Non Small Cell Lung Cancer Market

DelveInsight’s ‘Non-Small Cell Lung Cancer (NSCLC) - Market Insights, Epidemiology and Market Forecast - 2030’ report delivers an in-depth understanding of the Non-Small Cell Lung Cancer, historical and forecasted epidemiology as well as the Non-Small Cell Lung Cancer market trends in the United States, EU5 (Germany, France, Italy, Spain, and United Kingdom), and Japan.


The Non-Small Cell Lung Cancer market report provides current treatment practices, emerging drugs, Non-Small Cell Lung Cancer market share of the individual therapies, current and forecasted Non-Small Cell Lung Cancer market size from 2017 to 2030 segmented by seven major markets. The Report also covers current Non-Small Cell Lung Cancer treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses underlying potential of the market.



Geography Covered

  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan


Study Period: 2017-2030


Non-Small Cell Lung Cancer Disease Understanding and Treatment Algorithm

Lung cancer mainly begins in the lungs, and it may spread to lymph nodes or other organs in the body, such as the brain. However, cancer from other organs may also spread to the lungs. When cancer cells spread from one organ to another, they are called metastases.


There are mainly two types of lung cancer Small cell lung cancer (SCLC) and Non-small cell lung cancer (NSCLC).

NSCLC is the most common type of lung cancer accounted for approximately 85% of all lung cancers (IASLC, n.d.). However, NSCLC metastasizes to other organs slower in comparison to SCLC, and microscopically, SCLC is composed of much smaller cells. If untreated, SCLC can be fatal in a few weeks, in contrast to most cases of NSCLC.


NSCLC can be defined as any type of epithelial lung cancer other than SCLC. It is mainly subcategorized into adenocarcinomas, squamous cell carcinomas, large cell carcinomas and several other types that occur less frequently include adenosquamous carcinomas, and sarcomatoid carcinomas.

In the United States, according to the data published by the Institute for Clinical and Economic Review (ICER) and the National Institutes of Health (NIH) out of the total lung cancer cases approximately 85% of lung cancers are NSCLC. Among those cases, squamous cell carcinoma comprised 30% cases, adenocarcinoma comprised of 40% cases, and large-cell carcinoma comprised 15% cases. Also, all other country based registries have mentioned almost same percentage for NSCLC and its major subtypes.


NSCLC can be located in the mid-chest, but it is often also found in other parts of the lung too. Even though NSCLCs are associated with cigarette smoking, adenocarcinomas may also be found in patients who have never smoked. Also, itis relatively insensitive to chemotherapy and radiation therapy in comparison with SCLC.


NSCLC arises from the epithelial cells of the lung of the central bronchi to terminal alveoli. The histological type of NSCLC correlates with the site of origin, reflecting the variation in respiratory tract epithelium of the bronchi to alveoli. While squamous cell carcinoma starts near a central bronchus usually, Adenocarcinoma and bronchioloalveolar carcinoma typically originate in peripheral lung tissue.


The symptoms of NSCLC and SCLC can be similar, which may include a persistent cough, chest pain, shortness of breath, wheezing, loss of appetite, weight loss, and unusual tiredness.


Although tobacco smoking is the major risk factor for either type of lung cancer, a substantial number of patients diagnosed with lung cancer have no prior history of smoking. Besides, exposure to passive smoking, asbestos, and radon may also increase the risk of developing lung cancer.

Patients of NSCLC with the resectable disease may be cured by surgery or surgery followed by chemotherapy. Local control can be achieved by radiation therapy in a large number of patients with unresectable disease. On the other hand, patients with the locally advanced unresectable disease may achieve long-term survival with radiation therapy combined with chemotherapy and the patients with advanced metastatic disease may achieve improved survival and palliation of symptoms with chemotherapy, targeted agents, and other supportive measures



Diagnosis 

The diagnosis and staging of NSCLC are often done at the same time. The tests and procedures used in the diagnosis of NSCLC are Physical exam and history, Laboratory tests, Chest X-ray, CT scan, Sputum cytology, Thoracentesis, Fine-needle aspiration (FNA) biopsy of the Lung, Bronchoscopy, Thoracoscopy, Mediastinoscopy, Anterior Mediastinotomy, Lymph node biopsy, Molecular test, Immunohistochemistry, among others.


