{"id":4326,"date":"2019-02-27T17:02:23","date_gmt":"2019-02-27T11:32:23","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=4326"},"modified":"2025-05-07T12:19:20","modified_gmt":"2025-05-07T06:49:20","slug":"a-helping-hand-in-treatment-of-crc","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/a-helping-hand-in-treatment-of-crc","title":{"rendered":"A helping hand in treatment of CRC"},"content":{"rendered":"\n<p class=\"has-drop-cap\">Patients suffering from <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/colorectal-cancer-crc-market\">Colorectal Cancer <\/a>(CRC)<\/strong> usually gets affected with <strong>distant organ<\/strong> <strong>metastases<\/strong> spreading the tumor to other parts of the body. Patients with unresectable or borderline resectable <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/liver-cancer-market\">Colorectal liver metastases<\/a><\/strong> (CRLM) are given <strong>Neoadjuvant Chemotherapy (NC)<\/strong> to limit liver resection and to lower down the tumor burden. But the possible chances of chemotherapy-induced liver damage and associated effects do not get ruled out. <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/chemotherapy-induced-anemia-market\">Chemotherapy<\/a><\/strong> can potentially damage the healthy tissue surrounding the tumor. <\/p>\n\n\n\n<p>So, the discovery of a<strong> tissue-based molecular biomarker<\/strong> which will only target primary tumor proved to be a ray of sunshine in the rain. <\/p>\n\n\n\n<p>A recent study, published in the <strong>British Journal of Cancer <\/strong>(2019), explores the significance of prognostic and predictive enzyme <strong>pyruvate dehydrogenase<\/strong> <strong>isoenzyme 4<\/strong> (<strong>PDK4<\/strong>). This will help to identify those patients who will be benefited from NC. Effect of Transcription of PDK4 was assessed on the tissue of healthy liver, corresponding CRLM, healthy colon mucosa, and corresponding <g class=\"gr_ gr_7 gr-alert gr_spell gr_inline_cards gr_disable_anim_appear ContextualSpelling multiReplace\" id=\"7\" data-gr-id=\"7\"><a href=\"https:\/\/www.delveinsight.com\/report-store\/biliary-tumor-global-api-manufacturers-marketed-and-phase-iii-drugs-landscape\"><strong>tumour<\/strong><\/a><\/g>.\u00a0<\/p>\n\n\n\n<p>Patients were reviewed for <strong>perioperative hepato-toxic medication.<\/strong> And the Neoadjuvant Chemotherapy\nwas performed before the surgical resection of CRLM. <\/p>\n\n\n\n<p>The clinical data collected showed that the healthy liver <a href=\"https:\/\/www.delveinsight.com\/report-store\/soft-tissue-sarcoma-market\"><strong>tissue<\/strong><\/a> of patients with NC showed no significant increase of histological signs, such as liver <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/cystic-fibrosis-market\">fibrosis<\/a><\/strong>, steatosis or steatohepatitis which can be associated with chemotherapy-induced liver damage. Tests conducted like <strong>immunohistochemistry<\/strong> and <strong>Western blotting<\/strong> confirmed the abundant levels of PDK4 proteins in healthy liver tissue than in corresponding CRLM tissue.<\/p>\n\n\n\n<p>The increased patient survival directly propionates to a\nhigher level of PDK4 levels. Also, PDK4 helps in enhancing the postoperative\nliver function as well. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Patients suffering from Colorectal Cancer (CRC) usually gets affected with distant organ metastases spreading the tumor to other parts of the body. Patients with unresectable or borderline resectable Colorectal liver metastases (CRLM) are given Neoadjuvant Chemotherapy (NC) to limit liver resection and to lower down the tumor burden. But the possible chances of chemotherapy-induced liver [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4330,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[41],"tags":[2667,2668,160,174,2666,1471,2104,2308,2664,2665,2671,2670,2495,2669,2673,1705,2672],"industry":[17225],"therapeutic_areas":[17228],"class_list":["post-4326","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-snippets","tag-biomarker","tag-british-journal-of-cancer","tag-chemotherapy","tag-colorectal-cancer","tag-crlm","tag-fibrosis","tag-immunohistochemistry","tag-liver","tag-metastases","tag-neoadjuvant-chemotherapy","tag-pdk4","tag-perioperative-hepato-toxic-medication","tag-proteins","tag-pyruvate-dehydrogenase-isoenzyme-4","tag-steatosis","tag-tumor","tag-western-blotting","industry-pharmaceutical","therapeutic_areas-oncology"],"acf":[],"yoast_head":"<!-- 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href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Snippets - A Small piece of News or Article<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Snippets - A Small piece of News or Article<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">biomarker<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">British Journal of Cancer<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">chemotherapy<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Colorectal Cancer<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">CRLM<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">fibrosis<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">immunohistochemistry<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">liver<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">metastases<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Neoadjuvant Chemotherapy<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">PDK4<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">perioperative hepato-toxic medication<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">proteins<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">pyruvate dehydrogenase isoenzyme 4<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">steatosis<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Tumor<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/snippets\/\" class=\"advgb-post-tax-term\">Western blotting<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">biomarker<\/span>","<span class=\"advgb-post-tax-term\">British Journal of Cancer<\/span>","<span class=\"advgb-post-tax-term\">chemotherapy<\/span>","<span class=\"advgb-post-tax-term\">Colorectal Cancer<\/span>","<span class=\"advgb-post-tax-term\">CRLM<\/span>","<span class=\"advgb-post-tax-term\">fibrosis<\/span>","<span class=\"advgb-post-tax-term\">immunohistochemistry<\/span>","<span class=\"advgb-post-tax-term\">liver<\/span>","<span class=\"advgb-post-tax-term\">metastases<\/span>","<span class=\"advgb-post-tax-term\">Neoadjuvant Chemotherapy<\/span>","<span class=\"advgb-post-tax-term\">PDK4<\/span>","<span class=\"advgb-post-tax-term\">perioperative hepato-toxic medication<\/span>","<span class=\"advgb-post-tax-term\">proteins<\/span>","<span class=\"advgb-post-tax-term\">pyruvate dehydrogenase isoenzyme 4<\/span>","<span class=\"advgb-post-tax-term\">steatosis<\/span>","<span class=\"advgb-post-tax-term\">Tumor<\/span>","<span class=\"advgb-post-tax-term\">Western blotting<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 7 years ago","modified":"Updated 12 months ago"},"absolute_dates":{"created":"Posted on Feb 27, 2019","modified":"Updated on May 7, 2025"},"absolute_dates_time":{"created":"Posted on Feb 27, 2019 5:02 pm","modified":"Updated on May 7, 2025 12:19 pm"},"featured_img_caption":"A helping hand in treatment of 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