{"id":21592,"date":"2023-03-07T19:09:08","date_gmt":"2023-03-07T13:39:08","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=21592"},"modified":"2023-03-07T19:09:11","modified_gmt":"2023-03-07T13:39:11","slug":"pharma-news-for-incyte-eisai-reata-genenta-ikena","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-incyte-eisai-reata-genenta-ikena","title":{"rendered":"Incyte\u2019s Clinical Trial for Myelofibrosis; Eisai and Bioge\u2019s Leqembi; FDA Approves Reata Pharmaceuticals\u2019 SKYCLARYS; Temferon Lands FDA Orphan Drug Status for Glioblastoma; Harbour BioMed Announces Results from Phase III Trial of Batoclimab; FDA Fast Track Designation to Ikena\u2019s AHR Antagonist IK-175"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-69fea93965ab1\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-69fea93965ab1\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-incyte-eisai-reata-genenta-ikena\/#Incyte_Halts_Phase_III_Clinical_Trial_for_Myelofibrosis\" >Incyte Halts Phase III Clinical Trial for Myelofibrosis&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-incyte-eisai-reata-genenta-ikena\/#FDA_Sets_July_Verdict_Date_for_Eisai_and_Biogen%E2%80%98s_Leqembi\" >FDA Sets July Verdict Date for Eisai and Biogen&#8216;s Leqembi<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-incyte-eisai-reata-genenta-ikena\/#FDA_Approves_Reata_Pharmaceuticals_SKYCLARYS_for_Friedreichs_ataxia\" >FDA Approves Reata Pharmaceuticals\u2019 SKYCLARYS for Friedreich\u2019s ataxia<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-incyte-eisai-reata-genenta-ikena\/#Temferon_Lands_FDA_Orphan_Drug_Status_for_Glioblastoma_Multiforme\" >Temferon Lands FDA Orphan Drug Status for Glioblastoma Multiforme<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-incyte-eisai-reata-genenta-ikena\/#Harbour_BioMed_Announces_Positive_Topline_Results_from_Phase_III_Trial_of_Batoclimab_for_Treatment_of_Generalized_Myasthenia_Gravis\" >Harbour BioMed Announces Positive Topline Results from Phase III Trial of Batoclimab for Treatment of Generalized Myasthenia Gravis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-incyte-eisai-reata-genenta-ikena\/#Ikena_Oncology_Receives_FDA_Fast_Track_Designation_for_Novel_AHR_Antagonist_IK-175_in_Combination_with_Nivolumab_to_Treat_Urothelial_Carcinoma\" >Ikena Oncology Receives FDA Fast Track Designation for Novel AHR Antagonist IK-175 in Combination with Nivolumab to Treat Urothelial Carcinoma<\/a><\/li><\/ul><\/nav><\/div>\n\n<h2 class=\"wp-block-heading\" id=\"h-incyte-halts-phase-iii-clinical-trial-for-myelofibrosis\"><span class=\"ez-toc-section\" id=\"Incyte_Halts_Phase_III_Clinical_Trial_for_Myelofibrosis\"><\/span><strong>Incyte Halts Phase III Clinical Trial for Myelofibrosis&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Incyte <\/strong>announced the termination of <strong>Phase III LIMBER-304 trial<\/strong> after the results of a pre-planned interim analysis conducted by an independent data monitoring committee (IDMC) revealed that the study is unlikely to meet the primary endpoint in the intent-to-treat patient population. The recommendation to end the study was not based on safety concerns. LIMBER-304 is a randomized, double-blind study comparing the efficacy and safety of <strong>parsaclisib plus ruxolitinib (Jakafi\u00ae)<\/strong> versus placebo plus ruxolitinib in adult (age 18 years) <a href=\"https:\/\/www.delveinsight.com\/report-store\/myelofibrosis-market\">patients with myelofibrosis (MF)<\/a> who have not responded to ruxolitinib monotherapy.<\/p>\n\n\n\n<p>While the data is being reviewed further, Incyte will notify the investigators of the findings and work with them to appropriately conclude the study in the best interests of each patient. Data from this study will be presented at an upcoming scientific meeting.