{"id":7140,"date":"2019-12-20T19:13:24","date_gmt":"2019-12-20T13:43:24","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=7140"},"modified":"2025-05-08T13:00:13","modified_gmt":"2025-05-08T07:30:13","slug":"ischemia-treatment-market","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/ischemia-treatment-market","title":{"rendered":"Reversing Ischemia with Gene therapy"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-6a0a4bd0922cc\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-6a0a4bd0922cc\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/ischemia-treatment-market\/#What_is_Ischemia\" >What is Ischemia?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/ischemia-treatment-market\/#Types_of_Ischemia\" >Types of Ischemia<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/ischemia-treatment-market\/#Why_does_it_happen\" >Why does it happen?<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/ischemia-treatment-market\/#Occlusion\" >Occlusion<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/www.delveinsight.com\/blog\/ischemia-treatment-market\/#Ischemia_Treatment_market\" >Ischemia Treatment market&nbsp;<\/a><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><ul class='ez-toc-list-level-4' ><li class='ez-toc-heading-level-4'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/www.delveinsight.com\/blog\/ischemia-treatment-market\/#How_Gene_Therapy_is_fueling_Ischemia_treatment_market\" >How Gene Therapy is fueling Ischemia treatment market<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<p class=\"has-drop-cap\">A human body comprises of many small, long, narrow and broad blood vessels that carry oxygenated blood from the heart to other body parts for their normal functioning. However, due to life style-shifting more towards a sedentary one, and inculcation of bad food habits, there has been an increase in the number of non-communicable diseases like cardiovascular diseases, diabetes, obesity, and ultimately leading to Ischemia. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-ischemia\"><span class=\"ez-toc-section\" id=\"What_is_Ischemia\"><\/span><strong>What is Ischemia? <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p><strong>Ischemia<\/strong> is a condition that results in a blockade of\nthe arteries of the body. It is a restriction in the supply of the blood\nthrough the blood vessels resulting in scarcity of the oxygen. In the dearth of\nsufficient oxygen, there are disturbances in normal cellular and circulatory processes,\nthus resulting in tissue dysfunction. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-types-of-ischemia\"><span class=\"ez-toc-section\" id=\"Types_of_Ischemia\"><\/span><strong>Types of Ischemia<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Based on the arteries, Ischemia afflicts, it is categorised into five types, namely, <strong>Cardiac Ischemia<\/strong>, <strong>Bowel Ischemia<\/strong>, <strong><a href=\"https:\/\/www.delveinsight.com\/report-store\/brain-ischemia-pipeline-insight\">Brain Ischemia<\/a><\/strong>, <strong>Limb Ischemia<\/strong>, and <strong>Cutaneous Ischemia<\/strong>. &nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-why-does-it-happen\"><span class=\"ez-toc-section\" id=\"Why_does_it_happen\"><\/span><strong>Why does it happen?  <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>Impediment in the availability of enough oxygen results in a condition known as <strong>atherosclerotic plaque<\/strong>. The plaque which constitutes excess fat, cholesterol, and other products gets deposited on the walls of the coronary arteries narrowing their circumference. <\/p>\n\n\n\n<p class=\"has-very-light-gray-color has-vivid-red-background-color has-text-color has-background\"><strong>Whenever the demand for oxygen is more than the\nsupply, Ischemia develops<\/strong>. <\/p>\n\n\n\n<p>In layman language, Ischemia usually does not occur when the body is at leisure or rest.&nbsp; However, during extreme physical work like exercising oxygen demand soars up and plagued arteries fail to deliver the same, resulting in <strong><a href=\"https:\/\/www.delveinsight.com\/blog\/angina-pectoris-manifestation-of-coronary-artery-disease\/\">angina pectoris<\/a><\/strong>. It is a condition which describes pain and discomfort in the heart muscles due to insufficient blood supply. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-occlusion\"><span class=\"ez-toc-section\" id=\"Occlusion\"><\/span><strong>Occlusion<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>In addition to this, Ischemia can also occur if\nthere is a formation of embolus, a condition known as Arterial embolism. <strong>An\nembolus<\/strong> is a term for foreign materials that traverse through a blood\nvessel and adheres to the wall of an artery, which is too small for it to pass\nthrough. This is referred to as <strong>thromboembolism<\/strong> when the substance stuck\nin the artery is a blood clot. If the clot lyses, muscles will relax, and there\nwould be enough oxygen to fulfil the requirement preventing Ischemia. <\/p>\n\n\n\n<p>Moreover, Ischemia may occur due to undue\npressure on the blood vessels, known as <strong>Vasoconstriction. <\/strong><\/p>\n\n\n\n<p>There also exists chances that a patient may\nhave Ischemia and may be unaware of it. This is referred to as <strong>Silent\nIschemia<\/strong>, which has no symptoms. It is characterised by unusual pumping of\nthe heart and abnormal heart rhythms. