{"id":13241,"date":"2021-08-31T18:11:24","date_gmt":"2021-08-31T12:41:24","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=13241"},"modified":"2021-10-11T14:35:54","modified_gmt":"2021-10-11T09:05:54","slug":"pharma-news","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/pharma-news","title":{"rendered":"Ascendis&#8217;s SKYTROFA; MicroTransponder\u2019s VNS System (Vivistim); BioMarin&#8217;s Voxzogo; Zimmer-Canary&#8217;s Smart Knee Implant; COVID-19 impact on Solid Organ Transplants"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-69f8247e0f3fe\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-69f8247e0f3fe\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news\/#FDAs_Green_Flag_to_Ascendiss_Once-Weekly_SKYTROFA_for_Treatment_of_Pediatric_Growth_Hormone_Deficiency\" >FDA&#8217;s Green Flag to Ascendis&#8217;s Once-Weekly SKYTROFA for Treatment of Pediatric Growth Hormone Deficiency<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news\/#FDA_Sanctions_First_Vagus_Nerve_Stimulation_Developed_by_MicroTransponder_An_Implant_for_Stroke_Rehabilitation\" >FDA Sanctions First Vagus Nerve Stimulation Developed by MicroTransponder, An Implant for Stroke Rehabilitation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news\/#BioMarins_Voxzogo_Gets_European_Commissions_Nod_to_Treat_Achondroplasia_FDA_Approval_Anticipated\" >BioMarin&#8217;s Voxzogo Gets European Commission&#8217;s Nod to Treat Achondroplasia, FDA Approval Anticipated<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news\/#Changing_the_future_of_Orthopedics_%E2%80%93_FDAs_De_Novo_Classification_Grant_to_Zimmer_Biomet_and_Canary_Medicals_First_Smart_Knee_Implant\" >Changing the future of Orthopedics &#8211; FDA\u2019s De Novo Classification Grant to Zimmer Biomet and Canary Medical&#8217;s First Smart Knee Implant<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news\/#A_Study_at_the_European_Society_for_Organ_Transplantation_ESOT_Congress_2021_Exhibited_Massive_Decrement_in_Organ_Transplantation_During_the_First_Wave_of_the_COVID-19_Pandemic\" >A Study at the European Society for Organ Transplantation (ESOT) Congress 2021 Exhibited Massive Decrement in Organ Transplantation During the First Wave of the COVID-19 Pandemic<\/a><\/li><\/ul><\/nav><\/div>\n\n<h2 class=\"wp-block-heading\" id=\"h-fda-s-green-flag-to-ascendis-s-once-weekly-skytrofa-for-treatment-of-pediatric-growth-hormone-deficiency\"><span class=\"ez-toc-section\" id=\"FDAs_Green_Flag_to_Ascendiss_Once-Weekly_SKYTROFA_for_Treatment_of_Pediatric_Growth_Hormone_Deficiency\"><\/span><strong>FDA&#8217;s Green Flag to Ascendis&#8217;s Once-Weekly SKYTROFA for Treatment of Pediatric Growth Hormone Deficiency<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p id=\"h-for-the-treatment-of-growth-failure-due-to-deficiency-of-growth-hormones-the-usfda-approved-ascendis-pharma-s-skytrofa-lonapegsomatropin-tcgd-for-children-of-one-year-and-older-suffering-from-an-improper-secretion-of-endogenous-growth-hormone-gh-growth-hormone-deficiency-commonly-known-as-dwarfism-can-constitute-short-stature-and-complications-with-metabolism-which-arise-due-to-inadequate-production-of-growth-hormones-by-the-pituitary-gland-inside-the-body\">For the treatment of growth failure due to deficiency of growth hormones, the USFDA approved <a href=\"https:\/\/delveinsightblog.wordpress.com\/2021\/05\/27\/delveinsight-reports-contusion-market-growth-hormone-deficiency-market-giant-papillary-conjunctivitis-market-chronic-pruritus-market\/\"><strong>Ascendis Pharma&#8217;s<\/strong><\/a> Skytrofa (lonapegsomatropin-tcgd) for children of one year and older suffering from an improper secretion of endogenous growth hormone (GH).<strong> <\/strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/pediatric-growth-hormone-deficiency-market\"><strong>Growth Hormone Deficiency<\/strong><\/a>, commonly known as dwarfism, can constitute short stature and complications with metabolism, which arise due to inadequate production of growth hormones by the pituitary gland inside the body.<\/p>\n\n\n\n<p id=\"h-this-approval-became-denmark-based-pharmaceutical-s-first-fda-approval-beating-rival-drugs-from-pharma-giants-like-pfizer-and-opko-health-a-once-weekly-injection-skytrofa-can-be-stored-at-room-temperature-for-upto-6-months\">This approval became Denmark-based pharmaceutical&#8217;s first FDA approval beating rival drugs from pharma giants like Pfizer and Opko Health. A once-weekly injection, Skytrofa can be stored at room temperature for upto 6 months.