<\/p>\n\n\n\n<p>The proportion of patients achieving the targeted reduction in spleen volume as measured by magnetic resonance imaging or computed tomography was the primary endpoint of LIMBER-304. Secondary endpoints included the proportion of patients who had a targeted reduction in Total Symptom Score (TSS), the change in TSS, the time to the first<strong> 50%<\/strong> reduction in TSS, overall survival, the number of treatment-emergent adverse events, the time of onset of the targeted reduction in spleen volume, and the duration of maintenance of the targetted reduction in spleen volume.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FDA_Sets_July_Verdict_Date_for_Eisai_and_Biogen%E2%80%98s_Leqembi\"><\/span><strong>FDA Sets July Verdict Date for Eisai and Biogen<\/strong>&#8216;s <strong>Leqembi<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Eisai Co., Ltd. and Biogen Inc.<\/strong> announced that the FDA had accepted Eisai&#8217;s supplemental Biologics License Application (sBLA) for <strong>LEQEMBI (lecanemab-irmb) 100 mg\/mL<\/strong> <strong>injection <\/strong>for intravenous use, paving the way for LEQEMBI&#8217;s accelerated approval to be converted to a traditional approval. The LEQEMBI application has been granted Priority Review, with an action date of July 6, 2023, under the Prescription Drug User Fee Act (PDUFA). The FDA is currently planning an Advisory Committee meeting to discuss this application but has not yet publicly announced the date.<\/p>\n\n\n\n<p><strong>LEQEMBI <\/strong>is a humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble (protofibrils*) and insoluble forms of amyloid beta (A) that was approved under the Accelerated Approval Pathway on January 6, 2023, for the <a href=\"https:\/\/www.delveinsight.com\/report-store\/alzheimers-disease-ad-market\">treatment of Alzheimer&#8217;s Disease (AD)<\/a>. LEQEMBI treatment should be initiated only in patients with mild cognitive impairment or mild dementia and the presence of A pathology. On the same day that LEQEMBI received accelerated approval, Eisai submitted the sBLA to the FDA for traditional approval.<\/p>\n\n\n\n<p>The sBLA is based on the findings of Eisai&#8217;s recently published large, global confirmatory Phase III clinical trial, Clarity AD. LEQEMBI met the primary endpoint and all key secondary endpoints with highly statistically significant results. The results of the Clarity AD study were presented at the Clinical Trials on Alzheimer&#8217;s Disease (CTAD) conference in November 2022 and simultaneously published in the peer-reviewed medical journal, The New England Journal of Medicine.<\/p>\n\n\n\n<p>LEQEMBI received accelerated approval in the United States and was launched on January 18, 2023. The accelerated approval was based on Phase II data demonstrating that LEQEMBI reduced the accumulation of A plaque in the brain, a defining feature of AD, and its continued approval may be contingent on confirmation of LEQEMBI&#8217;s clinical benefit in a confirmatory trial. The FDA has determined that the results of Clarity AD can be used as a confirmatory study to verify the clinical benefit of lecanemab. Eisai is the global lead for LEQEMBI development and regulatory submissions, with Eisai and Biogen co-commercializing and co-promoting the product and Eisai having final decision-making authority.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FDA_Approves_Reata_Pharmaceuticals_SKYCLARYS_for_Friedreichs_ataxia\"><\/span><strong>FDA Approves Reata Pharmaceuticals\u2019 SKYCLARYS for Friedreich\u2019s ataxia<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Reata Pharmaceuticals<\/strong> declared that the U.S. Food and Drug Administration had approved <strong>SKYCLARYS <\/strong>for treating <a href=\"https:\/\/www.delveinsight.com\/report-store\/friedreichs-ataxia-market\"><strong>Friedreich&#8217;s ataxia<\/strong><\/a> in <strong>adults <\/strong>and <strong>adolescents aged 16<\/strong>. With this approval, the FDA awarded a priority review voucher for <strong>rare pediatric diseases<\/strong>.