{"id":11682,"date":"2021-01-29T14:38:31","date_gmt":"2021-01-29T09:08:31","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=11682"},"modified":"2025-05-06T15:52:13","modified_gmt":"2025-05-06T10:22:13","slug":"hyperkalemia-treatment-market","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/hyperkalemia-treatment-market","title":{"rendered":"Notorious Hyperkalemia: What are the causes, signs and new treatments?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-69d6f5a4e445b\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-69d6f5a4e445b\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/hyperkalemia-treatment-market\/#What_is_Hyperkalemia\" >What is Hyperkalemia?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/hyperkalemia-treatment-market\/#What_causes_Hyperkalemia\" >What causes Hyperkalemia?&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/hyperkalemia-treatment-market\/#How_to_treat_Hyperkalemia\" >How to treat Hyperkalemia?&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/hyperkalemia-treatment-market\/#How_are_Glucose_and_Insulin_used_to_treat_Hyperkalemia\" >How are Glucose and Insulin used to treat Hyperkalemia?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.delveinsight.com\/blog\/hyperkalemia-treatment-market\/#Why_is_Calcium_given_for_Hyperkalemia_treatment\" >Why is Calcium given for Hyperkalemia treatment?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.delveinsight.com\/blog\/hyperkalemia-treatment-market\/#What_are_the_new_treatments_for_Hyperkalemia_getting_launched\" >What are the new treatments for Hyperkalemia getting launched?&nbsp;<\/a><\/li><\/ul><\/nav><\/div>\n\n<p>Bananas! Mostly everyone loves bananas. Who wouldn\u2019t? They taste good and they are a rich source of potassium. Besides lovely bananas, oranges, cantaloupe, honeydew, apricots, grapefruit, red meat are some other rich sources of potassium that people include in their diets. On average, a healthy human body needs 4,700 milligrams (mg) of potassium every day, says researchers. When not, the deficiency of potassium can hinder the normal functioning of the body, hinder fluid balance, cause blood pressure irregularities, stroke or even osteoporosis and kidney stones. However, what if there are higher levels of potassium accrued in the body? What happens then? <strong>Hyperkalemia.&nbsp;<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_is_Hyperkalemia\"><\/span><strong>What is Hyperkalemia?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Hyperkalemia is a condition that is a consequence of higher than normal levels of a substance called potassium in the blood. Digging deeper into its etiology, Hyperkalemia is defined as a serum of plasma that constitutes potassium levels on higher sides, usually higher than 5.0 mEq\/L to 5.5 mEq\/L. Higher levels of potassium can prove to be life-threatening in several instances leading to cardiac arrhythmias, muscle weakness or paralysis. However, during the milder version of the condition, the patients are generally asymptomatic. Hyperkalemia symptoms develop at the point where potassium levels are equal or higher than 6.5 mEq\/L to 7 mEq\/L. It is also witnessed that the rate of shifts in the levels of potassium in Hyperkalemia is of great importance that forms the basis behind the asymptomatic and symptomatic Hyperkalemia cases. (Leslie V. Simon et. al.)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_causes_Hyperkalemia\"><\/span><strong>What causes Hyperkalemia?&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>To dispel the myth first, Hyperkalemia never occurs due to the intake of food items rich in potassium. Even if these are consumed in larger quantities, it is deemed to be safe, however, in patients suffering from kidney diseases, or other diseases that constitute high-risk factors of Hyperkalemia.&nbsp;<\/p>\n\n\n\n<p><strong>Pseudohyperkalemia, <\/strong>a condition which falsely reflects the exact serum potassium levels in the body, is a quite common cause of Hyperkalemia. It is most commonly due to hemolysis of the sample causing intracellular potassium to be measured in the serum. Hemolysis is more common when a syringe is used as compared to a vacuum device. Then, <strong>cell injuries<\/strong> can lead to a release of larger quantities of intracellular potassium into the extracellular space. <strong>Metabolic acidosis<\/strong> can cause a rapid shift in potassium levels elevating it in extracellular space without any cell damage. <strong>Sepsis <\/strong>or dehydration may lead to hypotension, thereby, decreased tissue perfusion causing metabolic acidosis and ultimately potassium elevation. <strong>Insulin deficiency<\/strong> and diabetic ketoacidosis can also hamper peace in a similar way.<\/p>\n\n\n\n<p>Besides the above-mentioned causes, <strong>certain medications<\/strong> (such as succinylcholine) are also listed as potential catalysts of Hyperkalemia. <strong>Tumor lysis syndrome<\/strong> is also known to create ruckus in patients receiving chemotherapies, causing acute Hyperkalemia due to massive cancer cell death.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_to_treat_Hyperkalemia\"><\/span><strong>How to treat Hyperkalemia?&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Before beginning the treatment,<strong> <\/strong>it is essential to confirm the actual reason behind the Hyperkalemia. The urgency of therapy depends on symptoms, serum levels and explanation for Hyperkalemia. The current Hyperkalemia treatment market comprises intravenous calcium, insulin\/dextrose, beta-2 adrenergic receptor agonists, sodium bicarbonate infusion, cation-exchange resins, sodium polystyrene sulfonate, calcium polystyrene sulphonate, Patiromer, sodium zirconium cyclosilicate, and loop diuretics in an emergency setting. The treatment often varies due to availability of pharmacologic agents. Whereas in an acute setting, a combination of <strong>insulin <\/strong>and <strong>glucose <\/strong>is the standard of Hyperkalemia treatment. <strong>Beta-2 adrenergic receptor agonists, <\/strong>\u00a0<strong>Sodium bicarbonate infusions<\/strong>, and <strong>Cation-exchange resins <\/strong>are other Hyperkalemia treatment options available to maintain potassium levels. Furthermore, body potassium levels can be managed with the help of hemodialysis, sodium-potassium exchange resin binders, and diuretics.