Glioblastoma Multiforme Market
DelveInsight’s ‘Glioblastoma Multiforme - Market Insights, Epidemiology and Market Forecast– 2030’ report delivers an in-depth understanding of the Glioblastoma Multiforme, historical and forecasted epidemiology as well as the Glioblastoma Multiforme market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.
The Glioblastoma Multiforme market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Glioblastoma Multiforme market size from 2019 to 2032. The report also covers current Glioblastoma Multiforme treatment practice/algorithm, market drivers, market barriers and Glioblastoma Multiforme unmet needs to curate the best of the opportunities and assesses the underlying potential of the market.
- The United States
- EU5 (Germany, France, Italy, Spain, and the United Kingdom)
Study Period: 2019-2032
Glioblastoma Multiforme Market Disease: Understanding and Treatment Algorithm
Glioblastoma Multiforme Overview
Glioblastoma (Glioblastoma Multiforme) is the most frequently occurring type of primary tumors of the central nervous system (CNS) mostly in adults, and its poor prognosis has not been significantly improved despite the fact that the innovative diagnostic strategies and new therapies have been developed. Somatic evolution promotes the progression of cancer in which the genome of the cancer cell is being deviated from that of the healthy cell due the accumulation of mutations. There is a remarkable development in Glioblastoma Multiforme because it occurs via a complex network of various different molecular and genetic aberrations, which leads to significant changes in major signaling pathways. Glioblastoma Multiformes, as they extensively disperse throughout the parenchyma, making maximal surgical resection unattainable and having high level of vascularization, are lethal in nature.
Glioblastoma Multiforme is often located in a region of the forebrain known as the cerebrum, which controls some of the most advanced process such as speech and emotions. While Glioblastoma Multiforme is highly locally invasive (invading normal brain tissue), it rarely spreads to other organs beyond the brain. A highly aggressive, fast-growing cancer and treatment is often limited by the tumor location and the ability of a patient to tolerate surgery. Consequently, it is a particularly difficult cancer to treat.
Glioma is considered as the general term which is used to describe the primary brain tumors, and it is also classified to their presumed cell of origin accordingly. The classification includes astrocytic tumors (astrocytoma, anaplastic astrocytoma and glioblastoma), oligodendrogliomas, ependymomas, and mixed gliomas. Gliomas are classified into grade I TO IV on the basis of malignancy that is determined by the histopathalogical criteria. Although the location of Glioblastoma Multiforme is commonly found in the supratentorial region (frontal, temporal, parietal, and occipital lobes), it is rarely located in the cerebellum part. Investigation of genetic and environmental factors of Glioblastoma Multiforme have been done. Prior radiography, decreased susceptibility to allergy, immune factors and immune genes, as well as some nucleotide polymorphisms detected by genomic analysis are all included in the risk factors of the respective disease. The histological classification and tumor grading is a critical step for Glioblastoma Multiforme diagnosis and prognosis.
Glioblastoma Multiforme is a grade IV glioma according to the WHO 2007 classification and is the most common and lethal primary malignancy of the central nervous system. Despite multidisciplinary treatments such as surgery, chemotherapy, and radiotherapy, the median survival time for patients with Glioblastoma Multiforme is only 14.6 months. Due to its high degree of invasiveness, radical tumor resection is not curative. From various experimental evidences it is explained that Glioblastoma Multiforme contains a subpopulation of highly tumorigenic cells (Glioblastoma Multiforme stem cells) from which recurrent Glioblastoma Multiforme is thought to derive, and that Glioblastoma Multiforme has the capacity to differentiate into multiple lineages of tumor genesis.
Glioblastoma Multiformes can be classified into primary and secondary Glioblastoma Multiformes:
- Primary Glioblastoma Multiforme occurs de novo without evidence of a less malignant precursor
- Secondary Glioblastoma Multiforme develops from initially low-grade diffuse astrocytoma (WHO grade II diffuse astrocytoma) or anaplastic astrocytoma (Grade III).
