{"id":21902,"date":"2023-03-28T17:48:28","date_gmt":"2023-03-28T12:18:28","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=21902"},"modified":"2023-03-28T17:52:35","modified_gmt":"2023-03-28T12:22:35","slug":"pharma-news-for-novartis-cyclerion-iovance-bpgbio","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-novartis-cyclerion-iovance-bpgbio","title":{"rendered":"Novartis Announces the Positive Results of Phase III NATALEE Trial Evaluating Kisqali; FDA Approves Pharming\u2019s Joenja for APDS; FDA Orphan Drug Designation to Cyclerion\u2019s Zagociguat; Iovance Completes BLA Submission for Lifileucel in Advanced Melanoma; BPGbio Announces Partnership with debra of America"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-69fc97267a7de\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-69fc97267a7de\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-novartis-cyclerion-iovance-bpgbio\/#Novartis_Announces_the_Positive_Results_of_Phase_III_NATALEE_trial_Evaluating_Kisqali\" >Novartis Announces the Positive Results of Phase III NATALEE trial Evaluating Kisqali<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-novartis-cyclerion-iovance-bpgbio\/#FDA_Approves_Pharmings_Joenja_as_the_First_and_Only_Treatment_Indicated_for_APDS\" >FDA Approves Pharming\u2019s Joenja as the First and Only Treatment Indicated for APDS<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-novartis-cyclerion-iovance-bpgbio\/#Cyclerion_Therapeutics_Receives_FDA_Orphan_Drug_Designation_for_Zagociguat\" >Cyclerion Therapeutics Receives FDA Orphan Drug Designation for Zagociguat&nbsp;<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-novartis-cyclerion-iovance-bpgbio\/#Iovance_Biotherapeutics_Completes_Biologics_License_Application_Submission_for_Lifileucel_in_Advanced_Melanoma\" >Iovance Biotherapeutics Completes Biologics License Application Submission for Lifileucel in Advanced Melanoma<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-novartis-cyclerion-iovance-bpgbio\/#BPGbio_Announces_Expanded_Partnership_with_debra_of_America_for_BPM_31510_for_Epidermolysis_Bullosa_Phase_IIIII_Trial\" >BPGbio Announces Expanded Partnership with debra of America for BPM 31510 for Epidermolysis Bullosa Phase II\/III Trial<\/a><\/li><\/ul><\/nav><\/div>\n\n<h2 class=\"wp-block-heading\" id=\"h-novartis-announces-the-positive-results-of-phase-iii-natalee-trial-evaluating-kisqali\"><span class=\"ez-toc-section\" id=\"Novartis_Announces_the_Positive_Results_of_Phase_III_NATALEE_trial_Evaluating_Kisqali\"><\/span><strong>Novartis Announces the Positive Results of Phase III NATALEE trial Evaluating Kisqali<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Novartis <\/strong>announced positive topline results from an interim analysis of <strong>NATALEE<\/strong>, a Phase III trial evaluating <strong>Kisqali\u00ae (ribociclib) plus endocrine therapy (ET)<\/strong> in a broad population of <a href=\"https:\/\/www.delveinsight.com\/report-store\/her2-negative-breast-cancer-market\">patients with hormone receptor-positive\/human epidermal growth factor receptor 2-negative (HR+\/HER2-) early breast cancer (EBC)<\/a> at risk of recurrence. The Independent Data Monitoring Committee recommended stopping the trial early as the primary endpoint of invasive disease-free survival (iDFS) has been met. Kisqali plus ET reduced the risk of disease recurrence significantly more than standard adjuvant ET alone, with consistent benefit in patients with stage II and stage III EBC regardless of nodal involvement.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>\u201cWhile most patients are diagnosed and treated early with the aim to cure breast cancer, the risk of cancer returning, often as metastatic disease, peaks within three years after diagnosis, but never goes away completely,\u201d said Dennis J. Slamon, MD, Director of Clinical\/Translational Research, University of California, Los Angeles Jonsson Comprehensive Cancer Center and Chairman and Executive Director of Translational Research In Oncology (TRIO) and NATALEE trial lead investigator. &#8220;There is an urgent need for new, well-tolerated options that keep patients cancer-free while maintaining their quality of life.