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-ischemia-treatment-market-nbsp\"><span class=\"ez-toc-section\" id=\"Ischemia_Treatment_market\"><\/span><strong>Ischemia Treatment market&nbsp; <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Ischemia treatment varies with the location of\nthe ischemia and its severity. However, Common factors that increase the risk of\nIschemia such as tobacco, diabetes, high blood pressure, high blood cholesterol\nlevel, and minimal or nil physical activity should be taken care of and\neliminated. Curbing them may help in preventing the Ischemia progression and\nreduces the chances of death. <\/p>\n\n\n\n<p><strong>The <a href=\"https:\/\/www.delveinsight.com\/report-store\/ischemic-stroke-global-api-manufacturers-marketed-and-phase-iii-drugs-landscape\" class=\"ek-link\">treatment goals of Ischemia<\/a> focus on increasing blood flow to the arteries.<\/strong> This can be accomplished in several ways: Medications, Exercise, and Surgery or Endovascular Procedures.<\/p>\n\n\n\n<p>Furthermore, <strong>medications<\/strong> <strong>are\nprescribed to stop Ischemia progression.<\/strong> Also, to limit the risk of\nIschemia, medications are prescribed for contributing factors such as diabetes,\nblood pressure and others. In addition to this, medicines are present in the\nIschemia treatment market to stop excess blood clotting. Ischemia patients are\nalso advised to follow a strict and supervised exercise routine. To address the\npain due to Ischemia, a condition known as <strong>claudication<\/strong>, medications exist.\n<\/p>\n\n\n\n<p>The symptomatic approach of Ischemia treatment\nlandscape includes cholesterol-lowering drug (<strong>statin<\/strong>), <strong>Cilostazol<\/strong>\n(Pletal) for reducing pain due to claudication by widening (dilating) the\narteries, and <strong>aspirin-dipyridamole<\/strong> as an antiplatelet therapy for acute\ncerebral ischemia are prescribed. <\/p>\n\n\n\n<p>In addition to the medicinal drugs, Ischemia\ntreatment market also comprises of <strong>Revascularization<\/strong> (<strong>Angioplasty<\/strong>,\nor <strong>bypass surgery) <\/strong>for the purpose of widening of the arteries. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-how-gene-therapy-is-fueling-ischemia-treatment-market\"><span class=\"ez-toc-section\" id=\"How_Gene_Therapy_is_fueling_Ischemia_treatment_market\"><\/span><strong>How Gene Therapy is fueling <\/strong>Ischemia treatment market <strong> <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h4>\n\n\n\n<p>The present Ischemia treatment landscape is symptomatic and has\nseveral limitations and unmet needs. For instance, the standard treatment for\nIschemic heart disease, as mentioned above, is percutaneous coronary\nintervention (PCI) or coronary artery bypass grafting (CABG). Yet, the\nafter-treatment phase of the patient\u2019s does not go as smoothly as it seems so. Treatment\napproaches undertaken for Ischemia treatment are often accompanied by several complications\nand side effects and demands the need for repeated procedures in case of\nrevascularisation. <\/p>\n\n\n\n<p>However, the last decades have brought many advances in the\nunderstanding of the different forms of Ischemia, their pathophysiology,\nsymptoms and the treatment of leading mortality causing forms Ischemia, i.e.,\nCritical Limb Ischemia and Ischemic Heart Disease. However, the present\nIschemia treatment landscape has several limitations and unmet needs. <\/p>\n\n\n\n<p><strong>Gene therapy<\/strong> offers a striking alternative approach to current supportive and pharmacological\ntreatments for Ischemia. Many\npieces of research and clinical studies have shown promising results of innovative\nDNA-based gene therapy. Gene therapy, the latter approach to offer a permanent\ntherapeutic cure to any disease with unmet needs, has been successful in\ntreating many disorders so far. Ischemia can be one of them. <\/p>\n\n\n\n<p><strong>Myocardial Ischemia<\/strong> and <strong>Critical limb ischemia<\/strong> (CLI) represent the most advanced stages of atherosclerotic and are often\nassociated with high rates of morbidity and mortality. &nbsp;In cases of Myocardial Ischemia death is often\nseen as about 150,000 individuals die of stroke every year, whereas in CLI amputations\nare common. Critical Limb Ischemia incidence is estimated to be ranging from 125,000\nto 250,000 patients per year in the United States.