{"id":4533,"date":"2019-03-25T17:46:54","date_gmt":"2019-03-25T12:16:54","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=4533"},"modified":"2024-09-18T13:26:55","modified_gmt":"2024-09-18T07:56:55","slug":"epilepsy-a-neurological-disorder","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/epilepsy-a-neurological-disorder","title":{"rendered":"EPILEPSY- A Neurological Disorder"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a14fa58d04d9\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a14fa58d04d9\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/epilepsy-a-neurological-disorder\/#What_is_Epilepsy\" >What\nis Epilepsy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/epilepsy-a-neurological-disorder\/#What_Causes_Epilepsy\" >What Causes Epilepsy?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/epilepsy-a-neurological-disorder\/#Now_what_exactly_is_a_seizure\" >Now, what exactly is a seizure?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/epilepsy-a-neurological-disorder\/#Stay_Safe_during_a_SEIZURE\" >Stay Safe during a SEIZURE<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.delveinsight.com\/blog\/epilepsy-a-neurological-disorder\/#Diagnosis\" >Diagnosis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.delveinsight.com\/blog\/epilepsy-a-neurological-disorder\/#Socio-Economic_Impacts\" >Socio-Economic Impacts<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/www.delveinsight.com\/blog\/epilepsy-a-neurological-disorder\/#The_Road_Ahead\" >The Road Ahead<\/a><\/li><\/ul><\/nav><\/div>\n\n<h4 class=\"wp-block-heading\" id=\"h-what-is-epilepsy\"><span class=\"ez-toc-section\" id=\"What_is_Epilepsy\"><\/span><strong>What\nis<\/strong> <strong>Epilepsy<\/strong>? <span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p class=\"has-drop-cap\">Epilepsy is a neurological disorder which mainly affects the central nervous system. It is a chronic and non-communicable disorder associated with unpredictable <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/seizures-pipeline-insight\">seizures<\/a><\/strong> which affect the body and can result in injuries hence is a physical condition too. <\/p>\n\n\n\n<p class=\"has-background\" style=\"background-color:#eacce6\"><strong>Anyone can develop Epilepsy at any age,\nat any point of time and anywhere. It usually affects people of all ages and\nraces<\/strong>. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-what-causes-epilepsy\"><span class=\"ez-toc-section\" id=\"What_Causes_Epilepsy\"><\/span><strong>What Causes Epilepsy?<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>Epilepsy<\/strong> has no identifiable cause. Some with no clear cause can blame their genetic profile. Sometimes the triggers run in families. It can be caused due to the way some genes have been manipulated to work. <strong>Brain infections<\/strong> or Brain injuries can change the way how neurons work. Thus, leading to seizures. <strong>Brain malformations, lack of oxygen during birth, maternal drug use<\/strong>, and <strong>low<\/strong> <strong>blood sugar level<\/strong> at the time of birth can lead to Epilepsy in newborns. In adults and children, brain injuries, fever, <strong>brain<\/strong> <strong>tumour<\/strong>, <strong>progressive genetic disorder<\/strong>, and other genetic factors can cause onset of <a href=\"https:\/\/www.delveinsight.com\/report-store\/seizures-market\" class=\"ek-link\">Seizures<\/a>. Stroke and <a href=\"https:\/\/www.delveinsight.com\/report-store\/alzheimers-disease-ad-market\" class=\"ek-link\">Alzheimer\u2019s disease<\/a> during old age. <\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-style-default is-layout-flow wp-block-quote-is-layout-flow\">\n<p><strong><em> Epilepsy is affecting 3.4 million people worldwide,&nbsp; and over 150,000 new cases are diagnosed each year accounting for 0.6% of the global burden of disease. <\/em><\/strong><\/p>\n<\/blockquote>\n\n\n\n<p>Looking at the numbers, the severity of the disorder is self-explanatory. <strong>It is likely to affect 1 in 26 people in their lifetime. <\/strong>Approximately 2.2 million Americans and roughly 1 million people in Japan are living with <strong>Epilepsy<\/strong>. Over 6, 00,000 people in the UK have Epilepsy. In Europe, at least 6 million people have epilepsy, and 15 million Europeans will have one seizure at some time in their lives. Moreover, 80% of people living with it are from low- or middle-income countries. Out of which 70% of them if diagnosed properly can live a seizure free-life. