Esophageal Cancer Market Report
Esophageal Cancer Market Report
Esophageal Cancer - Market Insight, Epidemiology And Market Forecast - 2032
  • Published Date : Sep 2023

  • Pages : 245

  • Delivery Time : 24 Hours

  • Region : United States, EU5, Japan

Esophageal Cancer Market

  • The Esophageal Cancer Market size in the 7MM was USD 1,050 million in 2022. As per DelveInsight, the Esophageal Cancer Market is expected to expand at a healthy growth rate during the forecast period (2023-2032), owing to the launch of new therapies in the market and the rise in the number of cases.
  • In 2022, the Esophageal Cancer market size was highest in the US, accounting for approximately USD 400 million, which is further expected to increase by 2032.
  • Several major pharma and biotech companies such as Merck & Co., Inc., AstraZeneca PLC, Bristol-Myers Squibb Company, Eli Lilly and Company, Roche Holding AG, Pfizer Inc., Takeda Pharmaceutical Company Limited, Novartis International AG, Amgen Inc., Bayer AG, Eisai Co., Ltd., Daiichi Sankyo Company, Limited, Sanofi S.A., Johnson & Johnson, AbbVie Inc., Celgene Corporation, Boehringer Ingelheim International GmbH, Gilead Sciences, Inc., Ipsen Biopharmaceuticals, Inc., Astellas Pharma Inc., among others, are actively working in the Esophageal Cancer Market.
  • Esophageal Cancer occurs in the esophagus – a long hollow muscular tube that transports food from the neck to the stomach. Esophageal cancer, also known as esophagus cancer, develops in the cells that line the esophagus and occurs when a malignant tumor arises in the esophagus lining.
  • Esophageal malignancies are often discovered as a result of a person’s indications or symptoms. Examinations, testing, and a biopsy (a sample of esophageal cells) will be required to confirm the diagnosis if esophageal cancer is suspected. If cancer is discovered, more tests will be performed to establish the stage of the malignancy. The gold standard for identifying esophageal cancer is Gastroscopy.
  • Histologically, there are two forms of primary Esophageal Cancer: squamous cell carcinoma and adenocarcinoma; small cell carcinoma is an uncommon type of Esophageal Cancer. These several types of cancer arise in various types of cells in the esophagus. They evolve in distinct ways, necessitating therapeutic techniques tailored to each individual.
  • The staging system most often used for Esophageal Cancer is the American Joint Committee on Cancer (AJCC) TNM system, which is based on three key pieces of information, that is the extent of the tumor (T), spread to nearby lymph nodes (N) and spread (metastasis) to distant sites (M).
  • The exact cause of Esophageal Cancer is unknown; however, it is thought to be related to abnormalities (mutations) in the DNA of esophageal cells. The DNA of Esophageal Cancer cells frequently shows changes in many different genes; however, it is unclear if specific gene changes can be found in all Esophageal Cancers.
  • In March 2021, the FDA approved KEYTRUDA (pembrolizumab) for use in combination with platinum and fluoropyrimidine-based chemotherapy for patients with metastatic or locally advanced esophageal or gastroesophageal carcinoma who are ineligible for surgical resection or definitive chemoradiation.
  • Esophageal Cancer, a relatively uncommon cancer, has very limited information and guidance available, with few opportunities for people to share experiences. This ends up leading to a lack of awareness about the disease. Its symptoms are also often mild until the cancer advances, and symptoms can be easily confused with other illnesses and digestive problems.
  • The emerging pipeline for Esophageal Cancer patients consists of drugs in different lines of therapies, adjuvant, and neoadjuvant settings. It is estimated that potential drugs that can significantly change the market during the forecast period include zanidatamab, sintilimab, tislelizumab, and sotigalimab. These drugs are in the late stages of clinical development, and other players are evaluating their potential candidates in different stages of clinical development.

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Esophageal Cancer Market

DelveInsight’s “Esophageal Cancer Market Insights, Epidemiology and Market Forecast – 2032” report delivers an in-depth understanding of historical and forecasted epidemiology as well as market trends of Esophageal Cancer in the United States, EU4 (Germany, France, Italy, Spain) and the United Kingdom, and Japan.

The Esophageal Cancer market report provides current treatment practices, emerging drugs, market share of individual therapies, and current and forecasted 7MM Esophageal Cancer market size from 2019 to 2032. The report also covers current Esophageal Cancer treatment practices/algorithms and unmet medical needs to curate the best opportunities and assess the market’s potential.

Report Metrics

Details

Study Period

2019 to 2032

Forecast Period

2023 to 2032

Geographies Covered

The US, EU4 (Germany, France, Italy, and Spain), the UK, and Japan

Esophageal Cancer Market Assessment

  • Total Market Size
  • Market Size by Therapies
  • Market Size by Class

Market CAGR

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Esophageal Cancer Market Size

USD 1,050 million in 2022

Esophageal Cancer Companies

Merck & Co., Inc., AstraZeneca PLC, Bristol-Myers Squibb Company, Eli Lilly and Company, Roche Holding AG, Pfizer Inc., Takeda Pharmaceutical Company Limited, Novartis International AG, Amgen Inc., Bayer AG, Eisai Co., Ltd., Daiichi Sankyo Company, Limited, Sanofi S.A., Johnson & Johnson, AbbVie Inc., Celgene Corporation, Boehringer Ingelheim International GmbH, Gilead Sciences, Inc., Ipsen Biopharmaceuticals, Inc., Astellas Pharma Inc., and Many Others.

Esophageal Cancer Treatment Algorithm and Disease Understanding

Esophageal Cancer Overview

Esophageal cancer develops when cancer cells form in the esophagus, a tube-like tissue that connects the throat and stomach. The esophagus transports food from the mouth to the stomach. The cancer begins in the esophagus’s inner layer and can spread to other layers of the esophagus and other organs of the body (metastasis).