<\/p>\n\n\n\n<p>Gene therapy promises a continuous supply of proteins\nrequired for the normal functioning of the body at the site of need. Not only\nGene therapy has the potential of offering one-time treatment, but it also has\nthe potential to reverse the pathophysiology associated with Ischemia. <\/p>\n\n\n\n<p>In a recent finding (by Sunkomat JN, Gaballa MA.), it was revealed that stem cells\ncontribute to the formation of new blood vessels a process known as neovascularisation,\ncan possibly revolutionise how the heart failures are treated. Stem cell-based\ntherapies deliver cells with regenerative properties, substantiates cardiac\nregeneration, improves cell survival, and tissue remodelling. Stem cells\ntherapies, when combined with gene therapy, shows a higher rate of success. &nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p>However, there is still a long way to go. Lack of positive\nresults due to the poor rate of survival and poor retention of transplanted\ncells in the injured tissues and cells along with the route of administration remain\nas the major areas that need attention. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>A human body comprises of many small, long, narrow and broad blood vessels that carry oxygenated blood from the heart to other body parts for their normal functioning. However, due to life style-shifting more towards a sedentary one, and inculcation of bad food habits, there has been an increase in the number of non-communicable diseases [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":7143,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[17910,17911,17909,191,17913,258,17908,7382,339,17912],"industry":[17225],"therapeutic_areas":[17242],"class_list":["post-7140","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-bowel-ischemia","tag-brain-ischemia","tag-cardiac-ischemia","tag-critical-limb-ischemia","tag-cutaneous-ischemia","tag-gene-therapy","tag-ischemia","tag-ischemia-treatment-market","tag-ischemic-heart-disease","tag-limb-ischemia","industry-pharmaceutical","therapeutic_areas-cardiovascular-diseases"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Reversing Ischemia with Gene therapy - Ischemia Treatment Market<\/title>\n<meta name=\"description\" content=\"The Ischemia treatment market has mainly remained symptomatic. 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href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Articles<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Articles<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Bowel Ischemia<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Brain Ischemia<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Cardiac Ischemia<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Critical Limb Ischemia<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Cutaneous Ischemia<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Gene therapy<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Ischemia<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Ischemia Treatment Market<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">ischemic heart disease<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Limb Ischemia<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Bowel Ischemia<\/span>","<span class=\"advgb-post-tax-term\">Brain Ischemia<\/span>","<span class=\"advgb-post-tax-term\">Cardiac Ischemia<\/span>","<span class=\"advgb-post-tax-term\">Critical Limb Ischemia<\/span>","<span class=\"advgb-post-tax-term\">Cutaneous Ischemia<\/span>","<span class=\"advgb-post-tax-term\">Gene therapy<\/span>","<span class=\"advgb-post-tax-term\">Ischemia<\/span>","<span class=\"advgb-post-tax-term\">Ischemia Treatment Market<\/span>","<span class=\"advgb-post-tax-term\">ischemic heart disease<\/span>","<span class=\"advgb-post-tax-term\">Limb Ischemia<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 6 years ago","modified":"Updated 1 year ago"},"absolute_dates":{"created":"Posted on Dec 20, 2019","modified":"Updated on May 8, 2025"},"absolute_dates_time":{"created":"Posted on Dec 20, 2019 7:13 pm","modified":"Updated on May 8, 2025 1:00 pm"},"featured_img_caption":"Ischemia treatment market","series_order":"","_links":{"self":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/7140","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/comments?post=7140"}],"version-history":[{"count":1,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/7140\/revisions"}],"predecessor-version":[{"id":31948,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/7140\/revisions\/31948"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media\/7143"}],"wp:attachment":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media?parent=7140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/categories?post=7140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/tags?post=7140"},{"taxonomy":"industry","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/industry?post=7140"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/therapeutic_areas?post=7140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}