<\/p>\n\n\n\n<p>The results were based on Phase 3, <strong>heiGHt<\/strong> study, where 161 children participated without any prior treatment and compared the results to daily injected <a href=\"https:\/\/www.delveinsight.com\/blog\/pharma-happenings-for-pfizer-opko-scone-antengene-sanbio\"><strong>Genotropin <\/strong><\/a>for around a year. It operates on Ascendis&#8217;s TransCon, short for Transient Conjugation Technology. It combines a unique potential to temporarily connect an inert carrier to a parent drug with known biology. So, the TransCon prodrugs can be designed based on the carrier used to meet a specific therapeutic goal. TransCon is widely applicable to proteins, peptides, or small molecules in multiple therapeutic areas.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FDA_Sanctions_First_Vagus_Nerve_Stimulation_Developed_by_MicroTransponder_An_Implant_for_Stroke_Rehabilitation\"><\/span><strong>FDA Sanctions First Vagus Nerve Stimulation Developed by MicroTransponder, An Implant for Stroke Rehabilitation<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>USFDA\u2019s approval to the MicroTransponder Vivistim Paired VNS System (Vivistim System) is first-of-its-kind, drug-free rehabilitation system that treats moderate to severe upper extremity motor deficits associated with chronic ischemic stroke using <a href=\"https:\/\/www.delveinsight.com\/report-store\/vagus-nerve-stimulator-market\"><strong>vagus nerve stimulation<\/strong><\/a> (VNS). The stroke occurs from blockages found in the blood flow, which travels to the brain, giving several long-lasting symptoms.<\/p>\n\n\n\n<p>Blood carries oxygen and nutrients inside the brain, and its interruption due to a stroke leads to the death of brain cells. Usually, the most prevalent stroke found among different types of stroke is &#8211; <a href=\"https:\/\/www.delveinsight.com\/report-store\/ischemic-stroke-market\"><strong>ischemic stroke<\/strong><\/a>. Here, the blood vessels connected to the brain become clogged, which obstructs the flow of blood that reaches the brain. Stroke is potentially very dangerous, going from disabilities to paralysis and even death in some cases.<\/p>\n\n\n\n<p>The Vivistim System is a newly developed rehabilitation system used for treating patients who experienced an <a href=\"https:\/\/www.delveinsight.com\/report-store\/ischemic-stroke-market\"><strong>ischemic stroke<\/strong><\/a> to stimulate the vagus nerve electrically, lessen certain deficiencies in upper limb and extremity motor function, and improve patients&#8217; ability to move their arms and hands.&nbsp;<\/p>\n\n\n\n<p>Alongside the implantable components is attached a clinician software preloaded onto a laptop and a wireless transmitter to be used only by a healthcare provider. The software lets the health care manager input required settings in the system, including amplitude, pulse, frequency, etc.<\/p>\n\n\n\n<p>The Vivistim System by MicroTransponder is a prescription device used in clinical and at-home settings to provide <a href=\"https:\/\/www.delveinsight.com\/report-store\/vagus-nerve-stimulator-market\"><strong>vagus nerve stimulation<\/strong><\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"BioMarins_Voxzogo_Gets_European_Commissions_Nod_to_Treat_Achondroplasia_FDA_Approval_Anticipated\"><\/span><strong>BioMarin&#8217;s Voxzogo Gets European Commission&#8217;s Nod to Treat Achondroplasia, FDA Approval Anticipated<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A once-daily injection administration of Voxzogo gets European Commission&#8217;s approval to treat <a href=\"https:\/\/www.delveinsight.com\/report-store\/achondroplasia-market\"><strong>Achondroplasia <\/strong><\/a>in children aged 2 years and above. Achondroplasia is short-limbed dwarfism caused by either a genetic mutation or is hereditary. People with this condition have shorter than regular limbs, i.e., arms and legs, and what usually appears is an enlarged head.