Typically, symptoms of Esophageal Cancer do not appear until the tumor has grown large enough to impede eating, swallowing, or digesting food. The most common symptom of Esophageal Cancer is difficulty swallowing, particularly a sensation that food is lodged in the throat; in some individuals, choking on food occurs. These symptoms develop with time, with greater discomfort while swallowing as the esophagus narrows due to cancer growth.

Esophageal Cancer Diagnosis

Esophageal malignancies are often discovered by indications or symptoms. Exams, testing, and a biopsy (a sample of esophageal cells) will be required to confirm the diagnosis; if cancer is identified, more tests will help establish the extent (stage). When diagnosed late, Esophageal Cancer has a terrible prognosis; however, if diagnosed early, curative therapy is feasible. Before symptoms cause individuals to seek medical assistance, the condition slowly advances. Effective presymptomatic screening procedures may enhance disease outcomes. Recent research has shed light on the early detection of Esophageal Cancer using blood testing, sophisticated endoscopic imaging, and artificial intelligence.

Further details related to country-based variations are provided in the report…

Esophageal Cancer Treatment

Everyone who has esophageal cancer receives some form of therapy. Several factors, including personal preferences, cancer stage, and overall health, determine the appropriate course of therapy for each patient. Many medical professionals regularly collaborate in cancer care to construct a patient’s comprehensive treatment plan, including various treatments.

Esophagectomy is the principal treatment for early-stage esophageal cancer, albeit its precise significance in superficial (T1A) cancers is still unclear, given the introduction of endoscopic mucosal therapy. A multimodal strategy for treating locally advanced cancers, comprising neoadjuvant chemotherapy or combination chemoradiotherapy (CRT) followed by surgery, is strongly recommended.

The cornerstone of contemporary esophageal cancer management is preoperative assessment. Preoperative staging accuracy is critical since the tumor board’s decisions on the use of multimodal therapy will be dependent on the precision and specifics of the clinical staging evaluation. Upper endoscopy, high-resolution contrast CT scan, FDG-PET scan, and EUS are all part of the standardized evaluation of a patient undergoing curative treatment for early-stage or advanced esophageal cancer.

Doctors typically recommend combining radiation treatment, chemotherapy, and surgery for a tumor that has not spread beyond the esophagus and lymph nodes. Locally advanced esophageal cancer is usually treated with radiation treatment, chemotherapy, and surgery. Radiation treatment and chemotherapy are often combined in “chemoradiotherapy.” Radiation treatment, chemotherapy, and other drug-based therapies are commonly used to treat metastatic esophageal cancer.

Esophageal Cancer Epidemiology

As the Esophageal Cancer market is derived using a patient-based model, the Esophageal Cancer epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by Total Diagnosed Incident Cases of Esophageal Cancer, Age-specific Cases of Esophageal Cancer, Histology-specific Cases of Esophageal Cancer, Gender-specific Cases of Esophageal Cancer, Mutation-specific Cases of Esophageal Cancer, Stage-specific Cases of Esophageal Cancer and Line wise treated Cases of Esophageal Cancer in the 7MM covering the United States, EU4 countries (Germany, France, Italy, Spain) and the United Kingdom, and Japan from 2019 to 2032.

Esophageal Cancer Epidemiology

Key Findings

  • The total diagnosed Esophageal Cancer incident cases in the US comprised ~20,000 cases in 2022 and are projected to reach ~24,000 cases by 2032 at a CAGR of 1.9%, accounting for the second-highest diagnosed incident cases in the 7MM.
  • In 2022, as per the age-specific cases, the 65 and above segment accounted for the highest number of cases of Esophageal Cancer. In contrast, the <45 age group accounted for the least number of cases in the United States.
  • In the United States, ~16,000 cases of Esophageal Cancer were found in case of males, whereas females accounted for ~4,200 cases of Esophageal Cancer in 2022.
  • As per the Histology-specific Esophageal Cancer incident cases, non-squamous Esophageal Cancer cases accounted for ~7,400 cases of Esophageal Cancer, whereas ~3,100 cases of squamous Esophageal Cancer were found in 2022 in the United Kingdom.

Esophageal Cancer Drug Chapters

The drug chapter segment of the Esophageal Cancer report encloses a detailed analysis of Esophageal Cancer marketed drugs and late-stage (Phase III and Phase II) pipeline drugs. It also helps understand the Esophageal Cancer clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug, and the latest news and press releases.

Marketed Esophageal Cancer Drugs

CYRAMZA (ramucirumab): Eli Lilly and Company

CYRAMZA, as a single agent or in combination with paclitaxel, is indicated for the treatment of patients with advanced or metastatic, gastric or gastroesophageal junction (GEJ) adenocarcinoma with disease progression on or after prior fluoropyrimidine- or platinum-containing chemotherapy. The recommended dosage of CYRAMZA as a single agent or combined with weekly paclitaxel is 8 mg/kg every 2 weeks, administered by IV infusion over 60 min. Ramucirumab is a VEGFR2 antagonist that binds VEGFR2 explicitly and blocks the binding of VEGFR ligands, VEGF-A, VEGF-C, and VEGF-D. As a result, ramucirumab inhibits ligand-stimulated activation of VEGFR2, thereby inhibiting ligand-induced proliferation and migration of human endothelial cells.

