{"id":2538,"date":"2018-02-09T11:02:08","date_gmt":"2018-02-09T05:32:08","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=2538"},"modified":"2021-07-24T12:56:56","modified_gmt":"2021-07-24T07:26:56","slug":"primary-sjogren-syndrome-pss","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/primary-sjogren-syndrome-pss","title":{"rendered":"Involvement of B cells in the pathogenesis of primary Sj\u00f6gren syndrome (pSS)"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Primary Sj\u00f6gren syndrome<\/strong> (pSS) is a<span style=\"color: #ffffff;\">.<\/span>prototypical <a href=\"https:\/\/www.delveinsight.com\/blog\/\">autoimmune<span style=\"color: #ffffff;\">.<\/span>disease<\/a>. The involvement<span style=\"color: #ffffff;\">.<\/span>of B cells in the pathogenesis<span style=\"color: #ffffff;\">.<\/span>of pSS has long been suspected<span style=\"color: #ffffff;\">.<\/span>on the basis of clinical<span style=\"color: #ffffff;\">.<\/span>observations that include the<span style=\"color: #ffffff;\">.<\/span>presence of serum<span style=\"color: #ffffff;\">.<\/span>autoantibodies, hypergammaglobulinemia, increased<span style=\"color: #ffffff;\">.<\/span>levels of free light chains and<span style=\"color: #ffffff;\">.<\/span>increased risk of B cell lymphoma. Moreover, the<span style=\"color: #ffffff;\">.<\/span>composition of the B cell subset is<span style=\"color: #ffffff;\">.<\/span>altered in <strong>Primary Sj\u00f6gren syndrome<\/strong>. The researchers have discussed about<span style=\"color: #ffffff;\">.<\/span>the mechanisms that support the<span style=\"color: #ffffff;\">.<\/span>increased activation of B cells in pSS, including genetic<span style=\"color: #ffffff;\">.<\/span>and epigenetic factors and environmental<span style=\"color: #ffffff;\">.<\/span>triggers that promote B cell activation via the<span style=\"color: #ffffff;\">.<\/span>innate immune system. B cell activating<span style=\"color: #ffffff;\">.<\/span>factor (<strong>BAFF<\/strong>, also known as <strong>TNF<\/strong> ligand superfamily<span style=\"color: #ffffff;\">.<\/span>member 13B) is at the crossroads<span style=\"color: #ffffff;\">.<\/span>of this process. An important role also<span style=\"color: #ffffff;\">.<\/span>exists for the target tissue (exocrine<span style=\"color: #ffffff;\">.<\/span>glands, namely the salivary and lachrymal<span style=\"color: #ffffff;\">.<\/span>glands), which promotes local B<span style=\"color: #ffffff;\">.<\/span>cell activation. This continuous<span style=\"color: #ffffff;\">.<\/span>stimulation of B cells is the main<span style=\"color: #ffffff;\">.<\/span>driver of lymphomatous escape. Identification<span style=\"color: #ffffff;\">.<\/span>of the multiple steps that support B cell<span style=\"color: #ffffff;\">.<\/span>activation has led to the development<span style=\"color: #ffffff;\">.<\/span>of promising targeted therapies that will<span style=\"color: #ffffff;\">.<\/span>hopefully, lead to the development<span style=\"color: #ffffff;\">.<\/span>of an efficient therapeutic<span style=\"color: #ffffff;\">.<\/span>strategy for pSS.<\/p>\n<p>&nbsp;<\/p>\n<p>For complete details please visit:\u00a0<a href=\"https:\/\/www.nature.com\/articles\/nrrheum.2018.1\">https:\/\/www.nature.com\/articles\/nrrheum.2018<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Primary Sj\u00f6gren syndrome (pSS) is a.prototypical autoimmune.disease. The involvement.of B cells in the pathogenesis.of pSS has long been suspected.on the basis of clinical.observations that include the.presence of serum.autoantibodies, hypergammaglobulinemia, increased.levels of free light chains and.increased risk of B cell lymphoma. Moreover, the.composition of the B cell subset is.altered in Primary Sj\u00f6gren syndrome. The researchers have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2539,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[1373,1118,1155,204,1372,381,1261,712,1332,1370,1371,1375,17616,1374],"industry":[17225],"therapeutic_areas":[17227],"class_list":["post-2538","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-baff","tag-business-research","tag-consultancy","tag-delveinsight","tag-hypergammaglobulinemia","tag-market-research","tag-pharma-consulting","tag-pharma-industry","tag-pharma-updates","tag-pharmaceutical-consulting","tag-primary-sjogren-syndrome","tag-pss","tag-sjogren-syndrome","tag-tnf-ligand","industry-pharmaceutical","therapeutic_areas-immunological-and-autoimmune-disorders"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>PSS DelveInsight Business Research LLP- Snippet (Pharma Industry)<\/title>\n<meta name=\"description\" content=\"Primary Sj\u00f6gren syndrome (pSS) is a prototypical autoimmune disease. 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