{"id":7666,"date":"2020-02-05T16:24:15","date_gmt":"2020-02-05T10:54:15","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=7666"},"modified":"2025-05-08T13:22:21","modified_gmt":"2025-05-08T07:52:21","slug":"nontuberculous-mycobacteria-drug-market","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market","title":{"rendered":"Nontuberculous Mycobacteria Infection Market: Current status of NTM infection drug discovery and development"},"content":{"rendered":"\n

Nontuberculous mycobacteria<\/strong> (NTM) are members of the Mycobacterium genus other than Mycobacterium tuberculosis complex and Mycobacterium leprae. NTM is a significant cause of chronic lung disease in immunosuppressed individuals and people suffering from chronic lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Majority of NTM-associated lung diseases are caused by Mycobacterium avium<\/em> complex (MAC) and Mycobacterium abscessus<\/em> complex (MAbsC).<\/p>\n\n\n\n

As per the American Thoracic Society, the number of people living with NTM lung disease<\/a><\/strong> and newly infected individuals are on the rise, especially among the older age group.  NTM infections are challenging to treat and involve a lengthy treatment course involving multiple antibiotics. Standard treatment consists of the combination of macrolides (azithromycin or clarithromycin), ethambutol, and rifampin. However, due to the development of antibiotic resistance in Non-tuberculous Mycobacterium, these drugs are not necessarily effective. Moreover, there are several toxicities and side effects related to these drugs. This creates an urgent medical need to discover and develop new drugs against NTM<\/a><\/strong>.<\/p>\n\n\n\n

Arikayce<\/strong>, a liposome inhalation suspension of amikacin is the first and only medication, which has been approved in September 2018 by the U.S. Food and Drug Administration (FDA) for the treatment of MAC lung disease as part of a combination antibacterial drug regimen for adult patients who have limited or no alternative treatment options. Arikayce was granted Orphan Drug, Qualified Infectious Disease Product (QIDP), and Fast Track designations from the FDA for the treatment of Non-tuberculous Mycobacterium lung infections. However, Arikayce is not recommended for patients with non-refractory MAC lung disease and has only been approved as a treatment for patients with refractory MAC lung disease. <\/p>\n\n\n\n

Arikayce is also being assessed for other non-MAC NTM species, such as MAbsC. Besides Arikayce, there are a few candidates that are being evaluated in clinical trials for NTM indications. Some of them include RHB-204 (Redhill Biopharma), Thiolanox (Novoteris), Molgradex (Savara Pharma), and Nitric Oxide (Beyond Air) in phase II of clinical trials; and SPR720 (Spero Therapeutics), and MAT2501 (Matinas Biopharma) in phase I. Redhill Biopharma\u2019s RHB-204, and Matinas Biopharma\u2019s MAT2501 have been designated as QIDP for the treatment of NTM by the FDA. Further, the FDA has also awarded MAT2501 and Beyond Air\u2019s novel formulation of Nitric Oxide with orphan drug designation for the treatment of infections caused by NTM. Apart from the candidates in clinical phases, therapeutic agents such as Clofazimine, Tedizolid, Bedaquiline and others are currently in discovery or development for the treatment of Non-tuberculous Mycobacterium pulmonary disease. <\/p>\n\n\n\n

Despite ongoing research and development, Non-tuberculous Mycobacterium drug discovery<\/a><\/strong> is still in its infancy with many issues of pathophysiology, resistance, and disease persistence remaining to be unveiled, and many assays and models to be developed and validated. As most of the current prospective agents are derived from repurposing and reformulation of existing antibiotics, it is not unseemly to conclude that not much has been accomplished in the treatment of Non-tuberculous Mycobacterium diseases owing to limited research efforts. <\/p>\n","protected":false},"excerpt":{"rendered":"

