{"id":6099,"date":"2019-10-01T16:58:53","date_gmt":"2019-10-01T11:28:53","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=6099"},"modified":"2021-07-24T12:57:33","modified_gmt":"2021-07-24T07:27:33","slug":"recent-pharma-happenings-for-sanofi-stipe-janssen","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/recent-pharma-happenings-for-sanofi-stipe-janssen","title":{"rendered":"STipe raises USD 22M; FDA approves Darzalex for multiple myeloma"},"content":{"rendered":"\n

Stipe Therapeutics (STipe) has raised USD 22 Million to move forward its\nclinical development of novel candidates to target intracellular\nprotein-protein interactions of the STING Pathway.<\/strong><\/h4>\n\n\n\n

The financing round was led by Sunstone\nLife Science Ventures Fund IV, Novo Holdings, Arix Bioscience, and Wellington\nPartners Life Science V Fund. <\/p>\n\n\n\n

STipe, an immuno-oncology company, with its STING pathway is planning to target a wide range of haematological and solid tumors. The company promises of the increased sensitivity of the immune system while detecting tumorous cells by its STING pathway. The pathway changes the environment tumour prospers in and accelerates the anti-tumour activity. <\/p>\n\n\n\n

The US FDA has given its recommendation to Darzalex (daratumumab) based combination for the treatment of newly diagnosed multiple myeloma patients eligible for a stem-cell transplant. <\/strong><\/h4>\n\n\n\n

Approved in combination with Velcade (bortezomib), thalidomide and dexamethasone (collectively known as VTd), Darzalex is an antibody which blocks CD38, found on the surface of multiple myeloma cells<\/a>. The drug, Darzalex, was at first developed by Genmab and was later on licensed to Janssen. <\/p>\n\n\n\n

The FDA gave its nod on the basis of the results of Phase III CASSIOPEIA study conducted by the Intergroupe Francophone du Myelome in collaboration with the Dutch-Belgian Cooperative Trial Group for Hematology Oncology and Janssen. <\/p>\n\n\n\n

The initial treatment for a myeloma patient depends upon whether or not the patient is a candidate for stem cell transplantation in the eligible patients, high-dose chemotherapy with autologous hematopoietic stem-cell transplantation (ASCT) has become the preferred treatment for patients under the age of 65. Patients who receive ASCT with high-dose induction chemotherapy have a median survival of 68 months. Other chemo drugs used to treat multiple myeloma include Melphalan, Vincristine (Oncovin), Cyclophosphamide (Cytoxan), Etoposide (VP-16), Doxorubicin (Adriamycin), Liposomal doxorubicin (Doxil), Bendamustine (Treanda), etc.<\/p>\n\n\n\n

For the supportive care measures,\nradiotherapy, vertebral augmentation and bisphosphonates may prove to be\nbeneficial. Opiates are often needed to manage bone pain. Moreover, for neuropathic\npain, calcium channel blockers (such as gabapentin) or serotonin noradrenaline\nreuptake inhibitors (such as amitriptyline) may help.<\/p>\n\n\n\n

Multiple other drugs that have been approved for the treatment of Multiple myeloma<\/a>, which include Carfilzomib (Kyprolis, Amgen), Ixazomib (Ninlaro, Millennium Pharmaceuticals, Inc.), Pomalidomide (Pomalyst, Celgene Corporation), Panobinostat (Farydak, Novartis), Elotuzumab (Empliciti, Bristol-Myers Squibb), and Daratumumab (Darzalex, Janssen Biotech) based on positive results from high-quality, phase 3 studies.<\/p>\n\n\n\n

Sanofi has launched its diabetes therapy Suliqua (insulin\nglargine\/lixisenatide) in the UK, eight months after it was approved by the\nEMA.<\/strong><\/h4>\n\n\n\n

The drug has been authorized for the administration in patients living with Type 2 diabetes<\/a>, in combination with metformin. To improve glycemic control, Suliqua is prescribed once-daily. <\/p>\n\n\n\n

The clinical trial evaluated the efficacy\nof the drug in combination with metformin in 1900 enrolled patients. <\/p>\n","protected":false},"excerpt":{"rendered":"

Stipe Therapeutics (STipe) has raised USD 22 Million to move forward its clinical development of novel candidates to target intracellular protein-protein interactions of the STING Pathway. The financing round was led by Sunstone Life Science Ventures Fund IV, Novo Holdings, Arix Bioscience, and Wellington Partners Life Science V Fund. STipe, an immuno-oncology company, with its […]<\/p>\n","protected":false},"author":1,"featured_media":6100,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[32],"tags":[1271,349,5789],"industry":[17225],"therapeutic_areas":[17228],"class_list":["post-6099","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-notizia","tag-delveinsight-pharma-news","tag-latest-pharma-news","tag-recent-pharma-news","industry-pharmaceutical","therapeutic_areas-oncology"],"acf":[],"yoast_head":"\nSTipe raises $22M; FDA's nod to Darzalex; Sanofi launches Suliqua in UK<\/title>\n<meta name=\"description\" content=\"Stipe Therapeutics (STipe) has 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