{"id":3758,"date":"2018-12-12T16:57:44","date_gmt":"2018-12-12T11:27:44","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=3758"},"modified":"2024-09-18T15:19:16","modified_gmt":"2024-09-18T09:49:16","slug":"snippet-9","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/snippet-9","title":{"rendered":"Baby gene edits could affect a range of traits"},"content":{"rendered":"<p style=\"text-align: justify;\"><strong>Chinese scientist &#8211; He Jiankui\u2019<\/strong>s extraordinary claim regarding making the first babies \u2014 twin girls \u2014 with edited genomes\u00a0astonished the world. Among researchers\u2019 principal concerns are the potential effects of the genetic alterations on the health of girls.<\/p>\n<p style=\"text-align: justify;\">He, a genome-editing researcher at the <strong>Southern University of Science and Technology of China<\/strong> in Shenzhen told that he impregnated a woman with embryos that had been edited to disable a gene that allows <a href=\"https:\/\/www.delveinsight.com\/report-store\/hiv-associated-lipodystrophy-market\">HIV <\/a>to infect cells. Then this gene, known as\u00a0<strong><em>CCR5<\/em><\/strong>, was targeted because it is well studied, and because its mutation offers protection against HIV infection. The\u00a0<em>CCR5<\/em>\u00a0gene has been the topic of research since long back and has roles beyond HIV that scientists are just beginning to understand. The loss of\u00a0<em>CCR5<\/em>\u00a0function increases the risk of severe or fatal reactions to some infectious diseases, for example, and has also been shown to enhance learning in mice.<\/p>\n<p style=\"text-align: justify;\"><strong>Target gene<\/strong><\/p>\n<p style=\"text-align: justify;\">The CCR5 protein is expressed on the surface of some immune cells, and HIV takes advantage of it. The scientists identified a mutation, known as\u00a0<strong><em>CCR5-\u039432<\/em><\/strong>, that makes carriers highly resistant to HIV. Although the\u00a0<em>CCR5-\u039432<\/em>\u00a0mutation disables the gene and makes carriers resistant to the dominant strain of HIV, <em>CCR5<\/em>\u00a0also helps to protect the <strong>lungs, liver and <a href=\"https:\/\/www.delveinsight.com\/report-store\/brain-hemorrhage-market\">brain<\/a><\/strong> during some other serious infections and chronic diseases.<\/p>\n<p style=\"text-align: justify;\"><strong>Virus protection<\/strong><\/p>\n<p style=\"text-align: justify;\">The CCR5 protein also interacts with proteins called <strong>\u03b2-chemokines<\/strong> that help the body mount an immune response against a group of viruses called <strong>flaviviruses<\/strong>. These include tick-borne viruses and the viruses that cause dengue and yellow fever, as well as West Nile virus. The people with the\u00a0<em>CCR5-\u039432<\/em>\u00a0are more likely to experience severe encephalitis from tick-borne diseases, and to have a severe reaction to the vaccine for yellow fever. \u00a0Influenza could also pose a greater risk to the twins. Also among people with multiple sclerosis, those with the\u00a0<em>CCR5-\u039432<\/em>\u00a0deletion are twice as likely to die early than are people without the mutation.<\/p>\n<p style=\"text-align: justify;\"><strong>Brain enhancement?<\/strong><\/p>\n<p style=\"text-align: justify;\">Although whether the twins will learn faster than they would have done without the mutation, other scientists are sceptical about the gene deletion will have a noticeable effect on the girls\u2019 learning<\/p>\n<p style=\"text-align: justify;\"><strong>Silva Alcino<\/strong>, a neuroscientist at the <strong>University of California Los Angeles<\/strong>, agrees that any effect will likely be unpredictable. The deletion of this receptor confers some advantages and very likely also results in deficits in some forms of cognitive function in neuroscience.<\/p>\n<p style=\"text-align: justify;\">Despite the growing body on the mutation research, it is difficult to draw conclusions about its overall effects. Only a small number of people has the mutation, making it difficult to recruit large numbers of participants for studies. However, the potential consequences of lacking a working\u00a0<em>CCR5<\/em> gene are probably greater than have been established so far.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Chinese scientist &#8211; He Jiankui\u2019s extraordinary claim regarding making the first babies \u2014 twin girls \u2014 with edited genomes\u00a0astonished the world. Among researchers\u2019 principal concerns are the potential effects of the genetic alterations on the health of girls. He, a genome-editing researcher at the Southern University of Science and Technology of China in Shenzhen told [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3759,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[2235,148,2307,2311,2310,2308,917,2312,2309],"industry":[17225],"therapeutic_areas":[17235],"class_list":["post-3758","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-brain","tag-ccr5","tag-ccr5-32","tag-dengue-and-yellow-fever","tag-flaviviruses","tag-liver","tag-lungs","tag-west-nile-virus","tag--chemokines","industry-pharmaceutical","therapeutic_areas-cell-and-gene-therapy"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Baby gene edits could affect a range of traits | DelveInsight<\/title>\n<meta name=\"description\" content=\"The\u00a0CCR5-\u039432\u00a0mutation disables the gene and makes carriers resistant to the dominant strain of HIV, CCR5\u00a0also helps to protect the lungs, liver and....\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.delveinsight.com\/blog\/snippet-9\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Baby gene edits could affect a range of traits | DelveInsight\" \/>\n<meta property=\"og:description\" content=\"The\u00a0CCR5-\u039432\u00a0mutation disables the gene and makes carriers resistant to the dominant strain of HIV, CCR5\u00a0also helps to protect the lungs, liver and....\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.delveinsight.com\/blog\/snippet-9\" \/>\n<meta property=\"og:site_name\" content=\"DelveInsight Business Research\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/DelveInsight-1423323754607782\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-12-12T11:27:44+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-18T09:49:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2018\/12\/09025957\/20-newtechnique.