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-now-what-exactly-is-a-seizure\"><span class=\"ez-toc-section\" id=\"Now_what_exactly_is_a_seizure\"><\/span>Now, what exactly is a seizure? <span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>A <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/seizures-epidemiology-forecast\">SEIZURE<\/a><\/strong> is a sudden alteration of behavior, a sudden surge in the brain activity that affects how a person acts or behaves. There present cells in the <g class=\"gr_ gr_10 gr-alert gr_gramm gr_inline_cards gr_run_anim Grammar only-ins replaceWithoutSep\" id=\"10\" data-gr-id=\"10\">brain<\/g> which are either responsible for exciting or stopping the chemical produced in the brain. <strong>During a Seizure there is either too much of excitation or too little inhibition, creating an imbalance<\/strong>. It itself isn\u2019t a disease but a symptom which can last for up to a minute. Although the sign of any seizure depends on the size of it <g class=\"gr_ gr_9 gr-alert gr_gramm gr_inline_cards gr_run_anim Grammar replaceWithoutSep\" id=\"9\" data-gr-id=\"9\">but<\/g> sometimes it is hard to even notice if a person is going through it. <br><strong>There are different types of Seizures. <\/strong><br><strong>Generalized onset Seizures <\/strong>affect both sides of the brain cells simultaneously. It results in an epileptic person to stare aimlessly, jerking movements, limp or tense muscles, repeated spasms or continuous eye twitching.\u00a0 <br><strong>Focal onset <a href=\"https:\/\/www.delveinsight.com\/report-store\/partial-seizure-market\">Seizures<\/a><\/strong> affect one side of the brain. And if a person is completely aware of the happenings around during a seizure it is <strong>Focal Onset Awake Seizure<\/strong>. If a person loses awareness then it is referred to as <strong>Focal onset Impaired <a href=\"https:\/\/www.delveinsight.com\/report-store\/partial-seizure-pipeline-insight\">Seizure<\/a><\/strong>. It includes lip-smacking, running or chewing, continuous rubbing of hands or clapping or behavioral and emotional changes. <br><strong>There exist phases of Seizures. <\/strong><br><strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/partial-seizure-global-api-manufacturers-marketed-and-phase-iii-drugs-landscape\">Seizures<\/a><\/strong> have a beginning, a middle and an end. Although not everyone going through a Seizure may feel or go through each of the phase listed above <g class=\"gr_ gr_81 gr-alert gr_gramm gr_inline_cards gr_run_anim Grammar replaceWithoutSep\" id=\"81\" data-gr-id=\"81\">but<\/g> some are aware of the upcoming attack hours or even days before. During a <strong>BEGINNING<\/strong>, a person can feel different smells, unfamiliar sounds, D\u00e9j\u00e0 vu, Jamais vu, visual loss, fear or light-headedness. The <strong>MIDDLE <\/strong>of a <a href=\"https:\/\/www.delveinsight.com\/report-store\/partial-seizure-epidemiology-forecast\">seizure<\/a> includes a person to black out, lose consciousness daydream, distractedness, unusual strange tastes or sounds, numbness, panic, repeated movements of body parts, uncontrollable shaking called <strong>fits,<\/strong> rigid body parts, drooling, racing heart or losing control over excretion. The<strong> Ending <\/strong>results in a slow response, dizziness, confusion, frustration, embarrassment, memory loss, injuries, thirst, or nausea.\u00a0 <\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-stay-safe-during-a-seizure\"><span class=\"ez-toc-section\" id=\"Stay_Safe_during_a_SEIZURE\"><\/span><strong>Stay Safe during a SEIZURE<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Maintain composure and Stay Calm.<\/strong><\/li>\n\n\n\n<li>Stay with the person until the seizure is over and the person is fully alert. <\/li>\n\n\n\n<li>Ease the person to the floor. <\/li>\n\n\n\n<li>Get rid of any sharp objects, any neck or wrist bands, and eyeglasses to prevent any injuries. Protect the head. <\/li>\n\n\n\n<li><strong>Do not<\/strong> try to give CPR or try to feed the person any kind of food. <strong>Do not<\/strong> try to hold the person. <\/li>\n\n\n\n<li><strong>Look for help if the seizure lasts for more than 5 minutes.<\/strong> <\/li>\n\n\n\n<li><strong>What causes Epilepsy? <\/strong><\/li>\n\n\n\n<li><strong>Head trauma <\/strong>or any type of brain injury can result in Epilepsy. <\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-diagnosis\"><span class=\"ez-toc-section\" id=\"Diagnosis\"><\/span><strong>Diagnosis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Diagnostic methods for Epilepsy ranges from Blood testing to Brain Imaging. <strong>Electroencephalogram (EEG) <\/strong>is the most common method to diagnose Epilepsy. This method includes placing electrodes on the brain to study the changes in brain electrical waves. Then there is <strong>High-density EEG<\/strong> as well in which the placement of electrodes is way more compact. <strong>Computerised-Tomography (CT) Scan <\/strong>which uses x-Rays, <strong>MRI<\/strong> uses powerful radio magnets to make a detailed view of the brain.