{"id":17192,"date":"2022-04-29T17:56:20","date_gmt":"2022-04-29T12:26:20","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=17192"},"modified":"2025-10-09T17:08:58","modified_gmt":"2025-10-09T11:38:58","slug":"organ-on-a-chip-market","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market","title":{"rendered":"Emerging Market for Organ on a Chip"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a0938291c6fb\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a0938291c6fb\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Organ_on_a_Chip_Device\" >Organ on a Chip Device<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Different_Organ_on_Chip_Technology\" >Different Organ on Chip Technology<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Liver_Organ_on_a_Chip\" >Liver Organ on a Chip<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Organ_on_a_Chip-Lung\" >Organ on a Chip-Lung<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Kidney_Organ_on_a_Chip\" >Kidney Organ on a Chip<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Organ_on_a_Chip-Heart\" >Organ on a Chip-Heart&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Intestine_Organ_on_a_Chip\" >Intestine Organ on a Chip<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Multi_Organ_on_a_Chip\" >Multi Organ on a Chip<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Factors_bolstering_the_growth_of_Organ_on_a_Chip_Market\" >Factors bolstering the growth of Organ on a Chip Market<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Top_players_in_the_Organ_on_a_Chip_Market\" >Top players in the Organ on a Chip Market<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#AxoSim_%E2%80%93_Los_Angeles_United_States\" >AxoSim &#8211; Los Angeles, United States<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Emulate-Massachussets_United_States\" >Emulate-Massachussets, United States<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#CN_Bio_Innovations_%E2%80%93_Cambridge_United_Kingdom\" >CN Bio Innovations &#8211; Cambridge, United Kingdom<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#TissUse_GmbH_%E2%80%93_Berlin_Germany\" >TissUse GmbH \u2013 Berlin, Germany<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#InSphero_%E2%80%93_Schlieren_Switzerland\" >InSphero &#8211; Schlieren, Switzerland<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Recent_Highlights_in_the_Organ_on_a_Chip_Market\" >Recent Highlights in the Organ on a Chip Market<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#Conclusion\" >Conclusion<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/www.delveinsight.com\/blog\/organ-on-a-chip-market\/#FAQs\" >FAQs<\/a><\/li><\/ul><\/nav><\/div>\n\n<p id=\"h-\">The organ on a chip is a microfluidic culture device that recapitulates the complicated structures and functions associated with the living human organs. The microdevices are composed of a clear flexible polymer that is almost the size of a USB memory stick and comprises hollow microfluidic channels lined up with living human organ cells and human blood vessel cells. These living, three-dimensional cross-sections of the human organs tend to provide a transparent window into their inner workings and the effects that the drugs can have on them, without involving any humans or animals.<\/p>\n\n\n\n<p>The organ on a chip has been designed in order to recreate the natural physiology and mechanical forces that are experienced by the cells within the human body in an accurate manner. The chips are made to be lined up with living human cells and their tiny fluidic channels help in reproducing both blood and\/or airflow just as within the human body. Their flexibility will in turn allow the chips for recreating breathing motions or undergoing muscular contractions. Every organ on chip comprising the lung, liver, intestine, or brain is about the size of an AA battery. The transparency of the organ on chips will allow the researchers in order to view the organ\u2019s functionality, behavior, and response at both the cellular as well as molecular level.