{"id":13065,"date":"2021-08-09T18:23:07","date_gmt":"2021-08-09T12:53:07","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=13065"},"modified":"2021-09-08T09:28:15","modified_gmt":"2021-09-08T03:58:15","slug":"primary-hyperoxaluria-market","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/primary-hyperoxaluria-market","title":{"rendered":"Primary Hyperoxaluria Market Size Observes Growth with a Substantial CAGR"},"content":{"rendered":"\n<p>Primary hyperoxaluria (PH) is a rare autosomal genetic form of Hyperoxaluria, a condition that leads to the excessive urinary excretion of oxalate. Till now, three distinct hereditary enzymatic deficiencies have been identified as a cause of PH, namely, PH type 1 (PH1), type 2 (PH2), and type 3 (PH3), with PH1 as the most common form of PH. Each of the three types is caused by a genetic aberration in a gene that regulates the production of a different hepatic enzyme, a mutation that results in the overproduction of oxalate by the liver.&nbsp;<\/p>\n\n\n\n<p>Worldwide Primary hyperoxaluria prevalence is estimated to range from 1 to 3 per million population. Primary hyperoxaluria causes the formation of kidney stones by the age of 20; approximately 50% of the affected population experience kidney failure by the age of 15 and around 80 percent experience kidney failure by age 30. According to DelveInsight estimates, the total <a href=\"https:\/\/www.delveinsight.com\/report-store\/primary-hyperoxaluria-epidemiology-forecast?utm_source=blog&amp;utm_medium=article&amp;utm_campaign=v\">Primary hyperoxaluria prevalent population<\/a> in the 7MM (the US, EU5, and Japan) in 2020 was estimated to be <strong>11,918 <\/strong>in 2020, which is expected to further increase by 2030.&nbsp;<\/p>\n\n\n\n<p>However rare the condition is, Primary hyperoxaluria continues to be a burdensome and challenging disease with no cure at hand. The treatment practices in Primary hyperoxaluria comprises conservative measures aiming at lowering down the levels of oxalate in the body, prevention of formation of oxalate crystals from forming in the kidneys and body organs. This is primarily tried to achieve by increasing the fluid intake, incorporating a diet plant that restricts oxalate intake, and using urinary crystallization inhibitors. These conservative therapy measures usually are initiated as soon as basal urinary oxalate measures have been completed and while renal function persists. After the disease has caused End-stage renal disease (ESRD), the only treatment that remains in the Primary hyperoxaluria therapy market is the use of pyridoxine for stone treatment.&nbsp;<\/p>\n\n\n\n<p>Over the decades, there has not been much improvement witnessed in the PH treatment market. The treatment begins with citrates, vitamin B6, and hyperhydration. PH patients with advanced kidney failure are left with the only option of kidney transplantation. Thus, there is a clear need for novel and effective therapy options specifically for patients who have reached ESRD. On the other hand, a lack of effective therapies and limited drug options in Primary Hyperoxaluria offers immense opportunities to pharmaceutical and biotech companies to invest in the Primary hyperoxaluria market and develop innovative, pocket-friendly therapies with better safety profiles and patient adherence.<\/p>\n\n\n\n<p>Recently, in November 2020, a small interfering ribonucleic acid (RNAi) therapy, <strong>Oxlumo <\/strong>(Alnylam Pharmaceuticals) entered the PH therapy market in the US and EU for the treatment of PH1 to lower urinary oxalate levels in pediatric and adult patients. The approval marked a breakthrough in the Primary Hyperoxaluria therapy market giving an advantage to Alnylam Pharmaceuticals in the US and European PH markets; however, Japan\u2019s PH therapy market still has no approved therapies.&nbsp;<\/p>\n\n\n\n<p>The company may be enjoying a monopoly in the PH market as of now, but there are several competitors such as Oxthera, Dicerna Pharmaceuticals, Inc., Allena Pharmaceuticals, Biocodex, and others, trailing behind with their novel therapies in the late stage of clinical trials. At present, the <a href=\"https:\/\/www.delveinsight.com\/report-store\/primary-hyperoxaluria-pipeline-insight?utm_source=blog&amp;utm_medium=article&amp;utm_campaign=v\">Primary hyperoxaluria pipeline <\/a>comprises two pipeline therapies in Phase III of the clinical trial namely <strong>Oxabact <\/strong>(OxThera) and <strong>Nedosiran <\/strong>(Dicerna Pharmaceuticals). These therapies are expected to get launched in the PH market in the next decade and are anticipated to negatively impact the market share of Oxulmo attributable to their efficiency in all types of PH and promising clinical activity.<\/p>\n\n\n\n<p><strong><em>DelveInsight estimates that the <\/em><\/strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/primary-hyperoxaluria-market?utm_source=blog&amp;utm_medium=article&amp;utm_campaign=v\"><strong><em>Primary hyperoxaluria market size<\/em><\/strong><\/a><strong><em> is expected to soar at a CAGR of 40.40% during the study period 2018-30 in the 7MM.<\/em><\/strong><\/p>\n\n\n\n<p>Even so, the overall PH market size shall experience a positive shift owing to an increase in the prevalence, a surge in the PH therapeutic clinical activity, and emerging pipeline therapy options. A lack of approved therapies in Primary hyperoxaluria gives room to pharma and biotech companies to explore with their novel innovative approaches towards addressing the rare disease, PH. Clearly,&nbsp; better diagnostics modalities and a better understanding of the disease clinical course shall further augment the addition of revenue to the PH market share.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Primary hyperoxaluria (PH) is a rare autosomal genetic form of Hyperoxaluria, a condition that leads to the excessive urinary excretion of oxalate. Till now, three distinct hereditary enzymatic deficiencies have been identified as a cause of PH, namely, PH type 1 (PH1), type 2 (PH2), and type 3 (PH3), with PH1 as the most common [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":13068,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17,17434],"tags":[18802,18800,18801],"industry":[17225],"therapeutic_areas":[17240,17238,17234],"class_list":["post-13065","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","category-facts-and-figures","tag-hyperoxaluria","tag-primary-hyperoxaluria","tag-primary-hyperoxaluria-market","industry-pharmaceutical","therapeutic_areas-endocrinology-and-metabolic-disorders","therapeutic_areas-genetic-disorders","therapeutic_areas-rare-diseases"],"acf":[],"yoast_head":"<!-- This site is optimized with the 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