Chronic Pain Market

DelveInsight’s ‘Chronic Pain - Market Insights, Epidemiology, and Market Forecast—2030’ report delivers an in-depth understanding of the Chronic Pain, historical and forecasted epidemiology as well as the Chronic Pain market trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

The Chronic Pain market report provides current treatment practices, emerging drugs, Chronic Pain market share of the individual therapies, current and forecasted Chronic Pain market size from 2018 to 2030 segmented by seven major markets. The Report also covers current Chronic Pain treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.

Geography Covered

• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan

Study Period: 2018–2030

Chronic Pain: Disease Understanding and Treatment Algorithm

Chronic Pain Overview

Chronic Pain is any pain that lasts for more than three months. The pain can gradually grow worse and recur intermittently, outlasting the normal process of recovery and adversely affecting the person’s well-being. Pain is supposed to cease after damaged tissue recovers until the root cause is treated. However, for no apparent biological reason, chronic pain can continue even after injuries heal. Depending on the cause, it may last up to 6 months or even longer. However, some painful conditions may persist for years.

The most common sources of chronic pain include low back pain, headache (migraine), neuropathic pain (Neuralgia), musculoskeletal pain (Fibromyalgia), cancer pain, post-operative pain, arthritic pain (Osteoarthritis, Rheumatoid Arthritis), and others. Chronic pain can cause significant psychological and emotional trauma and often limits an individual’s ability to function fully. It is a common complaint in older adults. A person may have more than one chronic pain condition at a time. Someone may experience chronic pain long after they are injured or without any apparent cause. In some cases, more than one factor may be involved.

Chronic pain often leads to vegetative signs (e.g., lassitude, sleep disturbance, decreased appetite, loss of taste for food, weight loss, diminished libido, constipation), which develop gradually. Constant, unremitting pain may lead to depression and anxiety and interfere with almost all activities. Patients may become inactive, withdraw socially, and become preoccupied with physical health. Psychological and social impairment may be severe, causing a virtual lack of function.

Chronic Pain Diagnosis

Diagnosing chronic pain is not easy, as there are no tools to quantify pain. Diagnosis often involves a series of tests and procedures, as well as a review of symptoms and medical history. There is no way to measure pain objectively. Only the person with chronic pain can describe how much pain he or she is feeling.

A doctor will first ask questions about the symptoms and factors that trigger pain, further investigating the location of the, how long it has been going on, and whether it is sharp or dull, constant, or occurs off and on. Sometimes a patient will be asked to rate how bad the pain is by using a numerical scale and giving more details. The doctor will do a physical exam and may order additional diagnostic tests. The diagnostic tests that are useful in the diagnosis of Chronic Pain include imaging tests like x-rays, bone scans, MRI, etc., and nerve tests like Electromyography (EMG), and some more. Other than this, physical, neurological, and mental health exams, some blood tests, and urine analysis may also be used.

Chronic Pain Treatment

There are several categories of medications that are used for the treatment of chronic pain. Oral medications include those that can be taken by mouth, such as nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, opioids, opioid-like agents, or combinations of opioids and non-narcotic analgesics, corticosteroids, antirheumatics/immunological agents, and anticonvulsants.

Opioids are most useful are usually reserved for cases of chronic pain when other pain relievers are not effective and when the negative side effects are manageable.

Many chronic pain patients may benefit from taking anti-depressant drugs. Types of antidepressants prescribed include tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and others.

Drugs approved for the treatment of chronic pain due to different indications include Emgality (galcanezumab-gnlm), Aimovig (Eptinezumab), Tarlige (Mirogabalin besylate), Aimovig (Erenumab-aooe), and Ajovy (Fremanezumab), among others.

Chronic Pain Epidemiology

The Chronic Pain epidemiology division provides insights about historical and current Chronic Pain patient pool and forecasted trends for every seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings

In the year 2020, the total prevalent case of Chronic Pain was 187,786,024 cases in the 7MM which are expected to grow during the study period, i.e., 2018–2030.

The disease epidemiology covered in the report provides historical as well as forecasted Chronic Pain epidemiology [segmented as Total Prevalent Cases of Chronic Pain, Total Diagnosed Cases of Chronic Pain, Age-specific Cases of Chronic Pain, Cause-specific Cases of Chronic Pain, Severity-specific Cases of Chronic Pain and Treated cases of Chronic Pain] in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan from 2018 to 2030.