Nontuberculous mycobacteria (NTM) are members of the Mycobacterium genus other than Mycobacterium tuberculosis complex and Mycobacterium leprae. NTM is a significant cause of chronic lung disease in immunosuppressed individuals and people suffering from chronic lung diseases such as chronic obstructive pulmonary disease and cystic fibrosis. Majority of NTM-associated lung diseases are caused by Mycobacterium avium […]<\/p>\n","protected":false},"author":1,"featured_media":8201,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[18014,18017,17469,18011,18013,18008,18006,8798,8795,8797,8796,18010,18007,2271,18012,18016,18015,18009],"industry":[17225],"therapeutic_areas":[17231],"class_list":["post-7666","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-beyond-air","tag-mat2501","tag-matinas-biopharma","tag-molgradex","tag-nitric-oxide","tag-non-tuberculous-mycobacterium-drug-discovery","tag-nontuberculous-mycobacteria-infection-market","tag-nontuberculous-mycobacterium","tag-nontuberculous-mycobacterium-drug-market","tag-nontuberculous-mycobacterium-epidemiology","tag-nontuberculous-mycobacterium-market","tag-novoteris","tag-ntm-lung-disease","tag-redhill-biopharma","tag-savara-pharma","tag-spero-therapeutics","tag-spr720","tag-thiolanox","industry-pharmaceutical","therapeutic_areas-infectious-diseases"],"acf":[],"yoast_head":"\nNontuberculous Mycobacteria Infection Market | NTM Infection Pipeline<\/title>\n<meta name=\"description\" content=\"Nontuberculous mycobacteria drug discovery is still in its infancy with many issues of pathophysiology, resistance, and disease persistence...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nontuberculous Mycobacteria Infection Market | NTM Infection Pipeline\" \/>\n<meta property=\"og:description\" content=\"Nontuberculous mycobacteria drug discovery is still in its infancy with many issues of pathophysiology, resistance, and disease persistence...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market\" \/>\n<meta property=\"og:site_name\" content=\"DelveInsight Business Research\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/DelveInsight-1423323754607782\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-05T10:54:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-08T07:52:21+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/02\/12095514\/Nontuberculous.png\" \/>\n\t<meta property=\"og:image:width\" content=\"772\" \/>\n\t<meta property=\"og:image:height\" content=\"482\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"DelveInsight\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@DelveInsight\" \/>\n<meta name=\"twitter:site\" content=\"@DelveInsight\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"DelveInsight\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Nontuberculous Mycobacteria Infection Market | NTM Infection Pipeline","description":"Nontuberculous mycobacteria drug discovery is still in its infancy with many issues of pathophysiology, resistance, and disease persistence...","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market","og_locale":"en_US","og_type":"article","og_title":"Nontuberculous Mycobacteria Infection Market | NTM Infection Pipeline","og_description":"Nontuberculous mycobacteria drug discovery is still in its infancy with many issues of pathophysiology, resistance, and disease persistence...","og_url":"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market","og_site_name":"DelveInsight Business Research","article_publisher":"https:\/\/www.facebook.com\/DelveInsight-1423323754607782\/","article_published_time":"2020-02-05T10:54:15+00:00","article_modified_time":"2025-05-08T07:52:21+00:00","og_image":[{"width":772,"height":482,"url":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/02\/12095514\/Nontuberculous.png","type":"image\/png"}],"author":"DelveInsight","twitter_card":"summary_large_image","twitter_creator":"@DelveInsight","twitter_site":"@DelveInsight","twitter_misc":{"Written by":"DelveInsight","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market","url":"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market","name":"Nontuberculous Mycobacteria Infection Market | NTM Infection Pipeline","isPartOf":{"@id":"https:\/\/www.delveinsight.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market#primaryimage"},"image":{"@id":"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market#primaryimage"},"thumbnailUrl":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/02\/12095514\/Nontuberculous.png","datePublished":"2020-02-05T10:54:15+00:00","dateModified":"2025-05-08T07:52:21+00:00","author":{"@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/5fbf6ca478835d03fdb5e17d905b520a"},"description":"Nontuberculous mycobacteria drug discovery is still in its infancy with many issues of pathophysiology, resistance, and disease persistence...","inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.delveinsight.com\/blog\/nontuberculous-mycobacteria-drug-market#primaryimage","url":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/02\/12095514\/Nontuberculous.png","contentUrl":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/02\/12095514\/Nontuberculous.png","width":772,"height":482,"caption":"Nontuberculous Mycobacteria Infection"},{"@type":"WebSite","@id":"https:\/\/www.delveinsight.com\/blog\/#website","url":"https:\/\/www.delveinsight.com\/blog\/","name":"DelveInsight Business Research","description":"Blog","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.delveinsight.