{"id":18004,"date":"2022-07-15T17:33:42","date_gmt":"2022-07-15T12:03:42","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=18004"},"modified":"2022-08-25T09:44:41","modified_gmt":"2022-08-25T04:14:41","slug":"denovoskin-personalized-skin-graft","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/denovoskin-personalized-skin-graft","title":{"rendered":"Can denovoSkin Be A Lifesaver for Burn Victims?"},"content":{"rendered":"\n

Burn is a global public health problem, causing more than 180,000<\/strong> deaths per year across the world. The vast majority of these occur in low- and middle-income nations. Moreover, non-fatal burns are a primary source of morbidity, resulting in lengthy hospitalization, deformity, and disability, as well as stigma and rejection. As per the analysis conducted by DelveInsight, among the seven major countries [the US, EU-5 (Germany, France, Italy, Spain, and the UK), and Japan], the burden of burn victims is high. In the US alone, the incident population of burn patients<\/a> requiring treatment was around 662K<\/strong> in 2021, which is expected to increase at a CAGR of 0.69%<\/strong> by 2032 in our forecasted period of 11 years (2022\u20132032).<\/p>\n\n\n\n

Burn injuries are often overlooked injuries responsible for causing significant morbidity and mortality. Severe burns are associated with an immune and inflammatory response, metabolic changes, and distributive shock, all of which are difficult to manage and can lead to multiple organ failures. They cause profound long-term changes that are needed to be addressed to maximize the quality of life. These injuries are generally classified based on their severity, depth, and size.<\/p>\n\n\n\n

Re-epithelialization in severe cases of burns is often difficult. Skin autografting by using full-thickness skin grafts (FTSGs) or a split-thickness skin graft (STSG) is used to treat the severe cases of burn victims<\/a> whose dermis is lost and have a full-thickness defect and is not possible for surgeons to treat. These grafts are harvested from the patients themselves and possess huge disadvantages. First, in the acute cases of burns, there is no site from where grafts can be harvested, and finding a match for allotransplantation is impossible in emergencies. Second, the harvested sites are scarred for life.<\/p>\n\n\n\n

CUTISS AG<\/strong>, a Swiss company, focused on regenerative skin medicine and tissue engineering, is developing an Advanced Therapy Medicinal Product (ATMP), denovoSkin,<\/strong> comprising cells isolated from a stamp-sized patient split-thickness biopsy and cultured over a collagen hydrogel. Re-harvesting and meshing of STSG have always been a major problem with the grafts available in the burns market. denovoSkin is a dermo-epidermal skin graft that addresses the issue of insufficient permanent skin coverage, which is a major problem in case of severe burn injuries. The Phase I burns clinical trials<\/strong> revealed a well-stratified epidermis and a dermal compartment, studied over 3 months.<\/p>\n\n\n\n

The current treatment for burns<\/a> is mainly dominated by advanced dressings, traditional burn care products, biologics, and others. Advanced dressings include alginate dressings, hydrogel dressings, foam dressings, hydrocolloid dressings, collagen dressings, <\/strong>and <\/strong>others. Biologics, including skin grafts and other traditional burn care products, are also widely used. The burn treatments and rehabilitation available for burns are quite expensive and still have huge unmet needs. <\/p>\n\n\n\n

Created with Highcharts 10.2.0<\/desc><\/rect><\/clipPath><\/rect><\/clipPath><\/rect><\/clipPath><\/defs><\/rect><\/rect><\/g><\/path><\/path><\/path><\/path><\/g><\/path><\/path><\/path><\/path><\/path><\/path><\/g><\/rect><\/path><\/g>Market Size in USD Million<\/text><\/path><\/g><\/rect><\/rect><\/rect><\/g><\/g><\/g>Burns Market Insight<\/text>Burns Market Size in 2021<\/text><\/text>827\u200b<\/tspan><\/tspan>827<\/text><\/g>491\u200b<\/tspan><\/tspan>491<\/text><\/g>222\u200b<\/tspan><\/tspan>222<\/text><\/g><\/g>US<\/text>EU5<\/text>Japan<\/text><\/g>0<\/text>200<\/text>400<\/text>600<\/text>800<\/text>1000<\/text><\/g>Burns Market Forecast – 2032<\/text><\/g><\/svg><\/div>