangiocarcinoma (BILE Duct cancer) is a type of uncommon CANCER. It arises in Bile ducts. The Bile duct is a long tubule like structure which connects the liver (hepatic duct) to the gall bladder (cystic duct). It carries bile, which helps in digestion of food, from gall-bladder (produced in the liver) to inte...

Find More

Isocitrate dehydrogenase (IDH) inhibitors– Emerging Anti-Cancer Therapeutics

The enzyme, isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate and CO2. It is found in the cytosol, mitochondrial matrix, and peroxisomes. IDH is responsible for cellular respiration in the TCA cycle. Isocitrate dehydrogenase exists in three isoforms i...

Find More