{"id":19837,"date":"2022-11-25T12:05:53","date_gmt":"2022-11-25T06:35:53","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=19837"},"modified":"2023-04-17T16:14:25","modified_gmt":"2023-04-17T10:44:25","slug":"egfr-and-alk-mutations-in-east-asian-lung-cancer-market","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market","title":{"rendered":"ESMO Asia 2022: Role of EGFR and ALK mutations in the East Asian Lung Cancer Market"},"content":{"rendered":"\n

Lung Cancer presents a heavy health and economic burden in Asia, being the most common form of cancer, with 60% of the world\u2019s lung cancers being diagnosed there<\/strong>. Lung cancer is also present in more than 30% of non-smokers in Asia<\/strong>, specifically in adenocarcinomas, which is a subtype largely defined by oncogenic driver gene mutations. Compared to that, in western countries<\/strong>, only about 10% of lung cancer patients are non-smokers<\/strong>. <\/p>\n\n\n\n

Epidermal Growth Factor Receptor (EGFR) and Anaplastic Lymphoma Kinase (ALK) are common sites for driver gene mutations; which are believed to vary significantly based on ethnicities, with EGFR mutations<\/strong> being present<\/strong> in about 15%<\/strong> of all lung adenocarcinoma patients in US<\/strong>, but in East Asia<\/strong>, they are present in about 46%<\/strong> patients. Similarly, ALK mutations are present in about 6%<\/strong> of adenocarcinoma patients in the West<\/strong> while being present in about 12%<\/strong> of patients in East Asia<\/strong>. <\/p>\n\n\n\n

Mutation status is of relevance only in late-stage patients, where oncogenic mutations like EGFR and ALK are used as key biomarkers for the detection, treatment selection, and monitoring of patients. These mutations are assessed by doing comprehensive biomarker testing on the blood assay of patients. With about 70% of patients with NSCLC being diagnosed in later stages<\/strong>, these driver mutations have risen in prominence in the prognosis of late-stage patients.<\/p>\n\n\n\n

Most common EGFR mutations in East Asian NSCLC-adenocarcinoma patients<\/strong><\/p>\n\n\n\n

\n\n\t\n\t\t\n\t\t\n\t\t\n\t<\/colgroup>\n\t\n\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t
\n\t\t\t

Mutation Type<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Specific Function<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Occurrence<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

exon 19 deletion<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

NIL<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

85-90%<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

exon 21 (L858R) substitution<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

T790M<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

TKI-resistance<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

~3%<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

exon 20 insertion<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t<\/tbody>\n<\/table>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n

Treatment of EGFR-positive NSCLC often faces resistance issues, wherein patients being treated with therapies start developing resistance. In first and second-generation TKIs, this resistance is developed by T790M or exon 20 insertion mutations. Even patients receiving third-generation treatments are prone to developing resistance. <\/p>\n\n\n\n

List of EGFR-TKIs used in East Asia<\/strong><\/p>\n\n\n\n

\n\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t<\/colgroup>\n\t\n\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t
\n\t\t\t

Generation<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Drug<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Company<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Specifics<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

First-Gen<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

IRESSA<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

AstraZeneca<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

reversible TKI<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

TARCEVA<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Genentech<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

reversible TKI<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

CONMANA<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Betta  Pharmaceuticals<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

reversible TKI<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

Second-Gen<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

GILOTRIF<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Boehringer Ingelheim<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

irreversible TKI<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

VIZIMPRO<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Pfizer<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

irreversible TKI<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

Third-Gen<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

TAGRISSO<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

AstraZeneca<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

irreversible TKI, specifically targeting T970M<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

AMEILE<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Jiangsu Hansoh <\/span><\/span><\/span><\/span><\/span><\/span> <\/span><\/span><\/span><\/span><\/span><\/span>Pharmaceutical<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

irreversible TKI, specifically targeting T970M<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

IVESA<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Allist Pharmaceuticals<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

irreversible TKI, specifically targeting T970M<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t<\/tbody>\n<\/table>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n