&nbsp;<\/p>\n\n\n\n<p>Voxzogo becomes the very first treatment of Achondroplasia in Europe and is expecting FDA approval in the coming November. <a href=\"https:\/\/www.delveinsight.com\/report-store\/achondroplasia-market\"><strong>Achondroplasia <\/strong><\/a>is usually diagnosed at birth, so parents who want their kids to initiate the Voxzogo treatment can use the injection on their children from 2 years of age till their puberty which is where the growth plate closes. An estimate indicates around 11,000 children present throughout Europe, Africa, and the Middle East with observed Achondroplasia and are potential candidates for the treatment.&nbsp;<\/p>\n\n\n\n<p>Voxzogo, also called vosoritide, is a type of modified C-type natriuretic peptide (CNP), promoting endochondral bone growth. It is accomplished by targeting the underlying pathophysiology of <a href=\"https:\/\/www.delveinsight.com\/report-store\/achondroplasia-market\"><strong>Achondroplasia <\/strong><\/a>by down-regulating fibroblast growth factor receptor 3 (FGFR3) signaling. The result was based on a placebo-controlled, randomized, and double-blind Phase 3 study evaluating the efficacy and safety of Voxzogo, with an enrollment of 121 participants experiencing Achondroplasia. Outcomes were that Voxzogo improved the growth velocity in children from age 5 to 14 years from baseline by almost 1.57 cm.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-changing-the-future-of-orthopedics-fda-s-de-novo-classification-grant-to-zimmer-biomet-and-canary-medical-s-first-smart-knee-implant\"><span class=\"ez-toc-section\" id=\"Changing_the_future_of_Orthopedics_%E2%80%93_FDAs_De_Novo_Classification_Grant_to_Zimmer_Biomet_and_Canary_Medicals_First_Smart_Knee_Implant\"><\/span><strong>Changing the future of Orthopedics &#8211; FDA\u2019s De Novo Classification Grant to Zimmer Biomet and Canary Medical&#8217;s First Smart Knee Implant<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p id=\"h-zimmer-biomet-holdings-and-canary-medical-s-persona-iq-system-the-first-and-only-smart-knee-implant-receives-the-usfda-s-de-novo-authorization-grant-for-medical-novel-devices-they-now-have-the-free-hand-to-market-the-tibial-extension-for-the-persona-iq-system-for-a-complete-knee-replacement-surgery\"><a href=\"https:\/\/www.delveinsight.com\/blog\/medical-device-2021\"><strong>Zimmer Biomet<\/strong><\/a> Holdings and <a href=\"https:\/\/www.delveinsight.com\/blog\/technological-innovations-in-healthcare\"><strong>Canary Medical&#8217;s Persona IQ system<\/strong><\/a>, the first and only &#8220;smart&#8221; knee implant, receives the USFDA&#8217;s De Novo authorization grant for <a href=\"https:\/\/www.delveinsight.com\/blog\/medical-device-2021\"><strong>medical novel devices<\/strong><\/a>. They now have the free hand to market the tibial extension for the Persona IQ system for a complete knee replacement surgery.&nbsp;<\/p>\n\n\n\n<p>It merges a device build-up from <a href=\"https:\/\/www.delveinsight.com\/blog\/technological-innovations-in-healthcare\"><strong>Zimmer Biomet&#8217;s Persona<\/strong><\/a><strong> <\/strong>line of patient-specific implants that was previously cleared and its intelligence from Canary&#8217;s gait-tracking sensor technology. Combining both of their properties becomes a <a href=\"https:\/\/www.delveinsight.com\/blog\/medical-device-2021\"><strong>hyper-personalized system<\/strong><\/a> that can work according to customized needs of a patient&#8217;s anatomy and the presence of Centurion TE sensor, simultaneously gathering data from gait metrics like the range of motion, step count, and walking speed. So these remotely controlled, anatomically accurate implants can be considered a breakthrough technology in orthopedics.&nbsp;<\/p>\n\n\n\n<p>&#8220;We are excited to introduce Persona IQ, the world&#8217;s first and only smart knee implant, which offers a wealth of objective data to monitor patients&#8217; post-operative progress,&#8221; said Bryan Hanson, Chairman, President, and CEO of Zimmer Biomet.<\/p>\n\n\n\n<p>&#8220;After almost a decade of development and designation by FDA as a Breakthrough Device, we&#8217;re proud that our CANARY canturio&#x2122; <em>te<\/em> technology has enabled Zimmer Biomet to debut the world&#8217;s first smart knee implant. Persona IQ reflects our shared belief that automatic, reliable and accurate data collection and analysis represents the future of orthopedic care,&#8221; said William L. Hunter, MD, MSC, and CEO of Canary Medical.