DelveInsight’s, “Alpha 1 Adrenergic Receptor Antagonist - Pipeline Insight, 2022,” report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in Alpha 1 Adrenergic Receptor Antagonist pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Alpha 1 Adrenergic Receptor Antagonist: Overview
Alpha-1–adrenergic receptors (ARs) are G protein–coupled receptors activated by catecholamines. The alpha-1A and alpha-1B subtypes are expressed in mouse and human myocardium, whereas the alpha-1D protein is found only in coronary arteries. The alpha-1 adrenergic receptors activate the Gq/11 family of G proteins leading to the dissociation of the α and βγ subunits and the subsequent stimulation of the enzyme phospholipase C. This enzyme hydrolyzes phosphatidylinositol 1,2-biphosphate in the membrane producing inositol trisphosphate (IP3) and diacylglycerol. These molecules act as second messengers mediating intracellular Ca2+ release via the IP3 receptor and activating protein kinase C. Alpha-1-adrenoreceptor antagonist drugs have the immediate attraction that there are no patient co-morbidities that constitute absolute contraindications to their use. Thus, alpha blockers can safely and appropriately be administered to hypertensive patients with concomitant disease states such as diabetes mellitus or obstructive airway disease or renal impairment.
The companies and academics are working to assess challenges and seek opportunities that could influence Alpha 1 Adrenergic Receptor Antagonist R&D. The therapies under development are focused on novel approaches for Alpha 1 Adrenergic Receptor Antagonist.
This segment of the Alpha 1 Adrenergic Receptor Antagonist report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Alpha 1 Adrenergic Receptor Antagonist Emerging Drugs
TNX-102 SL: Tonix Pharmaceuticals
TNX-102 SL is a small, rapidly-disintegrating, under the tongue (sublingual) product candidate containing 2.8 mg of cyclobenzaprine HCl. The unique formulation has been designed to optimize the delivery and absorption of cyclobenzaprine for the therapeutic benefit of improving sleep quality, while minimizing the potential residual effects of oral formulations of cyclobenzaprine. Tonix is developing TNX-102 SL* as a potential treatment for the symptoms of Fibromyalgia. It is currently in Phase 3 clinical development. TNX-102 SL targets mechanisms which are associated with disturbed sleep. It is believed that increasing sleep quality in fibromyalgia may facilitate the body's adaptive ability to modulate the perception of pain.
Roluperidone: Minerva Neurosciences
Roluperidone has been designed to block a specific subtype of serotonin receptor called 5-HT2A. When 5-HT2A is blocked, certain symptoms of schizophrenia, such as hallucinations, delusions, agitation and thought and movement disorders, as well as the side effects associated with antipsychotic treatments, can be minimized. Roluperidone has also been designed to block a specific subtype of sigma receptor called sigma2, which is involved in movement control, psychotic symptom control and learning and memory. Blocking sigma2, along with blocking the α‑adrenergic subtypes α1A, and to a lesser extent α1B, also increases calcium levels in neurons in the brain, which can improve memory. Pre-clinical findings provide evidence of the effect of roluperidone on Brain-Derived Neurotrophic Factor (“BDNF”), which has been associated with neurogenesis, neuroplasticity, neuroprotection, synapse regulation, learning and memory.
Further product details are provided in the report……..
This segment of the report provides insights about the different Alpha 1 Adrenergic Receptor Antagonist drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 12+ key companies which are developing the Alpha 1 Adrenergic Receptor Antagonist. The companies which have their Alpha 1 Adrenergic Receptor Antagonist drug candidates in the most advanced stage, i.e. Phase III include, Tonix Pharmaceuticals.
DelveInsight’s report covers around 12+ products under different phases of clinical development like
Alpha 1 Adrenergic Receptor Antagonist pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Alpha 1 Adrenergic Receptor Antagonist therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Alpha 1 Adrenergic Receptor Antagonist drugs.
Current Scenario and Emerging Therapies:
Introduction
Executive Summary
Alpha 1 Adrenergic Receptor Antagonist: Overview
Pipeline Therapeutics
Therapeutic Assessment
Alpha 1 Adrenergic Receptor Antagonist – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
TNX-102 SL: Tonix Pharmaceuticals
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
FKF 02SC: Fabre-Kramer Pharmaceuticals
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Centhaquine: Pharmazz
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
ACH 000029: Ache Laboratories
Drug profiles in the detailed report…..
Inactive Products
Alpha 1 Adrenergic Receptor Antagonist Key Companies
Alpha 1 Adrenergic Receptor Antagonist Key Products
Alpha 1 Adrenergic Receptor Antagonist- Unmet Needs
Alpha 1 Adrenergic Receptor Antagonist- Market Drivers and Barriers
Alpha 1 Adrenergic Receptor Antagonist- Future Perspectives and Conclusion
Alpha 1 Adrenergic Receptor Antagonist Analyst Views
Alpha 1 Adrenergic Receptor Antagonist Key Companies
Appendix
List of Table
Table 1: Total Products for Alpha 1 Adrenergic Receptor Antagonist
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Alpha 1 Adrenergic Receptor Antagonist
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• Tonix Pharmaceuticals
• Minerva Neurosciences
• INNOPHARMAX
• Bristol-Myers Squibb
• Kissei Pharmaceutical
• Pharmazz
• Ocularis Pharma
• Kinnov Therapeutics
• Ache Laboratories
• Ildong Pharmaceutical
• GL PharmTech
• Jeil Pharmaceutical
• Chong Kun Dang
• Ocuphire Pharma
• Fabre-Kramer Pharmaceuticals