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Organ_on_a_Chip_Device\"><\/span><strong>Organ on a Chip Device<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Need for Organ on a Chip Device<\/strong><\/p>\n\n\n\n<p>Drug development process is extremely tedious and has several demerits associated with it. It is both slow and expensive and it can take up to about 10 years with an average cost of <strong>USD 3 billion<\/strong> to bring a brand new compound from the lab bench to the market. A major reason for this inefficiency arises from the traditional reliance on testing the drugs in animals before they can be tested on humans. Moreover, the animal models do not tend to entirely reflect human physiology, suggesting that drugs that appear to be safe and effective in animals carry the risk to turn out harmful and ineffective in the case of humans. This mismatch in biology leads to several useless or toxic drugs, while they advance at a great expense through various clinical trials. On the other hand, the potentially effective compounds might actually never make it to the market. Therefore, the organ on chip model is a great alternative to human biology and diseases in vitro, in order to accelerate the development of new drugs and personalized medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Different_Organ_on_Chip_Technology\"><\/span><strong>Different Organ on Chip Technology<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-liver-organ-on-a-chip\"><span class=\"ez-toc-section\" id=\"Liver_Organ_on_a_Chip\"><\/span><strong>Liver Organ on a Chip<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The hepatic system is considered to be the major site of drug\/toxin metabolism. The liver comprises of a series of complex hepatic lobules which confer the multicellular functional communication. The maintenance of the physiology of hepatocytes for an extended period of time is quite challenging. Kane et al. had designed the first liver-based system that comprised the microfluidic pores in which the 3T3-J2 fibroblasts and the rat liver cells were cultured together in order to mimic an airway interface. The rat hepatocytes that were supposed to be cultured in the chip are capable of continuously and stably synthesizing albumin and undergoing metabolism.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Organ_on_a_Chip-Lung\"><\/span><strong>Organ on a Chip-Lung<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The gas exchange in the lungs can be regulated by the alveoli which can also be challenging to reproduce in vitro. Microfluidics is capable of establishing extracorporeal lung models as lung pathologies via accurate fluid flow, as well as sustained gaseous exchange. The current studies have also focused on regulating the airway mechanical pressure, the blood-blood barrier (BBB), and the effects of the shear forces on the pathophysiological processes.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-kidney-organ-on-a-chip\"><span class=\"ez-toc-section\" id=\"Kidney_Organ_on_a_Chip\"><\/span><strong>Kidney Organ on a Chip<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The kidneys are mainly responsible for maintaining the osmotic pressure drug excretion. The kidney toxicity will lead to an irreversible loss of renal infiltration thereby highlighting the need for drug screening systems. Both filtration and reabsorption tend to take place in the nephrons that comprise the glomerulus, renal capsules, and the renal tubule. Microfluidics also help in simulating the fluid environment that helps in supporting the tubular cell growth and helps in providing the porous membrane support for maintaining the cellular polarity. The major disadvantage associated with conventional cell culture systems is that the cell differentiation into the functional cells tends to require extended culture times and external signal detection systems.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Organ_on_a_Chip-Heart\"><\/span><strong>Organ on a Chip-Heart&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The emergence of microfluidics has given rise to in vitro bionic studies related to cardiac tissues. The myocardium can be considered to be a major component of the heart. The beating associated with the cardiomyocytes can be used in order to directly assess the drug effects and is directly related to the pumping of the heart. Also, in the year 2012, Grosberg et al. used PDMS for producing an elastic film along with a surface texture and implantable neonatal rat CMs on the membrane in order to form a muscular membrane.