DelveInsight’s, “Cell Wall Synthesis Inhibitors - Pipeline Insight, 2022,” report provides comprehensive insights about 40+ companies and 40+ pipeline drugs in Cell Wall Synthesis Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Cell Wall Synthesis Inhibitors: Overview
Cell wall biosynthesis inhibitors (CBIs) have historically been one of the most effective classes of antibiotics. They are the most extensively used class of antibiotics and their importance is exemplified by the β-lactams and glycopeptide antibiotics. Glycopeptide antibiotics, a subset of CBIs, have been traditionally used to treat drug-resistant pathogens. In fact, ever since its introduction, vancomycin, the first glycopeptide antibiotic approved, was used as a “drug of last resort” for a long time. However, resistance against glycopeptides and other CBIs has compromised the armamentarium greatly. This is of grave concern because it is estimated that around 700 000 patients die due to antimicrobial resistance (AMR) every year globally. Development of semi-synthetic antibiotics is another way to tackle the problem of AMR. Understanding the molecular mechanisms of natural product antibiotics helps in designing newer and more effective derivatives. This is reflected in the fact that most of the new drugs undergoing clinical trials are synthetic modifications of natural products. The use of bacterial cell wall biosynthesis inhibitors continues to be an effective way to combat bacterial infections.
"Cell Wall Synthesis Inhibitors - Pipeline Insight, 2022" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Cell Wall Synthesis Inhibitors pipeline landscape is provided which includes the disease overview and Cell Wall Synthesis Inhibitors treatment guidelines. The assessment part of the report embraces, in depth Cell Wall Synthesis Inhibitors commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Cell Wall Synthesis Inhibitors collaborations, licensing, mergers and acquisition, funding, designations and other product related details.
The companies and academics are working to assess challenges and seek opportunities that could influence Cell Wall Synthesis Inhibitors R&D. The therapies under development are focused on novel approaches to treat/improve Cell Wall Synthesis Inhibitors.
This segment of the Cell Wall Synthesis Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Cell Wall Synthesis Inhibitors Emerging Drugs
Tebipenem HBr: Spero Therapeutics
Tebipenem HBr (tebipenem pivoxil hydrobromide; formerly SPR994) is an oral antibiotic for the treatment of complicated urinary tract infection (cUTI) and acute pyelonephritis (AP) to help patients avoid hospitalizations (stay at home) and/or transition patient’s home after IV therapy (get home). ebipenem HBr has been granted Qualified Infectious Disease Product (QIDP) and Fast Track designations by the FDA for the treatment of cUTI and AP. Spero expects to submit a New Drug Application to the U.S. Food and Drug Administration (FDA) for tebipenem HBr in the second half of 2021. If approved, tebipenem HBr would be the first oral carbapenem to receive marketing approval in the United States.
Taniborbactam: VenatoRx Pharmaceuticals
Taniborbactam (formerly VNRX-5133), an injectable beta-lactamase inhibitor (BLI) that features selective and potent in vitro activity against both serine- and metallo-beta-lactamases (MBLs), including the following enzymes: extended spectrum beta-lactamase (ESBL); Oxacillinase (OXA); Klebsiella pneumoniae carbapenemase (KPC); New Delhi metallo-beta-lactamase (NDM); and Verona integron-encoded metallo-beta-lactamase (VIM). Venatorx is currently enrolling a Phase 3 clinical trial of cefepime-taniborbactam in patients with complicated urinary tract infections (cUTIs).
VNRX-7145: VenatoRx Pharmaceuticals
VNRX-7145, an orally bioavailable beta-lactamase inhibitor (BLI) that in a fixed combination with the third generation orally bioavailable cephalosporin, ceftibuten, has the potential to rescue activity of the partner antibiotic against extended spectrum beta-lactamases (ESBLs) and key carbapenem-resistant Enterobacterales (CRE), including those expressing Klebsiella pneumoniae carbapenemase (KPC) and Oxacillinase (OXA) carbapenemases. This project has been funded in part with Federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272201600029C.
Further product details are provided in the report……..
This segment of the report provides insights about the different Cell Wall Synthesis Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 40+ key companies which are developing the therapies for Cell Wall Synthesis Inhibitors. The companies which have their Cell Wall Synthesis Inhibitors drug candidates in the most advanced stage, i.e. Phase III include, VenatoRx Pharmaceuticals.
DelveInsight’s report covers around 40+ products under different phases of clinical development like
Cell Wall Synthesis Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Cell Wall Synthesis Inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Cell Wall Synthesis Inhibitors drugs.
Current Treatment Scenario and Emerging Therapies:
Introduction
Executive Summary
Cell Wall Synthesis Inhibitors: Overview
Pipeline Therapeutics
Therapeutic Assessment
Late Stage Products (Phase III)
Taniborbactam: VenatoRx Pharmaceuticals
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Drug Name: Company Name
Drug profiles in the detailed report…..
Early stage products (Phase I)
VNRX-7145: VenatoRx Pharmaceuticals
Drug profiles in the detailed report…..
Preclinical stage products
Drug Name: Company Name
Drug profiles in the detailed report…..
Inactive Products
Cell Wall Synthesis Inhibitors Key Companies
Cell Wall Synthesis Inhibitors Key Products
Cell Wall Synthesis Inhibitors- Unmet Needs
Cell Wall Synthesis Inhibitors- Market Drivers and Barriers
Appendix
List of Table
Table 1: Total Products for Cell Wall Synthesis Inhibitors
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Cell Wall Synthesis Inhibitors
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• Spero Therapeutics
• VenatoRx Pharmaceuticals
• Recce Pharmaceuticals
