{"id":19947,"date":"2022-11-30T17:20:55","date_gmt":"2022-11-30T11:50:55","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=19947"},"modified":"2023-07-12T12:02:06","modified_gmt":"2023-07-12T06:32:06","slug":"antibody-drug-conjugates-for-cancer-treatment","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/antibody-drug-conjugates-for-cancer-treatment","title":{"rendered":"Antibody-Drug Conjugate: The Smart Biological Bomb"},"content":{"rendered":"\n

Antibody-drug conjugate (ADCs) is a new emerging class of highly potent pharmaceutical drugs, which is a great combination of chemotherapy and immunotherapy. Over the past couple of decades, antibody-drug conjugates<\/a><\/strong> have revolutionized the field of cancer chemotherapy<\/strong>. ADCs are composed of 3 parts<\/strong>: an antibody<\/strong> drug<\/strong>, a cytotoxic<\/strong> payload<\/strong>, and a chemical linker<\/strong> protein to hold the 2 parts together.<\/p>\n\n\n\n

ADCs payloads<\/strong> can be classified into two major types<\/strong>: (i) tubulin inhibitors<\/strong> inhibit tubulin polymerization and trigger cell cycle arrest in the G2\/M phase and subsequent cell apoptosis; these inhibitors include monomethyl auristatin E (MMAE), monomethyl auristatin F (MMAF), and a derivative of maytansine 1 (DM1), (ii) DNA-damaging agents<\/strong> bind the minor groove in DNA, leading to cell death via DNA cleavage, DNA alkylation or interrupted DNA replication \u2013 these agents include calicheamicin, SN-38, DXd, and PBD. Other small-molecule payloads, such as \u03b1\u2010amanitin (a selective RNA polymerase II inhibitor), are also under investigation.<\/p>\n\n\n\n

Based on the mechanism of payload release, linkers<\/strong> can be categorized into cleavable<\/strong> or non-cleavable<\/strong> linkers. Cleavable linkers are designed to conditionally respond to the TME or intracellular environments, such as low pH, proteolysis, and high-glutathione concentrations. On the other hand, noncleavable linkers rely on complete lysosomal degradation of the antibody for payload release. Noncleavable linkers are more stable in circulating blood than cleavable linkers, but they are not able to kill neighboring cancer cells by bystander effect, due to the lack of cell permeability related to the charged amino acid appendage. Cleavable linkers<\/strong> enhance the bystander effect and can distinguish between the circulatory and target cells conditions, making them the preferred choice<\/strong> to treat the majority of cancer types.<\/strong><\/p>\n\n\n\n

\"Antibody
Leading ADCs Approved for Solid Tumors in Asia Healthcare Market<\/strong><\/figcaption><\/figure>\n\n\n\n

Drug-to-antibody ratio<\/strong> (DAR) is the average number of drugs conjugated to the antibodies, which is an important attribute of Antibody Drug Conjugate. The DAR value affects the efficacy of the drug, as low drug loading reduces the potency, while high drug loading can negatively affect pharmacokinetics (PK) and toxicity.<\/strong><\/p>\n\n\n\n

With the advancement in gene engineering technology,<\/strong> the ADC\u2019s generation has evolved from First to<\/strong> third-generation ADCs<\/strong>. Third-generation ADCs are replacing the second-generation ADCs as in this generation, a fully human antibody is used instead of a chimeric antibody.<\/p>\n\n\n\n

Antibody Drug Conjugate<\/strong> drugs <\/strong><\/a>are available<\/strong> earlier in the US<\/strong>, as compared to the Asian countries<\/strong> with up to 12 drugs on the market and sales well ahead of other regions, including Mylotarg<\/strong>(2010), Adcetris<\/strong>(2011), Kadcyla<\/strong>(2013), Besponsa<\/strong>(2017), Lumoxiti<\/strong> (2018), Polivy<\/strong>(2019), Padcev<\/strong>(2019), Enhertu<\/strong>(2019), Trodelvy<\/strong>(2020), Blenrep<\/strong>(2020) Zynlonta<\/strong>(2021) and Tridak<\/strong>(2021).<\/p>\n\n\n\n

ACDs are slowly making their way to Asian countries<\/strong> for example Japan<\/strong> approved seven<\/strong> Antibody Drug Conjugate including Mylotarg<\/strong> (2005), Adcetris<\/strong>(2014), Kadcyla<\/strong>(2014), Besponsa<\/strong> (2018), Enhertu<\/strong>(2020), Akalux<\/strong> (2020), Padcev<\/strong>(2021), and Enhertu<\/strong> (under review).<\/p>\n\n\n\n

The Chinese market<\/strong> has seen a boom in ADCs drugs<\/a><\/strong>. In 2020, Adcetris<\/strong> and Kadcyla<\/strong>, two of the world’s first Antibody Drug Conjugate drugs on the market, were approved for launch in China. In 2021, RemeGen’s Disitamab vedotin<\/strong> (Aidixi) and inotuzumab ozogamicin<\/strong> (Besponsa) were approved for marketing. In June 2022, the NMPA approved Trodelvy, <\/strong>also the regulatory approval of Enhertu<\/strong> is under review in China too. Many Chinese companies namely Hengrui<\/strong>, Miracogen, RemeGen, DAC Biotech, <\/strong>and many others, are developing Antibody Drug Conjugate.<\/p>\n\n\n\n