Glioblastoma Multiforme Diagnosis
A patient with any neurological symptoms will first be given a physical exam that includes neurologic function tests (reflexes, muscle strength, eye and mouth movement, coordination and alertness). If a tumor is suspected, the patient will have imaging tests so that doctors can look into the brain for any abnormality. A neurological exam alone is not sufficient to make a glioblastoma diagnosis, but the results will indicate whether additional testing is needed. If the results of a neurological exam suggest a potential glioblastoma diagnosis, imaging tests may then be used to produce an in-depth picture of the brain. Procedures that can be used for this purpose include:
- Neurological Exams
- Magnetic resonance imaging (MRI) and computerized Tomography (CT)
- Perfusion MRI
- MR spectroscopy
- Histological Diagnosis
- Surgical Biopsy
Glioblastoma Multiforme Treatment
Treatment for Glioblastoma Multiforme usually includes a combination of surgery, chemotherapy, radiation, or stereotactic radiosurgery. Surgery is usually one of the most important aspects of treatment, although rarely used alone. Since glioblastomas develop very rapidly, they are often difficult to remove in their entirety. Therefore, surgery is performed to achieve a maximum safe resection - removing as much of the tumor as possible while preserving the patient’s brain function and sparing healthy tissues. Residual cancer cells can be targeted with additional treatments, such as chemotherapy or radiation therapy, after surgery. Radiation therapy and chemotherapy usually follow surgery once the diagnosis or name of the tumor is determined. These treatments are called adjuvant treatments. Because this multispecialty approach can cause several side effects, steroids are often provided as another essential part of glioblastoma treatment, used to help alleviate the side effects of other therapies.
The mainstay of treatment for Glioblastoma is surgery, followed by radiation and chemotherapy. Glioblastoma surgery is performed to achieve a “maximum safe resection,” or removing as much of the tumor as possible without causing lasting neurological damage. Glioblastoma surgery options majorly include: Craniotomy , Awake craniotomy, Debulking surgery, Skull base surgery, Visualase and Kyphoplasty. In most cases, surgeons perform a craniotomy, opening the skull to reach the tumor site. This is done frequently with computer-assisted image-guidance and at times using intra-operative mapping techniques to determine the locations of the motor, sensory and speech/language cortex.
Currently, the first- and second-line treatment of Glioblastoma Multiforme is more prevalent throughout the 7MM. The first-line treatment involves drug therapy following surgery, which includes Temozolomide + Radiation Therapy and Temozolomide Monotherapy. While the second-line treatment for Glioblastoma Multiforme includes Bevacizumab Monotherapy, Bevacizumab Combination Therapy, Temozolomide (Both as Combination and Monotherapy), and Other Systemic Therapies (Concomitant and Adjuvant).
Glioblastoma Multiforme Epidemiology
The disease epidemiology covered in the report provides historical as well as forecasted Glioblastoma Multiforme Epidemiology Segmented by Total Diagnosed Incident Population of Glioblastoma Multiforme, Gender-specific Diagnosed Incidence of Glioblastoma Multiforme, Type-specific Diagnosed Incidence of Glioblastoma Multiforme, Age-specific Diagnosed Incidence of Glioblastoma Multiforme, Diagnosed Incident Population According To Primary Site Of Glioblastoma Multiforme Tumour and Diagnosed Incident Population According To Histologic Classification of Glioblastoma Multiforme Tumor in the 7MM market covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan from 2019 to 2032.
This section provides glimpse of the Glioblastoma Multiforme epidemiology in the 7MM.
- The total diagnosed incident population of Glioblastoma Multiforme in the 7 major markets was estimated to be 29,440 in 2020. In case of Glioblastoma Multiforme patients in the United States, the diagnosed incident cases were 15,426 in 2020.
- The total diagnosed incident cases of Glioblastoma Multiforme patients were maximum in males as compared to females in the 7 MM during the study period of 2018–2030.
- In the EU5 countries, the diagnosed incident population of Glioblastoma Multiforme was maximum in Germany with 2,945 cases followed by France with 2,772 cases in 2020. While, Spain accounted for the lowest diagnosed incident population of 1,462 in 2020.
- As per Delvelnsight’s analysis, Japan had 1,950 diagnosed incident cases of Glioblastoma Multiforme in 2020.
