DelveInsight’s, “Complement C1 Inhibitors - Pipeline Insight, 2022,” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Complement C1 Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Complement C1 Inhibitors: Overview
Complement C1 is the defining component of the classical pathway. Within the C1qC1r2C1s2 complex, C1q functions as a molecular scaffold for C1r2C1s2 and C1q binding to its ligands activates these two serine proteases. The classic C1q ligands are antigen-bound antibodies and activated C1s cleaves C4 and C2 to initiate the complement cascade.
Function - Activation of the C1 complex initiates the classical complement pathway. This occurs when C1q binds to antigen-antibody complexes. The antibodies IgM or certain subclasses of IgG complexed with antigens are able to initiate the complement system: a single pentameric IgM can initiate the pathway, while several monomeric IgG molecules are needed. C1q can also be activated in other ways, for example by binding to pentraxins such as C-reactive protein or directly to the surface of pathogens.
Complement C1 Inhibitors - C1 inhibitor is a protease inhibitor that targets C1r and C1s enzymes of the classical pathway of complement, Hageman factor (factor XII) of the coagulation pathway, and the kallikrein system.
The companies and academics are working to assess challenges and seek opportunities that could influence Complement C1 Inhibitors R&D. The therapies under development are focused on novel approaches for Complement C1 Inhibitors.
This segment of the Complement C1 Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Complement C1 Inhibitors Emerging Drugs
Sutimlimab : Bioverativ
Sutimlimab is a monoclonal antibody that binds to C1s, a protein that is part of the classical complement pathway. In this way, the treatment may block all of the downstream steps in the C1s-mediated complement pathway, and potentially reduce RBC lysis. The treatment may, therefore, be able to prevent hemolytic anemia in CAD patients.The advantage of sutimlimab is that it blocks only one of the three arms of the complement pathway, and does not affect the other two pathways — the lectin and alternative pathways. Therefore, sutimlimab ensures that the complement pathway is not totally ineffective. The drug is currently in preregistration stage of development.
ANX007 : Annexon
ANX007 is a clinical-stage investigational monoclonal antibody antigen-binding fragment (Fab) for the treatment of patients with complement-mediated neurodegenerative ophthalmic diseases. Formulated for IVT administration, ANX007 is designed to potently bind to C1q and inhibit activation of all downstream components of the classical complement cascade, including C3 and C5, but to not interfere with the normal function of C3 and C5 as part of other complement pathways. The drug is currently in phase II of development.
Further product details are provided in the report……..
This segment of the report provides insights about the different Complement C1 Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 5+ key companies which are developing the Complement C1 Inhibitors. The companies which have their Complement C1 Inhibitors drug candidates in the most advanced stage, i.e. preregistration include, Bioverativ.
DelveInsight’s report covers around 5+ products under different phases of clinical development like
Complement C1 Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Complement C1 Inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Complement C1 Inhibitors drugs.
Current Scenario and Emerging Therapies:
Introduction
Executive Summary
Complement C1 Inhibitors: Overview
Pipeline Therapeutics
Therapeutic Assessment
Complement C1 Inhibitors – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Complement C1 Inhibitors Collaboration Deals
Late Stage Products (Pre-registration)
Sutimlimab: Bioverativ
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
ANX007: Annexon
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
Drug name: Company name
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
Drug name: Company name
Drug profiles in the detailed report…..
Inactive Products
Complement C1 Inhibitors Key Companies
Complement C1 Inhibitors Key Products
Complement C1 Inhibitors- Unmet Needs
Complement C1 Inhibitors- Market Drivers and Barriers
Complement C1 Inhibitors- Future Perspectives and Conclusion
Complement C1 Inhibitors Analyst Views
Complement C1 Inhibitors Key Companies
Appendix
List of Table
Table 1: Total Products for Complement C1 Inhibitors
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Complement C1 Inhibitors
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• Bioverativ
• Annexon
• Pharming Group NV
• CSL Behring
• Takeda
• Octapharma
• BioGenius
• True North Therapeutics
