{"id":3248,"date":"2018-09-25T12:49:02","date_gmt":"2018-09-25T07:19:02","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=3248"},"modified":"2021-07-24T12:57:04","modified_gmt":"2021-07-24T07:27:04","slug":"notizia-74","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/notizia-74","title":{"rendered":"Notizia"},"content":{"rendered":"

The interleukin-33 antibody of AnaptysBio passes midstage test in asthma<\/strong><\/p>\n

The pipeline drug, etokimab<\/strong> of AnaptysBio<\/strong>, has positive data in a third indication that adds asthma<\/a> <\/strong>to one of its triumphs. The US-based company gets another proof-of-concept study for the interleukin-33 (IL-33) inhibitor<\/strong>, because of phase 2a<\/strong> trial in severe eosinophilic asthma<\/strong>, and a third phase 2b<\/strong> program that will be set up and commence soon. The study was conducted with only 25 patients, who received a single intravenous dose of etokimab (ANB020)<\/strong>, however, the antibody company showed that the anti-IL-33 drug<\/strong> had a quick impact on lung function that lasted for about two months.<\/p>\n

FDA uplifts hold on tazemetostat of Epizyme<\/strong><\/p>\n

The FDA<\/strong> has uplifted a partial clinical hold from tazemetostat<\/strong>, cancer drug of Epizyme<\/strong>. The company can resume enrolment in trials of the EZH2 inhibitor<\/strong> only after presenting the FDA data on the risk of secondary malignancies. The FDA did not approve Tazemetostat last time, because when a paediatric cancer patient has taken the drug, it had developed a secondary T-cell lymphoblastic lymphoma. The adverse event was observed across the 750 people, who were treated with tazemetostat. Nonetheless, with preclinical studies that links tazemetostat to secondary lymphomas, as a precaution, the FDA ceased enrolment in trials of the cancer drug.<\/p>\n

T-cell therapy eliminates HIV reservoirs<\/strong><\/p>\n

Antiretroviral drugs<\/strong> have become boon in the HIV treatment. HIV<\/a>, being the virus, can hide in the body in reservoirs that can surge at any time. Scientists at the University of North Carolina<\/strong> at Chapel Hill are doing efforts in using immunotherapy<\/strong>, a technology that is for eradicating HIV reservoirs. The technique includes collecting T cells from HIV patients, growing them outside the body to increase their population, then infusing them back into the body. The team ruminates to club the cells with drugs that make latent HIV reservoirs noticeable to the immune system so that T cells can recognize the virus and eradicate it.<\/p>\n

The chronic pancreatitis drug of AzurRx Biopharma hits the mark in phase 2<\/strong><\/p>\n

AzurRx Biopharma<\/strong> declared that its main asset met its primary and secondary endpoints in a phase 2a trial<\/strong>. The drug, a recombinant lipase, is designed to treat an enzyme condition linked to chronic pancreatitis<\/strong>. The medication, called MS1819-SD<\/strong>, is designed to treat exocrine pancreatic insufficiency (EPI)<\/strong>, which is caused by chronic pancreatitis. The pancreas is halted because of scarring and inflammation to make enough exocrine enzymes, that results in the inability to digest food properly, especially fats.<\/p>\n","protected":false},"excerpt":{"rendered":"

