{"id":12873,"date":"2021-07-27T17:45:01","date_gmt":"2021-07-27T12:15:01","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=12873"},"modified":"2021-10-13T12:51:04","modified_gmt":"2021-10-13T07:21:04","slug":"pharma-happenings-for-gsk-pfizer-biontech-biovac-seres-therapeutics","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/pharma-happenings-for-gsk-pfizer-biontech-biovac-seres-therapeutics","title":{"rendered":"Commencement of AAIC; GSK\u2019s Shingles Vaccine Expanded Approval; Pfizer\/ BioNtech Agreement with Biovac; Another Failure in Ulcerative Colitis Trial"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-69f5f8068ddff\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-69f5f8068ddff\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-happenings-for-gsk-pfizer-biontech-biovac-seres-therapeutics\/#Alzheimers_Association_International_Conference_AAIC_2021_Opens_With_Thrilling_Details_of_Pharmas_and_Powerful_Therapeutic_Discoveries\" >Alzheimer&#8217;s Association International Conference (AAIC) 2021 Opens With Thrilling Details of Pharmas and Powerful Therapeutic Discoveries&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-happenings-for-gsk-pfizer-biontech-biovac-seres-therapeutics\/#Expanded_Approval_in_GSKs_Pocket_for_Shingles_Expected_to_Generate_High_Sales\" >Expanded Approval in GSK\u2019s Pocket for Shingles Expected to Generate High Sales<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-happenings-for-gsk-pfizer-biontech-biovac-seres-therapeutics\/#An_Exclusive_Collab_Between_Pfizer_and_BioNTech_Alongside_South_Africas_Biovac\" >An Exclusive Collab Between Pfizer and BioNTech Alongside South Africa\u2019s Biovac&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-happenings-for-gsk-pfizer-biontech-biovac-seres-therapeutics\/#An_Awaited_Ulcerative_Colitis_Phase_2_Seres_Therapeutics_Trial_Drug_Crashed_Down\" >An Awaited Ulcerative Colitis Phase 2 Seres Therapeutics Trial Drug Crashed Down<\/a><\/li><\/ul><\/nav><\/div>\n\n<h2 class=\"wp-block-heading\" id=\"h-alzheimer-s-association-international-conference-aaic-2021-opens-with-thrilling-details-of-pharmas-and-powerful-therapeutic-discoveries\"><span class=\"ez-toc-section\" id=\"Alzheimers_Association_International_Conference_AAIC_2021_Opens_With_Thrilling_Details_of_Pharmas_and_Powerful_Therapeutic_Discoveries\"><\/span><strong>Alzheimer&#8217;s Association International Conference (AAIC) 2021 Opens With Thrilling Details of Pharmas and Powerful Therapeutic Discoveries&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The most awaited <strong>Alzheimer\u2019s Association International Conference 2021 (AAIC)<\/strong> commenced yesterday on July 26th, 2021 in Denver, Colorado, which was presented both virtually as well as in person. It will be held till 30<sup>th<\/sup> July 2021.&nbsp; Various Active Pharmaceuticals &amp; Biotechnological Companies including <strong>Cassava Sciences, INmune Bio, Cognito Therapeutics, Cortexyme <\/strong>among others presented their new and upcoming drugs, therapies, shared their research studies and clinical data.<\/p>\n\n\n\n<p><strong>Cassava Sciences<\/strong>, based in Austin, Texas, a clinical stage biopharmaceutical company dealing with neuroscience stated constructive results of an investigational diagnostic\/biomarker to mark<a href=\"https:\/\/www.delveinsight.com\/blog\/alzheimers-disease-market\/?utm_source=blog&amp;utm_medium=article&amp;utm_campaign=v\"> Alzheimer\u2019s disease (AD)<\/a> with a blood test. The biomarker is named <strong>SavaDx<\/strong> and it measures different levels of plasma in altered filamin A before and after the patients are treated with simufilam. Remarkable drop was observed in altered filamin A plasma levels after treatment with simufilam in Phase 2b trials. P-tau 181 plasma levels were also reduced in a good amount.<\/p>\n\n\n\n<p><strong>INmune Bio&nbsp;Inc.<\/strong>, a biotechnology (clinical stage immuno-oncology) company from California publicized the design of its new XPro therapy in Phase 2 clinical trials. XPro \/Xpro1595 is considered as a next-generation inhibitor of tumor necrosis factor (TNF) which is based on dominant-negative TNF technology. Also information about their biomarker Phase 1b trial indicated improvement in&nbsp;white matter (myelinated axons) that degrades in <a href=\"https:\/\/www.delveinsight.com\/report-store\/alzheimers-disease-ad-market?utm_source=blog&amp;utm_medium=article&amp;utm_campaign=v\">AD patients<\/a>.