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-intestine-organ-on-a-chip\"><span class=\"ez-toc-section\" id=\"Intestine_Organ_on_a_Chip\"><\/span><strong>Intestine Organ on a Chip<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>The oral form of drugs has to transverse the smaller intestine in order to enter the bloodstream. Villi are considered to be the key component in absorption and their morphology can be expected to be maintained on the chip. Imura et al. had also developed the chips for simulating the intestinal system, comprising of the glass slide permeable membrane and PDMS sheet containing the channels.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-multi-organ-on-a-chip\"><span class=\"ez-toc-section\" id=\"Multi_Organ_on_a_Chip\"><\/span><strong>Multi Organ on a Chip<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>An array of physiological pathways also requires continued media circulation and inter-tissue interactions. The single organ chips tend to fail to describe the full complexity, functional changes, as well as integrity of the organ function. The \u201cmulti organ on a chip\u201d, also known as the \u201chuman organ on a chip\u201d helps in constructing the multiple organs thereby attracting obvious attention. The multi organ on a chip culture cells of different organs and tissues simultaneously are connected by channel (such as the bionic blood vessel) in order to achieve the multi-organ integration, thereby permitting the examination of interactions for establishing a system.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Factors_bolstering_the_growth_of_Organ_on_a_Chip_Market\"><\/span><strong>Factors bolstering the growth of Organ on a Chip Market<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The increasing focus on the development of animal model substitutes and disease modeling has led to an increase in the demand for organ on chips, leading to a rise in the organ on a chip market growth. For instance, on <strong>May 03, 2021,<\/strong> the <strong>Wyss Institute<\/strong>-led collaboration that was spanning four labs had used the Institute\u2019s organ on chip technology for identifying the antimalarial drug amodiaquine as a potent inhibitor for infection with the <a href=\"https:\/\/www.delveinsight.com\/blog\/covid-19-vaccine-landscape\">SARS-CoV-2<\/a>, the virus causing COVID-19.<\/li>\n\n\n\n<li>The increase in research initiatives for the development of advanced bioartificial organs has also impacted the growth of the organ on a chip market. For instance, on <strong>April 01, 2020, MIT<\/strong> researchers developed the \u201cOrgan on a chip\u201d in order to aid the process of drug development.\u00a0<\/li>\n\n\n\n<li>The increasing demand for drug screening in the healthcare sector is another factor fostering the organ on a chip market growth. There is a very high demand for animal testing alternatives in the drug screening arena. It is majorly because the organ on chip technology plays an important role in the development of drugs and vaccines that are under clinical trials.<\/li>\n\n\n\n<li>The rising demand for organ on a chip for lung-based organ culture and kidney-related applications are also among the major factors behind the growth of the organ on a chip market. The research community and the biopharmaceutical industry have mobilized with unprecedented speed against the <a href=\"https:\/\/www.delveinsight.com\/covid19\">COVID-19 pandemic<\/a>. Therefore, the organ on a chip can be assumed to be one of the most promising and go-to-technology during the development of vaccines and drugs which have been under clinical studies for the treatment of infection. For instance, in the year <strong>March 2020,<\/strong> as part of the World Health Organization\u2019s (WHO) Research and Development Blueprint response to the COVID-19 outbreak, the emulated lung chip can be used for providing the preclinical insights into the efficacy of <a href=\"https:\/\/www.delveinsight.com\/blog\/hydroxychloroquine-and-covid-19\">hydroxychloroquine for COVID-19<\/a>.