DelveInsight’s, “CD137 Agonist Antibody – Pipeline Insight, 2021,” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in CD137 Agonist Antibody pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
CD137 Agonist Antibody: Overview
CD137, also known as 4-1BB, has long been known as a target of interest for cancer. It is a costimulatory immunoreceptor and a member of the TNF-receptor family. The selective expression of CD137 on cells of the immune system (e.g., T and DC cells) and oncogenic cells in several types of cancer leads this molecule to be an attractive target to discover cancer immunotherapy. CD137 (4-1BB) is a member of the TNFR superfamily that represents a promising target for cancer immunotherapy. Agonistic anti-CD137 antibody enhances anti-cancer immunity to protect from solid tumors. This outcome is due to an active effect of cytotoxic T cells, NK cells, and macrophages by this antibody.
"CD137 Agonist Antibody - Pipeline Insight, 2021" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the CD137 Agonist Antibody pipeline landscape is provided which includes the disease overview and CD137 Agonist Antibody treatment guidelines. The assessment part of the report embraces, in depth CD137 Agonist Antibody commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, CD137 Agonist Antibody collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
The companies and academics are working to assess challenges and seek opportunities that could influence CD137 Agonist Antibody R&D. The therapies under development are focused on novel approaches to treat/improve CD137 Agonist Antibody.
This segment of the CD137 Agonist Antibody report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
CD137 Agonist Antibody Emerging Drugs
Utomilumab: Pfizer
Utomilumab (PF-05082566) is a human IgG2 antibody agonist that targets the extracellular domain of 4-1BB (CD137), which is a co-stimulatory receptor expressed on activated T cells. The drug is being studied in Phase II clinical trials for the treatment of patients with Breast cancer.
LVGN6051: Lyvgen
LVGN6051 specifically binds human CD137 (4-1BB) and activates its signaling only when the engineered Fc of LVGN6051 engages FcγRIIB. In contrast to the first generation CD137 agonist antibodies that entered clinic, LVGN6051 has bi-specificity for CD137 and FcγRIIB. Lyvgen has initiated a Phase I clinical trial in October of 2019.
AGEN2373: Agenus, Inc.
AGEN2373 is a CD137 Agonist Antibody designed to leverage optimal CD137 and FcγR co-targeting to promote antitumor immunologic effects. The drug is currently in Phase I stage of development for the treatment of solid tumors.
Further product details are provided in the report……..
This segment of the report provides insights about the different CD137 Agonist Antibody drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 15+ key companies which are developing the therapies for CD137 Agonist Antibody. The companies which have their CD137 Agonist Antibody drug candidates in the most advanced stage, i.e. phase II include, Pfizer.
DelveInsight’s report covers around 15+ products under different phases of clinical development like
CD137 Agonist Antibody pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses CD137 Agonist Antibody therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging CD137 Agonist Antibody drugs.
Current Treatment Scenario and Emerging Therapies:
Introduction
Executive Summary
CD137 Agonist Antibody: Overview
Pipeline Therapeutics
Therapeutic Assessment
CD137 Agonist Antibody – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
CD137 Agonist Antibody Collaboration Deals
Mid Stage Products (Phase II)
Utomilumab: Pfizer
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
LVGN6051: Lyvgen
Drug profiles in the detailed report…..
Inactive Products
CD137 Agonist Antibody Key Companies
CD137 Agonist Antibody Key Products
CD137 Agonist Antibody- Unmet Needs
CD137 Agonist Antibody- Market Drivers and Barriers
CD137 Agonist Antibody- Future Perspectives and Conclusion
CD137 Agonist Antibody Analyst Views
CD137 Agonist Antibody Key Companies
Appendix
List of Table
Table 1: Total Products for CD137 Agonist Antibody
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for CD137 Agonist Antibody
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• Agenus, Inc.
• Lyvgen
• Compass therapeutics
• Bristol Myers Squibb
• F-star Therapeutics
• Adagene
• Bicycle therapeutics
• Alligator Biosciences
• Pfizer