<\/p>\n\n\n\n<p><strong>Cognito Therapeutics<\/strong> located in Cambridge is a clinical-stage company developing novel digital&nbsp;therapeutics that presented <a href=\"https:\/\/www.businesswire.com\/news\/home\/20210726005265\/en\/Cognito-Therapeutics-Presents-New-Clinical-Data-Demonstrating-Disease-Modifying-Effects-of-Gamma-Frequency-Neuro-modulation-on-Cognitive-Function-and-Brain-Atrophy-in-Alzheimer%E2%80%99s-Disease-at-AAIC-2021\">clinical data<\/a> on &nbsp;gamma frequency neuro-modulation on cognitive function from its lead digital therapeutic candidate in AD. It exhibited sleep improvement, betterments in memory and cognition, and lowered brain atrophy. It was a Phase 2 OVERTURE study&nbsp;with a potential 6 month study in patients experiencing mild-to-moderate AD. The study was based upon reduction in brain atrophy induced from gamma frequency neuro-modulation.<\/p>\n\n\n\n<p><strong>Cortexyme<\/strong>, a clinical stage biopharmaceutical company based in South San Francisco, CA introduced their clinical studies for biomarker data in AD. Escalated levels of p-tau 217 when linked with\u00a0P. gingivalis acted as a firm biomarker in patients. Around 643 patients\u2019 participation in Phase 2\/3 GAIN Trial study resulted in acknowledging that intracellular pathogen P. gingivalis, was present in the brain of more than 90% of Alzheimer\u2019s patients. Cortexyme\u2019s own drug candidate, atuzaginstat, is an oral, brain penetrant small molecule targeting<em> P. gingivalis<\/em>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Expanded_Approval_in_GSKs_Pocket_for_Shingles_Expected_to_Generate_High_Sales\"><\/span><strong>Expanded Approval in GSK\u2019s Pocket for Shingles Expected to Generate High Sales<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>GlaxoSmithKline announced the US Food and Drug Administration approval for its vaccine, Shingrix (Zoster Vaccine Recombinant, Adjuvanted) under trials&nbsp;in 18+ adults who are vulnerable or at an increased risk to <a href=\"https:\/\/www.delveinsight.com\/report-store\/shingles-market?utm_source=blog&amp;utm_medium=article&amp;utm_campaign=v\">Shingles<\/a>, which is already commercialized for patient group aged 50 and above.&nbsp;<\/p>\n\n\n\n<p>FDA\u2019s first green signal to Shingrix was given in 2017, where it was approved for prevention of Shingles in populations aged 50 and above. The clinical studies were based on adults who went through an autologous hematopoietic stem cell transplant (auHSCT) and those currently under treatment for hematological malignancies (post-hoc analysis).&nbsp;Additional data for safety and immunogenicity was generated considering adults who were immunodeficient or immunosuppressed due to any known disease or therapy (HIV, solid tumors, and renal transplants).<\/p>\n\n\n\n<p>Shingles is a viral infection that results in blisters and painful rashes, also it is caused by the same virus responsible for chickenpox i.e. <em>varicella-zoster virus. <\/em>It can be due to immunodeficiency\/immunocompromisation caused by a familiar disease or therapy in the body, putting individuals with compromised immune systems at a risk of developing it.<\/p>\n\n\n\n<p>Now, Shingrix is administered intramuscularly in two doses and provides exclusive protection only against Shingles, not chickenpox.&nbsp;<\/p>\n\n\n\n<p>Shingrix was earlier approved by the European Commission (EC) for prevention of shingles and <a href=\"https:\/\/www.delveinsight.com\/report-store\/postherpetic-neuralgia-market?utm_source=blog&amp;utm_medium=news&amp;utm_campaign=v\">postherpetic neuralgia<\/a> (PHN) in Shingles vulnerable 18+ adults. Afterwards on August 25, 2020 Shingrix received a proper commercial marketing authorization. In 2019 as the uptake increased, Shingrix sales double folded.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"An_Exclusive_Collab_Between_Pfizer_and_BioNTech_Alongside_South_Africas_Biovac\"><\/span><strong>An Exclusive Collab Between Pfizer and BioNTech Alongside South Africa\u2019s Biovac&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>With a cumulative data of only 1.5% were administered with COVID-19 shot out of Africa\u2019s total population i.e. 1.3 billion people. Africa currently holds one of the lowest rankings in continents with countries with lowest vaccination rate worldwide. It comes as a huge concern for WHO and several other health organizations. To deal with this challenge, a collaborative partnership between Pfizer, BioNTech and a South African local vaccine producer Biovac entered the scenario. This joint venture will account for around 100 million doses per year production.