{"id":7396,"date":"2020-01-24T14:48:53","date_gmt":"2020-01-24T09:18:53","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=7396"},"modified":"2025-05-08T13:15:19","modified_gmt":"2025-05-08T07:45:19","slug":"thyroid-eye-disease-market","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/thyroid-eye-disease-market","title":{"rendered":"Thyroid eye disease market: New therapies enter the TED market"},"content":{"rendered":"\n

The newly approved drug teprotumumab can offer hope to adults with thyroid eye disease, a rare and potentially blinding condition. It’s the first treatment specifically approved for thyroid eye disease. The drug of Horizon Therapeutics was approved by the U.S. Food and Drug Administration and is set to be marketed under the brand name Tepezza.<\/p>\n\n\n\n

Graves\u2019 Orbitopathy (GO)<\/strong> or Ophthalmopathy <\/strong>or Thyroid eye disease (TED) <\/strong><\/a>is an autoimmune disorder. The condition occurs when the same antibody causes thyroid dysfunction, which activates the receptors in the thyroid gland resulting in hyperthyroidism. This affects the eyes causing the inflammation of the eye tissues. <\/p>\n\n\n\n

In a study by Zagaria et al. [2011], it was observed that approximately 25\u201030% of patients with Graves\u2019 disease<\/a> have clinical evidence of Graves\u2019 ophthalmopathy. As per the study by Liaboe et al., titled \u201cAn Introductory Tutorial and Overview of Disease\u201d, TED has a higher prevalence in women than men (16 per 100,000 vs. 3 per 100,000, respectively). Both men and women demonstrate a bimodal pattern of age of diagnosis (40\u201344 and 60\u201364 yearsin women; 45\u201349 and 65\u201369 years in men).<\/p>\n\n\n\n

Thyroid eye disease treatment market<\/strong><\/h3>\n\n\n\n

Thyroid eye disease treatment involves two phases. The first phase of treatment involves treating active eye disease, lasting for two-three years. The Thyroid eye diseases treatment in the active phase focuses on preserving sight and the integrity of the cornea, along with addressing double vision. <\/p>\n\n\n\n

 Some Thyroid eye disease treatments include medication (local therapy, antioxidant therapy, immunomodulatory therapy), and surgery (thyroidectomy and thyroid ablation).<\/p>\n\n\n\n

Both active and inactive, thyroid eye disease treatment approaches are symptomatic in nature. <\/p>\n\n\n\n

Local therapeutic measures such as artificial tears and ointments, sunglasses, nocturnal taping of the eyes, prisms are available to control symptoms of dryness, photophobia, and grittiness, but only in mild thyroid eye disease cases. For temporary relief from diplopia, botulinum<\/strong> toxin A is administered via injection in the extraocular muscles. To address swelling, selenium supplements are given. <\/p>\n\n\n\n

In severe forms of the disease, high\u2010dose glucocorticoids and\/or orbital radiotherapy, or orbital decompression are the mainstay of the thyroid eye disease treatment. High\u2010dose systemic glucocorticoids<\/strong> (GCs) are currently the first\u2010line treatment for moderate\u2010to\u2010severe and active TED. Intravenously administered GCs are more effective and better tolerated than oral GCs. Oral<\/strong> prednisone<\/strong> is used most often when eye-bulging and swelling continue to get worse. High dose prednisone or an intravenous corticosteroid is used if there is compression of the optic nerve.<\/p>\n\n\n\n

Periocular injections<\/strong> of triamcinolone acetate effectively reduce diplopia and extraocular muscle size and Subconjunctival triamcinolone injections<\/strong> have proven to be effective in resolving eyelid swelling.<\/p>\n\n\n\n

Additionally, thyroid eye disease treatment market<\/strong> also includes Rehabilitative (extraocular muscle or eyelid) surgery. Correction of both hyper\u2010 and hypothyroidism is crucial for the ophthalmopathy. Antithyroid drugs<\/strong> and thyroidectomy<\/strong> do not influence the course of the ophthalmopathy, whereas radioiodine treatment may cause the progression of pre\u2010existing ophthalmopathy, especially in smokers. Glucocorticoids, however, do help in preventing an exacerbation.<\/p>\n\n\n\n

Other than Horizon therapeutics, Immunovant Sciences and others are working to change the dynamics of the Thyroid eye disease (TED) market is anticipated to change in the coming years owing to the expected launch of emerging therapies during the forecasted period [2019\u20102028].<\/p>\n","protected":false},"excerpt":{"rendered":"

The newly approved drug teprotumumab can offer hope to adults with thyroid eye disease, a rare and potentially blinding condition. It’s the first treatment specifically approved for thyroid eye disease. The drug of Horizon Therapeutics was approved by the U.S. Food and Drug Administration and is set to be marketed under the brand name Tepezza. 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