{"id":5851,"date":"2019-08-26T17:21:30","date_gmt":"2019-08-26T11:51:30","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=5851"},"modified":"2025-05-08T11:35:41","modified_gmt":"2025-05-08T06:05:41","slug":"hairy-cell-leukemia-therapy-landscape","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/hairy-cell-leukemia-therapy-landscape","title":{"rendered":"What to expect in the Coming Years for Hairy Cell Leukemia Therapy landscape?"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a08f350382cd\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a08f350382cd\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/hairy-cell-leukemia-therapy-landscape\/#Hairy_cell_leukaemia_Symptoms_and_Classification\" >Hairy cell leukaemia Symptoms and Classification<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/hairy-cell-leukemia-therapy-landscape\/#Hairy_cell_leukaemia_Epidemiology\" >Hairy cell leukaemia Epidemiology<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/hairy-cell-leukemia-therapy-landscape\/#Hairy_cell_leukaemia_Therapy_Market\" >Hairy cell leukaemia Therapy Market<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/hairy-cell-leukemia-therapy-landscape\/#Hairy_cell_leukaemia_Emerging_Therapies\" >Hairy cell leukaemia Emerging Therapies<\/a><\/li><\/ul><\/nav><\/div>\n\n<p class=\"has-drop-cap\">Every 3 minutes, one person in the United States (U.S.) is diagnosed with blood cancer, as estimated by The Leukemia &amp; Lymphoma Society (LLS). A total number of 176,200 people are expected to be diagnosed with leukaemia, lymphoma or myeloma in 2019. Out of which, 61,780 people are expected to be diagnosed with leukaemia.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hairy_cell_leukaemia_Symptoms_and_Classification\"><\/span><strong>Hairy cell leukaemia Symptoms and Classification<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p><strong>Hairy cell leukaemia abbreviated as HCL<\/strong> is a rare form of progressive leukaemia which accounts for one to two per cent of all cases of adult leukaemia. HCL results in an uncontrolled number of B-cells or lymphocytes in the bone marrow. The leukaemia is called so due to the \u2018hairy\u2019 appearance of the excess B-cells under the microscope. Hairy cell leukaemia results in an enlarged spleen (splenomegalia) but without an increase of lymph nodes. The other symptoms include fever, night sweats, fatigue, easy bruising, weight loss and reduced number of blood cells and platelets.<\/p>\n\n\n\n<p>Cancer occurs when there is a defect in the normal genome of the person. Similarly, it is believed that specific errors in the DNA might be a cause behind the loss of the ability of bone marrow cells to produce a controlled number of B-cells.<\/p>\n\n\n\n<p>However, the exact cause is still unknown according to the Hairy Cell Leukemia Foundation. The possible causes along with genetic mutations can be exposed to pesticides, herbicides and petrol or diesel fuel.<\/p>\n\n\n\n<p>There are two different types of Hairy cell leukaemia, i.e., Classical Hairy cell leukaemia (HCLc) and Variant Hairy cell leukaemia (HCLv). HCL-V is less common than classic hairy cell <a href=\"https:\/\/www.delveinsight.com\/report-store\/b-cell-chronic-lymphocytic-leukemia-epidemiology-forecast\">leukaemia<\/a>. It can develop at any age, however, it is more common in older people. HCL-V constitutes about 10% to 20% of patients with Hairy cell leukaemia and 0.4% of all lymphoid malignancies. There are approximately 60 to 75 new diagnosed cases of HCL-V each year in the United States.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hairy_cell_leukaemia_Epidemiology\"><\/span><strong>Hairy cell leukaemia Epidemiology <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>In the U.S., approximately 6,000 persons get affected by Hairy cell leukaemia and around 600-800 new cases are diagnosed each year. Hairy cell leukaemia affects males four times more often than females (M4: F1), as observed by Rare diseases organization. The mostly male population of age 50 and older are more prone to developing Hairy cell leukaemia. However, the Hairy Cell leukaemia occurs in individuals between 20 to 80 years of age.<\/p>\n\n\n\n<p>Literature suggests that most patients survive for ten years or longer with the disease. As per the Cancer Research U.K., around 90% of the patients will survive for five years or more after the diagnosis. DelveInsight estimates that the total <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/hairy-cell-leukemia-epidemiology-forecast\">Hairy Cell Leukemia incident population<\/a> <\/strong>in the 7MM was 2,364 in 2017. Out of which, there were 755 diagnosed incident HCL cases reported in the U.S.