- There were 13,884 patients affected with primary Glioblastoma Multiforme and 1,543 with secondary Glioblastoma Multiforme in 2020, in the United States
- The maximum number of the diagnosed incident population in the United States, in 2020, was found at the parietal site with 6,201 cases, followed by frontal tumors with 4,505 cases, temporal tumors with 2,391 cases, 1,620 cases of occipital tumors, and 710 cases of unknown and other tumors.
- In 2020, the maximum number of the diagnosed incident population according to the histological classification of Glioblastoma Multiforme were conventional Glioblastoma Multiforme type with 14,964 cases while the lowest incident cases were of GC-Glioblastoma Multiforme type with 123 cases, in the United States.
- In the United States, the maximum number of Glioblastoma Multiforme patients lie in the age group of 35–64, which accounted for 10,768 cases in 2020. In contrast, the least number of patients lie in the age group of <18, which was 617 in 2020.
Country Wise- Glioblastoma Multiforme Epidemiology
The epidemiology segment also provides the Glioblastoma Multiforme epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.
Glioblastoma Multiforme Drug Chapters
The drug chapter segment of the Glioblastoma Multiforme report encloses the detailed analysis of Glioblastoma Multiforme marketed drugs and mid and late stage pipeline drugs. It also helps to understand the Glioblastoma Multiforme clinical trials details, expressive pharmacological action, agreements and collaborations, approval and patent details of each included drug and the latest news and press releases.
Glioblastoma Multiforme Marketed Drugs
Avastin (Bevacizumab) is a recombinant humanized monoclonal IgG1 antibody, which acts as angiogenesis inhibitor by blocking its target, vascular endothelial growth factor (VEGF). Bevacizumab binds to the vascular endothelial growth factor (VEGF) with its receptor VEGFR-1 and VEGFR-2, which are present on the surface of endothelial cells. This helps in reducing the activity of VEGF and regressing the vascularization of tumors, which normalizes the tumor vasculature and inhibits the formation of new tumor vasculature, thereby preventing the tumor growth. VEGF is a chemical signal that stimulates angiogenesis in a variety of diseases, especially in cancer. Bevacizumab was the first clinically available angiogenesis inhibitor in the United States. In September 2014, Genentech reclassified the drug under “Specialty drugs,” only to be available through specialty pharmacies (under FDA’s Risk Evaluation and Mitigation Strategy (REMS) program).
The effectiveness of Avastin in glioblastoma is based on an improvement in objective response rate, wherein no data demonstrate any improvement in disease-related symptoms or increased survival with Avastin.
Product details in the report…
The active pharmaceutical ingredient in Temodar/Temodal, is an imidazotetrazine derivative of the alkylating agent dacarbazine. Temozolomide is used for the treatment of several brain cancer forms, e.g., as a second-line treatment for astrocytoma and as a first-line treatment for glioblastoma. The therapeutic benefit of temozolomide is due to its ability to alkylate/methylate DNA. This alkylation/methylation destroys the DNA and triggers the death of the tumor cells. Temozolomide targets selectively tumoral tissues; it has an anti-neoplastic effect; it has minimum influence on adjacent brain tissues; it has no severe systemic toxicity, and it is eliminated rapidly. Temodar/Temodal was initially commercialized by Merck in the different countries, whereas Baxter Oncology was responsible for the manufacture of Temodar injection. However, due to patent expiry, the market holds the generic version of the drug. Recently, the gel formulation of Temozolomide has also been approved by Double Bond Pharmaceuticals.
Product details in the report…
Glioblastoma Multiforme Emerging Drugs
Ofranergene obadenovec (VB-111): VBL Therapeutics
Ofranergene obadenovec (VB-111) is a first-in-class, targeted anticancer gene-therapy agent that is being developed VBL Therapeutics to treat a wide range of solid tumors such as Glioblastoma Multiforme. It is a non-replicating adenovirus 5 (Ad-5, El-deleted) carrying a proapoptotic human Fas-chimera transgene that targets angiogenic blood vessels and leads to vascular disruption. The drug is being investigated using VBL’s proprietary Vascular Targeting System (VTS) platform Technology to target endothelial cells in the tumor vasculature for cancer therapy. In November 2019, the company stated that an investigational new drug (IND) application from the US FDA. The IND is for a phase II randomized, controlled, Glioblastoma Multiforme clinical trials of VB-111 in recurrent Glioblastoma Multiforme (rGlioblastoma Multiforme) patients undergoing a second surgery. Currently, the trial is in recruiting phase. In March 2021, the company announced initiation of patient dosing in the Phase II trialThe drug has been rewarded Orphan Drug Designation from both the US FDA and EMA for the treatment of patients with Glioblastoma Multiforme. In addition, it has also been granted Fast Track Designation by the US FDA for prolongation of survival in patients with recurrent Glioblastoma Multiforme.