Country Wise- Chronic Pain Epidemiology

Estimates show that the highest cases of Chronic Pain in the 7MM were in the United States, followed by Japan, the United Kingdom, Germany, France, Italy, and Spain in the year 2020.

• In the United States, the total number of prevalent cases of Chronic Pain was 52,769,187 cases in the year 2020 which are expected to grow during the study period, i.e., 2018–2030.
• In the year 2020, the total prevalent cases of Chronic Pain were 92,698,547 cases in EU-5 which are expected to grow during the study period, i.e., 2018–2030.
• In Japan, the total number of prevalent cases of Chronic Pain was 42,318,290 cases in the year 2020 which are expected to grow during the study period, i.e., 2018–2030.

Chronic Pain Drug Chapters

The drug chapter segment of the Chronic Pain report encloses the detailed analysis of Chronic Pain marketed drugs and late stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Chronic Pain clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.

Chronic Pain Approved Drugs

Emgality/Galcanezumab (Elli Lilly and Company)

Emgality (Galcanezumab-gnlm) is a calcitonin gene-related peptide antagonist indicated for the preventive treatment of migraine in adults. Galcanezumab-gnlm is a humanized IgG4 monoclonal antibody specific for calcitonin-gene-related peptide (CGRP) ligand. Galcanezumab-gnlm is composed of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. Emgality is already approved in the US, Europe, and Japan for adult patients and currently, the company is also looking for its potential in adolescent patients 12 to 17 Years of age with chronic migraines.

Vyepti/ Eptinezumab (Alder Biopharmaceuticals [Acquired by Lundbeck])

Lundbeck Pharmaceutical's, Vyepti (eptinezumab), is part of a new class of antibody therapies developed to prevent migraine attacks before they start. These drugs block calcitonin gene-related peptide (CGRP), a protein associated with the onset of migraine pain. Eptinezumab is a monoclonal antibody (mAb) that is administered as a quarterly 30-minute IV infusion. Eptinezumab was designed for immediate and complete bioavailability with high specificity and strong binding for suppression of calcitonin gene-related peptide (CGRP), a neuropeptide believed to play a key role in mediating and initiating migraines, it is the first IV CGRP therapy for migraine prevention.

Tarlige/Mirogabalin (Daiichi Sankyo)

Mirogabalin besylate/Tarlige is an orally administered gabapentinoid developed by Daiichi Sankyo for the treatment of peripheral neuropathic pain (PNP), including diabetic PNP and post-herpetic neuralgia. The drug binds to and modulates the α2δ-1 subunit of the voltage-gated calcium channels widely found in the nervous system in areas that mediate pain transmission and processing. Mirogabalin has a unique binding profile and long duration of action. The drug was approved in Japan for the treatment of PNP in 2019.

Aimovig/Erenumab (Amgen/Novartis)

Aimovig (Erenumab), formerly known as AMG 334 is a human immunoglobulin G2 (IgG2) monoclonal antibody that has high-affinity binding to the calcitonin gene-related peptide receptor (CGRP-R). Aimovig is an EMA and the US FDA-approved migraine prevention treatment designed specifically to block the CGRP-R, which plays a critical role in migraine.

Ajovy/Fremanezumab (Teva Pharmaceuticals)

Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to calcitonin gene-related peptide (CGRP), a 37–amino acid neuropeptide involved in central and peripheral pathophysiological events of migraine. Fremanezumab targets both α and β isoforms of the CGRP ligand (not the receptor), has flexible dosing, and is administered through subcutaneous injection.