There has been a Pan-Asian adaptation<\/strong> of the European Society for Medical Oncology (ESMO) guidelines<\/strong>, which was developed in collaboration with several Asian oncological societies like the Chinese Society of Clinical Oncology, Japanese Society of Medical Oncology, Korean Society of Medical Oncology, and others. These guidelines recommend first-line therapy with EGFR TKIs, although with no preference for any particular therapy. Although physicians prefer the allocation of first and second-generation therapies to patients before allocating them to resistance-specific third-generation therapies. They not only ensure patients\u2019 treatment regimen are limited by resistance but also ensures the cost-effectiveness of their treatment.<\/p>\n\n\n\n

In the second-line setting, the guidelines recommend TAGRISSO<\/strong> for patients testing positive for EGFR T790M mutation or those with central nervous system disease. Of note, the first and second-generation EGFR TKIs<\/strong> are reimbursed<\/strong> in all countries, and TAGRISSO<\/strong> is reimbursed only in<\/strong> China, Japan, and Korea<\/strong>. Although there has been a lack of therapies addressing exon 20 insertions acquired resistance in the Asian markets, the approvals of third-generation EGFR-TKIs that specifically target exon 20 insertions like RYBREVANT [Janssen]<\/strong> and EXKIVITY [Takeda]<\/strong> by the US FDA goes to show their arrival, and of similar therapies in the Asian markets soon.<\/p>\n\n\n\n

TAGRISSO (Osimertinib)<\/strong> is a third-generation, irreversible EGFR-TKI<\/strong>. It was first approved in China<\/strong> in March 2017<\/strong> and added to the National Reimbursement Drug List (NRDL)<\/strong> effective from January 2019<\/strong> for the 2nd-line treatment<\/strong> of adult patients with locally-advanced or metastatic EGFR T790M mutation-positive NSCLC, whose disease has progressed on or after EGFR-TKI therapy. In September 2019<\/strong>, it was also approved as a first-line treatment<\/strong> for EGFR-mutated NSCLC and later included in the NRDL<\/strong>. Further, in April 2021<\/strong>, TAGRISSO became the only approved adjuvant treatment<\/strong> for patients with early-stage<\/strong> EGFR-positive cancer. <\/p>\n\n\n\n

TAGRISSO has been quite a profitable asset for AstraZeneca, being used as a treatment option across various lines of treatment in Asia, and also attaining reimbursement for them, increasing its market access across various patient groups. Although TAGRISSO faced struggles in 2021 in China<\/strong>, having a 10% decline in sales<\/strong> till September in China; they expect to counter it by implementing a price cut<\/strong>. AstraZeneca expects the sales volume of TAGRISSO to increase, hoping for it to compensate for the price reduction they took to gain national coverage. Amidst all this, AstraZeneca still managed to achieve a revenue of 1,336 million USD<\/strong> in Emerging Markets from TAGRISSO, being their largest-selling product of 2021<\/strong>.<\/p>\n\n\n\n

RYBREVANT is a bispecific antibody targeting EGFR and MET. It has two mechanisms of action:<\/p>\n\n\n\n

    \n
  1. Blocking ligand binding and degradation of EGFR and MET<\/li>\n\n\n\n
  2. Antibody-dependent cellular cytotoxicity and trogocytosis<\/li>\n<\/ol>\n\n\n\n

    In May 2021, it became the first targeted therapy approved by the US FDA for the treatment of NSCL patients with EGFR exon 20 insertion mutations who progressed from platinum chemotherapy. It is yet to gain approval in Asian markets, but Janssen is actively pursuing its developments there. Janssen is also pursuing the combination of amivantamab and lazertinib in EGFR-positive NSCLC patients who progressed on TAGRISSO<\/strong>.<\/p>\n\n\n\n

    Bispecific mAbs in development in East Asia<\/strong><\/p>\n\n\n\n

    \n\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t<\/colgroup>\n\t\n\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t
    \n\t\t\t