Product details in the report…
Trans Sodium Crocetinate: Diffusion Pharmaceuticals
Trans Sodium Crocetinate (TSC), being investigated by Diffusion Pharmaceuticals, is a first-in-class small molecule that, by its novel proprietary mechanism, safely re-oxygenates oxygen-deprived tissue. It can be used to enhance the cancer-killing power of radiation and chemotherapy for treating patients with Glioblastoma Multiforme. The company holds broad protection of their patent portfolio ranging through 2031 with possible extensions to 2036. In addition, Orphan Designation by the US FDA for the patients with Glioblastoma Multiforme serves as an additional 7 years of exclusivity as well. Additionally, the phase III trial of the drug for newly diagnosed Glioblastoma Multiforme was terminated in July 2021 (business decision on behalf of the sponsor).
Product details in the report…
Regorafenib is an oral multi-kinase inhibitor that potently blocks multiple protein kinases involved in tumor angiogenesis (VEGFR1, -2, -3, TIE2), oncogenesis (KIT, RET, RAF-1, BRAF), metastasis (VEGFR3, PDGFR, FGFR) and tumor immunity (CSF1R). The EMA has granted Bayer’s Regorafenib Orphan Drug Designation for the treatment of glioma, including Glioblastoma Multiforme. The drug is already approved under the brand name Stivarga in more than 90 countries, including the US, countries of the European Union, China and Japan for metastatic colorectal cancer, metastatic gastrointestinal stromal tumors and hepatocellular carcinoma. Currently, the drug is in phase III stage of Glioblastoma Multiforme clinical trials development for patients with newly diagnosed and recurrent Glioblastoma Multiforme. Besides, the company witnessed positive phase II REGOMA study results in June 2018 for patients with relapsed Glioblastoma Multiforme.
Product details in the report…
Durvalumab (MEDI4736): MedImmune
Durvalumab is an investigational human monoclonal antibody directed against the programmed cell death ligand 1 (PD-L1) protein in development by MedImmune. Signals from PD-L1 help tumors avoid detection by the immune system. The drug has been approved by brand name Imfinzi for several oncology indications. However, in the case of Glioblastoma Multiforme, the drug is being explored in phase II clinical trials.
Product details in the report…
Tasadenoturev (DNX-2401): DNAtrix
Tasadenoturev (DNX-2401), explored by DNAtrix, is oncolytic immunotherapy. Two stable genetic changes in the adenovirus genome were engineered that cause it to replicate selectively in retinoblastoma (Rb) pathway deficient cells and infect tumor cells efficiently in order to achieve safety and efficacy. The drug has been granted PRIME and Orphan designation by the EMA and Fast Track and Orphan designation by the FDA . In October 2015, Merck and DNAtrix entered into an oncology clinical study collaboration to evaluate DNX-2401 in combination with Keytruda in a phase II study of patients with rGlioblastoma Multiforme.