Note: Detailed Current therapies assessment will be provided in the full report of Chronic Pain

Chronic Pain Emerging Drugs

Tanezumab (Pfizer/Eli Lilly and Company)

Tanezumab is an investigational monoclonal antibody being developed by Pfizer and Eli Lilly and Company. It works by selectively targeting, binding to, and inhibiting NGF (nerve growth factor). NGF levels increase in the body as a result of injury, inflammation, or chronic pain states. By inhibiting NGF, tanezumab may help to keep pain signals produced by muscles, skin, and organs from reaching the spinal cord and brain. Tanezumab has a novel mechanism that acts in the periphery differently than opioids and other analgesics, including NSAIDs, and in studies to date, tanezumab has not demonstrated a risk of addiction, misuse, or dependence. In March 2020, Pfizer and Eli Lilly and Company announced that the US FDA accepted for review a Biologics License Application (BLA) for tanezumab for patients with chronic pain due to moderate-to-severe osteoarthritis (OA) who have experienced inadequate pain relief with other analgesics.

Fasinumab/REGN475 (Regeneron Pharmaceuticals/Teva Pharmaceuticals/Mitsubishi Tanabe Pharma Corporation)

Fasinumab (REGN475) is an investigational fully human IgG4κ monoclonal antibody under development by Regeneron Pharmaceuticals, Teva Pharmaceuticals, and Mitsubishi Tanabe Pharma Corporation. It is designed to target nerve growth factor (NGF), a protein that plays a central role in the regulation of pain signaling. Blocking NGF may reduce chronic low back pain (CLBP). It is under development by Mitsubishi Tanabe, Regeneron, and Teva, as a collaboration on the global development and commercialization of fasinumab. It is an investigational NGF antibody in clinical development for osteoarthritis pain and chronic low back pain. It was invented by Regeneron Pharmaceuticals using the company's proprietary VelocImmune technology that yields optimized fully-human antibodies. There is evidence that NGF levels are elevated in the synovial fluid of patients with chronic pain conditions.

Atogepant (Allergan [acquired by ABBVie])

Atogepant is an orally administered, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist (Gepant). It is specifically being developed by Allergan, which has now been acquired by AbbVie, for the preventive treatment of migraines. CGRP and its receptors are expressed in regions of the nervous system associated with migraine pathophysiology. Studies have shown that CGRP levels are elevated during migraine attacks and selective CGRP receptor antagonists confer clinical benefit in migraine.

Ampion (Ampio Pharmaceuticals)

Ampion is an investigational drug being developed by Ampio Pharmaceuticals. It is an intra-articular injection to treat the signs and symptoms of severe osteoarthritis of the knee (OAK). Ampion regulates key components of the immune response connected to pain, inflammation, and joint damage in osteoarthritis.

Ampion reduces the production of the cytokines responsible for inflammation (TNFα, IL-1β, IL-6, IL-12) by regulating with the genetic transcriptional pathways (NFκB, STAT) responsible for the overproduction of these cytokines while activating anti-inflammatory proteins responsible for tissue growth and healing. This mechanism of action has an overall clinical effect that has been shown to relieve pain and improve function in the knee for patients.

Rexlemestrocel/MPC-06-ID (Gruenthal/Mesoblast)

Rexlemestrocel, also known as Rexlemestrocel-L or MPC-06-ID is a late-stage development product candidate for the treatment of chronic low back pain caused by disc degeneration (CLBP). It is being developed for patients who have exhausted conservative treatment options, may have failed epidural steroid injections, and have no further treatment option other than invasive and costly surgical interventions. MPCs have anti-inflammatory effects and secrete multiple paracrine factors that stimulate new proteoglycan and collagen synthesis by chondrocytes in vitro and by resident cells in the nucleus and annulus in vivo. MPCs have also been shown to produce anti-inflammation factors.

Note: Detailed emerging therapies assessment will be provided in the final report.

Chronic Pain Market Outlook

Chronic or persistent pain is pain that carries on for longer than 12 weeks despite medication or treatment. Most people get back to normal after pain following an injury or operation. But sometimes the pain carries on for longer or comes on without any history of an injury or operation. Chronic pain may be related to several different medical conditions including (but not limited to) diabetes, arthritis, migraine, fibromyalgia, cancer, sciatica, and previous trauma or injury.

Several types of medications are being used in the management of chronic pain, including acetaminophen, ibuprofen, aspirin, COX-2 inhibitors, antimigraine medications, sedatives, opioids, and antidepressants. Nonpharmacologic treatments for chronic pain can include exercise, physical therapy, counseling, electrical stimulation, biofeedback, acupuncture, hypnosis, chiropractic medicine, and other treatments. There are several approved drugs for the treatment of chronic pain such as Emgality (Galcanezumab), Savella (Milnacipran), Vyepti (Eptinezumab), Tarlige (Mirogabalin), Aimovig (Erenumab), and Ajovy (Fremanezumab).

