Acetyl Coa Carboxylase Inhibitors Pipeline Insight

DelveInsight’s, “Acetyl-CoA Carboxylase Inhibitors - Pipeline Insight, 2022,” report provides comprehensive insights about 3+ companies and 3+ pipeline drugs in Acetyl-CoA Carboxylase Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

Geography Covered

  • Global coverage

Acetyl-CoA Carboxylase Inhibitors Understanding

Acetyl-CoA Carboxylase Inhibitors: Overview

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes and in the chloroplasts of most plants and algae, whereas it is a large, multi-domain enzyme in the cytoplasm of most eukaryotes. The most important function of ACC is to provide the malonyl-CoA substrate for the biosynthesis of fatty acids.


Function - Acetyl-CoA carboxylase catalyzes the carboxylation of acetyl-CoA to malonyl-CoA. Hydrolysis of ATP provides the energy to drive this essentially irreversible reaction. Acetyl-CoA carboxylase is considered the key regulatory enzyme in the conversion of citrate to long-chain fatty acids because (i) the concentrations of its substrates and products are far from thermodynamic equilibrium; (ii) the maximum velocity of the enzyme, as measured in cell extracts under optimal conditions, is usually the slowest of all enzymes in the pathway; (iii) the concentration of the product of the enzyme, malonyl-CoA, increases when flux through the pathway increases.


Acetyl-CoA Carboxylase Inhibitors - With the accumulation of information on the ACC functions and structures in the last decade, a variety of ACC inhibitors have been identified, some of which have been approved for clinical trials.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Acetyl-CoA Carboxylase Inhibitors R&D. The therapies under development are focused on novel approaches for Acetyl-CoA Carboxylase Inhibitors.

Acetyl-CoA Carboxylase Inhibitors Emerging Drugs Chapters

This segment of the Acetyl-CoA Carboxylase Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.


Acetyl-CoA Carboxylase Inhibitors Emerging Drugs


Firsocostat: Gilead Sciences

Firsocostat is being developed by Gilead Sciences for the treatment of Non-alcoholic fatty liver disease and Non-alcoholic steatohepatitis. The drug is currently in phase 2 of clinical trials.


Clesacostat: Pfizer

Clesacostat is an Acetyl-CoA carboxylase inhibitor developed by Pfizer for the treatment of Non-alcoholic fatty liver disease and Non-alcoholic steatohepatitis. The drug is currently in phase 2 of clinical trials.

Further product details are provided in the report……..

Acetyl-CoA Carboxylase Inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different Acetyl-CoA Carboxylase Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

  • Major Players working on Acetyl-CoA Carboxylase Inhibitors

There are approx. 3+ key companies which are developing the Acetyl-CoA Carboxylase Inhibitors. The companies which have their Acetyl-CoA Carboxylase Inhibitors drug candidates in the most advanced stage, i.e. phase II include, Gilead Sciences.

Phases

DelveInsight’s report covers around 3+ products under different phases of clinical development like

  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration


Acetyl-CoA Carboxylase Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical.
  • Molecule Type


Products have been categorized under various Molecule types such as

  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Acetyl-CoA Carboxylase Inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Acetyl-CoA Carboxylase Inhibitors therapeutic drugs key players involved in developing key drugs.


Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Acetyl-CoA Carboxylase Inhibitors drugs.

Acetyl-CoA Carboxylase Inhibitors Report Insights

  • Acetyl-CoA Carboxylase Inhibitors Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Acetyl-CoA Carboxylase Inhibitors Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

  • How many companies are developing Acetyl-CoA Carboxylase Inhibitors drugs?
  • How many Acetyl-CoA Carboxylase Inhibitors drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for Acetyl-CoA Carboxylase Inhibitors?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Acetyl-CoA Carboxylase Inhibitors therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Acetyl-CoA Carboxylase Inhibitors and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

Acetyl-CoA Carboxylase Inhibitors: Overview

  • Structure
  • Mechanism of Action 

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type 

Acetyl-CoA Carboxylase Inhibitors – DelveInsight’s Analytical Perspective

In-depth Commercial Assessment

  • Acetyl-CoA Carboxylase Inhibitors companies’ collaborations, Licensing, Acquisition -Deal Value Trends

Acetyl-CoA Carboxylase Inhibitors Collaboration Deals

  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis

Late Stage Products (Pre-registration) 

  • Comparative Analysis

Drug name: Company name

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Mid Stage Products (Phase II) 

  • Comparative Analysis

Firsocostat: Gilead Sciences

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Early Stage Products (Phase I) 

  • Comparative Analysis

Drug name: Company name

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Pre-clinical and Discovery Stage Products

  • Comparative Analysis

AK 1225: Akanocure Pharmaceuticals

  • Product Description
  • Research and Development 
  • Product Development Activities 

Drug profiles in the detailed report…..

Inactive Products

  • Comparative Analysis

Acetyl-CoA Carboxylase Inhibitors Key Companies

Acetyl-CoA Carboxylase Inhibitors Key Products

Acetyl-CoA Carboxylase Inhibitors- Unmet Needs

Acetyl-CoA Carboxylase Inhibitors- Market Drivers and Barriers

Acetyl-CoA Carboxylase Inhibitors- Future Perspectives and Conclusion

Acetyl-CoA Carboxylase Inhibitors Analyst Views

Acetyl-CoA Carboxylase Inhibitors Key Companies

Appendix

List of Table

Table 1: Total Products for Acetyl-CoA Carboxylase Inhibitors

Table 2: Late Stage Products

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for Acetyl-CoA Carboxylase Inhibitors

Figure 2: Late Stage Products

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Products    

• Gilead Sciences

• Pfizer

• Akanocure Pharmaceuticals

• Novo Nordisk

Forward to Friend

Need A Quote