<\/p>\n\n\n\n<p><strong>MOXIe Part 2<\/strong> was a <strong>randomized, double-blind, placebo-controlled study<\/strong>. Patients with genetically confirmed <strong>Friedreich&#8217;s ataxia<\/strong> and <strong>baseline-modified Friedreich&#8217;s Ataxia <\/strong>rating scale scores between <strong>20 <\/strong>and<strong> 80<\/strong> were randomized <strong>1:1<\/strong> to receive a <strong>placebo <\/strong>or <strong>150 mg<\/strong> of <strong>SKYCLARYS <\/strong>daily. The primary endpoint was a change from baseline in <strong>mFARS <\/strong>score compared to placebo at <strong>week 48<\/strong> in the full analysis population of patients without <strong>severe pes cavus<\/strong>. The mFARS is a clinical assessment tool to assess patient function and is used in clinical trials to evaluate the efficacy of investigational products for use in Friedreich&#8217;s ataxia.&nbsp;<\/p>\n\n\n\n<p>At <strong>week 48<\/strong>, treatment with SKYCLARYS led to a statistically significant decrease in mFARS scores compared to the placebo group. After adjusting for the placebo, the difference between the two groups was <strong>-2.41 points<\/strong>, with a p-value of <strong>0.0138<\/strong>. The most frequently reported adverse reactions in MOXIe Part 2 were elevated <strong>liver enzymes, headache, nausea, abdominal pain, fatigue, diarrhea, and musculoskeletal pain<\/strong>.<\/p>\n\n\n\n<p>Furthermore, a post hoc propensity-matched analysis was conducted to compare the mFARS progression of patients who received a daily dose of 150 mg of SKYCLARYS in the open-label MOXIe extension trial with propensity score-matched untreated patients in the most comprehensive natural history study of friedreich&#8217;s ataxia, clinical outcome measures in friedreich&#8217;s ataxia. All patients who participated in the MOXIe Extension study and had at least one post-baseline evaluation were matched with patients from the FA-COMS study. After three years, patients treated with SKYCLARYS showed lower (improved) mFARS scores compared to the matched group of untreated patients from the FA-COMS natural history study. These analyses are exploratory and should be interpreted with caution due to the limitations of data collected outside of a controlled study, which may be subject to confounding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Temferon_Lands_FDA_Orphan_Drug_Status_for_Glioblastoma_Multiforme\"><\/span><strong>Temferon Lands FDA Orphan Drug Status for Glioblastoma Multiforme<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Genenta Science<\/strong> declared that the U.S. Food and Drug Administration had granted Orphan Drug Designation to <strong>Temferon <\/strong>for treating <a href=\"https:\/\/www.delveinsight.com\/report-store\/glioblastoma-multiforme-gbm-market\"><strong>glioblastoma multiforme<\/strong><\/a>.<\/p>\n\n\n\n<p>Temferon is a distinctive cell therapy developed to reprogram the tumor microenvironment by providing immunomodulatory molecules directly to tumors. Genenta is evaluating Temferon in an ongoing <strong>Phase 1\/2a clinical trial<\/strong>, focusing on newly diagnosed patients with GBM with an <strong>unmethylated MGMT gene promoter<\/strong>.<\/p>\n\n\n\n<p>Around<strong> 60%<\/strong> of the GBM population is identified to have an unmethylated MGMT promoter status. GBM is recognized as the most prevalent malignant primary brain tumor and the most aggressive diffuse glioma.<\/p>\n\n\n\n<p>The <strong>ODD program<\/strong> aims to promote the development of treatments for diseases that impact fewer than <strong>200,000 individuals<\/strong> in the United States. Benefits associated with the designation include eligibility for federal grants, tax credits for qualified clinical trials, prescription drug user fee exemptions, and a seven-year marketing exclusivity period upon FDA approval.