{"id":11676,"date":"2021-01-28T15:58:02","date_gmt":"2021-01-28T10:28:02","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=11676"},"modified":"2021-07-24T12:58:15","modified_gmt":"2021-07-24T07:28:15","slug":"recent-pharma-happenings-for-nirogy-iterum-therapeutics-tscan","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-nirogy-iterum-therapeutics-tscan","title":{"rendered":"Nirogy rises with $16.5M;  Iterum presents a new drug application to FDA;  Gut Bacteria proffer insight into molecules protection; TScan adds another $100M for cancer trials"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a0f4ee272c0f\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a0f4ee272c0f\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-nirogy-iterum-therapeutics-tscan\/#Nirogy_Therapeutics_rises_with_USD_165_Million_to_target_metabolite_transporters\" >Nirogy Therapeutics rises with USD 16.5 Million to target metabolite transporters<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-nirogy-iterum-therapeutics-tscan\/#Iterum_Therapeutics_presents_new_drug_application_to_FDA_for_Oral_Sulopenem\" >Iterum Therapeutics presents new drug application to FDA for Oral Sulopenem<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-nirogy-iterum-therapeutics-tscan\/#Gut_Bacteria_proffer_insight_into_molecules_protective_against_asthma_and_COVID-19\" >Gut Bacteria proffer insight into molecules protective against asthma and COVID-19<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-nirogy-iterum-therapeutics-tscan\/#TScan_adds_another_USD_100_Million_for_new_TCR_cancer_trials\" >TScan adds another USD 100 Million for new TCR cancer trials<\/a><\/li><\/ul><\/nav><\/div>\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nirogy_Therapeutics_rises_with_USD_165_Million_to_target_metabolite_transporters\"><\/span><strong>Nirogy Therapeutics rises with USD 16.5 Million to target metabolite transporters<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Nirogy Therapeutics Inc., a privately-held biotechnology company developing novel small molecules for targeting cellular transporters, announced the closing of a USD 16.5 million Series A financing.&nbsp;<\/p>\n\n\n\n<p>Nirogy plans to use the proceeds to improve its drug discovery platform for generating a pipeline of small-molecule drugs designed to aim the solute carrier family of transporter proteins (SLCTs) embedded in the cell membrane. SLCTs are gatekeepers of vital physiological functions, comprising nutrient uptake and metabolite disposal, aberrantly altered in many diseases. Nirogy is developing first-in-class medicines with an initial aim on oncology and autoimmune diseases, empowered by its proprietary small-molecule compound library and fast development strategies.<\/p>\n\n\n\n<p>Nirogy&#8217;s lead program aims lactate transporters for cancer treatment and is anticipated to enter human clinical trials in 2022. Unlike normal cells, <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/non-small-cell-lung-cancer-market\">cancer <\/a><\/strong>cells devour large amounts of glucose and eliminate a massive excess of lactic acid to the tumour microenvironment through lactate transporters for their quick growth and survival. Lactate-rich tumors develop a hostile environment for immune cells to survive, hence overcoming anti-tumour immunity. Nirogy&#8217;s lactate transport inhibitors have shown robust anti-tumour efficacy in preclinical models, either as monotherapy or combination therapy. Nirogy&#8217;s pipeline also incorporates a second transporter target in cancer and the third program in immunology.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Iterum_Therapeutics_presents_new_drug_application_to_FDA_for_Oral_Sulopenem\"><\/span><strong>Iterum Therapeutics presents new drug application to FDA for Oral Sulopenem<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Iterum Therapeutics, a clinical-stage pharmaceutical company focused on developing next-generation oral and IV antibiotics for treating infections, which are caused by multi-drug resistant pathogens in both community and hospital settings, has declared that it has presented its New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) for sulopenem etzadroxil\/probenecid (oral sulopenem) for the <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/urinary-tract-infections-pipeline-insight\">uncomplicated urinary tract infections (uUTIs) treatment<\/a><\/strong> in patients with a quinolone non-susceptible pathogen.<\/p>\n\n\n\n<p>Corey Fishman, Chief Executive Officer, said that the submission of the NDA filing for oral sulopenem is a crucial step in bringing new antibiotics to patients to help address the challenge of antibiotic resistance. He also said that Oral sulopenem, if authorized, would mean that physicians and patients have the chance to take advantage from the proven efficacy and safety of penem antibiotics that, to date in the U.S., have only been obtainable in IV formulations. They are now one step closer to realizing the focus of bringing this much-needed medicine to over six million patients with cipro-resistant UTIs every year in the U.S.