DelveInsight’s, “Biliary Atresia – Pipeline Insight, 2022,” report provides comprehensive insights about 3+ companies and 3+ pipeline drugs in Biliary Atresia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Biliary Atresia: Overview
Biliary atresia is a blockage in the tubes (ducts) that carry bile from the liver to the gallbladder. This congenital condition occurs when the bile ducts inside or outside the liver do not develop normally. It is not known why the biliary system fails to develop normally. Typically, the first sign of biliary atresia is yellowing of the skin and whites of the eyes, called jaundice, which results from the buildup of bile in the body. Infants with biliary atresia typically develop jaundice by 3 to 6 weeks of age. Physical exam is performed to feel for an enlarged liver. Other tests include: Abdominal x-ray, Abdominal ultrasound, Blood tests to check total and direct bilirubin levels, Hepatobiliary iminodiacetic acid (HIDA) scan, also called cholescintigraphy, to help determine if the bile ducts and gallbladder are working properly, Liver biopsy to determine severity of cirrhosis or to rule out other causes of jaundice, and X-ray of the bile ducts (cholangiogram). Doctors treat biliary atresia with a surgery called the Kasai procedure and eventually, in most cases, a liver transplant. To make sure infants and children with biliary atresia get enough nutrients and calories, doctors may recommend a special eating plan and supplements.
"Biliary Atresia - Pipeline Insight, 2022" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Biliary Atresia pipeline landscape is provided which includes the disease overview and Biliary Atresia treatment guidelines. The assessment part of the report embraces, in depth Biliary Atresia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Biliary Atresia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
The companies and academics are working to assess challenges and seek opportunities that could influence Biliary Atresia R&D. The therapies under development are focused on novel approaches to treat/improve Biliary Atresia.
This segment of the Biliary Atresia report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Biliary Atresia Emerging Drugs
Odevixibat: Albireo Pharma
Bylvay is a potent, non-systemic ileal bile acid transport inhibitor. Inhibition of IBAT, which plays a main role in enterohepatic circulation, may lead to decreased bile acids returning to the liver. A4250 works through highly potent and selective inhibition and exerts minimal systemic exposure as it acts locally in the small intestine. Bylvay is currently being evaluated in the BOLD Phase III clinical trial in patients with biliary atresia. In January 2019 the Food and Drug Administration (FDA) has granted Orphan Drug designation to A4250 for the treatment of biliary atresia.
Further product details are provided in the report……..
This segment of the report provides insights about the different Biliary Atresia drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 3+ key companies which are developing the therapies for Biliary Atresia. The companies which have their Biliary Atresia drug candidates in the most advanced stage, i.e. Phase III include, Albireo Pharma.
DelveInsight’s report covers around 3+ products under different phases of clinical development like
Biliary Atresia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Biliary Atresia therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Biliary Atresia drugs.
Current Treatment Scenario and Emerging Therapies:
Introduction
Executive Summary
Biliary Atresia: Overview
Pipeline Therapeutics
Therapeutic Assessment
Late Stage Products (Pregistration)
Nefecon: Calliditas Therapeutics
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
BION-1301: Chinook therapeutics
Drug profiles in the detailed report…..
Early stage products (Phase I)
HR19042: Jiangsu HengRui Medicine
Drug profiles in the detailed report…..
Inactive Products
Biliary Atresia Key Companies
Biliary Atresia Key Products
Biliary Atresia- Unmet Needs
Biliary Atresia- Market Drivers and Barriers
Biliary Atresia- Future Perspectives and Conclusion
Biliary Atresia Analyst Views
Biliary Atresia Key Companies
Appendix
List of Table
Table 1: Total Products for Biliary Atresia
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Biliary Atresia
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• Mirium Pharmaceuticals
• Albireo
• Intercept Pharmaceuticals