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Top_players_in_the_Organ_on_a_Chip_Market\"><\/span><strong>Top players in the Organ on a Chip Market<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The organ on a chip market is emerging due to certain factors and as a result, many companies are exploring the domain. <\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"912\" height=\"423\" src=\"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/04\/29170242\/Key-Companies-in-the-Organ-on-a-Chip-Market.png\" alt=\"\" class=\"wp-image-17198\" style=\"width:912px;height:423px\" srcset=\"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/04\/29170242\/Key-Companies-in-the-Organ-on-a-Chip-Market.png 912w, https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/04\/29170242\/Key-Companies-in-the-Organ-on-a-Chip-Market-300x139.png 300w, https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/04\/29170242\/Key-Companies-in-the-Organ-on-a-Chip-Market-150x70.png 150w, https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/04\/29170242\/Key-Companies-in-the-Organ-on-a-Chip-Market-768x356.png 768w\" sizes=\"(max-width: 912px) 100vw, 912px\" \/><figcaption class=\"wp-element-caption\"><strong>Leading MedTech Giants in the Organ on a Chip Market<\/strong><\/figcaption><\/figure>\n\n\n\n<p>Some of the leading companies that are currently dominating the organ on a chip market are:<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-axosim-los-angeles-united-states\"><span class=\"ez-toc-section\" id=\"AxoSim_%E2%80%93_Los_Angeles_United_States\"><\/span><strong>AxoSim &#8211; Los Angeles, United States<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>AxoSim <\/strong>is a contract research organization that helps in empowering advancements in human neuroscience through their drug discovery platforms, comprising the NerveSim product powered by Nerve-on-a-Chip and the BrainSim. This organ on chip company helps the pharmaceutical companies in the development of drugs faster by mimicking the in vivo nervous system in an in vitro setting. The AxoSim\u2019s platforms are revolutionizing the way in which the biopharmaceutical companies help in the development of neurological drugs. AxoSim helps in delivering human data faster and easier.&nbsp; It reduces clinical failure, thereby enabling the companies to offer effective drugs quickly and at an easier cost. The company was founded for addressing unsustainably higher clinical failure rates that cost the pharmaceutical companies billions of dollars and patients waiting for new medicines as well as therapies related to <a href=\"https:\/\/www.delveinsight.com\/blog\/neurology\">neurological diseases<\/a>. The <strong>NerveSim and the BrainSim<\/strong> are the key products in AxoSim\u2019s product portfolio.<\/p>\n\n\n\n<div class=\"visualizer-front-container visualizer-lazy-render\" id=\"chart_wrapper_visualizer-17182-312666941\"><style type=\"text\/css\" name=\"visualizer-custom-css\" id=\"customcss-visualizer-17182\">.locker,.locker-loader{position:absolute;top:0;left:0;width:100%;height:100%}.locker{z-index:1000;opacity:.8;background-color:#fff;-ms-filter:\"progid:DXImageTransform.Microsoft.Alpha(Opacity=80)\";filter:alpha(opacity=80)}.locker-loader{z-index:1001;background:url(https:\/\/www.delveinsight.com\/blog\/wp-content\/plugins\/visualizer\/images\/ajax-loader.gif) no-repeat center center}.dt-button{display:none!important}.visualizer-front-container.visualizer-lazy-render{content-visibility: auto;}.google-visualization-controls-categoryfilter label.google-visualization-controls-label {vertical-align: middle;}.google-visualization-controls-categoryfilter li.goog-inline-block {margin: 0 0.2em;}.google-visualization-controls-categoryfilter li {padding: 0 0.2em;}.visualizer-front-container .dataTables_scrollHeadInner{margin: 0 auto;}<\/style><div id=\"visualizer-17182-312666941\" class=\"visualizer-front  visualizer-front-17182\"><\/div><!-- Not showing structured data for chart 17182 because title is empty --><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Emulate-Massachussets_United_States\"><\/span><strong>Emulate-Massachussets, United States<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Emulate Inc.<\/strong> is a privately held organ on chip company that helps in the creation of in vitro models for understanding how diseases, medicines, chemicals, and foods tend to affect human health. The lab-ready Human Emulation System had comprised of three basic components: Zo\u00eb\u00ae Culture Module, Organ-Chips, and analytical software applications. The platforms provide a window into the inner workings of human biology and diseases-thereby offering the researchers a new technology designed for the prediction of human response with greater precision and detail than the conventional cell culture or animal-based experimental testing. The <strong>Brain Chips, Colon Intestine-Chip, Duodenum Intestine-Chip, Kidney-Chips, Liver-Chips, and Lung-Chips<\/strong> are the key products in Emulate\u2019s product portfolio.