Product details in the report…
A novel therapeutic intervention of Imipridone class is in development by Chimerix, i.e., ONC201, which is a highly selective antagonist of dopamine receptor D2 (DRD2) and ClpP agonist that can penetrate the blood-brain-barrier effectively. The drug engages proven anticancer pathways that lead to apoptosis in cancer cells. The drug is targeting multiple brain cancer indications such as Glioblastoma Multiforme and Diffuse Intrinsic Pontine Gliomas or Diffuse Midline Glioma altogether. It has found been in early results that this drug can kill cancer cells but not normal cells and may be effective in patients with a specific genetic mutation in their tumour: the H3 K27M mutation. The US FDA has awarded Fast-Track designation to ONC201 for the treatment of adults with who have recurred Glioblastoma Multiforme. Currently, the drug is in phase II stage of clinical development for recurrent Glioblastoma Multiforme, H3 K27M-mutant Glioma and Diffuse Midline Glioma. Besides, recently, in November 2019, the company has witnessed positive interim phase II results of ONC201 in patients with recurrent Glioblastoma Multiforme. In November 2020, the company announced that it had received grants from Michael Mosier Defeat DIPG Foundation, Dragon Master Foundation and The ChadTough Foundation to fund an Expanded Access program for ONC201 in the United States. In January 2020, the National Brain Tumor Society (NBTS) committed to provide more than USD 200,000 funding to support Oncoceutics’ phase II clinical trial of ONC201, in a molecular subset of high grade gliomas.
Product details in the report…
Selinexor (KPT-330): Karyopharm Therapeutics
Selinexor (KPT-330) is a first-in-class, oral selective inhibitor of Nuclear Export/SINE compound in development by Karyopharm Therapeutics. It functions by binding with and inhibiting the nuclear export protein XPO1 (also called CRM1), leading to the accumulation of tumor suppressor proteins in the cell nucleus, which subsequently reinitiates and amplifies their tumor suppressor function. The drug has been approved with a brand name Xpovio for patients with relapsed or refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti‐CD38 monoclonal antibody. The phase II (KING) study was terminated due to sponsor decision (Karyopharm Therapeutics).
Product details in the report…
Paxalisib (GDC-0084): Kazia Therapeutics
Paxalisib (GDC-0084) inhibits the PI3K pathway that is thought to be critical to the development of certain kinds of tumours. The drug is currently involved in five clinical trials examining the drug in a range of forms of brain cancer, including glioblastoma, DIPG and breast cancer brain metastases (BCBM). The drug is distinguished by its ability to cross the blood-brain barrier (BBB), which prevents many drugs from fully affecting brain tissues. Kazia Therapeutics licensed Paxalisib (as GDC-0084) from Genentech in 2016 and is developing it as a potential treatment for glioblastoma in phase II clinical trial.
Product details in the report…
AV-Glioblastoma Multiforme-1: Aivita Biomedical
AV-Glioblastoma Multiforme-1 is a novel immunotherapy consisting of autologous dendritic cells loaded with autologous tumour antigens derived from self-renewing tumour-initiating cells derived from cultured autologous Glioblastoma Multiforme tumour cells, with potential immuno-stimulatory and antineoplastic activities. Upon a series of subcutaneous administration, the autologous TAA-loaded DCs AV-Glioblastoma Multiforme-1 expose the immune system to the Glioblastoma Multiforme neoantigens, which results in a cytotoxic T-lymphocyte (CTL)-mediated immune response against the autologous Glioblastoma Multiforme cells leading to Glioblastoma Multiforme cell lysis. Aivita Biomedical is investigating it as a potential treatment for newly diagnosed Glioblastoma Multiforme in a phase II clinical trial.
Product details in the report…
MDNA55: Medicenna Therapeutics
MDNA55 is a novel first in class Interleukin-4 Empowered Cytokine (IL4-EC). This proprietary targeted drug molecule was designed to harness the exceptional specificity and affinity of superkines (engineered cytokines) to selectively deliver cell-killing stimuli to the bulk tumor, tumor microenvironment (TME), and cancer stem cells (CSC) simultaneously. It has been granted both Fast Track and Orphan Drug Status from the FDA as well as Orphan Drug Designation from the EMA for the treatment of rGlioblastoma Multiforme. Medicenna is developing it as a potential treatment for recurrent or progressive Glioblastoma Multiforme and has completed its phase II clinical trial, in October 2019. In October 2020, the company provided an update on the clinical development of MDNA55. Following an End of Phase II Meeting with the FDA, the agency agreed that the company could conduct an open-label hybrid Phase III trial that allows use of a substantial number of subjects (two-thirds) from a matched external control arm to support regulatory approval of MDNA55 for rGlioblastoma Multiforme. The FDA also expressed willingness to consider an interim analysis of the trial if certain criteria are met. Medicenna is currently pursuing a partnership strategy to facilitate MDNA55’s further development and commercialization. Additionally, in May 2021, Medicenna’s proposed patient population shows a tumor control rate of 81% (26/32) based on modified RANO criteria. According to the company, the published data in clinical cancer research indicated that early determination of PFS with modified RANO criteria may be a strong surrogate for overall survival in recurrent glioblastoma.