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hairy_cell_leukaemia_Therapy_Market\"><\/span><strong>Hairy cell leukaemia Therapy Market <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>Chemotherapy is the backbone Hairy Cell Leukaemia treatment market and is usually effective at destroying the cancerous cells. The two main chemotherapy medications used are cladribine- administered as either an injection under the skin or through a drip infusion. Another medicine used is pentostatin, which can be only be given as an injection intravenously every two weeks. Rituximab is sometimes used in combination with chemotherapy. Surgery is another rarely used Hairy cell <a href=\"https:\/\/www.delveinsight.com\/report-store\/b-cell-chronic-lymphocytic-leukemia-pipeline-insight\">leukaemia <\/a>treatment to remove the spleen.<\/p>\n\n\n\n<p>There are FDA-approved treatments labelled as orphan products for the treatment of this condition. These are Cladribine injection which is a product of Ortho Biotec and is sold under the name Leustatin, AstraZeneca\u2018s Moxetumomab pasudotox under the Brand name Lumoxiti, and Pentostatin injection which is a product of SuperGen, Inc.<\/p>\n\n\n\n<p><strong>Leustatin <\/strong>and <strong>Nipent <\/strong>are the purine analogues and are approved as the first line of therapy for the <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/hairy-cell-leukemia-global-api-manufacturers-marketed-and-phase-iii-drugs-landscape\">Hairy Cell Leukemia Treatment.<\/a><\/strong> Since the effect of the P.A.s Pentostatin and Leustatin were discovered in HCL patients, treatment with these drugs currently remains the standard of care.<\/p>\n\n\n\n<p>Leustatin is approved for the active Hairy Cell Leukemia treatment as defined by clinically significant anaemia, neutropenia, thrombocytopenia or disease-related symptoms and <a href=\"https:\/\/www.delveinsight.com\/report-store\/non-hodgkins-lymphoma-nhl-market\">Non-Hodgkin\u2019s Lymphoma<\/a>. It is approved as the first line of therapy according to the NCCN guidelines. Cladribine results in prolonged complete remissions in most patients who have HCL.<\/p>\n\n\n\n<p>Pentostatin is also considered the first line of therapy purine analogue recommended by NCCN guidelines. It got approved in 1991 by the U.S. Food and Drug Administration. Although early approaches were carried out in refractory CLL, Pentostatin, a product of Streptomyces antibiotics and a pharmacologic inhibitor of adenosine deaminase (ADA), was introduced as the first P.A. in the therapy of HCL in the 1980s.<\/p>\n\n\n\n<p>Similarly, Lumoxiti, is the first in class therapy approved for the Hairy cell leukaemia treatment. It is the first treatment option for patients in over 20 years. It got approved in September 2018 by the U.S. Food and Drug Administration as the third line of therapy. It is a conjugated monoclonal antibody, which works by delivering a toxic substance directly to the cancer cells, limiting its effects on healthy cells. This is the first drug of this type approved to treat people with HCL.<\/p>\n\n\n\n<p><strong>Lumoxiti<\/strong> fills an unmet need for patients with hairy cell leukaemia whose disease has progressed after trying other FDA-approved therapies. This therapy is the result of important research conducted by the National Cancer Institute that led to the development and clinical trials of this new type of treatment for patients with this rare blood cancer. It was granted Orphan Drug Designation and Fast Track Designation by the US FDA in the year 2018.<\/p>\n\n\n\n<p>On the other hand, <strong>Roferon-A<\/strong> is a recombinant form of interferon alpha-2. This variant has lysine at position 23 and histamine at location 34. Interferon-alpha binds to type I interferon receptors (IFNAR1 and IFNAR2c) which, upon dimerization, activate two Jak (Janus kinase) tyrosine kinases (Jak1 and Tyk2). It is approved for the treatment of Hairy Cell Leukemia.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hairy_cell_leukaemia_Emerging_Therapies\"><\/span><strong>Hairy cell leukaemia Emerging Therapies<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>To overcome current unmet needs in the Hairy cell leukaemia market and to provide better <a href=\"https:\/\/www.delveinsight.com\/report-store\/hairy-cell-leukemia-pipeline-insight\"><strong>Hairy Cell Leukaemia treatment options<\/strong>,<\/a> several companies are working vigorously on developing new therapies with a novel mechanism of action, including Ibrutinib (Johnson and Johnson) &amp; Vemurafenib (Roche) which are expected to enter Hairy Cell Leukemia market by 2028.<\/p>\n\n\n\n<p>Ibrutinib (Imbruvica) is a first-in-class, oral, once-daily therapy that inhibits <a href=\"https:\/\/www.delveinsight.com\/report-store\/brutons-tyrosine-kinase-btk-inhibitor-pipeline-insight\"><strong>Bruton\u2019s Tyrosine Kinase (BTK)<\/strong>.