    Drug<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Company<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Targets<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Phase<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Line of Therapy<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

    \n\t\t\t

    RYBREVANT<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Janssen<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    EGFR and MET<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    III<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    1<\/span><\/span><\/span><\/span><\/span><\/span>st<\/sup><\/span><\/span><\/span><\/span><\/span><\/span> line<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

    \n\t\t\t

    SI-B001<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Sichuan Baili Pharmaceutical<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    EGFR and HER3<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    II\/III<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    2<\/span><\/span><\/span><\/span><\/span><\/span>nd<\/sup><\/span><\/span><\/span><\/span><\/span><\/span> line<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

    \n\t\t\t

    AK-112<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Akeso Biopharma<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    PD-1 and VGEF<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    III<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    2<\/span><\/span><\/span><\/span><\/span><\/span>nd<\/sup><\/span><\/span><\/span><\/span><\/span><\/span> line<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t<\/tbody>\n<\/table>\n<\/div>\n\n\n\n

    <\/div>\n\n\n\n

    For ALK mutations, standard chemotherapy is often used as the first line of therapy before EML4-ALK discovery. <\/p>\n\n\n\n

    List of ALK inhibitors used in East Asia<\/strong><\/p>\n\n\n\n

    \n\n\t\n\t\t\n\t\t\n\t\t\n\t<\/colgroup>\n\t\n\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t
    \n\t\t\t

    Generation<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Drug<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Company<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

    \n\t\t\t

    First-Gen<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    XALKORI<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Pfizer<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

    \n\t\t\t

    Second-Gen<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    ZYKADIA<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Novartis<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

    \n\t\t\t

    ALECENSA<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Genentech<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

    \n\t\t\t

    ALUNBRIG<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Takeda<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

    \n\t\t\t

    ENSACOVE<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Betta Pharmaceuticals<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

    \n\t\t\t

    Third-Gen<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    LORBRENA<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

    		\n\t\t\t

    Pfizer<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t<\/tbody>\n<\/table>\n<\/div>\n\n\n\n

    <\/div>\n\n\n\n

    Of these ALK-TKIs, only ENSACOV (ensartinib) is produced in China<\/strong>. It received its first National Medical Products Administration (NMPA) approval on December 2020<\/strong>, as a second-line treatment<\/strong> of choice for XALKORI (crizotinib) resistant patients of ALK-positive NSCLC, in China. In March 2022<\/strong>, the NMPA also approved ENSACOV<\/strong> as a first-line treatment<\/strong> of ALK-positive NSCLC. <\/p>\n\n\n\n

    The approval of ensartinib is set to have a significant impact on the treatment landscape of ALK-positive NSCLC, presenting itself as the most cost-effective option, when compared to other therapies. It was a cost-effective option compared with crizotinib, and was a dominant alternative to ZYKADIA (ceritinib)<\/strong> and ALUNBRIG (brigatinib)<\/strong>; and although LORBRENA (lorlatinib) <\/strong>and ALECENSA (alectinib)<\/strong> were associated with prolonged survival compared with ensartinib, they were less cost-effective than ensartinib due to the overwhelming total costs. Pfizer’s LORBRENA (lorlatinib)<\/strong> was the first third-generation ALK inhibitor<\/strong> approved in China<\/strong>, on April 2022<\/strong>, for the treatment of ALK-positive advanced NSCLC<\/strong>.<\/p>\n\n\n\n

    Brain Metastasis<\/strong> seems to be quite common in EGFR-positive and ALK-positive NSCLC patients, developing in up to 50 to 60% of patients<\/strong>. And although the primary choice of treatment is radiation therapy in combination with first-gen EGFR or ALK TKIs due to its low-cost, second and third-generation TKIs are slowly replacing them due to their improved action on brain metastasis as well.<\/p>\n\n\n\n

    The treatment landscape for NSCLC has evolved substantially over the past few decades. With the availability of several targeted treatments, there is substantial improvement in survival, making NSCLC a chronic disease that patients can survive over the years rather than months. Patients also understand the need for multiple lines of targeted therapies as the tumour eventually mutates.<\/p>\n\n\n\n