<\/p>\n\n\n\n<div class=\"visualizer-front-container visualizer-lazy-render\" id=\"chart_wrapper_visualizer-17184-1560453705\"><style type=\"text\/css\" name=\"visualizer-custom-css\" id=\"customcss-visualizer-17184\">.locker,.locker-loader{position:absolute;top:0;left:0;width:100%;height:100%}.locker{z-index:1000;opacity:.8;background-color:#fff;-ms-filter:\"progid:DXImageTransform.Microsoft.Alpha(Opacity=80)\";filter:alpha(opacity=80)}.locker-loader{z-index:1001;background:url(https:\/\/www.delveinsight.com\/blog\/wp-content\/plugins\/visualizer\/images\/ajax-loader.gif) no-repeat center center}.dt-button{display:none!important}.visualizer-front-container.visualizer-lazy-render{content-visibility: auto;}.google-visualization-controls-categoryfilter label.google-visualization-controls-label {vertical-align: middle;}.google-visualization-controls-categoryfilter li.goog-inline-block {margin: 0 0.2em;}.google-visualization-controls-categoryfilter li {padding: 0 0.2em;}.visualizer-front-container .dataTables_scrollHeadInner{margin: 0 auto;}<\/style><div id=\"visualizer-17184-1560453705\" class=\"visualizer-front  visualizer-front-17184\"><\/div><!-- Not showing structured data for chart 17184 because title is empty --><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"CN_Bio_Innovations_%E2%80%93_Cambridge_United_Kingdom\"><\/span><strong>CN Bio Innovations &#8211; Cambridge, United Kingdom<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>CN Bio<\/strong> is a leading bioengineering organ on chip company that specializes in both the single and multi-organ microphysiological systems as well as innovative lab technologies. The company\u2019s aim is to provide systems that generate clinically translatable data that can help in enhancing the development of medicines in the future. The company\u2019s organ on a chip, also known as the PhysioMimix allows the modeling of human biology in the lab. As a micro physiological system, it can be used for culturing the healthy and diseased tissue models and studying the multi-organ interactions, and investigation of the ADME and toxicity.&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<div class=\"visualizer-front-container visualizer-lazy-render\" id=\"chart_wrapper_visualizer-17186-1767027130\"><style type=\"text\/css\" name=\"visualizer-custom-css\" id=\"customcss-visualizer-17186\">.locker,.locker-loader{position:absolute;top:0;left:0;width:100%;height:100%}.locker{z-index:1000;opacity:.8;background-color:#fff;-ms-filter:\"progid:DXImageTransform.Microsoft.Alpha(Opacity=80)\";filter:alpha(opacity=80)}.locker-loader{z-index:1001;background:url(https:\/\/www.delveinsight.com\/blog\/wp-content\/plugins\/visualizer\/images\/ajax-loader.gif) no-repeat center center}.dt-button{display:none!important}.visualizer-front-container.visualizer-lazy-render{content-visibility: auto;}.google-visualization-controls-categoryfilter label.google-visualization-controls-label {vertical-align: middle;}.google-visualization-controls-categoryfilter li.goog-inline-block {margin: 0 0.2em;}.google-visualization-controls-categoryfilter li {padding: 0 0.2em;}.visualizer-front-container .dataTables_scrollHeadInner{margin: 0 auto;}<\/style><div id=\"visualizer-17186-1767027130\" class=\"visualizer-front  visualizer-front-17186\"><\/div><!-- Not showing structured data for chart 17186 because title is empty --><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"TissUse_GmbH_%E2%80%93_Berlin_Germany\"><\/span><strong>TissUse GmbH \u2013 Berlin, Germany<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>TissUse is a vibrant growth company that had developed the \u201cMulti-Organ-Chip\u201d platform that helps in providing unparalleled preclinical insights at the systemic level using human tissues. The enabling organ on chip technology platform comprises a miniaturized construct that can closely simulate the activities of several human organs in their true physiological construct. The TissueUse\u2019s Multi-Organ Chips tend to provide a new approach for prediction, for example, the toxicity, ADME, profiles, and efficacy in vitro, thereby reducing and replacing animal laboratory animal testing and streamlining the human clinical trials.