{"id":2161,"date":"2017-06-07T15:26:26","date_gmt":"2017-06-07T09:56:26","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=2161"},"modified":"2021-10-12T11:16:20","modified_gmt":"2021-10-12T05:46:20","slug":"the-snippet-gut-bacteria-can-stop-cancer-drugs-from-working","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/the-snippet-gut-bacteria-can-stop-cancer-drugs-from-working","title":{"rendered":"Gut bacteria can stop cancer drugs from working"},"content":{"rendered":"<p style=\"text-align: justify;\">In the quest for personalized therapies, most research has focused on how an individual\u2019s genome controls their body\u2019s responses to drugs. However, there is increasing evidence that a person\u2019s unique microbiome \u2014 the population of bacteria and other microbes that live in their body \u2014 can be key to determining whether or not a drug works for their condition. Researchers now have evidence that healthy people metabolize some drugs in different ways depending on their microbial make-up. They presented their data on 4 June at the meeting of the American Society for Microbiology in New Orleans, Louisiana. Bacteria living in the human body will eat any nutrient that comes their way, whether it\u2019s food from the host\u2019s diet or a drug that the person is taking. But this dietary flexibility can become problematic if the microbes metabolize a drug into useless or toxic compounds. To see whether a person\u2019s microbiome affected how they metabolized drugs, Guthrie and her colleagues collected faecal samples from 20 healthy people. When the researchers analysed the proteins produced in the faecal samples, they found that those from people with high bacterial metabolisms contained strains that made more \u03b2-glucuronidases. These people also had increased levels of proteins that transport sugar into cells, which suggests they would be more likely to absorb the toxic compound and develop gastrointestinal problems. It\u2019s a nice step towards understanding how gut-bacterial enzymes interact with drugs, says Matthew Redinbo, a structural biologist at the University of North Carolina at Chapel Hill who also studies irinotecan. \u201cOur biggest insight is to look at gut enzymes and think about them the same way as human\u201d enzymes, he says.<\/p>\n<p style=\"text-align: justify;\">To know more, click <a href=\"https:\/\/www.nature.com\/news\/gut-bacteria-can-stop-cancer-drugs-from-working-1.22109\">Gut bacteria can Impact cancer drug<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the quest for personalized therapies, most research has focused on how an individual\u2019s genome controls their body\u2019s responses to drugs. However, there is increasing evidence that a person\u2019s unique microbiome \u2014 the population of bacteria and other microbes that live in their body \u2014 can be key to determining whether or not a drug [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2070,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[41],"tags":[121,137,160,833,923,17535,678],"industry":[17225],"therapeutic_areas":[17228],"class_list":["post-2161","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-snippets","tag-biotechnology","tag-cancer","tag-chemotherapy","tag-gut-microbiome","tag-innovation","tag-metabolisms","tag-research","industry-pharmaceutical","therapeutic_areas-oncology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ 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Cancer chemotherapy.^b Female patient receiving anticancer drugs from an intravenous drip bag. This continuously supplies the patient with a controlled amount of drugs that target cancer cells. The drugs target all rapidly dividing cells, which causes them to have a range of side effects, including hair loss. Cancer is a disease caused by the uncontrolled replication of abnormal cells, which can invade and destroy healthy tissue. The drugs in use here are ^Icytoxan^i and ^Iadriamycin^i. Photographed at Massachusetts General Hospital, USA."},{"@type":"WebSite","@id":"https:\/\/www.delveinsight.com\/blog\/#website","url":"https:\/\/www.delveinsight.com\/blog\/","name":"DelveInsight Business Research","description":"Blog","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.delveinsight.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/5fbf6ca478835d03fdb5e17d905b520a","name":"DelveInsight","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/afdd550c64e18f6ad8957080b017c6ae55f4916951d641d3cd40264176aa0e86?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/afdd550c64e18f6ad8957080b017c6ae55f4916951d641d3cd40264176aa0e86?s=96&d=mm&r=g","caption":"DelveInsight"}}]}},"author_meta":{"display_name":"DelveInsight","author_link":"https:\/\/www.delveinsight.com\/blog\/author\/gtadmin"},"featured_img":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2017\/04\/06175101\/CINV-300x197.jpg","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Snippets - A Small piece of News or Article<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Snippets - A Small piece of News or Article<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Biotechnology<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Cancer<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">chemotherapy<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Gut Microbiome<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">innovation<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Metabolisms<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">research<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Biotechnology<\/span>","<span class=\"advgb-post-tax-term\">Cancer<\/span>","<span class=\"advgb-post-tax-term\">chemotherapy<\/span>","<span class=\"advgb-post-tax-term\">Gut Microbiome<\/span>","<span class=\"advgb-post-tax-term\">innovation<\/span>","<span class=\"advgb-post-tax-term\">Metabolisms<\/span>","<span class=\"advgb-post-tax-term\">research<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 9 years ago","modified":"Updated 5 years ago"},"absolute_dates":{"created":"Posted on Jun 7, 2017","modified":"Updated on Oct 12, 2021"},"absolute_dates_time":{"created":"Posted on Jun 7, 2017 3:26 pm","modified":"Updated on Oct 12, 2021 11:16 am"},"featured_img_caption":"^BMODEL RELEASED. Cancer chemotherapy.^b Female patient receiving anticancer drugs from an intravenous drip bag. This continuously supplies the patient with a controlled amount of drugs that target cancer cells. The drugs target all rapidly dividing cells, which causes them to have a range of side effects, including hair loss. Cancer is a disease caused by the uncontrolled replication of abnormal cells, which can invade and destroy healthy tissue. The drugs in use here are ^Icytoxan^i and ^Iadriamycin^i. Photographed at Massachusetts General Hospital, USA.","series_order":"","_links":{"self":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/2161","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/comments?post=2161"}],"version-history":[{"count":0,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/2161\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media\/2070"}],"wp:attachment":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media?parent=2161"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/categories?post=2161"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/tags?post=2161"},{"taxonomy":"industry","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/industry?post=2161"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/therapeutic_areas?post=2161"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}