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Harbour_BioMed_Announces_Positive_Topline_Results_from_Phase_III_Trial_of_Batoclimab_for_Treatment_of_Generalized_Myasthenia_Gravis\"><\/span><strong>Harbour BioMed Announces Positive Topline Results from Phase III Trial of Batoclimab for Treatment of Generalized Myasthenia Gravis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>On March 6, 2023, Harbour BioMed announced the positive topline results of its phase III clinical trial evaluating batoclimab (HBM9161) for the <a href=\"https:\/\/www.delveinsight.com\/report-store\/generalized-myasthenia-gravis-gmg-pipeline-insight\"><strong>treatment of generalized myasthenia gravis (gMG)<\/strong><\/a>. It is also the first positive pivotal trial outcome for batoclimab worldwide.&nbsp;<\/p>\n\n\n\n<p>The clinical study aimed to confirm the efficacy and safety of batoclimab in <a href=\"https:\/\/www.delveinsight.com\/report-store\/generalized-myasthenia-gravis-gmg-epidemiology-forecast\"><strong>patients with gMG<\/strong><\/a> in China. Data received from the phase III trial met the primary endpoint as well as key secondary endpoints. Meanwhile, batoclimab treatment was overall safe and well-tolerated, and no new safety signal was identified.<\/p>\n\n\n\n<p>Harbour BioMed\u2019s Batoclimab is a fully human anti-FcRn mAb, blocks FcRn-IgG interactions, accelerating the degradation of autoantibodies and leading to the treatment of pathogenic IgG-mediated autoimmune diseases. Phase 2 study in myasthenia gravis showed that batoclimab can quickly and significantly alleviate patients&#8217; symptoms and improve quality of life. Earlier studies demonstrated that batoclimab is well tolerated and can rapidly reduce total IgG in many pathogenic IgG-mediated autoimmune diseases.<\/p>\n\n\n\n<p>Dr. Jingsong Wang, Founder, Chairman and CEO of Harbour BioMed has said, \u201cthis breakthrough therapy represents a significant advance in the treatment of multiple pathogenic-IgG mediated autoimmune diseases, where there remains a significant unmet medical need such as gMG indication.\u201d<\/p>\n\n\n\n<p>Earlier in early 2021, Batoclimab received the &#8220;Breakthrough Therapy Certificate&#8221; from NMPA and subsequently received a positive outcome of the proof-of-concept study for the treatment of Chinese <a href=\"https:\/\/www.delveinsight.com\/report-store\/generalized-myasthenia-gravis-gmg-market\"><strong>gMG patients<\/strong><\/a> completed in August 2021. In October 2022, the Company entered into an agreement with NBP Pharma, a wholly owned subsidiary of the CSPC Group, to co-develop batoclimab in Great China. The Company was responsible for developing and operating the full clinical trial of batoclimab for gMG in China and will receive tiered royalties based on annual net sales of batoclimab in Greater China according to the agreement.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ikena_Oncology_Receives_FDA_Fast_Track_Designation_for_Novel_AHR_Antagonist_IK-175_in_Combination_with_Nivolumab_to_Treat_Urothelial_Carcinoma\"><\/span><strong>Ikena Oncology Receives FDA Fast Track Designation for Novel AHR Antagonist IK-175 in Combination with Nivolumab to Treat Urothelial Carcinoma<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>On March 06, 2023, Ikena Oncology, Inc. announced that the US FDA had granted Fast Track designation for IK-175, the Company\u2019s novel aryl hydrocarbon receptor (AHR) antagonist, in combination with immune checkpoint inhibitors in <a href=\"https:\/\/www.delveinsight.com\/report-store\/urothelial-carcinoma-epidemiology-forecast\"><strong>patients with advanced urothelial carcinoma<\/strong><\/a> who have progressed on or within three months of receiving the last dose of checkpoint inhibitors. Ikena\u2019s IK-175 targets AHR, a compelling cancer-driving transcription factor that prevents immune recognition in a multitude of cancers by modulation of innate and adaptive immunity. The IK-175 program is being developed in collaboration with Bristol Myers Squibb, and they have an option to exclusively license the program through early 2024.