VITRAKVI (larotrectinib): Bayer

VITRAKVI (larotrectinib) is an oral TRK inhibitor for the treatment of adult and pediatric patients with solid tumors with an NTRK gene fusion without a known acquired resistance mutation that is either metastatic or where surgical resection will likely result in severe morbidity and have no satisfactory alternative treatments or have progressed following treatment. It is indicated for the treatment of adult and pediatric patients with solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation, are metastatic or where surgical resection is likely to result in severe morbidity, and have no satisfactory alternative treatments or that have progressed following treatment.

Note: Detailed current therapies assessment will be provided in the full report of Esophageal Cancer…

Emerging Esophageal Cancer Drugs

Zanidatamab: Zymeworks

Zanidatamab is given with chemotherapy plus or minus Tislelizumab as a combination therapy in HER2-Expressing Gastrointestinal (GI) Cancers, including Gastroesophageal Adenocarcinoma (GEA). Zanidatamab is given along with oxaliplatin (CAPOX) or 5-fluorouracil (5-FU) and cisplatin (FP) with or without tislelizumab. This emerging asset has a novel mechanism of action. It uses biparatropic binding as it targets two HER2 epitopes. The drug has also received fast-track designation in combination with SoC chemotherapy for first-line Gastroesophageal Adenocarcinoma. As far as safety is concerned, no severe treatment-related adverse events (TRAE) were observed. The most common Grade =3 TRAE was diarrhea which was manageable in the outpatient setting.

Sintilimab: Innovent Biologics

Sintilimab is an investigational PD-1 inhibitor developed by Innovent and Eli Lilly. The drug is currently in the Phase III stage of clinical development in combination with chemotherapy as first-line treatment in subjects with unresectable, locally advanced recurrent or metastatic esophageal squamous cell carcinoma. It is a first-line treatment option with cisplatin + paclitaxel or cisplatin + fluorouracil regimen for patients with unresectable, locally advanced recurrent or metastatic esophageal squamous cell carcinoma, as per the clinical assessment of sintilimab, a 12-month overall survival of 64% was found as compared to the 88% overall survival rate of zanidatamab. The Objective Response Rate (ORR) was also slightly lesser than zanidatamab. The safety profile of Sinitilimab was not as good as zanidatamab. A decrease in neutrophil count, WBCs, and hypokalemia was observed.

Note: Detailed emerging therapies assessment will be provided in the final report…

Esophageal Cancer Drug Class Insights

The therapies used for esophageal cancer include chemotherapy, targeted therapy, and immunotherapy. Chemotherapy uses medications to eradicate cancer cells, often by preventing cancer cells from growing, dividing, and proliferating. Targeted therapy for esophageal cancer includes HER2-targeted therapy and anti-angiogenesis therapy.

A chemotherapy regimen, or schedule, typically consists of a predetermined number of cycles administered over a predetermined period. A patient may be administered one medicine at a time or a mixture of drugs simultaneously. As previously stated, chemotherapy and radiation therapy are frequently used concurrently to treat esophageal cancer, a procedure known as chemoradiotherapy. Immunotherapy uses the body’s natural defenses to fight cancer by improving your immune system’s ability to attack cancer cells.

Two types of immunotherapy drugs are approved to treat adenocarcinoma and squamous cell carcinoma of the esophagus and the gastroesophageal junction. This cancer grows where the stomach and esophagus meet. Pembrolizumab (KEYTRUDA) and nivolumab (OPDIVO) are both checkpoint inhibitors that target the PD-1/PD-L1 pathway.

Esophageal Cancer Market Outlook

As few potential therapies are being investigated to manage Esophageal Cancer, predicting that the treatment space will experience significant reconstitution during 2023–2032 is safe.

Esophageal Cancer Market Outlook

The Esophageal Cancer companies are actively working in the domain and hold the potential to significantly change the market dynamics during the forecast period. Some of the emerging Esophageal Cancer therapies in the market include zanidatamab, sintilimab, tislelizumab, and sotigalimab. All the aforementioned drugs are given in combination with chemotherapies. These drugs are in the late stages of clinical development, and other players are evaluating their potential candidates in different stages of clinical development.

  • Among the 7MM countries, the United States comprised the largest Esophageal Cancer market size, accounting for ~40% of the total Esophageal Cancer market size.
  • Among the EU4 and the UK, Italy captured the smallest Esophageal Cancer market size, accounting for ~8% of the total Esophageal Cancer market size of EU4 and the UK.
  • Regarding neoadjuvant therapies, platinum + taxane is expected to garner market revenue of USD 0.8 million by 2022.
  • The Esophageal Cancer market size in Japan is expected to increase at a CAGR of 0.6% during the forecast period (2023–2032).

Esophageal Cancer Drugs Uptake

This section focuses on the uptake rate of potential drugs expected to be launched in the market during 2019–2032. For example, for Zanidatamab + CAPOX + Fluoropyrimidine ± Tislelizumab, which is expected to be launched in the US by 2025, the drug uptake is expected to be medium, with a probability-adjusted peak patient share of ~5% in the US, expected to peak at 6 years from the year of launch.

Further detailed analysis of emerging therapies drug uptake in the report…

Esophageal Cancer Pipeline Development Activities

The Esophageal Cancer report provides insights into Esophageal Cancer Clinical Trials within Phase III, Phase II, and Phase I stage. It also analyzes the Esophageal Cancer companies involved in developing targeted therapeutics.

Pipeline Development Activities in the Esophageal Cancer Market

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Esophageal Cancer emerging therapies.

KOL Views

To keep up with current market trends, we take KOLs and SME’s opinions working in the domain through primary research to fill the data gaps and validate our secondary research. Industry experts contacted for insights on Esophageal Cancer evolving treatment landscape, patient reliance on conventional therapies, patient’s therapy switching acceptability, and drug uptake, along with challenges related to accessibility, including Medical/scientific writers and Professors from renowned universities in the US, Europe, the UK, and Japan.