Still, there are some unmet needs in the chronic pain market. There are various challenges in identifying biomarkers for chronic pain. Also, the mechanism-based diagnosis has not been feasible, as its pathophysiological components are not elucidated yet. Therefore, the current diagnosis of chronic pain is based solely on clinical signs and symptoms.

Nevertheless, recently some developmental initiatives have been taken towards the management of chronic pain. Several pharmaceutical key players have taken to the initiative to meet the unmet needs of the present situation of the chronic pain market. Some of the key players are in the late and mid clinical development stages with their leading drug candidates.

Key players such as Centrexion Therapeutics (CNTX-4975), Pfizer and Eli Lilly and Company (Tanezumab), Regeneron, Teva Pharmaceuticals and Mitsubishi Tanabe Pharma Corporation (Fasinumab), Sorrento Therapeutics (Resiniferatoxin), Taiwan Liposome Company (TLC599), Ampio Pharmaceuticals (Ampion), Samumed (Lorecivivint), Gruenthal and Mesoblast (MPC-06-ID), Biogen (BIIB074), Allergan (Atogepant) and several others are investigating their candidates for the management of chronic pain in the 7MM.

Key Findings

The Chronic Pain market size in the 7MM is expected to change during the study period 2018–2030. The therapeutic market of Chronic Pain in the seven major markets is expected to increase during the study period (2018–2030) with a CAGR of 3.0%. According to the estimates, the highest market size of Chronic Pain is found in the United States followed by Japan.

The United States Market Outlook

The total market size of Chronic Pain therapies in the United States is expected to increase with a CAGR of 2.7% in the study period (2018–2030).

EU-5 Countries: Market Outlook

The total market size of Chronic Pain therapies in EU-5 countries is expected to increase with a CAGR of 3.2% in the study period (2018–2030).

Japan Market Outlook

The total market size of Chronic Pain therapies in Japan is expected to increase with a CAGR of 3.4% in the study period (2018–2030).

Chronic Pain Pipeline Development Activities

The drugs which are in pipeline include:

1. Tanezumab (Pfizer/Eli Lilly and Company)

2. Fasinumab/REGN475 (Regeneron/Teva Pharmaceuticals/Mitsubishi Tanabe Pharma Corporation)

3. Atogepant (Allergan [acquired by ABBVie])

4. STA363 (Stayble Therapeutics)

5. NYX-2925 (Aptinyx)

6. LAT8881 (Lateral Pharma)

7. LY-3451838 (Eli Lilly and Company)

8. Lorecivivint/SM04690 (Samumed)

9. Resiniferatoxin/MCP-101 (Sorrento Therapeutics)

10. Ampion (Ampio Pharmaceuticals)

11. SP-102/Semdexa (Semnur Pharmaceuticals)

12. CAM2038 (Braeburn Pharmaceuticals/Camurus)

13. TLC599 (Taiwan Liposome Company)

14. CNTX-4975 (Centrexion Therapeutics)

15. Vixotrigine/BIIB074 (Biogen)

16. ALLOD-2 (Allodynic Therapeutics)

17. LX9211 (Lexicon Pharmaceuticals)

18. LY3556050 (Eli Lilly and Company)

19. Rexlemestrocel/MPC-06-ID (Gruenthal/Mesoblast)

20. LY3016859 (Eli Lilly and Company)

21. Ricolinostat/ACY-1215 (Regenacy Pharmaceuticals)

22. AP-325 (Algiax Pharmaceuticals)

23. BAY1817080/Eliapixant (Bayer)

24. VX-150 (Vertex Pharmaceuticals)

25. Omnitram/Desmetramadol (Syntrix Biosystems)

26. NFX88 (Neurofix Pharma)

27. AminoFix/dHACM (MiMedx)

Note: Detailed emerging therapies assessment will be provided in the final report.