<\/p>\n\n\n\n<p>On achieving the significant milestone, Sergio Santillana, MD, Chief Medical Officer, Ikena has said, \u201cthere is an urgent need for new <a href=\"https:\/\/www.delveinsight.com\/report-store\/urothelial-carcinoma-market\"><strong>treatment options for urothelial carcinoma patients<\/strong><\/a>, many of whom find themselves out of options after progressing on checkpoint inhibitors. The Fast Track designation for IK-175 reflects the FDA\u2019s interest in the potential role of our AHR antagonist to overcome the development of resistance to checkpoint inhibitors and supports our strategy of combining IK-175 with nivolumab to expand the number of cancer patients that can benefit from immunotherapy,\u201d.<\/p>\n\n\n\n<p>IK-175 is currently being studied in a Phase 1a\/b clinical trial as a monotherapy and in combination with nivolumab in patients with advanced or metastatic solid tumors, including urothelial carcinoma for which standard therapy is no longer effective or is intolerable (NCT04200963, or IK-175-001).<\/p>\n\n\n\n<p>According to the data\u00a0 Initial clinical data presented at the Society for Immunotherapy of Cancer (SITC) 2022 Annual Meeting, IK-175 is well tolerated and showed encouraging, durable, antitumor activity in stage 1 of the trial\u2019s <a href=\"https:\/\/www.delveinsight.com\/report-store\/urothelial-carcinoma-pipeline-insight\" class=\"ek-link\"><strong>monotherapy and combination arms in urothelial carcinoma patients<\/strong><\/a>. As per the update from Ikena Oncology, IK-175 is the company\u2019s second candidate to receive Fast Track designation; the FDA has also granted the designation to IK-930, the Company\u2019s novel TEAD inhibitor, in patients with unresectable NF2-deficient malignant pleural mesothelioma.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Incyte Halts Phase III Clinical Trial for Myelofibrosis&nbsp; Incyte announced the termination of Phase III LIMBER-304 trial after the results of a pre-planned interim analysis conducted by an independent data monitoring committee (IDMC) revealed that the study is unlikely to meet the primary endpoint in the intent-to-treat patient population. The recommendation to end the study [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":21598,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[32],"tags":[830,1541,251,18983,20450,1787,16690,1714,20451,1107,349,5005,18063,420,639,1615,18814],"industry":[17225],"therapeutic_areas":[17233,17227,17245,17228],"class_list":["post-21592","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizia","tag-biogen","tag-eisai","tag-friedreichs-ataxia","tag-generalized-myasthenia-gravis","tag-generalized-myasthenia-gravis-gmg","tag-glioblastoma","tag-glioblastoma-multiforme","tag-harbour-biomed","tag-ikena-oncology","tag-incyte","tag-latest-pharma-news","tag-myelofibrosis","tag-myelofibrosis-treatment","tag-news","tag-pharma-news","tag-reata-pharmaceuticals","tag-urothelial-carcinoma","industry-pharmaceutical","therapeutic_areas-hematological-disorders","therapeutic_areas-immunological-and-autoimmune-disorders","therapeutic_areas-neurology","therapeutic_areas-oncology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pharma News | Incyte, Eisai, Reata, Genenta, Ikena Oncology<\/title>\n<meta name=\"description\" content=\"Incyte\u2019s LIMBER-304; Eisai and Bioge\u2019s Leqembi; Reata\u2019s SKYCLARYS; Genenta Science&#039;s Temferon; Harbour BioMed&#039;s Batoclimab; Ikena\u2019s IK-175\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-incyte-eisai-reata-genenta-ikena\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pharma News | Incyte, Eisai, Reata, Genenta, Ikena Oncology\" \/>\n<meta property=\"og:description\" content=\"Incyte\u2019s LIMBER-304; Eisai and Bioge\u2019s Leqembi; Reata\u2019s SKYCLARYS; 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