&nbsp;<\/p>\n\n\n\n<p>This approval comes as the second consecutive FDA grant to Zimmer Biomet soon after its clearance for Rosa Hip, part of connected orthopedic surgery technologies. Rosa Hip is a robotic surgery system to manage anterior hip replacements<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-a-study-at-the-european-society-for-organ-transplantation-esot-congress-2021-exhibited-massive-decrement-in-organ-transplantation-during-the-first-wave-of-the-covid-19-pandemic\"><span class=\"ez-toc-section\" id=\"A_Study_at_the_European_Society_for_Organ_Transplantation_ESOT_Congress_2021_Exhibited_Massive_Decrement_in_Organ_Transplantation_During_the_First_Wave_of_the_COVID-19_Pandemic\"><\/span><strong>A Study at the European Society for Organ Transplantation (ESOT) Congress 2021 Exhibited Massive Decrement in Organ Transplantation During the First Wave of the COVID-19 Pandemic<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A new global study at ESOT-European Society for Organ Transplantation Congress 2021 presented that solid <a href=\"https:\/\/www.delveinsight.com\/blog\/antibody-mediated-rejection-market\"><strong>organ transplantations<\/strong><\/a> carried out during the first wave of <a href=\"https:\/\/www.delveinsight.com\/covid19\"><strong>COVID-19<\/strong><\/a> in 2020 decreased by a massive 31% compared to 2019\u2019s data. According to modeling calculations, an estimated 48,000 years of patient life loss was found due to a slowdown in transplants.<\/p>\n\n\n\n<p>The research accumulated data from around 22 countries and revealed significant variations in the response of transplant programs to the<strong> <\/strong><a href=\"https:\/\/www.delveinsight.com\/covid19\"><strong>COVID-19 pandemic<\/strong><\/a>, with transplant activity dropping by more than 90% in some countries.<\/p>\n\n\n\n<p>As the pandemic increased, hospitals delayed potentially life-saving organ transplant surgery due to the unavailability of intensive care beds being utilized for Covid patients and concerns, including whether it was safe to treat transplant recipients in hospitals. <a href=\"https:\/\/www.delveinsight.com\/report-store\/kidney-transplant-rejection-market\"><strong>Kidney transplants <\/strong><\/a>were at the bottom of transplants occurring in almost all the countries during 2020 compared to 2019.<\/p>\n\n\n\n<p>Researchers said that while some countries experienced considerable reductions in transplant numbers, others did not even though brutal hit by Covid, meaning further analysis is required on a regional, national and global level to understand the differences.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>FDA&#8217;s Green Flag to Ascendis&#8217;s Once-Weekly SKYTROFA for Treatment of Pediatric Growth Hormone Deficiency For the treatment of growth failure due to deficiency of growth hormones, the USFDA approved Ascendis Pharma&#8217;s Skytrofa (lonapegsomatropin-tcgd) for children of one year and older suffering from an improper secretion of endogenous growth hormone (GH). Growth Hormone Deficiency, commonly known [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":13246,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[32],"tags":[10830,420,639],"industry":[17225],"therapeutic_areas":[17229,17240,17241,17245],"class_list":["post-13241","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizia","tag-covid-19","tag-news","tag-pharma-news","industry-pharmaceutical","therapeutic_areas-central-nervous-system","therapeutic_areas-endocrinology-and-metabolic-disorders","therapeutic_areas-musculoskeletal","therapeutic_areas-neurology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Ascendis&#039;s Skytrofa; BioMarin&#039;s Voxzogo; MicroTransponder\u2019s VNS System<\/title>\n<meta name=\"description\" content=\"Ascendis&#039;s SKYTROFA; MicroTransponder\u2019s VNS System; BioMarin&#039;s Voxzogo; Zimmer&#039;s Smart Knee Implant; COVID-19 impact on Organ Transplants\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ascendis&#039;s Skytrofa; BioMarin&#039;s Voxzogo; MicroTransponder\u2019s VNS System\" \/>\n<meta property=\"og:description\" content=\"Ascendis&#039;s SKYTROFA; MicroTransponder\u2019s VNS System; BioMarin&#039;s Voxzogo; Zimmer&#039;s 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