Delveinsight’s analysts connected with 50+ KOLs to gather insights; however, interviews were conducted with 15+ KOLs in the 7MM. National Cancer Center Hospital, University of Kentucky, etc., were contacted. Their opinion helped understand and validate current and emerging therapy treatment patterns of Esophageal Cancer market trends. This will support the clients in potential upcoming novel treatments by identifying the overall scenario of the market and the unmet needs.

Qualitative Analysis

We perform Qualitative and Market Intelligence analysis using SWOT analysis. In the SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of disease diagnosis, patient awareness, patient burden, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided. These pointers are based on the Analyst’s discretion and assessment of the patient burden, cost analysis, and existing and evolving treatment landscape.

Esophageal Cancer Market Access and Reimbursement

The cost of newly approved medications is usually high, so patients escape from proper treatment or opt for off-label and cheap medications. It affects market access to newly launched medications, and reimbursement is crucial. The decision to reimburse often comes down to the ’drug’s price relative to the benefit it produces in treated patients. Market access and reimbursement options can differ depending on regulatory status, target population size, the setting of care, unmet needs, the magnitude of incremental benefit claims, and costs.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Scope of the Esophageal Cancer Market Report

  • The report covers a segment of key events, an executive summary, and a descriptive overview of Esophageal Cancer, explaining the definition of Esophageal Cancer, types and risk factors involved in Esophageal Cancer, pathophysiology, and the treatment of Esophageal Cancer.
  • Comprehensive insights into the epidemiology segments and forecasts, the future growth potential of diagnosis rate, disease progression, and treatment guidelines have been provided.
  • Additionally, an all-inclusive account of the current and emerging therapies and the elaborative profiles of late-stage and prominent therapies will impact the current treatment landscape.
  • A detailed review of the Esophageal Cancer market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies, by understanding trends, through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help shape and drive the 7MM Esophageal Cancer market.

Esophageal Cancer Market Report Insights

  • Esophageal Cancer Patient Population
  • Esophageal Cancer Therapeutic Approaches
  • Esophageal Cancer Pipeline Analysis
  • Esophageal Cancer Market Size and Trends
  • Existing and future Market Opportunity

Esophageal Cancer Report Key Strengths

  • 10 years Forecast
  • The 7MM Coverage
  • Esophageal Cancer Epidemiology Segmentation
  • Key Cross Competition
  • Attribute analysis
  • Esophageal Cancer Drugs Uptake
  • Key Esophageal Cancer Market Forecast Assumptions

Esophageal Cancer Market Report Assessment

  • Current Esophageal Cancer Treatment Practices
  • Esophageal Cancer Unmet Needs
  • Esophageal Cancer Pipeline Product Profiles
  • Esophageal Cancer Market Attractiveness
  • Qualitative Analysis (SWOT)
  • Esophageal Cancer Market Drivers
  • Esophageal Cancer Market Barriers

Key Questions Answered In The Esophageal Cancer Market Report

Esophageal Cancer Market Insights

  • What was the total Esophageal Cancer market size, the market size by therapies, market share (%) distribution in 2019, and what would it look like by 2032? What are the contributing factors for this growth?
  • What kind of uptake the new therapies approved will witness in Esophageal Cancer patients in the coming years?
  • Which therapy is going to be the largest contributor by 2032?
  • What are the pricing variations among different geographies for approved Esophageal Cancer therapies?
  • How would the market drivers, barriers, and future opportunities affect the Esophageal Cancer market dynamics and subsequent analysis of the associated trends?

Esophageal Cancer Epidemiology Insights

  • What are the disease risk, burdens, and unmet needs of Esophageal Cancer? What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Esophageal Cancer?
  • What is the historical and forecasted Esophageal Cancer patient pool in the United States, EU4 (Germany, France, Italy, Spain) and the United Kingdom, and Japan?
  • What is the diagnostic pattern of Esophageal Cancer?
  • Which clinical factors will affect Esophageal Cancer market dynamics?
  • Which factors will affect the increase in the Esophageal Cancer diagnosis?

Current Esophageal Cancer Treatment Scenario, Marketed Drugs, and Emerging Therapies

  • What are the current options for the treatment of Esophageal Cancer? What are the current guidelines for treating Esophageal Cancer in the US, Europe, the UK, and Japan?
  • How many companies are developing therapies for the treatment of Esophageal Cancer?
  • How many emerging therapies are in the mid-stage and late stage of development for treating Esophageal Cancer?
  • What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the limitation of existing therapies?
  • What key designations have been granted for the emerging Esophageal Cancer therapies?
  • What is the cost burden of approved therapies on the patient?
  • Patient acceptability in terms of preferred treatment options as per real-world scenarios?
  • What are the country-specific accessibility issues of expensive, recently approved Esophageal Cancer therapies?
  • What is the 7MM historical and forecasted Esophageal Cancer market?

Reasons to buy Esophageal Cancer Market Report

  • The report will help develop business strategies by understanding the latest trends and changing treatment dynamics driving the Esophageal Cancer market.
  • Insights on patient burden/disease incidence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years.
  • Understand the existing market opportunity in varying geographies and the growth potential over the coming years.
  • Distribution of historical and current patient share based on real-world prescription data along with reported sales of approved products in the US, EU4 (Germany, France, Italy, Spain) and the United Kingdom, and Japan.
  • Identifying strong upcoming Esophageal Cancer companies in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis of emerging therapies to provide visibility around leading classes.
  • Highlights of Access and Reimbursement policies of approved therapies, barriers to accessibility of expensive therapies, and patient assistance programs.
  • To understand Key Opinion Leaders’ perspectives around the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights on the unmet need of the existing market so that the upcoming Esophageal Cancer companies can strengthen their development and launch strategy.