    \"\"<\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"

    Lung Cancer presents a heavy health and economic burden in Asia, being the most common form of cancer, with 60% of the world\u2019s lung cancers being diagnosed there. Lung cancer is also present in more than 30% of non-smokers in Asia, specifically in adenocarcinomas, which is a subtype largely defined by oncogenic driver gene mutations. […]<\/p>\n","protected":false},"author":6,"featured_media":19846,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[17518,137,841,927,19725,19959,19958,6733,979,12555,1111,12558,12560,19011],"industry":[17225],"therapeutic_areas":[17228],"class_list":["post-19837","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-alk-mutations","tag-cancer","tag-cancer-research","tag-cancer-treatment","tag-esmo-2022","tag-esmo-asia","tag-esmo-asia-2022","tag-non-small-cell-lung-cancer","tag-non-small-cell-lung-cancer-nsclc","tag-non-small-cell-lung-cancer-market","tag-nsclc","tag-nsclc-market","tag-nsclc-pipeline","tag-nsclc-treatment","industry-pharmaceutical","therapeutic_areas-oncology"],"acf":[],"yoast_head":"\nEGFR and ALK Mutations in East Asian Lung Cancer Market | Analysis<\/title>\n<meta name=\"description\" content=\"The treatment landscape for EGFR and ALK mutations in the East Asian Lung Cancer Market is expected to evolve with the launch of therapies\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EGFR and ALK Mutations in East Asian Lung Cancer Market | Analysis\" \/>\n<meta property=\"og:description\" content=\"The treatment landscape for EGFR and ALK mutations in the East Asian Lung Cancer Market is expected to evolve with the launch of therapies\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market\" \/>\n<meta property=\"og:site_name\" content=\"DelveInsight Business Research\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/DelveInsight-1423323754607782\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-11-25T06:35:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-17T10:44:25+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/11\/25120126\/EGFR-and-ALK-mutations-in-the-East-Asian-Lung-Cancer-Market.png\" \/>\n\t<meta property=\"og:image:width\" content=\"772\" \/>\n\t<meta property=\"og:image:height\" content=\"482\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"DelveInsight\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@DelveInsight\" \/>\n<meta name=\"twitter:site\" content=\"@DelveInsight\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"DelveInsight\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"EGFR and ALK Mutations in East Asian Lung Cancer Market | Analysis","description":"The treatment landscape for EGFR and ALK mutations in the East Asian Lung Cancer Market is expected to evolve with the launch of therapies","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market","og_locale":"en_US","og_type":"article","og_title":"EGFR and ALK Mutations in East Asian Lung Cancer Market | Analysis","og_description":"The treatment landscape for EGFR and ALK mutations in the East Asian Lung Cancer Market is expected to evolve with the launch of therapies","og_url":"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market","og_site_name":"DelveInsight Business Research","article_publisher":"https:\/\/www.facebook.com\/DelveInsight-1423323754607782\/","article_published_time":"2022-11-25T06:35:53+00:00","article_modified_time":"2023-04-17T10:44:25+00:00","og_image":[{"width":772,"height":482,"url":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/11\/25120126\/EGFR-and-ALK-mutations-in-the-East-Asian-Lung-Cancer-Market.png","type":"image\/png"}],"author":"DelveInsight","twitter_card":"summary_large_image","twitter_creator":"@DelveInsight","twitter_site":"@DelveInsight","twitter_misc":{"Written by":"DelveInsight","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market","url":"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market","name":"EGFR and ALK Mutations in East Asian Lung Cancer Market | Analysis","isPartOf":{"@id":"https:\/\/www.delveinsight.