<\/p>\n\n\n\n<div class=\"visualizer-front-container visualizer-lazy-render\" id=\"chart_wrapper_visualizer-17188-1736934405\"><style type=\"text\/css\" name=\"visualizer-custom-css\" id=\"customcss-visualizer-17188\">.locker,.locker-loader{position:absolute;top:0;left:0;width:100%;height:100%}.locker{z-index:1000;opacity:.8;background-color:#fff;-ms-filter:\"progid:DXImageTransform.Microsoft.Alpha(Opacity=80)\";filter:alpha(opacity=80)}.locker-loader{z-index:1001;background:url(https:\/\/www.delveinsight.com\/blog\/wp-content\/plugins\/visualizer\/images\/ajax-loader.gif) no-repeat center center}.dt-button{display:none!important}.visualizer-front-container.visualizer-lazy-render{content-visibility: auto;}.google-visualization-controls-categoryfilter label.google-visualization-controls-label {vertical-align: middle;}.google-visualization-controls-categoryfilter li.goog-inline-block {margin: 0 0.2em;}.google-visualization-controls-categoryfilter li {padding: 0 0.2em;}.visualizer-front-container .dataTables_scrollHeadInner{margin: 0 auto;}<\/style><div id=\"visualizer-17188-1736934405\" class=\"visualizer-front  visualizer-front-17188\"><\/div><!-- Not showing structured data for chart 17188 because title is empty --><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"InSphero_%E2%80%93_Schlieren_Switzerland\"><\/span><strong>InSphero &#8211; Schlieren, Switzerland<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>InSphero<\/strong> is made for perfecting the 3D cell organ on chip technology in order to get more physiologically relevant in-vitro insights. The company aims to predict the human responses to therapies that will improve the lives of patients around the world. InSphero assay-ready spheroid microtissues have been engineered and certified for use in critical drug development applications, validated to ensure uniform size, robust functionality, and give reproducible results. This organ on chip company develops the 3D InSight\u2122 Microtissues using the most advanced 3D cell culture technologies that are available for producing highly predictive, fully QC\u2019d organotypic in vitro models ready to use in pharma drug discovery, efficacy, and safety. The microtissues form the foundation of 3D InSight\u2122 platforms in both drug discovery and safety that we all tend to rely on our research collaborations as well as services. Many of our liver and islet models are also available as assay-ready microtissues, shipped live and ready to use to labs throughout Europe and North America.<\/p>\n\n\n\n<div class=\"visualizer-front-container visualizer-lazy-render\" id=\"chart_wrapper_visualizer-17190-848673741\"><style type=\"text\/css\" name=\"visualizer-custom-css\" id=\"customcss-visualizer-17190\">.locker,.locker-loader{position:absolute;top:0;left:0;width:100%;height:100%}.locker{z-index:1000;opacity:.8;background-color:#fff;-ms-filter:\"progid:DXImageTransform.Microsoft.Alpha(Opacity=80)\";filter:alpha(opacity=80)}.locker-loader{z-index:1001;background:url(https:\/\/www.delveinsight.com\/blog\/wp-content\/plugins\/visualizer\/images\/ajax-loader.gif) no-repeat center center}.dt-button{display:none!important}.visualizer-front-container.visualizer-lazy-render{content-visibility: auto;}.google-visualization-controls-categoryfilter label.google-visualization-controls-label {vertical-align: middle;}.google-visualization-controls-categoryfilter li.goog-inline-block {margin: 0 0.2em;}.google-visualization-controls-categoryfilter li {padding: 0 0.2em;}.visualizer-front-container .dataTables_scrollHeadInner{margin: 0 auto;}<\/style><div id=\"visualizer-17190-848673741\" class=\"visualizer-front  visualizer-front-17190\"><\/div><!-- Not showing structured data for chart 17190 because title is empty --><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Recent_Highlights_in_the_Organ_on_a_Chip_Market\"><\/span><strong>Recent Highlights in the Organ on a Chip Market<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>On <strong>October 12, 2021, Koppes<\/strong> was awarded a <strong>USD 1.96 million<\/strong> early-stage investigator grant from NIH.<\/li>\n\n\n\n<li>On <strong>September 07, 2021,<\/strong> a <strong>Boston\u2019s<\/strong> biotech startup, <strong>Emulate <\/strong>that was working on the \u201cOrgan on a Chip\u201d system raised approximately <strong>USD 82 million<\/strong>.<\/li>\n\n\n\n<li>On <strong>March 10, 2021<\/strong>, the organ on a chip project received a huge grant in order to make the leap from the lab.<\/li>\n\n\n\n<li>On <strong>March 02, 2021<\/strong>, <strong>CN Bio<\/strong> had awarded <strong>Innovate UK<\/strong> grant for developing the single and multi-organ models for COVID-19 research.