1. Key Insights

2. Report Introduction

3. Esophageal Cancer (EC) Market Overview at a Glance

3.1. Market Share (%) Distribution of Esophageal Cancer (EC) in 2019

3.2. Market Share (%) Distribution of Esophageal Cancer (EC) in 2032

4. Executive Summary of Esophageal Cancer (EC)

5. Key Events

6. Disease Background and Overview

6.1. Introduction

6.2. Histological Classification of Esophageal Cancer

6.3. Stage-wise Classification of Esophageal Cancer

6.4. Causes of Esophageal Cancer

6.5. Risk Factors of Esophageal Cancer

6.6. Signs and Symptoms of Esophageal Cancer

6.7. Major Mutations in Esophageal Cancer

6.7.1. Molecular abnormalities of EAC

6.7.2. Molecular abnormalities of ESCC

7. Esophageal Cancer Diagnosis

7.1. Imaging tests for Esophageal Cancer

7.2. Diagnostic Algorithm

7.3. Endoscopy for Cancer of the Esophagus

7.4. Biopsy and Lab Tests for Cancer of the Esophagus

7.5. Blood tests

7.6. Differential Diagnosis

7.7. Diagnostic Guidelines

7.7.1. ESMO Clinical Practice Guideline for Diagnosis (2022)

7.7.2. National Guidelines for the Diagnosis of Esophageal Carcinoma 2022 in China

7.7.3. NCCN Guidelines for Esophageal Cancer (2022)

8. Esophageal Cancer Treatment and Management of EC

8.1. Types of Treatment for Esophageal Cancer

8.1.1. Surgery

8.1.2. Endoscopic Treatments for Esophageal Cancer

8.1.3. Radiation Therapy

8.1.4. Therapies Using Medication

8.2. Treatment Algorithm

8.3. Treatment Guidelines

8.3.1. ESMO Clinical Practice Guideline for Treatment and Follow-up

8.3.2. SEOM-GEMCAD-TTD Clinical Guideline for the Diagnosis and Treatment of Esophageal Cancer (2021)

8.3.3. The Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland, the British Society of Gastroenterology, and the British Association of Surgical Oncology