&#8221; The NATALEE trial, where ribociclib was given for three years plus ET, was designed with these unmet needs in mind, and it is extremely encouraging that this study met its primary endpoint.\u201d<\/em><\/p>\n<\/blockquote>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>&#8220;The positive topline results from NATALEE represent a significant milestone in our ambition to extend the benefits of Kisqali to patients in earlier stages of breast cancer, building on the legacy of this effective treatment in HR+\/HER2- metastatic breast cancer,&#8221; said Shreeram Aradhye, M.D., Novartis&#8217; President, Global Drug Development and Chief Medical Officer. &#8220;These findings can potentially change the game for patients at risk of recurrence, including those with no nodal involvement, who currently have few well-tolerated options for preventing recurrence.&#8221; Our teams are working on submissions to health authorities worldwide in the hopes of bringing Kisqali to many more breast cancer patients.&#8221;<\/em><\/p>\n<\/blockquote>\n\n\n\n<p>These findings extend <strong>Kisqali&#8217;s<\/strong> legacy in metastatic breast cancer (MBC), where it has consistently demonstrated an overall survival benefit while preserving or improving quality of life in three Phase III trials. In January 2023, updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) for breast cancer recommend ribociclib (Kisqali) as the only Category 1 preferred CDK4\/6 inhibitor for <a href=\"https:\/\/www.delveinsight.com\/report-store\/her2-negative-metastatic-breast-cancer-market\">first-line treatment of patients with HR+\/HER2- MBC<\/a> when combined with an aromatase inhibitor (AI).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"FDA_Approves_Pharmings_Joenja_as_the_First_and_Only_Treatment_Indicated_for_APDS\"><\/span><strong>FDA Approves Pharming\u2019s Joenja as the First and Only Treatment Indicated for APDS<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Pharming Group N.V. <\/strong>announced that <strong>Joenja\u00ae (leniolisib)<\/strong> had been approved by the US Food and Drug Administration (FDA) for the treatment of activated phosphoinositide 3-kinase delta (PI3K) syndrome (APDS) in adult and pediatric patients 12 years of age and older. Joenja\u00ae is the first and only treatment approved in the United States for APDS, a rare and progressive primary immunodeficiency. The FDA evaluated the <strong>Joenja\u00ae <\/strong>application for APDS under Priority Review, which is granted to therapies that have the potential to significantly improve the treatment, diagnosis, or prevention of serious conditions. <strong>Joenja\u00ae <\/strong>is set to launch in the United States in early April, with shipments beginning in mid-April.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>&#8220;The FDA approval of Joenja\u00ae is an exciting moment for the APDS community and offers to transform the treatment pathway for patients and families affected by this rare disease,&#8221; said <\/em><strong><em>Dr. Eveline Wu, MD, MSCR, Division Chief, Paediatric Rheumatology &amp; Associate Professor of Paediatric Rheumatology and Allergy\/Immunology at The University of North Carolina School of Medicine. <\/em><\/strong><em>This approval means that they will have access to an approved treatment for the first time, which has the potential to change the standard of care for the patient population suffering from APDS.&#8221;<\/em><\/p>\n<\/blockquote>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>&#8220;The approval of Pharming&#8217;s Joenja\u00ae is an important step toward making a difference in the lives of individuals living with APDS who experience severe, life-altering, and progressive symptoms,&#8221; said <\/em><strong><em>Vicki Modell, co-founder of the Jeffrey Modell Foundation<\/em><\/strong><em>, an international, non-profit organization dedicated to helping individuals and family members affected by primary immunodeficiency disorders. The FDA&#8217;s approval of a treatment option for one of the over 450 primary immunodeficiencies is also a watershed moment for the primary immunodeficiency community as a whole. The Jeffrey Modell Foundation is dedicated to early diagnosis, genetic sequencing, treatments, and, ultimately, future cures for primary immunodeficiencies.