Product details in the report…
Glioblastoma Multiforme Market Outlook
Glioblastoma is a malignant (cancerous) brain tumor that develops from a specific type of brain cell called an astrocyte. These cells help support and nourish neurons (nerve cells of the brain) and form scar tissue that helps repair brain damage in response to injury. Glioblastomas are often very aggressive and grow into surrounding brain tissue. Unfortunately, there is no cure for glioblastoma. Glioblastoma treatment is quite challenging as some cells may respond well to certain therapies, while others may not be affected at all. Because of this, the treatment plan for glioblastoma may combine several approaches. The treatment often comprises a combination of several therapies, including surgery, chemotherapy, radiation, or stereotactic radiosurgery followed by the additional/adjuvant treatments, such as chemotherapy or radiation therapy, after surgery. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy. The best treatment options for each person depending on many factors like the size and location of the tumor; the extent to which the tumor has grown into the surrounding normal brain tissues; and the affected person’s age and overall health.
In April 2005, the FDA approved a new indication for Temodar capsules (temozolomide) for concurrent use with radiotherapy for the treatment of adults with newly diagnosed Glioblastoma Multiforme and as maintenance therapy after radiotherapy. Inaddition, in December 2017, the FDA granted full approval of bevacizumab (Avastin) for the treatment of adults with recurrent glioblastoma that has progressed following prior therapy. In case of European and Japanese market, only Temodar has been approved by the EMA and MHLW respectively, for the treatment of patients with Glioblastoma Multiforme.
Glioblastoma Multiforme pipeline is robust and possesses multiple potential drugs in late and mid-stage developments, which is yet to be launched. The pipeline involves drugs with a varied mechanism of action along with different routes of administration, ranging from oral, intravenous, intratumoral, subcutaneous, etc. It is interesting to note that the emerging market of Glioblastoma Multiforme includes budding gene therapy, i.e., Ofranergene obadenovec (VB-111) by VBL Therapeutics, followed by four vaccine/immunotherapy candidates such as VBI-1901, AV-Glioblastoma Multiforme-1 and ITI-1000 (pp65 DC Vaccine), Tasadenoturev (DNX-2401) by VBI Vaccines, Aivita Biomedical, Immunomic Therapeutics, and DNAtrix, respectively.
The potential candidates with promising results in late- and mid-phase of clinical development include Ofranergene obadenovec (VB-111; VBL Therapeutics), Tasadenoturev (DNX-2401; DNAtrix), ONC201 (Chimerix), Selinexor (KPT-330; Karyopharm Therapeutics), VBI-1901 (VBI Vaccines), Paxalisib (GDC-0084; Kazia Therapeutics), AV-Glioblastoma Multiforme-1 (Aivita Biomedical), Regorafenib (Bayer) and others.
This section includes a glimpse of the Glioblastoma Multiforme 7MM market.
- The market size of Glioblastoma Multiforme in the seven major markets was estimated to be USD 1,022.1 Million in 2020.
- The United States accounts for the largest market size of Glioblastoma Multiforme throughout the study period of 2018-2030, in comparison to EU5 (the United Kingdom, Germany, Italy, France, and Spain) and Japan, which was estimated to be USD 674 Million in 2020.
- Among the EU5 countries, Germany had the highest market size with USD 72.1 Million in 2020, while Spain had the lowest market size with USD 35.8 Million.
- The market size of Japan was estimated to be USD 52.6 Million in 2020
The United States Market Outlook
This section provides the total Glioblastoma Multiforme market size and market size by therapies in the United States.
EU-5 Market Outlook
The total aspregillosis market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.
Japan Market Outlook
The total Glioblastoma Multiforme market size and market size by therapies in Japan are provided.