8.3.4. German S3 Guidelines on Esophageal Cancer

8.3.5. Esophageal Cancer Practice Guidelines 2022 by the Japan Esophageal Society

9. Methodology

10. Esophageal Cancer Epidemiology and Patient Population

10.1. Key Findings

10.2. Assumptions and Rationale: 7MM

10.3. Total Diagnosed Incident Cases of EC in the 7MM

10.4. Epidemiology Scenario in the United States

10.4.1. Total Diagnosed Incident Cases of EC in the US

10.4.2. Age-specific Cases of EC in the US

10.4.3. Histology-specific Cases of EC in the US

10.4.4. Gender-specific Cases of EC in the US

10.4.5. Mutation-specific Cases of EC in the US

10.4.6. Stage-specific Cases of EC in the US

10.4.7. Linewise Treated Cases of EC in the US

10.5. Epidemiology Scenario in EU4 and the UK

10.5.1. Total Diagnosed Incident Cases of EC in EU4 and the UK

10.5.2. Age-specific Cases of EC in EU4 and the UK

10.5.3. Histology-specific Cases of EC in EU4 and the UK

10.5.4. Gender-specific Cases of EC in EU4 and the UK

10.5.5. Mutation-specific Cases of EC in EU4 and the UK

10.5.6. Total Stage-specific Cases of EC in EU4 and the UK

10.5.7. Linewise Treated cases of EC in EU4 and the UK

10.6. Epidemiology Scenario in Japan

10.6.1. Total Diagnosed Incident Cases of EC in Japan

10.6.2. Age-specific cases of EC in Japan

10.6.3. Histology-specific Cases of EC in Japan

10.6.4. Gender-specific Cases of EC in Japan

10.6.5. Mutation-specific Cases of EC in Japan

10.6.6. Stage-specific Cases of EC in Japan

10.6.7. Linewise Treated Cases of EC in Japan

11. Esophageal Cancer Patient Journey

12. Marketed Esophageal Cancer Therapies

12.1. Key Cross Competition

12.2. ROZLYTREK (entrectinib): Hoffmann-La Roche

12.2.1. Product Description

12.2.2. Regulatory Milestones

12.2.3. Other Developmental Activities

12.2.4. Clinical Development

12.2.5. Safety and Efficacy

12.3. VITRAKVI (larotrectinib): Bayer

12.3.1. Product Description

12.3.2. Regulatory Milestones

12.3.3. Other Developmental Activities

12.3.4. Clinical Development

12.3.5. Safety and Efficacy

12.4. KEYTRUDA (Pembrolizumab): Merck Sharp & Dohme

12.4.1. Product Description

12.4.2. Regulatory Milestones

12.4.3. Clinical Developmental Activities

12.4.4. Safety and Efficacy

12.5. CYRAMZA (ramucirumab): Eli Lilly and Company

12.5.1. Product Description

12.5.2. Regulatory Milestones

12.5.3. Clinical Developmental Activities

12.5.4. Safety and Efficacy

12.6. OPDIVO (nivolumab): Bristol-Myers Squibb/Ono Pharmaceutical

12.6.1. Product Description

12.6.2. Regulatory Milestones

12.6.3. Clinical Developmental Activities

12.6.4. Safety and Efficacy

12.7. YERVOY (ipilimumab): Bristol-Myers Squibb/Ono Pharmaceutical

12.7.1. Product Description

12.7.2. Regulatory Milestones

12.7.3. Clinical Developmental Activities

12.7.4. Safety and Efficacy

13. Emerging Esophageal Cancer Therapies

13.1. Key Cross Competition

13.2. Zanidatamab: Zymeworks

13.2.1. Product Description

13.2.2. Other Developmental Activities

13.2.3. Clinical Development

13.2.4. Safety and efficacy

13.3. Sintilimab: Innovent Biologics

13.3.1. Product Description

13.3.2. Other Developmental Activities

13.3.3. Clinical Development

13.3.4. Safety and Efficacy

13.4. Tislelizumab: BeiGene

13.4.1. Product Description

13.4.2. Other Developmental Activities

13.4.3. Clinical Development

13.4.4. Safety and Efficacy

13.5. Sotigalimab (APX005M): Apexigen

13.5.1. Product Description

13.5.2. Other Developmental Activities

13.5.3. Clinical Development

13.5.4. Safety and Efficacy

14. Esophageal Cancer (EC): 7MM Analysis

14.1. Key Findings

14.2. Attribute Analysis

14.3. Key Market Forecast Assumptions

14.4. 7MM Esophageal Cancer Market Outlook

14.5. Market Size of Esophageal Cancer in the 7MM

14.5.1. Total Market Size of EC in the 7MM

14.5.2. Market Size of EC by Therapies (Adjuvant/Neo-adjuvant) in the 7MM

14.5.3. Market Size of EC by Therapies (First-line) in the 7MM

14.5.4. Market Size of EC by Therapies (Second-line plus) in the 7MM

14.6. Market Size of Esophageal Cancer in the United States

14.6.1. Total Market Size of EC in the United States

14.6.2. Market Size of EC by Therapies (Adjuvant/Neo-adjuvant) in the United States

14.6.3. Market Size of EC by Therapies (First-line) in the United States

14.6.4. Market Size of EC by Therapies (Second-line plus) in the United States

14.7. Market Size of Esophageal Cancer in EU4 and the United Kingdom

14.7.1. Total Market Size of EC in EU4 and the UK

14.7.2. Market Size of EC by Therapies (Adjuvant/Neo-adjuvant) in EU4 and the UK

14.7.3. Market Size of EC by Therapies (First-line) in EU4 and the UK

14.7.4. Market Size of EC by Therapies (Second-line plus) in EU4 and the UK

14.8. Market Size of Esophageal Cancer in Japan

14.8.1. Total Market Size of EC in Japan

14.8.2. Market Size of EC by Therapies (Adjuvant/Neo-adjuvant) in Japan

14.8.3. Market Size of EC by Therapies (First-line) in Japan

14.8.4. Market Size of EC by Therapies (Second-line plus) in Japan

15. KOL Views

16. SWOT Analysis

17. Esophageal Cancer Unmet Needs

18. Esophageal Cancer Market Access and Reimbursement

18.1. The United States

18.1.1. Centre for Medicare & Medicaid Services (CMS)

18.2. EU4 and the UK

18.2.1. Germany

18.2.2. France

18.2.3. Italy

18.2.4. Spain

18.2.5. United Kingdom

18.3. Japan

18.3.1. MHLW

19. Appendix

19.1. Bibliography

19.2. Report Methodology

20. DelveInsight Capabilities

21. Disclaimer

List of Tables:

    Table 1: Summary of Esophageal Cancer, Market and Epidemiology (2019–2032)

    Table 2: Key Events

    Table 3: AJCC Staging of Esophageal Cancer

    Table 4: SEOM-GEMCAD-TTD Clinical Guideline for the Treatment of Esophageal Cancer (2021)

    Table 5: Guidelines for the Management of Esophageal Cancer

    Table 6: Total Diagnosed Incident Cases of EC in the 7MM (2019–2032)

    Table 7: Total Diagnosed Incident Cases of EC in the US (2019–2032)

    Table 8: Age-specific Cases of EC in the US (2019–2032)

    Table 9: Histology-specific Cases of EC in the US (2019–2032)

    Table 10: Gender-specific Cases of EC in the US (2019–2032)

    Table 11: Mutation-specific Cases of EC in the US (2019–2032)

    Table 12: Stage-specific Cases of EC in the US (2019–2032)

    Table 13: Linewise Treated Cases of EC in the US (2019–2032)

    Table 14: Total Diagnosed Incident Cases of EC in EU4 and the UK (2019–2032)

    Table 15: Age-specific Cases of EC in EU4 and the UK (2019–2032)

    Table 16: Histology-specific Cases of EC in EU4 and the UK (2019–2032)

    Table 17: Gender-specific Cases of EC in EU4 and the UK (2019–2032)

    Table 18: Mutation-specific cases of EC in EU4 and the UK (2019–2032)

    Table 19: Total Stage-specific Cases of EC in EU4 and the UK (2019–2032)

    Table 20: Linewise Treated Cases of EC in EU4 and the UK (2019–2032)

    Table 21: Total Diagnosed Incident Cases of EC in Japan (2019–2032)

    Table 22: Age-specific Cases of EC in Japan (2019–2032)

    Table 23: Histology-specific Cases of EC in Japan (2019–2032)

    Table 24: Gender-specific Cases of EC in Japan (2019–2032)

    Table 25: Mutation-specific Cases of EC in Japan (2019–2032)

    Table 26: Stage-specific Cases of EC in Japan (2019–2032)

    Table 27: Linewise Treated Cases of EC in Japan (2019–2032)

    Table 28: Comparison of Marketed Drugs for Esophageal Cancer

    Table 29: ROZLYTREK (entrectinib), Clinical Trial Description, 2023

    Table 30: VITRAKVI (larotrectinib), Clinical Trial Description, 2023

    Table 31: KEYTRUDA, Clinical Trial Description, 2023

    Table 32: Efficacy Results in Patients With Locally Advanced Unresectable or Metastatic Esophageal Cancer in KEYNOTE-590