&nbsp;<\/p>\n\n\n\n<p>This globalized <a href=\"https:\/\/www.delveinsight.com\/report-store\/covid-19-novel-coronavirus-19-therapeutic-pipeline-vaccines-diagnostics-competitive-landscape?utm_source=blog&amp;utm_medium=news&amp;utm_campaign=v\">COVID-19 vaccine<\/a> supply chain and manufacturing network, incorporates 3 continents and will contain around 20 manufacturing facilities. As suggested by analysts, the most rapid, cost-effective and easiest way of vaccine development is regional partnership with prominent vaccines developers. Biovac\u2019s Cape town\u2019s facility shall immediately begin processing, technical transfer, on-site development and installation of equipment.&nbsp;<\/p>\n\n\n\n<p>Johnson &amp; Johnson, another major manufacturer in the <a href=\"https:\/\/www.delveinsight.com\/blog\/coronavirus-vaccine-candidates\/?utm_source=blog&amp;utm_medium=news&amp;utm_campaign=v\">COVID-19 vaccine market landscape<\/a> is also not at all lagging behind in the race for African vaccine production. A deal occurring for around 400 million doses of its single shot COVID-19 vaccine will be produced from a facility in Port Elizabeth which is the resultant of an agreement with J&amp;J\u2019s African manufacturing partner &#8211; Aspen Pharmacare.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"An_Awaited_Ulcerative_Colitis_Phase_2_Seres_Therapeutics_Trial_Drug_Crashed_Down\"><\/span><strong>An Awaited <\/strong><strong>Ulcerative Colitis<\/strong><strong> Phase 2 Seres Therapeutics Trial Drug Crashed Down<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>When positive results were observed in the early stages by an experimental drug from Seres Therapeutics, many expectations were built up; however, the hopes lie flat now. An emerging drug in trial in the <a href=\"https:\/\/www.delveinsight.com\/report-store\/ulcerative-colitis-uc-market?utm_source=blog&amp;utm_medium=news&amp;utm_campaign=v\">Ulcerative Colitis (UC) market <\/a>falls short after failed Clinical Phase 2 trials. This drug was dealing with a novel kind of therapy, namely microbiome therapeutics.<\/p>\n\n\n\n<p>A study with 203 participants in comparison with placebo was under effect, with the main aim of limiting inflammation in patients dealing with UC, medicine did not outperform the placebo. Another impact was supposed to eliminate a few symptoms related with the disease, where more side effects associated with the drug could be seen.&nbsp;<\/p>\n\n\n\n<p>Seres was in a joint partnership with Nestl\u00e9 Health Science (NHS) for development of different&nbsp; bacteria-based drugs, many of which are&nbsp; under clinical development.<\/p>\n\n\n\n<p>However, Seres is not planning on abandoning the treatment for the same. With another type of treatment already in the developing phase, there are still hopes for carrying the drug forward. An early phase, second treatment may prove fruitful as assumed by the company\u2019s researchers &amp; scientists.<\/p>\n\n\n\n<p>Share prices still faced an abrupt downward trend after the announcement of failed emerging drug news throughout. The company\u2019s total gain from previous year was wiped out completely.&nbsp;<\/p>\n\n\n\n<p>Few other companies like Finch and Vedanta Biosciences are also working on developing microbiome drugs associated with inflammatory bowel disease (IWD). Vedanta is developing a Phase 2 clinical trial for it\u2019s novel UC drug whereas Finch is in pre-clinical testing phase.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Alzheimer&#8217;s Association International Conference (AAIC) 2021 Opens With Thrilling Details of Pharmas and Powerful Therapeutic Discoveries&nbsp; The most awaited Alzheimer\u2019s Association International Conference 2021 (AAIC) commenced yesterday on July 26th, 2021 in Denver, Colorado, which was presented both virtually as well as in person. It will be held till 30th July 2021.&nbsp; Various Active Pharmaceuticals [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":12880,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[32],"tags":[420,639],"industry":[17225],"therapeutic_areas":[17239,17231,17245],"class_list":["post-12873","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizia","tag-news","tag-pharma-news","industry-pharmaceutical","therapeutic_areas-gastroenterology","therapeutic_areas-infectious-diseases","therapeutic_areas-neurology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AAIC 2021 | GSK\u2019s Shingles Vaccine | Pfizer-BioNtech&#039;s Deal with Biovac<\/title>\n<meta name=\"description\" content=\"Commencement of AAIC 2021; 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