{"id":8599,"date":"2020-03-02T16:54:35","date_gmt":"2020-03-02T11:24:35","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=8599"},"modified":"2025-05-08T13:28:38","modified_gmt":"2025-05-08T07:58:38","slug":"opioid-withdrawal-syndrome-pipeline","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/opioid-withdrawal-syndrome-pipeline","title":{"rendered":"Opioid Withdrawal Syndrome Pipeline: What lies in the future for those facing withdrawal symptoms"},"content":{"rendered":"\n<p class=\"has-drop-cap\">Every time an opioid therapy is in the option for any patient to overcome the pain due to some chronic ailment, the risk of opioid abuse, misuse, or dependence always lingers at the back of mind. After termination of the opioids, the patient finds it difficult to stop the use of drugs and begins to crave for it. The condition of the patient after the termination of the use of opioid drugs and the phase the patient experiences is referred to as <a href=\"https:\/\/www.delveinsight.com\/blog\/opioid-withdrawal-syndrome\/\">Opioid Withdrawal syndrome<\/a> (OWS).&nbsp;<\/p>\n\n\n\n<p>The patients going through Opioid withdrawal syndrome often have symptoms that may vary, however, are similar in one way or other, such as anxiety, yawning, sweating, eyes tearing, goosebumps, runny nose, hot\/cold flashes, <a href=\"https:\/\/www.delveinsight.com\/report-store\/chemotherapy-induced-nausea-and-vomiting-market\">nausea<\/a>, vomiting, <a href=\"https:\/\/www.delveinsight.com\/report-store\/travelers-diarrhea-market\">diarrhea<\/a>, restlessness, muscle and bone pain, and so on. Patients taking prescribed opioid drugs are monitored for aberrant behavioural changes, assessed on their risk levels and prescribed a therapy to cope with the withdrawal.&nbsp;&nbsp;&nbsp;&nbsp;<\/p>\n\n\n\n<p>The half-life of the opioid, duration of the opioid dosage, and the condition for which the patient was being administered the opioid are some factors that define the severity of OWS the patient will go through.&nbsp;<\/p>\n\n\n\n<p>At present, the approaches to treat the condition present in opioid withdrawal syndrome treatment market are <strong>gradual cessation of an opioid agonist<\/strong> (methadone); Short-term use of a <strong>partial mu-opioid agonist <\/strong>(buprenorphine) and <strong>detoxification<\/strong> <strong>using opioid antagonists<\/strong> (naltrexone and naloxone). Other off-label treatment includes the use of clonidine, which is used extensively to <strong>reduce blood pressure<\/strong> in OWS.<\/p>\n\n\n\n<p>The present Opioid withdrawal syndrome has several unmet needs like the absence of effective therapy and addressing psychological symptoms. Recently, the approval of non-opioid lofexidine hydrochloride (Lucemyra) has advanced the growth of Opioid withdrawal syndrome market in the forecasted period (2020\u20122030).<\/p>\n\n\n\n<p>Further therapies in the Opioid Withdrawal syndrome pipeline that will address the present issues with the therapies and provide relief to the ones living with withdrawal are: <\/p>\n\n\n\n<p style=\"background-color:#0b2d37;color:#f2f3f3\" class=\"has-text-color has-background\">Therapy \u2013 <strong>APH-1501<\/strong><br> Company \u2013 Aphios Pharmaceutical <br> Condition \u2013 Addiction, Opioid Dependence, Opioid Withdrawal<br> Clinical trial- Phase IIa \u2013 Yet to initiate <br> MoA \u2013 CBD encapsulated in biodegradable polymer nanospheres<br> RoA \u2013 Oral<br> Controlled substance class \u2013 Schedule I<\/p>\n\n\n\n<p style=\"color:#0071a1\" class=\"has-text-color\">Therapy \u2013 <strong>BXCL501<\/strong><br> Company \u2013 BioXcel Therapeutics<br> Condition &#8211; Opioid withdrawal <br> Clinical trial &#8211; Yet to initiate<br> MoA \u2013 Dexmedetomidine<br> RoA \u2013 Intravenous <br> Controlled substance class \u2013 Not a controlled substance <\/p>\n\n\n\n<p style=\"background-color:#0b2d37;color:#f8f8f8\" class=\"has-text-color has-background\">Therapy \u2013 <strong>CHF6563<\/strong><br> Company \u2013 Chiesi Farmaceutici S.p.A.<br> Condition \u2013 Neonatal Opioid Withdrawal Syndrome<br> Clinical trial \u2013 Phase II<br> MoA \u2013 Not defined <br> RoA \u2013 Oral <br> Controlled substance class \u2013 Not defined<\/p>\n\n\n\n<p>The Opioid withdrawal syndrome market is going to leap forward attributed to the enhancement and strengthening of weak clinical Opioid withdrawal syndrome pipeline. Key pharma players such as Chiesi Farmaceutici, BioXcel Therapeutics, Aphios Pharmaceutical and others are going to advance the OWS therapy market further in future.  <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Every time an opioid therapy is in the option for any patient to overcome the pain due to some chronic ailment, the risk of opioid abuse, misuse, or dependence always lingers at the back of mind. After termination of the opioids, the patient finds it difficult to stop the use of drugs and begins to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8609,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17],"tags":[18087,18086,18077,11487,11531,11488,18085,11530],"industry":[17225],"therapeutic_areas":[17245],"class_list":["post-8599","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","tag-aphios-pharmaceutical","tag-bioxcel-therapeutics","tag-chiesi-farmaceutici","tag-opioid","tag-opioid-withdrawal-symptoms","tag-opioid-withdrawal-syndrome","tag-opioid-withdrawal-syndrome-market","tag-opioid-withdrawal-syndrome-pipeline","industry-pharmaceutical","therapeutic_areas-neurology"],"acf":[],"yoast_head":"<!-- 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