{"id":8717,"date":"2020-03-23T16:03:32","date_gmt":"2020-03-23T10:33:32","guid":{"rendered":"https:\/\/www.delveinsight.com\/blog\/?p=8717"},"modified":"2024-09-18T15:18:41","modified_gmt":"2024-09-18T09:48:41","slug":"retinitis-pigmentosa-epidemiology-forecast","status":"publish","type":"post","link":"https:\/\/www.delveinsight.com\/blog\/retinitis-pigmentosa-epidemiology-forecast","title":{"rendered":"Retinitis Pigmentosa: A complex disease, and the increasing gap between prevalence and diagnosed prevalence"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_76 counter-hierarchy ez-toc-counter ez-toc-white ez-toc-container-direction\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Table of Contents<\/p>\n<label for=\"ez-toc-cssicon-toggle-item-69d5a501e78d8\" class=\"ez-toc-cssicon-toggle-label\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/label><input type=\"checkbox\"  id=\"ez-toc-cssicon-toggle-item-69d5a501e78d8\"  aria-label=\"Toggle\" \/><nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/www.delveinsight.com\/blog\/retinitis-pigmentosa-epidemiology-forecast\/#Retinitis_Pigmentosa_Defects_and_Diagnosis\" >Retinitis Pigmentosa Defects and Diagnosis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/www.delveinsight.com\/blog\/retinitis-pigmentosa-epidemiology-forecast\/#Retinitis_Pigmentosa_Epidemiology_Forecast_and_Analysis\" >Retinitis Pigmentosa Epidemiology Forecast and Analysis<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/www.delveinsight.com\/blog\/retinitis-pigmentosa-epidemiology-forecast\/#Retinitis_Pigmentosa_Gender-specific_Epidemiology\" >Retinitis Pigmentosa Gender-specific Epidemiology<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/www.delveinsight.com\/blog\/retinitis-pigmentosa-epidemiology-forecast\/#Retinitis_Pigmentosa_type-specific_epidemiology\" >Retinitis Pigmentosa type-specific epidemiology<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n\n<p class=\"has-text-align-center\"><em>DelveInsight\u2019s Retinitis Pigmentosa Epidemiology forecast analysis revealed that the prevalent population of the disease is expected to increase during the study period 2017-30.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Retinitis_Pigmentosa_Defects_and_Diagnosis\"><\/span><strong>Retinitis Pigmentosa Defects and Diagnosis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>A group of inherited genetic retinal diseases \u2013 <a href=\"https:\/\/www.delveinsight.com\/report-store\/retinitis-pigmentosa-market\">Retinitis pigmentosa<\/a> \u2013 leads to progressive deterioration of the ability of eyes to see. The name was first used by Dr Franciscus Donder, a Dutch ophthalmologist, in the year 1857.&nbsp;<\/p>\n\n\n\n<p>The defect inflicted upon the light-sensitive tissue \u2013 the retina &#8211; of the eye, Retinitis pigmentosa is the main cause of inherited form of blindness.&nbsp;<\/p>\n\n\n\n<p>First and foremost, the sign of Retinitis pigmentosa is usually a loss in the ability to see during the night, which becomes apparent in the early childhood of a person. The disease progresses with the formation of blind spots in the peripheral vision, which further merges to become tunnel vision, eventually leading to loss of vision.&nbsp;<\/p>\n\n\n\n<p>Retinitis \u2013 is an inflammation of the retina; however, the condition Retinitis pigmentosa does not involve any type of inflammation of the eye. Hence, many claims that here the term defies the meaning of the disorder. The main reason behind the diseases involves genetic mutations in any one of more than 50 genes \u2013 genes that are responsible for transcribing proteins necessary&nbsp;<\/p>\n\n\n\n<p>In some mutations, there is a dearth of the protein required, in some, there is a production of a toxic protein, and in remaining cases, there is a presence of abnormal protein, which is good for nothing. The result of mutation might differ; however, the result is the same &#8211; damaged photoreceptors.&nbsp;<\/p>\n\n\n\n<p>Usually, during Retinitis pigmentosa diagnosis and physical examination of the retina through an ophthalmoscope, dark pigmentation &#8211; spots are revealed on the retina. Other tests are also in the order for Retinitis pigmentosa diagnosis such as Genetic testing \u2013 for confirmation of inheritance pattern, Electroretinography, Visual field testing, and Optimal coherence tomography.&nbsp;&nbsp;<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Retinitis_Pigmentosa_Epidemiology_Forecast_and_Analysis\"><\/span><strong>Retinitis Pigmentosa Epidemiology Forecast and Analysis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p>Being a rare disease, gathering and evaluating Retinitis Pigmentosa epidemiological data is rather a challenging task, and the data is often available in fragments and partial form.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"752\" src=\"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/03\/23154937\/Retinitis-Pigmentosa-Epidemiological-Analysis-1024x752.jpg\" alt=\"Retinitis Pigmentosa Epidemiological Analysis\" class=\"wp-image-8720\" srcset=\"https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/03\/23154937\/Retinitis-Pigmentosa-Epidemiological-Analysis-1024x752.jpg 1024w, https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/03\/23154937\/Retinitis-Pigmentosa-Epidemiological-Analysis-300x220.jpg 300w, https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/03\/23154937\/Retinitis-Pigmentosa-Epidemiological-Analysis-768x564.jpg 768w, https:\/\/assets.delveinsight.com\/blog\/wp-content\/uploads\/2020\/03\/23154937\/Retinitis-Pigmentosa-Epidemiological-Analysis.jpg 1200w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption>Retinitis Pigmentosa Epidemiological Analysis<\/figcaption><\/figure>\n\n\n\n<p>As per DelveInsight\u2019s Retinitis pigmentosa, epidemiological model, the diagnosed Retinitis Pigmentosa prevalent population in the 7MM (the US, EU5 and Japan) was observed to be <strong>253,420 <\/strong>in 2017. The most diagnosed cases of the disease were observed in the <strong>US, around 108,787<\/strong>. In EU5, Germany recorded the highest diagnosed Retinitis Pigmentosa prevalent population with 30,642 cases, followed by France and the UK. Spain was observed with least Retinitis pigmentosa prevalent population, with Japan reported being around 28,051 Retinitis pigmentosa prevalent cases.