{"id":3864,"date":"2018-12-26T16:36:03","date_gmt":"2018-12-26T11:06:03","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=3864"},"modified":"2023-06-16T11:06:13","modified_gmt":"2023-06-16T05:36:13","slug":"transmissible-alzheimers-theory-gains-traction","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/transmissible-alzheimers-theory-gains-traction","title":{"rendered":"\u2018Transmissible\u2019 Alzheimer\u2019s theory gains traction"},"content":{"rendered":"\n<p><br><\/p>\n\n\n\n<p class=\"has-drop-cap\">Neuroscientists have garnered more evidence for the hypothesis regarding sticky proteins, which is a symbol of <strong>neurodegenerative diseases<\/strong>. This can be transferred between people under particular conditions and also cause new damage in a brain of recipient. Their research does not hint that disorders such as Alzheimer\u2019s disease are contagious, however it raises eyebrows that medical and surgical procedures pose a risk of transmitting such proteins between humans. The researchers revealed regarding wide deposits of a protein called <strong>amyloid-beta<\/strong> during post-mortem studies of the <a href=\"https:\/\/www.delveinsight.com\/report-store\/brain-hemorrhage-market\">brains<\/a> of four people in the United Kingdom. It is treated for short stature during childhood with growth-hormone preparations derived from the pituitary glands of donors after death. The recipients had died in middle-age of a rare but deadly\u00a0neurodegenerative condition called <strong>Creutzfeldt-Jakob disease\u00a0(CJD)<\/strong>, caused by the presence in some of the growth-hormone preparations of an infectious, and misfolded protein or prion, which causes CJD. <\/p>\n\n\n\n<p><strong>Seeds of trouble<\/strong><\/p>\n\n\n\n<p><strong>Amyloid plaques<\/strong> in blood vessels in the brain are a hallmark of a disease called <strong>cerebral amyloid angiopathy (CAA)<\/strong> and cause local bleeding. In <a href=\"https:\/\/www.delveinsight.com\/report-store\/alzheimers-disease-ad-market\">Alzheimer\u2019s<\/a> disease, amyloid plaques are typically accompanied by another protein called tau and lead the researchers concern regarding transmission. The team has squarely tested the hypothesis that these proteins could be transmitted between humans through contaminated biological preparations. When the researchers analysed the samples, their suspicions were confirmed: they found that some of the batches contained substantial levels of amyloid-beta and tau proteins.<\/p>\n\n\n\n<p><strong>Mouse tests<\/strong><\/p>\n\n\n\n<p>To test whether the amyloid-beta in\nthe batches could cause the amyloid pathology, they injected samples directly\ninto the brains of young mice, which are genetically engineered, to be\nsusceptible to amyloid pathology. The mice had developed extensive amyloid\nplaques and CAA by mid-life. Control mice that received either no treatment or\ntreatment with synthetic growth hormone didn\u2019t have amyloid build up.<\/p>\n\n\n\n<p><strong>Surgical implications<\/strong><\/p>\n\n\n\n<p>The transmissibility of the\namyloid-beta could be preserved after so many decades underlines that is the\nneed for caution. The sticky amyloid clings tightly to materials used in\nsurgical instruments, resisting standard decontamination methods. But as\ndegenerative diseases take a long time to develop, the danger of any transfer\nmay be in the case of childhood surgery where instruments have also been used\non old people.\ufeff<\/p>\n\n\n\n<p>The epidemiologists have not been able to assess whether a history of surgery increases the risk of developing <g class=\"gr_ gr_4 gr-alert gr_gramm gr_inline_cards gr_run_anim Grammar only-del replaceWithoutSep\" id=\"4\" data-gr-id=\"4\">a neurodegenerative<\/g> disease in later life. Major population cohort studies, such as the US Framingham Heart Study, are open to collect information about participants\u2019 past surgical procedures, along with other medical data.<\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neuroscientists have garnered more evidence for the hypothesis regarding sticky proteins, which is a symbol of neurodegenerative diseases. This can be transferred between people under particular conditions and also cause new damage in a brain of recipient. Their research does not hint that disorders such as Alzheimer\u2019s disease are contagious, however it raises eyebrows that [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":3865,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[2347,2235,2349,2348,2346],"industry":[17225],"therapeutic_areas":[17245],"class_list":["post-3864","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-amyloid-beta","tag-brain","tag-cerebral-amyloid-angiopathy-caa","tag-creutzfeldt-jakob-disease-cjd","tag-neurodegenerative-diseases","industry-pharmaceutical","therapeutic_areas-neurology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - 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href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Articles<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Articles<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">amyloid-beta<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">brain<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">cerebral amyloid angiopathy (CAA)<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Creutzfeldt-Jakob disease (CJD)<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">neurodegenerative diseases<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">amyloid-beta<\/span>","<span class=\"advgb-post-tax-term\">brain<\/span>","<span class=\"advgb-post-tax-term\">cerebral amyloid angiopathy (CAA)<\/span>","<span class=\"advgb-post-tax-term\">Creutzfeldt-Jakob disease (CJD)<\/span>","<span class=\"advgb-post-tax-term\">neurodegenerative diseases<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 7 years ago","modified":"Updated 3 years ago"},"absolute_dates":{"created":"Posted on Dec 26, 2018","modified":"Updated on Jun 16, 2023"},"absolute_dates_time":{"created":"Posted on Dec 26, 2018 4:36 pm","modified":"Updated on Jun 16, 2023 11:06 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