The interleukin-33 antibody of AnaptysBio passes midstage test in asthma The pipeline drug, etokimab of AnaptysBio, has positive data in a third indication that adds asthma to one of its triumphs. The US-based company gets another proof-of-concept study for the interleukin-33 (IL-33) inhibitor, because of phase 2a trial in severe eosinophilic asthma, and a third […]<\/p>\n","protected":false},"author":1,"featured_media":2465,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[32],"tags":[1870,1873,1876,82,1875,1860,1861,1867,1871,1862,1868,704,297,1609,315,1874,1863,1872,1869,1865,1866,1864],"industry":[17225],"therapeutic_areas":[17239,17230,17231,17228,17433,17243],"class_list":["post-3248","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizia","tag-anb020","tag-anaptysbio","tag-anti-il-33-drug","tag-antiretroviral-drugs","tag-asthma","tag-azurrx-biopharma","tag-chronic-pancreatitis","tag-epizyme","tag-etokimab","tag-exocrine-pancreatic-insufficiency-epi","tag-ezh2-inhibitor","tag-fda","tag-hiv","tag-hiv-reservoirs","tag-immunotherapy","tag-interleukin-33-il-33-inhibitor","tag-ms1819-sd","tag-severe-eosinophilic-asthma","tag-t-cell-lymphoblastic-lymphoma","tag-t-cell-therapy","tag-tazemetostat","tag-university-of-north-carolina","industry-pharmaceutical","therapeutic_areas-gastroenterology","therapeutic_areas-genito-urinary-system-and-sex-hormones","therapeutic_areas-infectious-diseases","therapeutic_areas-oncology","therapeutic_areas-pediatrics","therapeutic_areas-respiratory-diseases"],"acf":[],"yoast_head":"\nNotizia 25\/09\/2018 - DelveInsight Business Research LLP<\/title>\n<meta name=\"description\" content=\"The pipeline drug, etokimab of AnaptysBio, has positive data in a third indication that adds asthma to one of its triumphs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.delveinsight.com\/blog\/notizia-74\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Notizia 25\/09\/2018 - DelveInsight Business Research LLP\" \/>\n<meta property=\"og:description\" content=\"The pipeline drug, etokimab of AnaptysBio, has positive data in a third indication that adds asthma to one of its triumphs.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.delveinsight.com\/blog\/notizia-74\" \/>\n<meta property=\"og:site_name\" content=\"DelveInsight Business Research\" \/>\n<meta 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href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">Notizia - Recent Pharma, Healthcare and Biotech Happenings<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Notizia - Recent Pharma, Healthcare and Biotech Happenings<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">(ANB020)<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">AnaptysBio<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">anti-IL-33 drug<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">antiretroviral drugs<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">asthma<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">AzurRx Biopharma<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">chronic pancreatitis.<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">Epizyme<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">etokimab<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">exocrine pancreatic insufficiency (EPI)<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">EZH2 inhibitor<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">FDA<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">HIV<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">HIV reservoirs<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">Immunotherapy<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">interleukin-33 (IL-33) inhibitor<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">MS1819-SD<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">severe eosinophilic asthma<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">T-cell lymphoblastic lymphoma<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">T-cell therapy<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">tazemetostat<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/notizia\/\" class=\"advgb-post-tax-term\">University of North Carolina<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">(ANB020)<\/span>","<span class=\"advgb-post-tax-term\">AnaptysBio<\/span>","<span class=\"advgb-post-tax-term\">anti-IL-33 drug<\/span>","<span class=\"advgb-post-tax-term\">antiretroviral drugs<\/span>","<span class=\"advgb-post-tax-term\">asthma<\/span>","<span class=\"advgb-post-tax-term\">AzurRx Biopharma<\/span>","<span class=\"advgb-post-tax-term\">chronic pancreatitis.<\/span>","<span class=\"advgb-post-tax-term\">Epizyme<\/span>","<span class=\"advgb-post-tax-term\">etokimab<\/span>","<span class=\"advgb-post-tax-term\">exocrine pancreatic insufficiency (EPI)<\/span>","<span class=\"advgb-post-tax-term\">EZH2 inhibitor<\/span>","<span class=\"advgb-post-tax-term\">FDA<\/span>","<span class=\"advgb-post-tax-term\">HIV<\/span>","<span class=\"advgb-post-tax-term\">HIV reservoirs<\/span>","<span class=\"advgb-post-tax-term\">Immunotherapy<\/span>","<span class=\"advgb-post-tax-term\">interleukin-33 (IL-33) inhibitor<\/span>","<span class=\"advgb-post-tax-term\">MS1819-SD<\/span>","<span class=\"advgb-post-tax-term\">severe eosinophilic asthma<\/span>","<span class=\"advgb-post-tax-term\">T-cell lymphoblastic lymphoma<\/span>","<span class=\"advgb-post-tax-term\">T-cell therapy<\/span>","<span class=\"advgb-post-tax-term\">tazemetostat<\/span>","<span class=\"advgb-post-tax-term\">University of North Carolina<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 8 years ago","modified":"Updated 5 years ago"},"absolute_dates":{"created":"Posted on Sep 25, 2018","modified":"Updated on Jul 24, 2021"},"absolute_dates_time":{"created":"Posted on Sep 25, 2018 12:49 pm","modified":"Updated on Jul 24, 2021 12:57 pm"},"featured_img_caption":"transthyretin 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