{"id":11720,"date":"2021-02-04T17:28:29","date_gmt":"2021-02-04T11:58:29","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=11720"},"modified":"2025-05-06T15:56:20","modified_gmt":"2025-05-06T10:26:20","slug":"recent-pharma-happenings-for-bms-prothena-canon-medical-immunovant","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-bms-prothena-canon-medical-immunovant","title":{"rendered":"Plaque psoriasis drug outshines in phase III trial; Immunovant announces pause in trial of IMVT-1401; Prothena brings AL amyloidosis drug back; Canon Medical expands its MRI AI programs"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a017c4317869\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a017c4317869\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-bms-prothena-canon-medical-immunovant\/#Plaque_psoriasis_drug_outshines_the_competition_in_phase_III_trial\" >Plaque psoriasis drug outshines the competition in phase III trial<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-bms-prothena-canon-medical-immunovant\/#Immunovant_announces_pause_in_a_clinical_trial_of_IMVT-1401\" >Immunovant announces pause in a clinical trial of IMVT-1401<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-bms-prothena-canon-medical-immunovant\/#Prothena_brings_AL_amyloidosis_drug_back_to_the_clinic\" >Prothena brings AL amyloidosis drug back to the clinic&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-bms-prothena-canon-medical-immunovant\/#Canon_Medical_expands_the_reach_of_its_MRI_artificial_intelligence_programs\" >Canon Medical expands the reach of its MRI artificial intelligence programs<\/a><\/li><\/ul><\/nav><\/div>\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Plaque_psoriasis_drug_outshines_the_competition_in_phase_III_trial\"><\/span><strong>Plaque psoriasis drug outshines the competition in phase III trial<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Bristol Myers Squibb\u2019s psoriasis drug, the TYK2 inhibitor outshone placebo and Amgen\u2019s Otezla in a second phase 3 study, setting discussions with regulators.<\/p>\n\n\n\n<p>The study, known as POETYK PSO-2, trialled the drug, deucravacitinib, against placebo and Otezla in 1,020 patients with moderate to severe <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/plaque-psoriasis-market\">plaque psoriasis<\/a><\/strong> as per announced by the company. After 16 weeks of treatment, remarkably more patients taking Bristol Myers\u2019 drug than placebo had a 75% depletion of psoriasis area and severity and clear or almost transparent skin as measured by the static Physician\u2019s Global Assessment, a visual evaluation of psoriasis.<\/p>\n\n\n\n<p>Moreover, meeting these co-primary endpoints, deucravacitinib also beat Otezla on these measures, hitting vital secondary endpoints.<\/p>\n\n\n\n<p>The company displayed broad strokes with plans to show complete data at a future medical meeting. The news comes three months after Bristol Myers reported a similar performance in the 666-patient POETYK PSO-1 study, in which deucravacitinib also outperformed placebo and Otezla.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immunovant_announces_pause_in_a_clinical_trial_of_IMVT-1401\"><\/span><strong>Immunovant announces pause in a clinical trial of IMVT-1401<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Immunovant, a clinical-stage biopharmaceutical company focused on enabling everyday lives for patients with autoimmune diseases, announced a voluntary pause of dosing in its ongoing clinical trials for IMVT-1401.<\/p>\n\n\n\n<p>The company has become aware of a physiological signal comprising elevated total cholesterol and LDL levels in IMVT-1401-treated patients in ASCEND GO-2, a Phase 2b trial in <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/thyroid-eye-disease-ted-market\">Thyroid Eye Disease (TED)<\/a><\/strong>. <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/cholesterol-absorption-inhibitor-pipeline-insight\">Cholesterol <\/a><\/strong>levels were not measured in prior clinical trials of IMVT-1401 in <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/myasthenia-gravis-market\">Myasthenia Gravis (MG)<\/a><\/strong> and healthy participants. Out of caution, the company has decided to voluntarily pause dosing in ongoing clinical studies in both TED and <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/warm-autoimmune-hemolytic-anemia-waiha-market\">Warm Autoimmune Hemolytic Anemia<\/a><\/strong> to apprise patients, investigators, and regulators as well as to modify the monitoring program.<\/p>\n\n\n\n<p>ASCEND GO-2 is a randomised, placebo-controlled trial in TED evaluating different doses, each given weekly for 12 weeks. In this study, cholesterol parameters are evaluated at baseline, twelve weeks, and week 20 following eight weeks off drug. Based on preliminary, unblinded data from about 40 patients through week 12, mean LDL cholesterol at week 12 increased by approximately 65% in the 680mg dose group, by approximately 40% in the 340mg dose and did not increase in the control group. Average HDL and triglyceride levels increased to a much lesser degree. For context, commercially available statins report a reduction in LDL cholesterol between 27-60%. At the twenty-week timepoint, average LDL levels had declined to baseline or lower in the 680mg dose group, the 340mg dose group, and the control group. No serious cardiovascular events have been reported to date in IMVT-1401 clinical trials.