In June 2022, the Health Sciences Authority of Singapore <\/strong>approved PADCEV<\/strong> (enfortumab vedotin) as the first antibody-drug conjugate approved in Singapore<\/strong> for locally advanced or metastatic urothelial cancer<\/strong> also Trodelvy, <\/strong>and Enhertu<\/strong> are approved in Singapore<\/strong>.<\/p>\n\n\n\n

\n\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t<\/colgroup>\n\t\n\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t\n\t\t\t
\n\t\t\t

Antibody-Drug Conjugate (ADCs) in Pipeline<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

ADC<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Company<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Target<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Indication<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Phase<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

Trastuzumab Duocarmazine<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Byondis<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

HER2<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Breast and Endometrial cancer<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

III<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

Patritumab deruxtecan<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Daiichi Sankyo<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

HER3<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

NSCLC, Breast and Colorectal cancer<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

III<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

Tusamitamab ravtansine<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Sanofi<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

CEACAM5<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

NSCLC<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

III<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

L-DOS47<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Helix BioPharma<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

CEACAM6<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

NSCLC, pancreatic cancer<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

II<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

Ladiratuzumab vedotin<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Seagen\/Merck<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

LIV1<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Solid Tumors<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

II<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

MRG003\/MRG002<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Miracogen<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

EGFR<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

BTC, NSCLC, Metastatic Gastric Cancer<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

II<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t\t

\n\t\t\t

RC88<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

RemeGen<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Mesothelin<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

Solid Tumors<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t\t

\n\t\t\t

I\/II<\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n\t\t\t<\/td>\n\t\t<\/tr>\n\t<\/tbody>\n<\/table>\n<\/div>\n\n\n\n

<\/div>\n\n\n\n

The pharmaceutical industry is witnessing a dynamic shift from conventional technologies to newer and more robust approaches for the development of such complex biomolecules, with approximately 50 ADCs being investigated in more than 150 clinical trials. As the technology advances even further, personalized Antibody Drug Conjugate<\/a><\/strong> may be a possibility in the future and there may be the most appropriate antibody, linker, and payload based on the patient\u2019s tumor antigens and other characteristics. Generating personalized ADCs within an acceptable timeframe and without prohibitively high costs will be a challenge. Wherever chemotherapy is currently used, ADCs could serve as the replacements of the future, and with personalized ADCs, the opportunities are enormous.<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n","protected":false},"excerpt":{"rendered":"

Antibody-drug conjugate (ADCs) is a new emerging class of highly potent pharmaceutical drugs, which is a great combination of chemotherapy and immunotherapy. Over the past couple of decades, antibody-drug conjugates have revolutionized the field of cancer chemotherapy. ADCs are composed of 3 parts: an antibody drug, a cytotoxic payload, and a chemical linker protein to […]<\/p>\n","protected":false},"author":6,"featured_media":19951,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[63,19969,19970,137,988,841,140,927,427,930],"industry":[17225],"therapeutic_areas":[17228],"class_list":["post-19947","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-adcs","tag-antibody-drug-conjugates-4","tag-asia-healthcare-market","tag-cancer","tag-cancer-drugs","tag-cancer-research","tag-cancer-therapy","tag-cancer-treatment","tag-oncology","tag-oncology-research","industry-pharmaceutical","therapeutic_areas-oncology"],"acf":[],"yoast_head":"\nAntibody Drug Conjugates for Cancer Treatment | Asia Healthcare Market<\/title>\n<meta name=\"description\" content=\"Antibody Drug Conjugates (ADCs) are revolutionizing cancer treatment. 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href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Articles<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Articles<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">ADCs<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Antibody Drug Conjugates<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Asia Healthcare Market<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Cancer<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">cancer drugs<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Cancer research<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">cancer therapy<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Cancer Treatment<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Oncology<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Oncology Research<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">ADCs<\/span>","<span class=\"advgb-post-tax-term\">Antibody Drug Conjugates<\/span>","<span class=\"advgb-post-tax-term\">Asia Healthcare Market<\/span>","<span class=\"advgb-post-tax-term\">Cancer<\/span>","<span class=\"advgb-post-tax-term\">cancer drugs<\/span>","<span class=\"advgb-post-tax-term\">Cancer research<\/span>","<span class=\"advgb-post-tax-term\">cancer therapy<\/span>","<span class=\"advgb-post-tax-term\">Cancer Treatment<\/span>","<span class=\"advgb-post-tax-term\">Oncology<\/span>","<span class=\"advgb-post-tax-term\">Oncology Research<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 3 years ago","modified":"Updated 3 years ago"},"absolute_dates":{"created":"Posted on Nov 30, 2022","modified":"Updated on Jul 12, 2023"},"absolute_dates_time":{"created":"Posted on Nov 30, 2022 5:20 pm","modified":"Updated on Jul 12, 2023 12:02 pm"},"featured_img_caption":"Antibody Drug Conjugates for Cancer Treatment in Asia Healthcare 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