Analyst Commentary

• Opioids have been the mainstay of treatment for patients experiencing moderate to severe pain. Although in the US, the overall national opioid dispensing rate declined from 2012 to 2019, and in 2019, the dispensing rate had fallen to the lowest in the 14 years. Still, opioids usage is seen in the range of 40 to 50% in the US cases in moderate to severe chronic pain.
• The pipeline of Chronic Pain is very robust, many potential therapies are being investigated for the management of chronic pain, and it is safe to predict that the treatment space will experience a significant impact on the market during the forecast period
• Among the emerging therapies, Rexlemestrocel, also known as Rexlemestrocel-L or MPC-06-ID from Gruenthal and Mesoblast is expected to garner the highest patient share owing to promising efficacy signals shown in phase II trial, and the company is well on track with two-phase III multicenter randomized controlled clinical trials.
• There is a huge opportunity for alternative options to addictive opioids to address chronic pain particularly in chronic back pain and arthritis pain, but safety issues have prevented higher-efficacy dosing of NGF targeted drugs, limiting their potential for approval or commercial uptake in the significant patient pool.

Access and Reimbursement Scenario in Chronic Pain Therapies

A hospital-based fee plan offers the highest degree of reimbursement in most cases. However, locating the pain center on the campus of the hospital is not the only option. According to Centers for Medicare and Medicaid Services (CMS) rules, whether it is within 35 miles of the hospital itself and satisfies other criteria that generally involve the center functioning under the hospital’s license, an offsite facility may be refunded under the hospital-based fee schedule.

Access to pain relief facilities is highly inconsistent at present, both within and across countries in Europe. Also, the level of care offered by available pain health facilities differs. For all people with chronic pain in Europe, a new minimum standard of care is needed.

It is worth noting that patients often experience obstacles related to almost absent or inadequate insurance coverage and reimbursement for pain management services for the persistent pain. There is a lack of consistency in insurance coverage and a lack of coverage alignment with current practice guidelines for pain management. Recently, the Health and Human Services National Pain Strategy called for prominent coverage for pain management services. This is especially valid for nonpharmacologic and behavioral health interventions.

Additionally, the reimbursement system does not facilitate lifestyle counseling, nor does it align with encouraging prevention. It is not conducive to treating chronic pain optimally and prescribing opioids safely. The whole process of chronic pain treatment and safe-opioid practices takes time, and currently, providers lack adequate time. Given that explaining physical therapy, cognitive behavioral therapy, and other medicines can take significantly more time than writing an opioid prescription, it is very likely that the current reimbursement system and the time constraints it has fostered have contributed to the over-prescription of opioids.

Teva Pharmaceuticals offer a savings program for Ajoy (fremanezumab-vfrm). Eligible patients can use the Savings Offer for Ajoy, which may cost as little as USD 5 for each prescription. Patients can take the Savings Offer and pharmacist instructions to the pharmacy. Also, Aimovig Ally Access Card offers eligible commercially insured patients to pay as little as USD 5 per month per the prescription of Aimovig with a maximum benefit of USD 3500 annually, and to remain eligible in the program patient must re-enroll every 12 months. This applies to patient out-of-pocket costs, including deductible, co-insurance, and copayments for Aimovig. Also, if the patient’s health plan does not cover Aimovig or requires prior authorization, the patient can qualify for the Bridge to Commercial Coverage Offer and receive Aimovig free for up to 3 doses, while pursuing approval from their health plan. 

Note: Detailed HTA assessment will be provided in the final report.

KOL-Views

To keep up with current market trends, we take KOLs' and SMEs ’ opinions working in the Chronic Pain domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps to understand and validate current and emerging therapies treatment patterns or Chronic Pain market trends. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the market and the unmet needs.

Competitive Intelligence Analysis

We perform Competitive and Market Intelligence analysis of the Chronic Pain Market by using various Competitive Intelligence tools that includes – SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report

• The report covers the descriptive overview of Chronic Pain, explaining its causes, signs and symptoms, pathophysiology, and currently available therapies.
• Comprehensive insight has been provided into the Chronic Pain epidemiology and treatment in the 7MM.
• Additionally, an all-inclusive account of both the current and emerging therapies for Chronic Pain is provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.
• A detailed review of the Chronic Pain market; historical and forecasted is included in the report, covering drug outreach in the 7MM.
• The report provides an edge while developing business strategies, by understanding trends shaping and driving the global Chronic Pain market.