<\/a> It blocks signals that translate malignant B cells to multiply and spread uncontrollably. It is currently in the Phase II stage for the Hairy Cell Leukemia Treatment. It is also approved for the <strong>Mantle cell lymphoma<\/strong> (MCL);<strong> <\/strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/b-cell-chronic-lymphocytic-leukemia-market\"><strong>Chronic lymphocytic leukaemia<\/strong><\/a> (CLL); Chronic lymphocytic leukaemia with 17p deletion and Waldenstrom\u2019s macroglobulinemia (W.M.). The launch of Ibrutinib in June 2021 is expected to increase the HCL market share.<\/p>\n\n\n\n<p><strong>Vemurafenib <\/strong>(Zelboraf), under development by Roche (Genentech), is an orally available, ATP-competitive, a small-molecule inhibitor of BRAF (V600E) kinase being developed as the first line of therapy. It is currently in the Phase II stage for the treatment of Hairy Cell Leukemia. It is also approved for the treatment of patients with unresectable or metastatic melanoma with BRAF V600E mutation as detected by an FDA- approved test and <strong>Erdheim-Chester disease<\/strong> (ECD). It is expected to be launched in April 2021 and has a significant market share.<\/p>\n\n\n\n<p>The Hairy cell leukaemia emerging therapies are anticipated to progressively replace the current Hairy cell leukaemia therapies such as purine analogues, rituximab, and interferon. Overall, the increasing Hairy cell leukaemia incidence along with the better Hairy cell leukaemia emerging therapies, diagnosis methods and promising and novel mechanism of actions to combat cancer will fuel the <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/hairy-cell-leukemia-market-insight-epidemiology-and-market-forecast\">Hairy Cell Leukemia market<\/a> <\/strong>during the forecasted period of 2018- 2028.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Every 3 minutes, one person in the United States (U.S.) is diagnosed with blood cancer, as estimated by The Leukemia &amp; Lymphoma Society (LLS). A total number of 176,200 people are expected to be diagnosed with leukaemia, lymphoma or myeloma in 2019. Out of which, 61,780 people are expected to be diagnosed with leukaemia. Hairy [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":5855,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[96,5872,5873,17760,17757,17758,17759,2734,524],"industry":[17225],"therapeutic_areas":[17228],"class_list":["post-5851","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-astrazeneca","tag-hairy-cell-leukaemia","tag-hairy-cell-leukaemia-market","tag-hairy-cell-leukaemia-treatments","tag-hairy-cell-leukemia","tag-hairy-cell-leukemia-market","tag-hairy-cell-leukemia-pipeline","tag-johnson-and-johnson","tag-roche","industry-pharmaceutical","therapeutic_areas-oncology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hairy Cell Leukemia Epidemiology Forecast and Emerging Therapies<\/title>\n<meta name=\"description\" content=\"The Hairy cell leukaemia emerging therapies are anticipated to progressively replace the current Hairy cell leukaemia therapies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.delveinsight.com\/blog\/hairy-cell-leukemia-therapy-landscape\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hairy Cell Leukemia Epidemiology Forecast and Emerging Therapies\" \/>\n<meta property=\"og:description\" content=\"The Hairy cell leukaemia emerging therapies are anticipated to progressively replace the current Hairy cell leukaemia 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class=\"advgb-post-tax-term\">Hairy Cell Leukemia Pipeline<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Johnson and Johnson<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Roche<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">AstraZeneca<\/span>","<span class=\"advgb-post-tax-term\">Hairy cell leukaemia<\/span>","<span class=\"advgb-post-tax-term\">Hairy cell leukaemia MARKET<\/span>","<span class=\"advgb-post-tax-term\">Hairy cell leukaemia Treatments<\/span>","<span class=\"advgb-post-tax-term\">Hairy Cell Leukemia<\/span>","<span class=\"advgb-post-tax-term\">Hairy Cell Leukemia Market<\/span>","<span class=\"advgb-post-tax-term\">Hairy Cell Leukemia Pipeline<\/span>","<span class=\"advgb-post-tax-term\">Johnson and Johnson<\/span>","<span class=\"advgb-post-tax-term\">Roche<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 7 years ago","modified":"Updated 1 year ago"},"absolute_dates":{"created":"Posted on Aug 26, 2019","modified":"Updated on May 8, 2025"},"absolute_dates_time":{"created":"Posted on Aug 26, 2019 5:21 pm","modified":"Updated on May 8, 2025 11:35 am"},"featured_img_caption":"Hairy cell leukaemia 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