    Table 33: Efficacy Results in Patients With Recurrent or Metastatic ESCC (CPS = 10) in KEYNOTE-181

    Table 34: CYRAMZA, Clinical Trial Description, 2023

    Table 35: Efficacy Results in REGARD

    Table 36: Efficacy Results in RAINBOW

    Table 37: OPDIVO, Clinical Trial Description, 2023

    Table 38: Efficacy Results – CHECKMATE-577

    Table 39: Efficacy Results – CHECKMATE-648

    Table 40: Efficacy Results – ATTRACTION-3

    Table 41: Efficacy Results – CHECKMATE-649

    Table 42: YERVOY, Clinical Trial Description, 2023

    Table 43: Efficacy Results – CHECKMATE-648

    Table 44: Key cross competition – Emerging Therapies Included in the Model

    Table 45: Key cross competition – Late-stage Emerging Therapies Not Included in the Model

    Table 46: Key cross competition

    Table 47: Zanidatamab Clinical Trial Description, 2023

    Table 48: Sintilimab Clinical Trial Description, 2023

    Table 49: Tislelizumab Clinical Trial Description, 2023

    Table 50: Sotigalimab (APX005M) Clinical Trial Description, 2023

    Table 51: Key Market Forecast Assumptions for OPDIVO + YERVOY

    Table 52: Key Market Forecast Assumptions for Nivolumab + Fluoropyrimidine + Platinum

    Table 53: Key Market Forecast Assumptions for Zanidatamab + chemotherapy ± tislelizumab

    Table 54: Key Market Forecast Assumptions for Sintilimab + (Cisplatin + paclitaxel/Cisplatin + fluorourcil)

    Table 55: Key Market Forecast Assumptions for Tislelizumab + Platinum + 5-FU/Capecitabine/Paclitaxel

    Table 56: Key Market Forecast Assumptions for Pembrolizumab + Fluoropyrimidine + Platinum

    Table 57: Key Market Forecast Assumptions for larotrectinib

    Table 58: Total Market Size of EC in the 7MM, USD million (2019–2032)

    Table 59: Market size of EC by Therapies (Adjuvant/Neo-adjuvant) in the 7MM, USD million (2019–2032)

    Table 60: Market size of EC by Therapies (First-line) in the 7MM, USD million (2019–2032)

    Table 61: Market size of EC by therapies (Second-line plus) in the 7MM, USD million (2019–2032)

    Table 62: Total Market Size of EC in the US, in USD million (2019–2032)

    Table 63: Market Size of EC by Therapies (Adjuvant/Neo-adjuvant) in the United States, in USD million (2019–2032)

    Table 64: Market Size of EC by Therapies (First-line) in the United States, in USD million (2019–2032)

    Table 65: Market Size of EC by Therapies (Second-line plus) in the United States, in USD million (2019–2032)

    Table 66: Total Market Size of EC in EU4 and the UK, in USD million (2019–2032)

    Table 67: Market size of EC by therapies (Adjuvant/Neo-adjuvant) in EU4 and the UK, in USD million (2019–2032)

    Table 68: Market Size of EC by Therapies (First-line) in EU4 and the UK, in USD million (2019–2032)

    Table 69: Market Size of EC by Therapies (Second-line plus) in EU4 and the UK, in USD million (2019–2032)

    Table 70: Total Market Size of EC in Japan, in USD million (2019–2032)

  • Table 71: Market Size of EC by Therapies (Adjuvant/Neo-adjuvant) in Japan, in USD million (2019–2032)

List of Figures:

    Figure 1: Understanding Gastroesophageal Reflux Induced Esophageal Tumorigenesis

    Figure 2: Predominant Types of Primary Esophageal Cancers

    Figure 3: Staging of Esophageal Cancer

    Figure 4: The Risk Factors Profiles for Esophageal Squamous Cell Carcinoma and Esophageal Adenocarcinoma

    Figure 5: Esophageal Cancer Warning Signs

    Figure 6: Top Alterations in Esophageal Squamous Cell Carcinoma

    Figure 7: Esophageal Cancer (Upper Endoscopy)

    Figure 8: Algorithm for the Symptoms Suggestive of Esophageal Cancer

    Figure 9: Imaging Differential Diagnosis

    Figure 10: Esophagectomy

    Figure 11: Treatment Algorithm for Local/Locoregional Resectable Esophageal and OGJ Cancer

    Figure 12: Treatment Algorithm for Advanced Esophageal SCC

    Figure 13: The Algorithm Showing the Surgical Procedure Recommended by the Guideline for Esophageal Carcinomas

    Figure 14: Treatment Algorithm for Stage 0–I Esophageal Cancer

    Figure 15: Treatment Algorithm for Stage II–III Esophageal Cancer

    Figure 16: Treatment Algorithm for Stage IVA Esophageal Cancer

    Figure 17: Treatment Algorithm for Stage IVB Esophageal Cancer

    Figure 18: Chemotherapy Regimen for Stage IVB Esophageal Cancer

    Figure 19: Total Diagnosed Incident Cases of EC in the 7MM (2019–2032)

    Figure 20: Total Diagnosed Incident Cases of EC in the US (2019–2032)

    Figure 21: Age-specific Cases of EC in the US (2019–2032)

    Figure 22: Histology-specific Cases of EC in the US (2019–2032)

    Figure 23: Gender-specific Cases of EC in the US (2019–2032)

    Figure 24: Mutation-specific Cases of EC in the US (2019–2032)

    Figure 25: Stage-specific Cases of EC in the US (2019–2032)