&#8221;<\/em><\/p>\n<\/blockquote>\n\n\n\n<p>APDS is a rare primary immunodeficiency first characterized in 2013 and is currently estimated to affect 1 to 2 people per million. Genetic variants cause it in either one of two identified genes, known as PIK3CD or PIK3R1, which are vital to the normal development and function of immune cells in the body. The FDA reviewed <strong>Joenja&#8217;s <\/strong>New Drug Application (NDA) under priority review and approved the drug based on the results of a multinational, triple-blind, placebo-controlled, randomized Phase II\/III clinical trial that evaluated efficacy and safety in 31 patients diagnosed with APDS aged 12 years and older. Data from a long-term, open-label extension clinical trial in which 38 patients received Joenja\u00ae for a median of two years were also included in the application.<\/p>\n\n\n\n<p>The European Medicines Agency&#8217;s (EMA) Committee for Human Medicinal Products (CHMP) is currently reviewing the Marketing Authorisation Application (MAA) for leniolisib. Pharming anticipates that the CHMP will issue its opinion on the MAA in the second half of 2023.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cyclerion_Therapeutics_Receives_FDA_Orphan_Drug_Designation_for_Zagociguat\"><\/span><strong>Cyclerion Therapeutics Receives FDA Orphan Drug Designation for Zagociguat&nbsp;<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Cyclerion Therapeutics<\/strong> declared that the U.S. Food and Drug Administration had granted orphan drug designation to <strong>zagociguat <\/strong>for treating <strong>mitochondrial diseases<\/strong>. <strong>Zagociguat<\/strong>, a <strong>CNS-penetrant sGC stimulator<\/strong>, has been developed as a potential therapy for serious diseases involving the <strong>CNS<\/strong>, with symptomatic and disease-modifying effects. In a <strong>29-day open-label <\/strong>study of <strong>MELAS patients<\/strong>, treatment with zagociguat showed improvements in several biomarkers relevant to the disease, including mitochondrial function, inflammation, cerebral blood flow, functional brain connectivity, and visually evoked brain activation. These findings, combined with preclinical data from studies on cells from mitochondrial disease patients and zebrafish disease models, suggest that zagociguat holds promise as a treatment for MELAS or other mitochondrial diseases.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>FDA&#8217;s designation of zagociguat as an orphan drug highlights its potential as a groundbreaking therapy for MELAS, a rare genetic mitochondrial disease. He added that Cyclerion is actively working to accelerate the development of this potential treatment to meet the urgent needs of MELAS patients, who currently lack effective therapies.<\/p>\n<cite><strong>Peter Hecht, Ph.D., Chief Executive Officer of Cyclerion<\/strong><\/cite><\/blockquote>\n\n\n\n<p>Drugs designed to treat, diagnose, or prevent rare diseases affecting fewer than 200,000 people in the United States are eligible for orphan status under the FDA&#8217;s Orphan Drug Designation program. Sponsors of drugs granted orphan designation may qualify for various development incentives, such as tax credits for qualified clinical testing, exemptions from prescription drug user fees, and seven-year marketing exclusivity if the drug is approved by the FDA.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Iovance_Biotherapeutics_Completes_Biologics_License_Application_Submission_for_Lifileucel_in_Advanced_Melanoma\"><\/span><strong>Iovance Biotherapeutics Completes Biologics License Application Submission for Lifileucel in Advanced Melanoma<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Iovance Biotherapeutics<\/strong> has announced the completion of its rolling <strong>Biologics License Application <\/strong>submission for lifileucel to the U.S. Food and Drug Administration. <strong>Lifileucel <\/strong>is a therapy using <strong>tumor-infiltrating lymphocytes<\/strong> and is intended for the treatment of patients with <a href=\"https:\/\/www.delveinsight.com\/report-store\/advanced-melanoma-market\"><strong>advanced melanoma<\/strong><\/a> that is either <strong>unresectable <\/strong>or <strong>metastatic<\/strong>, and has progressed following prior <strong>anti-PD-1\/L1 therapy<\/strong> and targeted therapy, where applicable. This treatment setting currently lacks any FDA-approved therapies.