<br>  <br><strong>Seizures can be controlled. <\/strong><br>Medications can help people live a seizure-free life. The current market for Epilepsy is dominated by the use of several <strong>Anti-epileptic drugs<\/strong> <strong>(AEDs). <\/strong>They have the potential to treat the <a href=\"https:\/\/www.delveinsight.com\/report-store\/seizures-global-api-manufacturers-marketed-and-phase-iii-drugs-landscape\">seizures<\/a> completely in almost 70% of the cases. <strong>Antiepileptic Drugs <\/strong>(AEDs) which can be broadly classified as per their mechanism of action, these are <strong>Gamma-Aminobutyric Acid<\/strong> \u00a0(<strong>GABA) Enhancers\/ Inhibitors<\/strong>, <strong>Calcium<\/strong> <strong>Channel Blockers<\/strong>, Sodium <strong>(Na) Channel Blockers<\/strong>, medication inhibiting both Ca and Na Channel Blockers, <strong>AMPA Receptor Blockade<\/strong>, the new AEDs falling under the category of <strong>Synaptic vesicle protein 2a (SV2a) vesicle inhibition<\/strong>, the <strong>plant-based approved cannabidiol<\/strong>, <strong>Epidiolex, which is the only approved therapy in this category. <\/strong>These medications do have the side effects- mild ones include skin rashes, fatigue, dizziness, and the severe ones include suicidal thoughts, depression and severe rashes. Finding the right dosage is critical for the patient as well as the Doctor. <strong>Because the right medication in the right amounts can change the lives of the epileptic-patients. <\/strong><br>When the medications fail, <strong>surgery is opted<\/strong>. Doctors try to remove the specific part of the brain that is causing seizures keeping in mind that it doesn\u2019t affect any vital functions of the brain like motor function, speech, vision or hearing. <br>There are dietary options as well which have shown benefits to 70% of the patients. <strong>Ketogenic Diet<\/strong> is a special high fat, adequate protein, <g class=\"gr_ gr_127 gr-alert gr_gramm gr_inline_cards gr_run_anim Punctuation only-ins replaceWithoutSep\" id=\"127\" data-gr-id=\"127\">and<\/g> low carbohydrate diet, and a <strong>modified Atkins diet <\/strong>is although a similar one but less restrictive. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-socio-economic-impacts\"><span class=\"ez-toc-section\" id=\"Socio-Economic_Impacts\"><\/span><strong>Socio-Economic Impacts<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Epilepsy poses an economic burden to health care systems and the affected ones. The impact may vary depending upon the severity, duration and the income group of the country. Even if the economic impact doesn\u2019t affect much the social stigma associated can cause much more harm than expected. Social acceptance matters the most. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-the-road-ahead\"><span class=\"ez-toc-section\" id=\"The_Road_Ahead\"><\/span><strong>The Road Ahead<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>Delveinsight<\/strong> believes that the current market of Epilepsy will slightly increase in the upcoming years with the emergence of several new <strong>Antiepileptic Drugs <\/strong>while few of them with a <g class=\"gr_ gr_4 gr-alert gr_gramm gr_inline_cards gr_run_anim Grammar only-ins replaceWithoutSep\" id=\"4\" data-gr-id=\"4\">novel<\/g> mechanism of action in the market. Among all these upcoming years, <strong>NRL-1(Neurelis)<\/strong>, <strong>Cannabidiol<\/strong> (INSYS Therapeutics) and <strong>Fintepla<\/strong> (Zogenix) are expected to hold the largest market share after their launch in the market in 2020 followed by the <strong>USL-261<\/strong> (<strong>UCB<\/strong> <strong>Pharma<\/strong>) and <strong>ZYN-002<\/strong> (<strong>Zynerba<\/strong>) with expected launch in 2019 and 2024 respectively as<strong> ZYN-002<\/strong> is still in Mid Stage of development in the clinical trials for Epilepsy.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>What is Epilepsy? Epilepsy is a neurological disorder which mainly affects the central nervous system. It is a chronic and non-communicable disorder associated with unpredictable seizures which affect the body and can result in injuries hence is a physical condition too. Anyone can develop Epilepsy at any age, at any point of time and anywhere. