DelveInsight’s, “Complement C5 Inhibitors - Pipeline Insight, 2022,” report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in Complement C5 Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Complement C5 Inhibitors: Overview
Complement component C5 is the initiator of the effector terminal phase of the complement system and shares the molecular structure consisting of two chains-α and β, linked by disulfide bonds, with C3 and C4, with the only difference being that complement component C5 does not contain an internal thio-ester bond. The terminal phase is similar for the classical, lectin, and alternative pathways. Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes.
Function - Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Complement C5 Inhibitors - The complement inhibitor that has achieved the widest attention as a therapeutic agent is a monoclonal antibody to C5. The advantage to this strategy is that it prevents the generation of C5a, the most potent of the anaphylatoxins, and of the MAC. The generation of C3b and C4b opsonins still would occur, allowing proper clearance of pathogens and immune complexes even if C5 conversion were inhibited chronically. Because there is evidence that activation of early complement components is important for the maintenance of tolerance to self-antigens, inhibition of C5 activation may be less worrisome than inhibition of C3 activation.
The companies and academics are working to assess challenges and seek opportunities that could influence Complement C5 Inhibitors R&D. The therapies under development are focused on novel approaches for Complement C5 Inhibitors.
This segment of the Complement C5 Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Complement C5 Inhibitors Emerging Drugs
Ravulizumab: Alexion Pharmaceuticals
Ravulizumab is the first and only long-acting C5 complement inhibitor. The medication works by inhibiting the C5 protein in the terminal complement cascade, a part of the body’s immune system. When activated in an uncontrolled manner, the complement cascade over-responds, leading the body to attack its own healthy cells. It is approved in the United States (U.S.), European Union (EU) and Japan as a treatment for adults with paroxysmal nocturnal hemoglobinuria (PNH). It is also approved in the U.S. and Japan for atypical hemolytic uremic syndrome (aHUS) to inhibit complement-mediated thrombotic microangiopathy (TMA) in adult and pediatric (one month of age and older) patients, as well as in the EU for the treatment of adults and children with a body weight of at least 10 kg with aHUS. Currently, in phase 3 stage of development for the treatment of Acute lung injury; Amyotrophic lateral sclerosis; and various other disorders.
Pozelimab: Regeneron Pharmaceuticals
Pozelimab is an investigational, fully-human monoclonal antibody designed to block complement factor C5 and prevent the destruction of red blood cells (hemolysis) that cause the symptoms of PNH and other diseases mediated by complement pathway activity. It is an IgG4 antibody that binds with high affinity to wild-type and variant human C5 and blocks its activity. Currently, in phase 3 stage of development for the treatment of Paroxysmal nocturnal haemoglobinuria.
Further product details are provided in the report……..
This segment of the report provides insights about the different Complement C5 Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 12+ key companies which are developing the Complement C5 Inhibitors. The companies which have their Complement C5 Inhibitors drug candidates in the most advanced stage, i.e. phase III include, Regeneron Pharmaceuticals.
DelveInsight’s report covers around 12+ products under different phases of clinical development like
Complement C5 Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Complement C5 Inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Complement C5 Inhibitors drugs.
Current Scenario and Emerging Therapies:
Introduction
Executive Summary
Complement C5 Inhibitors: Overview
Pipeline Therapeutics
Therapeutic Assessment
Complement C5 Inhibitors – DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Complement C5 Inhibitors Collaboration Deals
Late Stage Products (Phase III)
Pozelimab: Regeneron Pharmaceuticals
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Cemdisiran: Alnylam Pharmaceuticals
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
ISU 305: ISU Abxis
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
RA 101295: Ra Pharmaceuticals
Drug profiles in the detailed report…..
Inactive Products
Complement C5 Inhibitors Key Companies
Complement C5 Inhibitors Key Products
Complement C5 Inhibitors- Unmet Needs
Complement C5 Inhibitors- Market Drivers and Barriers
Complement C5 Inhibitors- Future Perspectives and Conclusion
Complement C5 Inhibitors Analyst Views
Complement C5 Inhibitors Key Companies
Appendix
List of Table
Table 1: Total Products for Complement C5 Inhibitors
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Complement C5 Inhibitors
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• Alexion Pharmaceuticals
• Regeneron Pharmaceuticals
• Chugai Pharmaceutical
• Swedish Orphan Biovitrum
• Ra Pharmaceuticals
• Amgen
• Biocad
• MorphoSys
• UCB
• ISU Abxis
• Samsung Bioepis
• Alexion Pharmaceuticals
• Alnylam Pharmaceuticals
• IVERIC bio