Glioblastoma Multiforme Pipeline Drugs Uptake
This section focusses on the rate of uptake of the potential Glioblastoma Multiforme drugs recently launched in the Glioblastoma Multiforme market or expected to get launched in the market during the study period 2018-2030. The analysis covers Glioblastoma Multiforme market uptake by drugs; patient uptake by therapies; and sales of each drug.
This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new glioblastoma multiforme drugs and allows the comparison of the drugs on the basis of market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.
Glioblastoma Multiforme Development Activities
The report provides insights into different therapeutic candidates in phase II, and phase III stage. It also analyzes Glioblastoma Multiforme companies involved in developing targeted therapeutics.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing and patent details for Glioblastoma Multiforme emerging therapies.
Competitive Intelligence Analysis
We perform competitive and market Intelligence analysis of the Glioblastoma Multiforme market by using various competitive intelligence tools that include–SWOT analysis, PESTLE analysis, Porter’s five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.
2019 to 2032
2023 to 2032
Glioblastoma Multiforme Market Size
Glioblastoma Multiforme Companies
|Genentech, Merck, Daiichi Sankyo, VBL Therapeutics, Diffusion Pharmaceuticals Bayer, MedImmune, DNAtrix, Chimerix, Karyopharm Therapeutics, VBI Vaccines, Kazia Therapeutics, Aivita Biomedical, Medicenna Therapeutics, Kintara Therapeutics, Laminar Pharmaceuticals, Immunomic Therapeutics, Inovio Pharmaceuticals, Treovir, Istari Oncology, and others|
Glioblastoma Multiforme Market Report Scope
- The report covers the descriptive overview of Glioblastoma Multiforme explaining its causes, signs and symptoms, pathogenesis and currently available therapies.
- Comprehensive insight has been provided into the Glioblastoma Multiforme epidemiology and treatment.
- Additionally, an all-inclusive account of both the current and emerging therapies for Glioblastoma Multiforme are provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.
- A detailed review of Glioblastoma Multiforme market; historical and forecasted is included in the report, covering the 7MM drug outreach.
- The Patient-Based Glioblastoma Multiforme Market Forecasting report provides an edge while developing business strategies, by understanding trends shaping and driving the 7MM Glioblastoma Multiforme market.
Glioblastoma Multiforme Market Report Highlights
- In the coming years, Glioblastoma Multiforme market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
- The Glioblastoma Multiforme companies and academics are working to assess challenges and seek opportunities that could influence Glioblastoma Multiforme R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.
- DelveInsight has analyzed type-specific data of Glioblastoma Multiforme according to which there are two main types of Glioblastoma: Primary (de novo) and Secondary Glioblastoma, where the majority of cases (> 90%) are primary Glioblastoma that develop rapidly de novo, without clinical or histological evidence of a less malignant precursor lesion.
- Diagnosed incidence according to histological classification of Glioblastoma Multiforme tumor was also assessed, which suggests that the conventional Glioblastoma Multiforme type is more prevalent than giant cell Glioblastoma Multiforme (GC-Glioblastoma Multiforme), and gliosarcoma (GS).
- In addition, gener-specific incidence of Glioblastoma Multiforme was also assessed. As per the analysis, Glioblastoma Multiforme is more prevalent in males than in females.
- The epidemiology segmentation also encompasses diagnosed incident population according to primary site of Glioblastoma. As per the DelveInsight estimates, it has been found that the primary site of Glioblastoma Multiforme included maximum cases at parietal site, while minimum number of cases were found in unknown and other sites. This trend is clearly evident across all the 7MM countries for the study period 2018-2030.
- The report also encompasses another major segment, i.e., Age-specific Diagnosed Incident Population of Glioblastoma Multiforme, wherein various age groups have been considered, such as <18, 18–34, 35–64, 65–74 and 75+. It has been found that Glioblastoma Multiforme incidence increases with age peaking at 75–84 years and drops after 85 years.