<\/li>\n\n\n\n<li>On <strong>September 29, 2020, NIH<\/strong> awarded <strong>USD 35.5 million<\/strong> for using the tiny, bioengineered organ models for improving the development and design of the clinical trial.<\/li>\n\n\n\n<li>On <strong>April 01, 2020<\/strong>, <strong>MIT Researchers<\/strong> developed the \u201cOrgan on a chip\u201d model that can aid in the drug development process.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span><strong>Conclusion<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>The development of an organ on a chip has attracted worldwide attention, thereby making greater scientific advancements in the organ on a chip market. Various numbers of organ on a chip device have been designed and prepared so far by several key organ on chip companies. Numerous human organs have been studied thoroughly for the construction of the organ on a chip device. The ultimate goal of an organ on a chip device is that it involves the integration of numerous organs onto a single chip and thereby building a complicated multi organ on a chip model, achieving a \u201chuman-on-a-chip\u201d.<\/p>\n\n\n\n<p>Furthermore, organ on a chip devices has seen widespread use in biomedical science and technology, including experimental regenerative medicine and precision healthcare. The fundamental advantages of organ on a chip technology are the ability to create a customized human model with functional responses at the organ or tissue level, avoiding the need for animal models, vastly improving novel drug discovery processes for personal healthcare, and providing new opportunities in the organ on a chip market. The study of internal irradiation for humans is an emerging organ on a chip application that presents problems because of the lack of a defined model for risk calculation of internal irradiation.<\/p>\n\n\n\n<p>Despite the organ on a chip device which is being constructed rapidly, the humans-on-a-chip theory remains quite distant. The PDMS material or the polydimethylsiloxane material is relatively thicker than the in vivo morphology, however, it is the most widely used material for development. A decrease in the absorbance of small hydrophobic molecules will also affect solvent safety and efficacy. Therefore, it is necessary for the identification of suitable alternative materials.<\/p>\n\n\n\n<p>The other major problem that can be observed at present is that the manufacturing organ on a chip cost and the experimental implementation is expensive and time-consuming, which is not at all conducive to the widespread use and development of the organ chips, therefore the components should be of lower cost and should be easier to dispose of. More expensive components should be considered to be reusable. Also, in terms of the integrated system components, the media volume and the connector size should be reduced for general usage. The collection of the samples on the chip might also interfere with the operations, thereby resulting in changes in the concentration of various metabolites. Thus, more suitable types of sensors are required for such purposes. Also, universal cell culture mediums that seemed to be suitable for different types of organs are also required. Most critically, as the number of organs on the chip tends to increase, the functionality tends to become more complex and the generated data carries non-translatable risks.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-faqs\"><span class=\"ez-toc-section\" id=\"FAQs\"><\/span>FAQs<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<div class=\"schema-faq wp-block-yoast-faq-block\"><div class=\"schema-faq-section\" id=\"faq-question-1760009894209\"><strong class=\"schema-faq-question\"><strong>What types of organs can be modeled on a chip?<\/strong><\/strong> <p class=\"schema-faq-answer\">Various organs have been successfully modeled on chips, including Liver-on-a-Chip, Lung-on-a-Chip, Kidney-on-a-Chip, Intestine-on-a-Chip, Heart-on-a-Chip, and Multi-Organ-on-a-Chip.<\/p> <\/div> <div class=\"schema-faq-section\" id=\"faq-question-1760009900312\"><strong class=\"schema-faq-question\"><strong>Who are the leading companies in the organ-on-a-chip market?<\/strong><\/strong> <p class=\"schema-faq-answer\">Some of the leading companies that are currently dominating the organ on a chip market are AxoSim, Emulate, CN Bio Innovations, TissUse GmbH, InSphero, and others.