<\/p>\n\n\n\n<p>Positive clinical data from the <strong>C-144-01 trial<\/strong> in patients with advanced <strong>post-anti-PD1 melanoma<\/strong> supports the BLA submission for lifileucel. Following a productive pre-BLA meeting with the FDA, Iovance is pursuing accelerated approval for this indication. In addition, Iovance has reached an agreement with the FDA on the design of the registrational <strong>Phase 3 TILVANCE-301 trial<\/strong>, which will investigate lifileucel in combination with pembrolizumab for advanced frontline melanoma. The TILVANCE-301 trial is expected to support full approval of lifileucel in post-anti-PD-1 advanced melanoma, as well as the registration of lifileucel and pembrolizumab as frontline therapy for advanced melanoma. Startup activities for TILVANCE-301 are ongoing, and the trial is expected to be well underway at the time of potential accelerated approval for lifileucel in advanced post-anti-PD-1 melanoma.<\/p>\n\n\n\n<p>Upon receipt of the complete rolling BLA submission for lifileucel, the FDA has a 60-day window to assess the BLA&#8217;s acceptability for review. With the rolling BLA, Iovance was able to submit portions of the application to the FDA on a continuous basis, thereby allowing the FDA to begin the review process as soon as the documents were received. Expedited programs for severe conditions, such as priority review, allow for a quicker six-month review period from BLA acceptance. Moreover, the FDA had previously granted a regenerative medicine advanced therapy designation for lifileucel in advanced melanoma.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"BPGbio_Announces_Expanded_Partnership_with_debra_of_America_for_BPM_31510_for_Epidermolysis_Bullosa_Phase_IIIII_Trial\"><\/span><strong>BPGbio Announces Expanded Partnership with debra of America for BPM 31510 for Epidermolysis Bullosa Phase II\/III Trial<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>On March 27, 2023,<\/strong> BPGbio Inc (BPG) announced that the company had reached a partnership agreement with Dystrophic Epidermolysis Bullosa Research Association of America (debra of America) for BPGbio\u2019s BPM 31510 for Epidermolysis Bullosa Phase II\/III trial, which is anticipated to launch in the second half of the year. As per the agreement, debra of America will support awareness, understanding, and key information toward patient recruitment and advocacy for the clinical trial.<\/p>\n\n\n\n<p>Preliminary evidence from the Phase 1 clinical trial suggests BPGbio\u2019s BPM 31510 appears to be well tolerated and potentially efficacious in improving wound healing in all subtypes of EB patients. Preclinical data demonstrate that BPGbio\u2019s BPM 31510 influences several key elements of the wound healing process to help in the treatment and management of EB wounds.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u201cWe are pleased to expand our partnership with debra of America to our BPM 31510 for EB Phase II\/III trial. This is an important milestone in our efforts to launch the next phase of clinical development for our EB drug candidate later this year.\u201d<\/p>\n<cite><strong>Niven R. Narain, Ph.D., President and CEO of BPGbio<\/strong><\/cite><\/blockquote>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\u201cHaving seen the encouraging results from BPBbio\u2019s Phase I trial for EB, we are excited to partner with them on the next phase and create meaningful advancements that positively impact the EB community.&#8221;<\/p>\n<cite><strong>Brett Kopelan, Executive Director of debra of America and father to a 15-year-old with a severe form of the disease.<\/strong><\/cite><\/blockquote>\n\n\n\n<p>Since 2017, BPGbio has been working with debra of America, using BPGbio\u2019s expertise and innovative research platforms to provide scientific support and advocate on behalf of patients and families affected by EB. On May 23, 2018, US FDA granted orphan-drug designation to BPM 31510 (ubidecarenone) for the <a href=\"https:\/\/www.delveinsight.com\/report-store\/epidermolysis-bullosa-pipeline-insight\"><strong>treatment of patients with Epidermolysis Bullosa<\/strong><\/a>.