<\/p>\n\n\n\n<p>As per DelveInsight\u2019s Retinitis Pigmentosa Epidemiology Forecast analysis, <em>the prevalence of the disease is expected to rise<\/em> in the coming decade in the 7MM.&nbsp;<\/p>\n\n\n\n<p>Analysis of Retinitis pigmentosa epidemiological data is segmented based on various further factors such as the prevalence in males as compared to females, types of Retinitis pigmentosa, and further sub-types of types of the disease as described below.&nbsp;&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Retinitis_Pigmentosa_Gender-specific_Epidemiology\"><\/span><strong>Retinitis Pigmentosa Gender-specific Epidemiology<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p>A higher preponderance of <strong>Retinitis pigmentosa is observed in males<\/strong>, as compared to females in the US and EU5 in 2017 However; the case reverses, in case of Japan, where females form a large pool of Retinitis pigmentosa prevalent population, estimated DelveInsight\u2019s Retinitis pigmentosa epidemiological analysis and forecast.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Retinitis_Pigmentosa_type-specific_epidemiology\"><\/span><strong>Retinitis Pigmentosa type-specific epidemiology<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p><a href=\"https:\/\/www.delveinsight.com\/report-store\/retinitis-pigmentosa-market\">Retinitis pigmentosa<\/a> can be categorized into two major sub-types \u2013 <em>Syndromic Retinitis Pigmentosa<\/em> and <em>Non-syndromic Retinitis Pigmentosa<\/em>.&nbsp;<\/p>\n\n\n\n<p>Majority of the patients get diagnosed with non-syndromic Retinitis pigmentosa, which in 2017 was recorded to be 172,256 cases in the 7MM.&nbsp;<\/p>\n\n\n\n<p>However; if the disease is present with symptoms such as photopsia (sensation of lights flashing), abnormal central vision, abnormal colour vision, or marked asymmetry in ocular involvement, then it is not necessary the reason behind is Retinitis pigmentosa. The patient may have other retinal degeneration disorders, such as Usher syndrome, and other genetic syndromes, including Bardet-Biedl syndrome; Refsum disease; and neuropathy, ataxia, and retinitis pigmentosa (NARP), Retinitis pigmentosa do sometimes occur in syndromic form.&nbsp;<\/p>\n\n\n\n<p>They are considered in the differential diagnosis of typical retinitis pigmentosa (RP).&nbsp;<\/p>\n\n\n\n<p>In the 7MM, only <strong>one-fourth<\/strong> of the total diagnoses Retinitis pigmentosa prevalent population were observed to be suffering from a <strong>syndromic <\/strong>form of the disease.&nbsp;&nbsp;<\/p>\n\n\n\n<p>Among the Syndromic Retinitis pigmentosa cases Usher Syndrome and Bardet-Biedl syndrome are the most diagnosed prevalent subtypes of the disease. Whereas Non-syndromic Retinitis pigmentosa cases presented a varied picture in the 7MM, for some geographies like in the US, it was sporadic non-syndromic Retinitis pigmentosa with are the highest contribution, for others like in Spain Autosomal recessive Retinitis Pigmentosa accounted for the maximum cases.&nbsp; However, in all the 7MM countries, X-linked RP and Leber congenital amaurosis remain the least occurring subtypes of the disease<\/p>\n\n\n\n<p><strong>Way forward &#8211;<\/strong> <strong>Retinitis pigmentosa Epidemiological forecast&nbsp;<\/strong><\/p>\n\n\n\n<p>The overall management of Retinitis pigmentosa or any rare disease is quite difficult due to several issues including epidemiological ones. Non-availability of data or availability in an unorganized manner is not one of the major <a href=\"https:\/\/www.delveinsight.com\/sample-request\/retinitis-pigmentosa-market\">Retinitis pigmentosa market barriers<\/a>. For any epidemiological model to present accurate values, quantitative estimation of the disease and adequate Retinitis pigmentosa registers worldwide are indispensable.&nbsp;<\/p>\n\n\n\n<p>However; standardizations of the diagnosis, proper classification of the disease, and better therapeutic and rehabilitative approaches will help in better diagnosing of the disease, hence will help in bridging the gap between diagnosed and prevalent Retinitis pigmentosa population. <\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DelveInsight\u2019s Retinitis Pigmentosa Epidemiology forecast analysis revealed that the prevalent population of the disease is expected to increase during the study period 2017-30. Retinitis Pigmentosa Defects and Diagnosis A group of inherited genetic retinal diseases \u2013 Retinitis pigmentosa \u2013 leads to progressive deterioration of the ability of eyes to see. The name was first used [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":8719,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","footnotes":""},"categories":[17,17434],"tags":[11777,11779],"industry":[17225],"therapeutic_areas":[17244],"class_list":["post-8717","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles","category-facts-and-figures","tag-retinitis-pigmentosa","tag-retinitis-pigmentosa-market","industry-pharmaceutical","therapeutic_areas-ophthalmology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.8 (Yoast SEO v25.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ 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