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/5fbf6ca478835d03fdb5e17d905b520a","name":"DelveInsight","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.delveinsight.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/afdd550c64e18f6ad8957080b017c6ae55f4916951d641d3cd40264176aa0e86?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/afdd550c64e18f6ad8957080b017c6ae55f4916951d641d3cd40264176aa0e86?s=96&d=mm&r=g","caption":"DelveInsight"}}]}},"author_meta":{"display_name":"DelveInsight","author_link":"https:\/\/www.delveinsight.com\/blog\/author\/gtadmin"},"featured_img":"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/02\/12095514\/Nontuberculous-300x187.png","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Articles<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Articles<\/span>"]},"tags":{"linked":["<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Beyond Air<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">MAT2501<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Matinas BioPharma<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Molgradex<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Nitric Oxide<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Non Tuberculous Mycobacterium Drug Discovery<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Nontuberculous Mycobacteria Infection Market<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Nontuberculous Mycobacterium<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Nontuberculous Mycobacterium Drug Market<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Nontuberculous Mycobacterium Epidemiology<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Nontuberculous Mycobacterium Market<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Novoteris<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">NTM Lung Disease<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">RedHill Biopharma<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Savara Pharma<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Spero Therapeutics<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">SPR720<\/a>","<a href=\"https:\/\/www.delveinsight.com\/blog\/articles\/\" class=\"advgb-post-tax-term\">Thiolanox<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Beyond Air<\/span>","<span class=\"advgb-post-tax-term\">MAT2501<\/span>","<span class=\"advgb-post-tax-term\">Matinas BioPharma<\/span>","<span class=\"advgb-post-tax-term\">Molgradex<\/span>","<span class=\"advgb-post-tax-term\">Nitric Oxide<\/span>","<span class=\"advgb-post-tax-term\">Non Tuberculous Mycobacterium Drug Discovery<\/span>","<span class=\"advgb-post-tax-term\">Nontuberculous Mycobacteria Infection Market<\/span>","<span class=\"advgb-post-tax-term\">Nontuberculous Mycobacterium<\/span>","<span class=\"advgb-post-tax-term\">Nontuberculous Mycobacterium Drug Market<\/span>","<span class=\"advgb-post-tax-term\">Nontuberculous Mycobacterium Epidemiology<\/span>","<span class=\"advgb-post-tax-term\">Nontuberculous Mycobacterium Market<\/span>","<span class=\"advgb-post-tax-term\">Novoteris<\/span>","<span class=\"advgb-post-tax-term\">NTM Lung Disease<\/span>","<span class=\"advgb-post-tax-term\">RedHill Biopharma<\/span>","<span class=\"advgb-post-tax-term\">Savara Pharma<\/span>","<span class=\"advgb-post-tax-term\">Spero Therapeutics<\/span>","<span class=\"advgb-post-tax-term\">SPR720<\/span>","<span class=\"advgb-post-tax-term\">Thiolanox<\/span>"]}},"comment_count":"0","relative_dates":{"created":"Posted 6 years ago","modified":"Updated 1 year ago"},"absolute_dates":{"created":"Posted on Feb 5, 2020","modified":"Updated on May 8, 2025"},"absolute_dates_time":{"created":"Posted on Feb 5, 2020 4:24 pm","modified":"Updated on May 8, 2025 1:22 pm"},"featured_img_caption":"Nontuberculous Mycobacteria Infection","series_order":"","_links":{"self":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/7666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/comments?post=7666"}],"version-history":[{"count":1,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/7666\/revisions"}],"predecessor-version":[{"id":31964,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/posts\/7666\/revisions\/31964"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media\/8201"}],"wp:attachment":[{"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/media?parent=7666"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/categories?post=7666"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/tags?post=7666"},{"taxonomy":"industry","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/industry?post=7666"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/www.delveinsight.com\/blog\/wp-json\/wp\/v2\/therapeutic_areas?post=7666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}