- Expected Launch of potential therapies may increase the market size in the coming years, assisted by an increase in the incident population of Glioblastoma Multiforme. The market is expected to witness a significant positive shift owing to the positive outcomes of the several products during the developmental stage by companies such as Bayer, Diffusion Pharmaceuticals, VBL Therapeutics, AstraZeneca, DNAtrix, Kintara Therapeutics, Chimerix, KaryoPharma, VBI Vaccines, Kazia Therapeutics, Aivita Biomedical, Medicenna Therapeutics, Immunomic Therapeutics, Treovir, Istari Oncology and Inovio Pharmaceuticals.
Glioblastoma Multiforme Market Report Insights
- Patient-Based Glioblastoma Multiforme Market Forecasting
- Therapeutic Approaches
- Glioblastoma Multiforme Pipeline Analysis
- Glioblastoma Multiforme Market Size and Trends
- Glioblastoma Multiforme Market Opportunities
- Impact of upcoming Therapies
Glioblastoma Multiforme Report Key Strengths
- 10 Years Forecast
- 7MM Coverage
- Glioblastoma Multiforme Epidemiology Segmentation
- Key Cross Competition
- Highly Analyzed Market
- Drugs Uptake
Glioblastoma Multiforme Report Assessment
- Current Treatment Practices
- Glioblastoma Multiforme Unmet Needs
- Glioblastoma Multiforme Pipeline Product Profiles
- Glioblastoma Multiforme Market Attractiveness
- Glioblastoma Multiforme Market Drivers
- Glioblastoma Multiforme Market Barriers
- What was the Glioblastoma Multiforme market share (%) distribution in 2019 and how it would look like in 2032?
- What would be the Glioblastoma Multiforme total market size as well as market size by therapies across the 7MM during the forecast period (2023-2032)?
- What are the key findings pertaining to the market across the 7MM and which country will have the largest Glioblastoma Multiforme market size during the forecast period (2023-2032)?
- At what CAGR, the Glioblastoma Multiforme market is expected to grow at the 7MM level during the forecast period (2023-2032)?
- What would be the Glioblastoma Multiforme market outlook across the 7MM during the forecast period (2023-2032)?
- What would be the Glioblastoma Multiforme market growth till 2030 and what will be the resultant market size in the year 2032?
- How would the market drivers, barriers and future opportunities affect the market dynamics and subsequent analysis of the associated trends?
- What is the disease risk, burden and Glioblastoma Multiforme unmet needs?
- What is the historical Glioblastoma Multiforme patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK) and Japan?
- What would be the forecasted patient pool of Glioblastoma Multiforme at the 7MM level?
- What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Glioblastoma Multiforme?
- Out of the above-mentioned countries, which country would have the highest incident population of Glioblastoma Multiforme during the forecast period (2021-2030)?
- At what CAGR the population is expected to grow across the 7MM during the forecast period (2021-2030)?
Current Treatment Scenario, Marketed Drugs and Emerging Therapies:
- What are the current options for the treatment of Glioblastoma Multiforme along with the approved therapy?
- What are the current treatment guidelines for the treatment of Glioblastoma Multiforme in the US and Europe?
- What are the Glioblastoma Multiforme marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety and efficacy, etc.?
- How many companies are developing therapies for the treatment of Glioblastoma Multiforme?
- How many therapies are developed by each company for the treatment of Glioblastoma Multiforme?
- How many emerging therapies are in the mid-stage and late stage of development for the treatment of Glioblastoma Multiforme?
- What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Glioblastoma Multiforme therapies?
- What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?
- What are the clinical studies going on for Glioblastoma Multiforme and their status?
- What are the key designations that have been granted for the emerging therapies for Glioblastoma Multiforme?
- What are the 7MM historical and forecasted market of Glioblastoma Multiforme?
Reasons to buy
- The Patient-Based Glioblastoma Multiforme Market Forecasting report will help in developing business strategies by understanding trends shaping and driving the Glioblastoma Multiforme.
- To understand the future market competition in the asprgillosis market and Insightful review of the key market drivers and barriers.
- Organize sales and marketing efforts by identifying the best opportunities for Glioblastoma Multiforme in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan.
- Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors.
- Organize sales and marketing efforts by identifying the best opportunities for Glioblastoma Multiforme market.
- To understand the future market competition in the Glioblastoma Multiforme market.