&nbsp;<\/p>\n\n\n\n<p>At the beginning of 2023, BPGbio acquired Berg Health LLC.&nbsp; BPGbio\u2019s EB therapeutics are a vital component of its acquisition of substantially all assets of BERG, LLC, which includes BERG\u2019s proprietary Interrogative Biology\u00ae Platform, a strong pipeline consisting of more than a dozen promising candidates in the areas of oncology, neurology, and rare diseases and a robust portfolio of more than 400 U.S. and international granted and pending patents. Similarly, BPGbio, Inc announced the appointment of four key executives.<\/p>\n\n\n\n<p>As per DelveInsigh\u2019s assessment, the total prevalent population of Epidermolysis Bullosa in seven major markets was 42,600+ in 2021, which is anticipated to grow in the coming years. The total number of <a href=\"https:\/\/www.delveinsight.com\/report-store\/epidermolysis-bullosa-epidemiology-forecast\"><strong>diagnosed prevalent cases of Epidermolysis Bullosa<\/strong><\/a> in the 7MM was observed to be 40,238 in 2020. Similarly, in the United States, EB affects approximately one in every 20,000 children born in the US. In 2021, there were close to 26,900+ prevalent cases of epidermolysis bullosa.<\/p>\n\n\n\n<p>Epidermolysis Bullosa significantly diminishes the quality of life for those living with it. In the more severe cases, patients may succumb early for many reasons, including a severe form of squamous cell carcinoma. Several major pharma and biotech giants are actively working in the <a href=\"https:\/\/www.delveinsight.com\/report-store\/epidermolysis-bullosa-market\"><strong>Epidermolysis Bullosa market<\/strong><\/a> to provide a better treatment option. In recent years, several major clinical development and commercial agreements have been registered in the therapeutic areas. Similarly, BPGbio\u2019s BPM 31510 holds immense potential to transform the <a href=\"https:\/\/www.delveinsight.com\/report-store\/epidermolysis-bullosa-pipeline-insight\"><strong>Epidermolysis Bullosa treatment<\/strong><\/a> scenario.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Novartis Announces the Positive Results of Phase III NATALEE trial Evaluating Kisqali Novartis announced positive topline results from an interim analysis of NATALEE, a Phase III trial evaluating Kisqali\u00ae (ribociclib) plus endocrine therapy (ET) in a broad population of patients with hormone receptor-positive\/human epidermal growth factor receptor 2-negative (HR+\/HER2-) early breast cancer (EBC) at risk [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":21921,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":7,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[32],"tags":[20527,20528,20525,16730,704,20526,349,3879,420,423,19756,639,20524],"industry":[17225],"therapeutic_areas":[17237,17228,17234],"class_list":["post-21902","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizia","tag-advanced-melanoma","tag-bpgbio","tag-cyclerion-therapeutics","tag-epidermolysis-bullosa","tag-fda","tag-iovance-biotherapeutics","tag-latest-pharma-news","tag-metastatic-breast-cancer","tag-news","tag-novartis","tag-orphan-drug-designation","tag-pharma-news","tag-pharming-group","industry-pharmaceutical","therapeutic_areas-dermatology","therapeutic_areas-oncology","therapeutic_areas-rare-diseases"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pharma News | Novartis, Pharming, Cyclerion, Iovance, BPGbio<\/title>\n<meta name=\"description\" content=\"Novartis&#039;s Kisqali; Pharming\u2019s Joenja; Cyclerion\u2019s Zagociguat; Iovance&#039;s Lifileucel; BPGbio-debra of America Announces Partnership\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.delveinsight.com\/blog\/pharma-news-for-novartis-cyclerion-iovance-bpgbio\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pharma News | Novartis, Pharming, Cyclerion, Iovance, BPGbio\" \/>\n<meta property=\"og:description\" content=\"Novartis&#039;s Kisqali; Pharming\u2019s Joenja; Cyclerion\u2019s Zagociguat; Iovance&#039;s 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