Report Highlights

• In the coming years, the Chronic Pain market is set to change due to the rising awareness of the disease and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
• The companies and academics are working to assess challenges and seek opportunities that could influence Chronic Pain R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.
• Major players are involved in developing therapies for Chronic Pain. The launch of emerging therapies will significantly impact the Chronic Pain market.
• A better understanding of disease pathogenesis will also contribute to the development of novel therapeutics for Chronic Pain.
• Our in-depth analysis of the pipeline assets across different stages of development (Phase III and Phase II), different emerging trends, and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.

Chronic Pain Report Insights

• Patient Population
• Therapeutic Approaches
• Chronic Pain Pipeline Analysis
• Chronic Pain Market Size and Trends
• Market Opportunities
• Impact of upcoming Therapies

Chronic Pain Report Key Strengths

• 10 Years Forecast
• 7MM Coverage
• Chronic Pain Epidemiology Segmentation
• Key Cross Competition
• Highly Analyzed Market
• Drugs Uptake

Chronic Pain Report Assessment

• SWOT Analysis
• Current Treatment Practices
• Unmet Needs
• Pipeline Product Profiles
• Conjoint Analysis
• Market Attractiveness
• Market Drivers and Barriers

Key Questions

Market Insights:

• What was the Chronic Pain Market share (%) distribution in 2018 and how it would look like in 2030?
• What would be the Chronic Pain total market size as well as market size by therapies across the 7MM during the study period (2018–2030)?
• What are the key findings of the market across the 7MM and which country will have the largest Chronic Pain market size during the study period (2018–2030)?
• At what CAGR, the Chronic Pain market is expected to grow in the 7MM during the study period (2018–2030)?
• What would be the Chronic Pain market outlook across the 7MM during the study period (2018–2030)?
• What would be the Chronic Pain market growth till 2030 and what will be the resultant market size in the year 2030?
• How would the market drivers, barriers, and future opportunities affect the market dynamics and subsequent analysis of the associated trends?
• Chronic Pain patient types/pool where unmet need is more and whether emerging therapies will be able to address the residual unmet need?
• How emerging therapies are performing on the parameters like efficacy, safety, route of administration (RoA), treatment duration, and frequencies based on their clinical trial results?
• Among the emerging therapies, what are the potential therapies which are expected to disrupt the Chronic Pain market?

Epidemiology Insights:

• What are the disease risks, burdens, and unmet needs of Chronic Pain?
• What is the historical Chronic Pain patient pool in the seven major markets covering the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan?
• What would be the forecasted patient pool of Chronic Pain in the 7 major markets covering the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan?
• What will be the growth opportunities in the 7MM concerning the patient population about Chronic Pain?
• Out of all the 7MM countries, which country would have the highest prevalent population of Chronic Pain during the study period (2018–2030)?
• At what CAGR the population is expected to grow in the 7MM during the study period (2018–2030)?
• What are the various recent and upcoming events which are expected to improve the diagnosis of Chronic Pain?

Current Treatment Scenario and Emerging Therapies:

• What are the current options for the treatment of Chronic Pain?
• What are the current treatment guidelines for the treatment of Chronic Pain in the US, Europe, and Japan?
• How many companies are developing therapies for the treatment of Chronic Pain?
• How many therapies are developed by each company for the treatment of Chronic Pain?
• How many emerging therapies are in the mid-stage and late stages of development for the treatment of Chronic Pain?
• What are the key collaborations (Industry–Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to Chronic Pain therapies?
• What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Chronic Pain and their status?
• What are the key designations that have been granted for the emerging therapies for Chronic Pain?
• What is the global historical and forecasted market of Chronic Pain?

Reasons to buy

• The report will help in developing business strategies by understanding trends shaping and driving the Chronic Pain market.
• To understand the future market competition in the Chronic Pain market and Insightful review of the key market drivers and barriers.
• Organize sales and marketing efforts by identifying the best opportunities for Chronic Pain in the US, Europe (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
• Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors.
• Organize sales and marketing efforts by identifying the best opportunities for the Chronic Pain market.
• To understand the future market competition in the Chronic Pain market.