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_are_Glucose_and_Insulin_used_to_treat_Hyperkalemia\"><\/span><strong>How are Glucose and Insulin used to treat Hyperkalemia?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A combination of Insulin and Glucose are heralded as the mainstay of the Hyperkalemia treatment. Insulin lowers the serum potassium levels by activating sodium-potassium ATPase (Na\u2013K ATPase) and trading sodium out of the cell in exchange of potassium into the cell. Serum potassium concentration starts to decrease within 15 min of administering insulin, thereby, restoring the optimum levels. In a nutshell, insulin can drive the potassium back into the cells.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Why_is_Calcium_given_for_Hyperkalemia_treatment\"><\/span><strong>Why is Calcium given for Hyperkalemia treatment?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>According to the research, the concurrent calcium concentration helps in balancing the effect potassium has on myocytes. It does not interfere with the serum concentrations of potassium and is the first line of therapy in the setting of cardiac toxicity. Calcium chloride and calcium gluconate are the available options, however, <strong>calcium gluconate<\/strong> is often the initial drug of choice in patients with evidence of cardiac toxicity. Recently, in Japanese Hyperkalemia treatment market, <strong>Sodium zirconium cyclosilicate<\/strong> (Lokelma) got approved.&nbsp; <strong>Patiromer, <\/strong>a calcium exchange resin<strong> <\/strong>is the newest resin blessed by the FDA.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_are_the_new_treatments_for_Hyperkalemia_getting_launched\"><\/span><strong>What are the new treatments for Hyperkalemia getting launched?&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>At present, the treatment of Hyperkalemia is based on physical examinations, blood tests, urinalysis, electrocardiogram tests and other such tests conducted for proper knowledge of the cause of the condition and patient\u2019s state. However, the treatment should also focus on the efficacy and ability of the treatment by which they lower down the serum potassium levels along with a watchful eye on their side effects. The new drugs for Hyperkalemia need to be tailored as per the individuals for the best outcomes.&nbsp;<\/p>\n\n\n\n<p>To bridge the gaps in the Hyperkalemia treatment market, several companies including <strong>Zeria Pharmaceutical\/Vifor<\/strong> <strong>Pharma <\/strong>and <strong>Ardelyx <\/strong>are proactively working to cut the mustard in the developing a standard treatment option in the <a href=\"https:\/\/www.delveinsight.com\/report-store\/hyperkalemia-pipeline-insight?utm_source=article&amp;utm_medium=pr&amp;utm_campaign=v\" target=\"_blank\" rel=\"noreferrer noopener\">Hyperkalemia pipeline<\/a> to create a significant positive shift in Hyperkalemia treatment market size.<\/p>\n\n\n\n<p>Zeria\u2019s <strong>Patiromer <\/strong>(ZG-801), an oral, non-absorbed, cation exchange polymer that contains a calcium-sorbitol counterion, was approved in 2015 in the US for Hyperkalemia treatment. Now the drug is commercially out in the market in several other countries, including those of the EU. Vifor, in March 2018, got the exclusive commercial rights to Patiromer for Japanese Hyperkalemia treatment market.&nbsp;<\/p>\n\n\n\n<p>Then, there is <strong>RDX013, <\/strong>a candidate Ardelyx swears by. It is a novel, small molecule that works by leveraging the GI tract\u2019s natural ability to secrete potassium into the gut\u2019s lumen to reduce serum potassium levels. The company is planning to proceed for the Phase II clinical trials after the results from the Phase I study demonstrated the drug to be safe and well-tolerated.&nbsp;<\/p>\n\n\n\n<p>In a lump sum, growing R&amp;D is going to bolster the demand for better drugs for Hyperkalemia. At present, there is a paucity of effective therapies and safety data from clinical trials. Further, the lack of standard treatment protocols and guidelines, and a high cost of approved therapies also adds to the burden. No doubt that recent years have witnessed drugs walking the carpets in the <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/hyperkalemia-market?utm_source=article&amp;utm_medium=pr&amp;utm_campaign=v\" target=\"_blank\" rel=\"noreferrer noopener\">Hyperkalemia treatment market <\/a><\/strong>with novel MoA; however, there still remains a lot to traverse.\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Bananas! Mostly everyone loves bananas. Who wouldn\u2019t? They taste good and they are a rich source of potassium. Besides lovely bananas, oranges, cantaloupe, honeydew, apricots, grapefruit, red meat are some other rich sources of potassium that people include in their diets. On average, a healthy human body needs 4,700 milligrams (mg) of potassium every day, [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":11684,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[16868,16872,16870,16871,16869],"industry":[17225],"therapeutic_areas":[17229,17240],"class_list":["post-11682","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-hyperkalemia","tag-hyperkalemia-incidence","tag-hyperkalemia-market","tag-hyperkalemia-new-treatment","tag-hyperkalemia-treatment-market","industry-pharmaceutical","therapeutic_areas-central-nervous-system","therapeutic_areas-endocrinology-and-metabolic-disorders"],"acf":[],"yoast_head":"<!-- This site is optimized with 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