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market#primaryimage"},"image":{"@id":"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market#primaryimage"},"thumbnailUrl":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/11\/25120126\/EGFR-and-ALK-mutations-in-the-East-Asian-Lung-Cancer-Market.png","datePublished":"2022-11-25T06:35:53+00:00","dateModified":"2023-04-17T10:44:25+00:00","author":{"@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/0d96a31a370c143ffdb481d985d7edfd"},"description":"The treatment landscape for EGFR and ALK mutations in the East Asian Lung Cancer Market is expected to evolve with the launch of therapies","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.delveinsight.com\/blog\/egfr-and-alk-mutations-in-east-asian-lung-cancer-market#primaryimage","url":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/11\/25120126\/EGFR-and-ALK-mutations-in-the-East-Asian-Lung-Cancer-Market.png","contentUrl":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/11\/25120126\/EGFR-and-ALK-mutations-in-the-East-Asian-Lung-Cancer-Market.png","width":772,"height":482,"caption":"EGFR and ALK mutations in the East Asian Lung Cancer Market"},{"@type":"WebSite","@id":"https:\/\/www.delveinsight.com\/blog\/#website","url":"https:\/\/www.delveinsight.com\/blog\/","name":"DelveInsight Business Research","description":"Blog","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.delveinsight.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/0d96a31a370c143ffdb481d985d7edfd","name":"DelveInsight","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/f9314f22b8c5b61d496451e91f32488d2457ecb59283b7b2ad7e82d330b47aba?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/f9314f22b8c5b61d496451e91f32488d2457ecb59283b7b2ad7e82d330b47aba?s=96&d=mm&r=g","caption":"DelveInsight"}}]}},"author_meta":{"display_name":"DelveInsight","author_link":"https:\/\/www.delveinsight.com\/blog\/author\/arawat"},"featured_img":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2022\/11\/25120126\/EGFR-and-ALK-mutations-in-the-East-Asian-Lung-Cancer-Market-300x187.png","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Articles<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Articles<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">ALK Mutations<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Cancer<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Cancer research<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Cancer Treatment<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">ESMO 2022<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">ESMO Asia<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">ESMO Asia 2022<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Non-small cell lung cancer<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Non-Small Cell Lung Cancer (NSCLC)<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Non-Small Cell Lung Cancer Market<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">NSCLC<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">NSCLC Market<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">NSCLC Pipeline<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">NSCLC treatment<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">ALK Mutations<\/span>","<span class=\"advgb-post-tax-term\">Cancer<\/span>","<span class=\"advgb-post-tax-term\">Cancer research<\/span>","<span class=\"advgb-post-tax-term\">Cancer Treatment<\/span>","<span class=\"advgb-post-tax-term\">ESMO 2022<\/span>","<span class=\"advgb-post-tax-term\">ESMO Asia<\/span>","<span class=\"advgb-post-tax-term\">ESMO Asia 2022<\/span>","<span class=\"advgb-post-tax-term\">Non-small cell lung cancer<\/span>","<span class=\"advgb-post-tax-term\">Non-Small Cell Lung Cancer (NSCLC)<\/span>","<span class=\"advgb-post-tax-term\">Non-Small Cell Lung Cancer Market<\/span>","<span class=\"advgb-post-tax-term\">NSCLC<\/span>","<span class=\"advgb-post-tax-term\">NSCLC Market<\/span>","<span class=\"advgb-post-tax-term\">NSCLC Pipeline<\/span>","<span class=\"advgb-post-tax-term\">NSCLC treatment<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 3 years ago","modified":"Updated 3 years ago"},"absolute_dates":{"created":"Posted on Nov 25, 2022","modified":"Updated on Apr 17, 2023"},"absolute_dates_time":{"created":"Posted on Nov 25, 2022 12:05 pm","modified":"Updated on Apr 17, 2023 4:14 pm"},"featured_img_caption":"EGFR and ALK mutations in the East Asian Lung Cancer Market","series_order":"","_links":{"self":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/19837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/comments?post=19837"}],"version-history":[{"count":0,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/19837\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media\/19846"}],"wp:attachment":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media?parent=19837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/categories?post=19837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/tags?post=19837"},{"taxonomy":"industry","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/industry?post=19837"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/therapeutic_areas?post=19837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}