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":4540,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":4,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[2972,72,2956,2949,2952,2950,2960,2955,1494,2963,2958,2953,2967,2968,2966,2280,2962,2951,2964,2954,2886,548,2164,2965],"industry":[17225],"therapeutic_areas":[17245],"class_list":["post-4533","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-1in26","tag-alzheimers-disease","tag-antiepileptic-drugs","tag-brain-infection","tag-brain-injury","tag-brain-tumour","tag-calcium-channel-blockers","tag-electrical-storm","tag-epilepsy","tag-epileptic","tag-fintepla-zogenix","tag-fits","tag-focal-onset-awake-seizure","tag-focal-onset-impaired-seizure","tag-focal-onset-seizures","tag-ketogenic-diet","tag-modified-atkins-diet","tag-neurological-disorder","tag-nsys-therapeutics","tag-progressive-genetic-disorder","tag-seizures","tag-stroke","tag-surgery","tag-usl-261-ucb-pharma","industry-pharmaceutical","therapeutic_areas-neurology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>EPILEPSY- A Neurological Disorder - DelveInsight Business Research<\/title>\n<meta name=\"description\" content=\"Epilepsy is a neurological disorder which mainly affects the central nervous system. 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href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Articles<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Articles<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">1in26<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Alzheimer\u2019s disease<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Antiepileptic Drugs<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Brain infection<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">brain injury<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">brain tumour<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Calcium Channel Blockers<\/a>","<a 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class=\"advgb-post-tax-term\">ketogenic diet<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">modified Atkins diet<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">neurological disorder<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">NSYS Therapeutics<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">progressive genetic disorder<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Seizures<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">stroke<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">surgery<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">USL-261 (UCB Pharma)<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">1in26<\/span>","<span class=\"advgb-post-tax-term\">Alzheimer\u2019s disease<\/span>","<span class=\"advgb-post-tax-term\">Antiepileptic Drugs<\/span>","<span class=\"advgb-post-tax-term\">Brain infection<\/span>","<span class=\"advgb-post-tax-term\">brain injury<\/span>","<span class=\"advgb-post-tax-term\">brain tumour<\/span>","<span class=\"advgb-post-tax-term\">Calcium Channel Blockers<\/span>","<span class=\"advgb-post-tax-term\">electrical storm<\/span>","<span class=\"advgb-post-tax-term\">Epilepsy<\/span>","<span class=\"advgb-post-tax-term\">epileptic<\/span>","<span class=\"advgb-post-tax-term\">Fintepla (Zogenix)<\/span>","<span class=\"advgb-post-tax-term\">FITS<\/span>","<span class=\"advgb-post-tax-term\">Focal Onset Awake Seizure<\/span>","<span class=\"advgb-post-tax-term\">Focal onset Impaired Seizure<\/span>","<span class=\"advgb-post-tax-term\">Focal onset Seizures<\/span>","<span class=\"advgb-post-tax-term\">ketogenic diet<\/span>","<span class=\"advgb-post-tax-term\">modified Atkins diet<\/span>","<span class=\"advgb-post-tax-term\">neurological disorder<\/span>","<span class=\"advgb-post-tax-term\">NSYS Therapeutics<\/span>","<span class=\"advgb-post-tax-term\">progressive genetic disorder<\/span>","<span class=\"advgb-post-tax-term\">Seizures<\/span>","<span class=\"advgb-post-tax-term\">stroke<\/span>","<span class=\"advgb-post-tax-term\">surgery<\/span>","<span class=\"advgb-post-tax-term\">USL-261 (UCB Pharma)<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 7 years ago","modified":"Updated 2 years ago"},"absolute_dates":{"created":"Posted on Mar 25, 2019","modified":"Updated on Sep 18, 2024"},"absolute_dates_time":{"created":"Posted on Mar 25, 2019 5:46 pm","modified":"Updated on Sep 18, 2024 1:26 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