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"900\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"DelveInsight\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@DelveInsight\" \/>\n<meta name=\"twitter:site\" content=\"@DelveInsight\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"DelveInsight\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Baby gene edits could affect a range of traits | DelveInsight","description":"The\u00a0CCR5-\u039432\u00a0mutation disables the gene and makes carriers resistant to the dominant strain of HIV, CCR5\u00a0also helps to protect the lungs, liver and....","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.delveinsight.com\/blog\/snippet-9","og_locale":"en_US","og_type":"article","og_title":"Baby gene edits could affect a range of traits | DelveInsight","og_description":"The\u00a0CCR5-\u039432\u00a0mutation disables the gene and makes carriers resistant to the dominant strain of HIV, CCR5\u00a0also helps to protect the lungs, liver and....","og_url":"https:\/\/www.delveinsight.com\/blog\/snippet-9","og_site_name":"DelveInsight Business Research","article_publisher":"https:\/\/www.facebook.com\/DelveInsight-1423323754607782\/","article_published_time":"2018-12-12T11:27:44+00:00","article_modified_time":"2024-09-18T09:49:16+00:00","og_image":[{"width":1500,"height":900,"url":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2018\/12\/09025957\/20-newtechnique.jpg","type":"image\/jpeg"}],"author":"DelveInsight","twitter_card":"summary_large_image","twitter_creator":"@DelveInsight","twitter_site":"@DelveInsight","twitter_misc":{"Written by":"DelveInsight","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.delveinsight.com\/blog\/snippet-9","url":"https:\/\/www.delveinsight.com\/blog\/snippet-9","name":"Baby gene edits could affect a range of traits | DelveInsight","isPartOf":{"@id":"https:\/\/www.delveinsight.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.delveinsight.com\/blog\/snippet-9#primaryimage"},"image":{"@id":"https:\/\/www.delveinsight.com\/blog\/snippet-9#primaryimage"},"thumbnailUrl":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2018\/12\/09025957\/20-newtechnique.jpg","datePublished":"2018-12-12T11:27:44+00:00","dateModified":"2024-09-18T09:49:16+00:00","author":{"@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/5fbf6ca478835d03fdb5e17d905b520a"},"description":"The\u00a0CCR5-\u039432\u00a0mutation disables the gene and makes carriers resistant to the dominant strain of HIV, CCR5\u00a0also helps to protect the lungs, liver and....","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.delveinsight.com\/blog\/snippet-9"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.delveinsight.com\/blog\/snippet-9#primaryimage","url":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2018\/12\/09025957\/20-newtechnique.jpg","contentUrl":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2018\/12\/09025957\/20-newtechnique.jpg","width":1500,"height":900,"caption":"gene edit"},{"@type":"WebSite","@id":"https:\/\/www.delveinsight.com\/blog\/#website","url":"https:\/\/www.delveinsight.com\/blog\/","name":"DelveInsight Business Research","description":"Blog","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.delveinsight.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/5fbf6ca478835d03fdb5e17d905b520a","name":"DelveInsight","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/afdd550c64e18f6ad8957080b017c6ae55f4916951d641d3cd40264176aa0e86?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/afdd550c64e18f6ad8957080b017c6ae55f4916951d641d3cd40264176aa0e86?s=96&d=mm&r=g","caption":"DelveInsight"}}]}},"author_meta":{"display_name":"DelveInsight","author_link":"https:\/\/www.delveinsight.com\/blog\/author\/gtadmin"},"featured_img":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2018\/12\/09025957\/20-newtechnique-300x180.jpg","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Articles<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Articles<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">brain<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">CCR5<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">CCR5-\u039432<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">dengue and yellow fever<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">flaviviruses<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">liver<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">lungs<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">West Nile virus<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">\u03b2-chemokines<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">brain<\/span>","<span class=\"advgb-post-tax-term\">CCR5<\/span>","<span class=\"advgb-post-tax-term\">CCR5-\u039432<\/span>","<span class=\"advgb-post-tax-term\">dengue and yellow fever<\/span>","<span class=\"advgb-post-tax-term\">flaviviruses<\/span>","<span class=\"advgb-post-tax-term\">liver<\/span>","<span class=\"advgb-post-tax-term\">lungs<\/span>","<span class=\"advgb-post-tax-term\">West Nile virus<\/span>","<span class=\"advgb-post-tax-term\">\u03b2-chemokines<\/span>"]}},"comment_count":"1","relative_dates":{"created":"Posted 7 years ago","modified":"Updated 2 years ago"},"absolute_dates":{"created":"Posted on Dec 12, 2018","modified":"Updated on Sep 18, 2024"},"absolute_dates_time":{"created":"Posted on Dec 12, 2018 4:57 pm","modified":"Updated on Sep 18, 2024 3:19 pm"},"featured_img_caption":"","series_order":"","_links":{"self":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/3758","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/comments?post=3758"}],"version-history":[{"count":1,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/3758\/revisions"}],"predecessor-version":[{"id":29632,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/3758\/revisions\/29632"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media\/3759"}],"wp:attachment":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media?parent=3758"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/categories?post=3758"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/tags?post=3758"},{"taxonomy":"industry","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/industry?post=3758"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/therapeutic_areas?post=3758"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}