<\/p> <\/div> <div class=\"schema-faq-section\" id=\"faq-question-1760009913106\"><strong class=\"schema-faq-question\"><strong>What are the potential applications of organ-on-a-chip technology?<\/strong><\/strong> <p class=\"schema-faq-answer\">Applications span various fields, including Drug development, Disease modeling, Personalized medicine, Regenerative medicine, and Toxicology testing.<\/p> <\/div> <div class=\"schema-faq-section\" id=\"faq-question-1760009923503\"><strong class=\"schema-faq-question\"><strong>What is the market outlook for organ-on-a-chip technology?<\/strong><\/strong> <p class=\"schema-faq-answer\">The organ-on-a-chip market is experiencing significant growth, driven by technological advancements, increased research funding, and the demand for more accurate and ethical testing methods. This trend is expected to continue as the technology matures and finds broader applications in biomedical research and healthcare.<\/p> <\/div> <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Key Companies in the Organ on a Chip Market<\/p>\n","protected":false},"author":6,"featured_media":17204,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[10830,17020,17021,16975,19295],"industry":[17226],"therapeutic_areas":[17229,17240,17245,17243],"class_list":["post-17192","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-covid-19","tag-medical-devices","tag-medical-devices-market","tag-medtech-market","tag-organ-on-a-chip","industry-medical-devices","therapeutic_areas-central-nervous-system","therapeutic_areas-endocrinology-and-metabolic-disorders","therapeutic_areas-neurology","therapeutic_areas-respiratory-diseases"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Organ on a Chip Market: Key Trends, Developments and Major Companies<\/title>\n<meta name=\"description\" content=\"The development in the organ on a chip market has attracted worldwide attention. 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This trend is expected to continue as the technology matures and finds broader applications in biomedical research and healthcare.","inLanguage":"en-US"},"inLanguage":"en-US"}]}},"author_meta":{"display_name":"DelveInsight","author_link":"https:\/\/www.delveinsight.com\/blog\/author\/arawat"},"featured_img":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/04\/29175529\/Organ-on-a-Chip-Market-Trends-and-Developments-300x187.png","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Articles<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Articles<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">COVID-19<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Medical Devices<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Medical Devices Market<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">MedTech Market<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Organ on a Chip<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">COVID-19<\/span>","<span class=\"advgb-post-tax-term\">Medical Devices<\/span>","<span class=\"advgb-post-tax-term\">Medical Devices Market<\/span>","<span class=\"advgb-post-tax-term\">MedTech Market<\/span>","<span class=\"advgb-post-tax-term\">Organ on a Chip<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 4 years ago","modified":"Updated 7 months ago"},"absolute_dates":{"created":"Posted on Apr 29, 2022","modified":"Updated on Oct 9, 2025"},"absolute_dates_time":{"created":"Posted on Apr 29, 2022 5:56 pm","modified":"Updated on Oct 9, 2025 5:08 pm"},"featured_img_caption":"Organ on a Chip Market Trends and Developments","series_order":"","_links":{"self":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/17192","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/comments?post=17192"}],"version-history":[{"count":1,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/17192\/revisions"}],"predecessor-version":[{"id":33643,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/17192\/revisions\/33643"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media\/17204"}],"wp:attachment":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media?parent=17192"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/categories?post=17192"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/tags?post=17192"},{"taxonomy":"industry","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/industry?post=17192"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/therapeutic_areas?post=17192"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}