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Prothena_brings_AL_amyloidosis_drug_back_to_the_clinic\"><\/span><strong>Prothena brings AL amyloidosis drug back to the clinic&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Prothena canned its <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/al-amyloidosis-market\">AL amyloidosis<\/a><\/strong> program in 2018 after it flunked a mid-stage trial and a data monitoring committee regarded a separate phase 3 study doomed to flunk. Now, the biotech is reviving the program after analysing the phase 3 data found the drug benefited the sickest patients to live longer.<\/p>\n\n\n\n<p>That study labelled VITAL, examined the drug, called as birtamimab or NEOD001, against the standard of care in 269 patients with <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/al-amyloidosis-pipeline-insight\">AL amyloidosis,<\/a><\/strong> short for amyloid light-chain amyloidosis. After finishing the study for futility, Prothena crunched the data and observed that the sickest patients, those whose disease was classed as Mayo stage 4 at the start of the study, did significantly better birtamimab than on placebo.<\/p>\n\n\n\n<p>At the nine-month mark, the analysis received nearly three-quarters of the sickest patients on birtamimab were still alive as compared to about half of the sickest patients receiving placebo (74% versus 49%). These numbers are from just 77 patients or 30% of the total patients in the trial, but they have convinced Prothena and the FDA that there is a potential in this drug in these patients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Canon_Medical_expands_the_reach_of_its_MRI_artificial_intelligence_programs\"><\/span><strong>Canon Medical expands the reach of its MRI artificial intelligence programs<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Canon Medical is expanding the clinical reach of its artificial intelligence programs designed to enhance MRI image quality, announcing that it can now be used in 96% of all scanning procedures.<\/p>\n\n\n\n<p>The company\u2019s Advanced intelligent Clear-IQ Engine, or AiCE, aims to sharpen scans taken by lower-dose, 1.5 Tesla MRIs, to bring their image quality up to par with 3.0 Tesla machines.<\/p>\n\n\n\n<p>The FDA previously cleared the system for the specific brain- and knee-focused indications, using Canon Medical\u2019s Vantage Orian 1.5 Tesla system. Now its applications span all joints, as well as <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/cardiac-ablation-devices-market\">cardiac<\/a><\/strong>, abdomen, <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/spine-augmentation-systems-devices-market\">spine <\/a><\/strong>and <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/pelvic-floor-stimulation-devices-market\">pelvic<\/a><\/strong> scans.&nbsp;<\/p>\n\n\n\n<p>Jonathan Furuyama, managing director of Canon Medical\u2019s MR business unit, said in a statement that in today\u2019s environment, making images easy to grasp and acquire is more vital than ever, and this is the recent demonstration of their commitment to offering accessible AI that clinicians can utilise to make the most significant impact on patient care.<\/p>\n\n\n\n<p>The expansion follows two recent FDA clearances for Canon Medical in December and January, comprising an AI-equipped, large-bore CT scanner and software designed to improve 3D MRI imaging times.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Plaque psoriasis drug outshines the competition in phase III trial Bristol Myers Squibb\u2019s psoriasis drug, the TYK2 inhibitor outshone placebo and Amgen\u2019s Otezla in a second phase 3 study, setting discussions with regulators. The study, known as POETYK PSO-2, trialled the drug, deucravacitinib, against placebo and Otezla in 1,020 patients with moderate to severe plaque [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":11725,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[32],"tags":[18762,18760,639,1546,18761,5789],"industry":[17225],"therapeutic_areas":[17237,17239,17233,17227,17231,17243],"class_list":["post-11720","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizia","tag-canon-medical","tag-immunovant","tag-pharma-news","tag-plaque-psoriasis","tag-prothena","tag-recent-pharma-news","industry-pharmaceutical","therapeutic_areas-dermatology","therapeutic_areas-gastroenterology","therapeutic_areas-hematological-disorders","therapeutic_areas-immunological-and-autoimmune-disorders","therapeutic_areas-infectious-diseases","therapeutic_areas-respiratory-diseases"],"acf":[],"yoast_head":"<!-- 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href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">Notizia - Recent Pharma, Healthcare and Biotech Happenings<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Notizia - Recent Pharma, Healthcare and Biotech Happenings<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">Canon Medical<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">Immunovant<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">pharma news<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">Plaque Psoriasis<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">Prothena<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">recent pharma news<\/a>"],"unlinked":["<span 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