<\/p>\n\n\n\n<p>The NDA submission comprises data from the SURE-1, SURE-2 and SURE-3 phase 3 clinical trials, in which oral sulopenem was well tolerated with no major drug-related adverse events. The SURE-1 clinical trial (uUTIs) showed the statistical superiority of oral sulopenem to the mostly used comparator, ciprofloxacin, for the primary efficacy endpoint of clinical and microbiologic outcome the test-of-cure visit for patients with a quinolone non-susceptible pathogen.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Gut_Bacteria_proffer_insight_into_molecules_protective_against_asthma_and_COVID-19\"><\/span><strong>Gut Bacteria proffer insight into molecules protective against asthma and COVID-19<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A team of researchers from Monash University&#8217;s Central Clinical School in Melbourne, Australia, set out to explain that question, and in the process discovered two molecules the scientists believe could proffer new treatment strategies for <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/asthma-market\">asthma<\/a><\/strong>.<\/p>\n\n\n\n<p>One of the molecules, L-tyrosine, is sold over the counter as a dietary supplement. So, the researchers intend to fast-track it into clinical trials. If it works, they contemplate it might also be used for <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/acute-respiratory-distress-syndrome-ards-market\">acute respiratory distress syndrome (ARDS) treatment<\/a><\/strong> in <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/covid-19-novel-coronavirus-19-therapeutic-pipeline-vaccines-diagnostics-competitive-landscape\">COVID-19 patients<\/a><\/strong>, reported in the journal Nature Immunology.<\/p>\n\n\n\n<p>The researchers began by transplanting gut bacteria from an immune-deficient mouse model into normal mice and observing the animals&#8217; immune systems. They were astonished to discover that the gut bacteria exhibited enhanced L-tyrosine metabolism, resulting in a byproduct known as p-cresol sulfate (PCS).<\/p>\n\n\n\n<p>They gave either L-tyrosine or PCS to mice and discovered that the supplements protected the animals from lung inflammation. The lead author and Monash professor Benjamin Marsland, PhD, in a statement, said that PCS travels from the gut to the lungs, and acts on epithelial cells lining the airways to prohibit the allergic asthma response.<\/p>\n\n\n\n<p>Further to testing L-tyrosine and PCS in mouse asthma models, the Australian team attempted them in animal models of ARDS, a common lung disorder in <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/covid-19-therapeutic-pipeline-vaccines\">severe cases of COVID-19<\/a><\/strong>. They observed a protective effect there too.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TScan_adds_another_USD_100_Million_for_new_TCR_cancer_trials\"><\/span><strong>TScan adds another USD 100 Million for new TCR cancer trials<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>TScan Therapeutics has raised another USD 100 million in a Series C to start 2021 on the positive notes it rang throughout 2020.<\/p>\n\n\n\n<p>Boston area-based TScan aims to identify new targets for <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/t-cell-inhibitor-pipeline-insight\">T-cell therapies<\/a><\/strong> in both <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/non-hodgkins-lymphoma-nhl-market\">blood cancers<\/a><\/strong> and <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/soft-tissue-sarcoma-market\">solid tumors<\/a><\/strong>. It started with USD 48 million and later collaborated with its Big Pharma backer Novartis to research kidney cancer.<\/p>\n\n\n\n<p>Then, late last year, it aimed COVID-19, turning its genome-based, high-throughput discovery platform for parsing T-cell receptors (TCRs) toward the coronavirus pandemic and how those immune cells reacted and inked a licensing agreement with Qiagen.<\/p>\n\n\n\n<p>It has now raised a hefty USD 100 million series C, adding new investors including BlackRock, RA Capital Management, and two undisclosed healthcare-focused funds.<\/p>\n\n\n\n<p>Proceeds from this financing will improve TScan&#8217;s TCR-T cell therapy pipeline for solid and liquid tumors into the clinic.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nirogy Therapeutics rises with USD 16.5 Million to target metabolite transporters Nirogy Therapeutics Inc., a privately-held biotechnology company developing novel small molecules for targeting cellular transporters, announced the closing of a USD 16.5 million Series A financing.&nbsp; Nirogy plans to use the proceeds to improve its drug discovery platform for generating a pipeline of small-molecule [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":11679,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[32],"tags":[18758,18757,18756,639,5789,18759],"industry":[17225],"therapeutic_areas":[17228],"class_list":["post-11676","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizia","tag-gut-bacteria","tag-iterum","tag-nirogy","tag-pharma-news","tag-recent-pharma-news","tag-tscanlatest-pharma-news","industry-pharmaceutical","therapeutic_areas-oncology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ 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