Epidermolysis Bullosa Market
DelveInsight's 'Epidermolysis Bullosa (EB)—Market Insights, Epidemiology, and Market Forecast—2028' report deliver an in-depth understanding of the disease, historical and forecasted epidemiology as well as the market trends of EB in the United States, EU5 (Germany, France, Italy, Spain and the United Kingdom), and Japan.
EB is generally caused by mutations involving at least 18 genes encoding structural proteins within keratin intermediate filaments, focal adhesions, desmosome cell junctions, and hemidesmosome attachment complexes, which form the intraepidermal adhesion and dermo-epidermal anchoring complex within the basement membrane zone (BMZ) of the skin and mucosae. Epidermolysis bullosa usually is diagnosed in babies and children, but milder types can develop later in adulthood.
EB may be inherited in either a dominant or recessive form. In dominant EB, one parent usually carries the gene and is affected by the condition themselves, while the birth of a child suffering from the recessive form is usually totally unexpected since both parents can carry the EB gene without displaying the condition themselves. In dominant EB, there is a 50% chance of passing the disorder to children: in recessive EB the chance is 25%.
Geography Covered
• The United States
• EU5 (Germany, France, Italy, Spain, and the United Kingdom)
• Japan
Study Period: 2017-2028
Epidermolysis Bullosa (EB)—Disease Understanding and Treatment Algorithm
Epidermolysis Bullosa (EB) is a group of skin diseases that cause various degrees of skin and mucous membrane fragility. The skin becomes fragile when proteins essential for skin integrity are absent, reduced, or abnormal. It is characterized by blister formation in response to mechanical trauma. To date, there is no treatment or cure for EB.
There are four major types of EB, depending on the location of the target proteins and level of the blisters: EB simplex (epidermolytic), junctional EB (lucidolytic), dystrophic EB (dermolytic), and Kindler syndrome (mixed levels of blistering). Apart from this when EB also occurs due to any defect in the immune system it is called epidermolysis bullosa acquisita (EBA).
Epidermolysis Bullosa (EB) Epidemiology
The disease epidemiology covered in the report provides historical as well as forecasted epidemiology (Total Prevalent Cases of Epidermolysis Bullosa (EB) in 7MM, Total Diagnosed Prevalent Cases of Epidermolysis Bullosa (EB) in 7MM, and Type-specific Diagnosed Prevalent Cases of Epidermolysis Bullosa (EB) in 7MM) scenario of Epidermolysis Bullosa (EB) in the 7MM covering United States, EU5 countries (Germany, Spain, Italy, France and United Kingdom) and Japan from 2017-2028.
According to DelveInsight, the total diagnosed cases of Epidermolysis Bullosa (EB) were found out to be 39,433 in 2017, in the 7MM. The number of Epidermolysis Bullosa (EB) cases in the 7MM is expected to increase during the study period of 2017-2028.?
Epidermolysis Bullosa (EB) Drug Chapters
There is currently no cure for EB and treatments focus on preventing blisters or managing the wounds caused by the condition. There are different types of EB that are associated with blisters forming in different locations on the body and that vary in severity. Different treatments are used depending on the type of epidermolysis bullosa.
There are no EB-specific medications. Depending on the severity of the condition, doctors may recommend over-the-counter pain medication or may prescribe stronger painkillers, such as morphine, if needed. If the patient is experiencing chronic pain, then medicines such as amitriptyline, gabapentin or pregabalin may be prescribed. If a wound becomes infected, it may be treated with antibiotics. These can be applied as a topical lotion, a soaking solution, or taken as an oral tablet. Anti-inflammatory drugs such as corticosteroids may be prescribed to reduce pain from swallowing, making it easier to eat. With systemic corticosteroids, steroid-sparing agents, including colchicine, diaminodiphenyl sulfone (DDS, dapsone), methotrexate (MTX), azathioprine (AZA), cyclosporine (CSA), mycophenolate mofetil (MMF), and cyclophosphamide (CPA), have been reported in the treatment of EBA. Other therapeutic options, including high-dose intravenous Immunoglobulin (IVIG), rituximab (RTX), plasmapheresis and immune adsorption (IA), and extracorporeal photochemotherapy (ECP) also have been reported.
Epidermolysis Bullosa (EB) Market Outlook
The market size of Epidermolysis Bullosa (EB) in seven major markets (7MM) is estimated to be USD 2,296.31 million in 2017. The United States accounts for the highest market size of Epidermolysis Bullosa, in comparison to the other major markets i.e., EU5 countries (Germany, France, Italy, Spain and the United Kingdom), and Japan. Among the EU5 countries, the UK had the highest market size with USD 195.25 million in 2017, while Spain had the lowest market size of Epidermolysis Bullosa with USD 35.99 million in 2017.
Epidermolysis Bullosa (EB) Drugs Uptake
With the launch of emerging therapies that includes FCX-007 (Fibrocell Technologies), CCP-020 (Castle Creek Pharmaceuticals), RGN-137 (RegeneRx); AP-101 (Amryt Pharma), EB-101 (Abeona Therapeutics), KB103 (Krystal Biotech), and Ex-vivo expanded autologous with a COL7A1-encoding retroviral vector and LAMB3 encoding gene therapy (Holostem Terapie Avanzate), the market of EB is anticipated to change during the forecasted period (2019-2028).
Epidermolysis Bullosa (EB) Report Insights
• Patient Population by total diagnosed cases
• Type-specific diagnosed population
• Therapeutic Approaches
• Pipeline Analysis
• Market Size and Trends
• Market Opportunities
• Impact of upcoming Therapies
Epidermolysis Bullosa (EB) Report Key Strengths
• 10-Year Forecast
• 7MM Coverage
• Epidemiology Segmentation
• Drugs Uptake
• Highly Analyzed Market
• Key Cross Competition
Epidermolysis Bullosa (EB) Report Assessment
• Current Treatment Practices
• Unmet Needs
• Detailed Pipeline Product Profiles
• Market Attractiveness
• Market Drivers and Barriers
Key Benefits
• This DelveInsight report will help to develop Business Strategies by understanding the trends shaping and driving EB market
• Organize sales and marketing efforts by identifying the best opportunities for EB market
• To understand the future market competition in the EB market.