    Figure 26: Linewise Treated Cases of EC in the US (2019–2032)

    Figure 27: Total Diagnosed Incident Cases of EC in EU4 and the UK (2019–2032)

    Figure 28: Age-specific Cases of EC in EU4 and the UK (2019–2032)

    Figure 29: Histology-specific Cases of EC in EU4 and the UK (2019–2032)

    Figure 30: Gender-specific Cases of EC in EU4 and the UK (2019–2032)

    Figure 31: Mutation-specific Cases of EC in EU4 and the UK (2019–2032)

    Figure 32: Total Stage-specific Cases of EC in EU4 and the UK (2019–2032)

    Figure 33: Linewise Treated Cases of EC in EU4 and the UK (2019–2032)

    Figure 34: Total Diagnosed Incident Cases of EC in Japan (2019–2032)

    Figure 35: Age-specific Cases of EC in Japan (2019–2032)

    Figure 36: Histology-specific Cases of EC in Japan (2019–2032)

    Figure 37: Gender-specific Cases of EC in Japan (2019–2032)

    Figure 38: Mutation-specific Cases of EC in Japan (2019–2032)

    Figure 39: Stage-specific Cases of EC in Japan (2019–2032)

    Figure 40: Linewise Treated cases of EC in Japan (2019–2032)

    Figure 41: Total Market Size of EC in the 7MM, USD million (2019–2032)

    Figure 42: Market size of EC by Therapies (Adjuvant/Neo-adjuvant) in the 7MM, USD million (2019–2032)

    Figure 43: Market size of EC by Therapies in the 7MM (First-line), USD million (2019–2032)

    Figure 44: Market Size of EC by Therapies (Second-line plus) in the 7MM, USD million (2019–2032)

    Figure 45: Total Market Size of Esophageal Cancer in EU4 and the UK, USD million (2019–2032)

    Figure 46: Market size of Esophageal Cancer by Therapies (Adjuvant/Neo-adjuvant) in EU4 and the UK, USD million (2019–2032)

    Figure 47: Market Size of Esophageal Cancer by Therapies (First-line) in EU4 and the UK, USD million (2019–2032)

    Figure 48: Market Size of Esophageal Cancer by Therapies (Second-line plus) in EU4 and the UK, USD million (2019–2032)

    Figure 49: Total Market Size of Esophageal Cancer in Japan, USD million (2019–2032)

    Figure 50: Market Size of Esophageal Cancer by Therapies (Adjuvant/Neo-adjuvant) in Japan, USD million (2019–2032)

    Figure 51: Market Size of Esophageal Cancer by Therapies (First-line) in Japan, USD million (2019–2032)

    Figure 52: Market Size of Esophageal Cancer by Therapies (Second-line plus) in Japan, in USD million (2019–2032)

    Figure 53: Health Technology Assessment

    Figure 54: Reimbursement Process in Germany

    Figure 55: Reimbursement Process in France

    Figure 56: Reimbursement Process in Italy

    Figure 57: Reimbursement Process in Spain

    Figure 58: Reimbursement Process in the United Kingdom

    Figure 59: Reimbursement Process in Japan

List of Companies:

    • Merck & Co., Inc.
    • AstraZeneca PLC
    • Bristol-Myers Squibb Company
    • Eli Lilly and Company
    • Roche Holding AG
    • Pfizer Inc.
    • Takeda Pharmaceutical Company Limited
    • Novartis International AG
    • Amgen Inc.
    • Bayer AG
    • Eisai Co., Ltd.
    • Daiichi Sankyo Company, Limited
    • Sanofi S.A.
    • Johnson & Johnson
    • AbbVie Inc.
    • Celgene Corporation
    • Boehringer Ingelheim International GmbH
    • Gilead Sciences, Inc.
    • Ipsen Biopharmaceuticals, Inc.
    • Astellas Pharma Inc., and others.

Frequently Asked Questions

Esophageal cancer is a malignancy affecting the tube connecting the throat to the stomach. It often presents with symptoms like swallowing difficulties and chest pain. Risk factors include smoking, alcohol use, and GERD, while treatments involve surgery, chemotherapy, and radiation.

Yes, the Esophageal Cancer market is anticipated to transform in the upcoming years. Some of the key factors such as the advances in surgical techniques, chemotherapy protocols, and radiation therapies, better understanding of the molecular and genetic factors, ongoing research efforts uncovering novel treatment options, and a multidisciplinary approach to treatment will change the Esophageal Cancer market dynamics in the upcoming years.

The Esophageal Cancer Market size in the 7MM was USD 1,050 million in 2022, and it is expected to expand in the upcoming years.

In 2022, the Esophageal Cancer market size was highest in the US, accounting for approximately USD 400 million, which is further expected to increase by 2032.

The total Esophageal Cancer diagnosed incident cases in the US was 20,000 cases in 2022, and it is projected to reach 24,000 cases by 2032.

The Esophageal Cancer epidemiology scenario is expected to change in the 7MM owing to the rising prevalence and incidence, lifestyle factors leading to a higher number of cases, awareness of the risk factors, advancements in early detection, among others.

Some of the major pharma and biotech companies such as AbbVie, Amgen, Astellas Pharma, AstraZeneca, Bayer, Boehringer Ingelheim International, Bristol-Myers Squibb, Celgene, Daiichi Sankyo Company, Eisai, Eli Lilly and Company, Gilead, Ipsen, Johnson & Johnson, Merck, Novartis International, Pfizer., Roche Holding, Sanofi, Takeda, among others, are actively working to develop Esophageal Cancer drugs for better treatment outcomes.

DelveInsight’s “Esophageal Cancer Market Report” covers an in-depth market outlook, epidemiology trends, and therapeutic development for the study period.

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