Some of the tests that are used to diagnose NSCLC also determine the stage of the disease such as MRI (magnetic resonance imaging), CT scan, PET scan (positron emission tomography scan), bone scan, pulmonary function test (PFT), and bone marrow aspiration and biopsy. The staging system of NSCLC is divided into various stages such as Occult (hidden) cancer, Stage 0, Stage IA1, IA2, IA3, IB, IIA, IIB, IIIA, IIIB, IIIC, IVA, and IVB. 


Treatment 

There are different types of treatment available for NSCLC; however, mainly 10 types of standard treatment are used, which include: Surgery, Radiation therapy, Chemotherapy, Targeted therapy, Immunotherapy, Laser therapy, Photodynamic therapy (PDT), Cryosurgery, Electrocautery, and Watchful waiting.

Chemotherapy is used to stop the growth of cancer cells, either by killing the cells or by stopping their division. Targeted therapy is a type of treatment that uses drugs or other substances to attack specific cancer cells. These therapies usually cause less harm to normal cells than chemotherapy or radiation therapy. Monoclonal antibodies and tyrosine kinase inhibitors are the two main types of targeted therapy being used to treat advanced, metastatic, or recurrent NSCLC. Immunotherapy is a type of treatment that uses the patients’ immune system to fight cancer. Radiation therapy uses high-energy x-rays or other types of radiations to kill cancer cells or keep them from developing.


The therapies that are approved for the treatment of NSCLC are Rozlytrek (Entrectinib), Imfinzi (Durvalumab), Opdivo (Nivolumab), Tecentriq (Atezolizumab), Keytruda (Pembrolizumab), Tafinlar (Dabrafenib) in combination with Mekinist (Trametinib), Tagrisso (osimertinib), Lorbrena/Lorviqua (Lorlatinib), Vizimpro (Dacomitinib), Alunbrig (Brigatinib), Alecensa (Alectinib), Vitrakvi (Larotrectinib), Portrazza (Necitumumab), among others.


Non-Small Cell Lung Cancer Epidemiology  

The Non-Small Cell Lung Cancer epidemiology division provides the insights about historical and current Non-Small Cell Lung Cancer patient pool and forecasted trend for each seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the DelveInsight report also provides the diagnosed patient pool and their trends along with assumptions undertaken.


The disease epidemiology covered in the report provides historical as well as forecasted Non-Small Cell Lung Cancer epidemiology segmented as [Total Incident cases of NSCLC patients, Total Incident cases of NSCLC patients by Histology, Total Diagnosed cases of NSCLC patients by Stages, Total NSCLC cases of patients by Genetic mutation/Biomarkers, and Total Treated Cases of NSCLC patients by Line of Therapies] scenario of NSCLC in the 7MM covering the United States, EU5 countries (Germany, France, Italy , Spain, and United Kingdom), and Japan from 2017 to 2030. 


Key Findings

  • As per the DelveInsight analysis, the total incident cases of NSCLC in the 7MM were observed to be 484,726 cases in the year 2017. These cases are expected to grow with a significant CAGR in the study period 2017–2030.
  • As per the DelveInsight estimates, the total incident cases of NSCLC patients by histology in the 7MM were observed to be 142,566, 228,106, 57,027, and 57,027 cases of squamous cell carcinoma, adenocarcinoma, large cell carcinoma, and others in the year 2017. These cases are expected to grow with a significant CAGR in the study period 2017–2030.
  • As per the DelveInsight estimates, the total diagnosed cases of NSCLC patients by stages in the 7MM were observed to be 86,590, 31,552, 56,297, 65,410, and 244,876 cases of stage I, stage II, stage IIIA, stage IIIB, and stage IV in the year 2017.
  • As per the DelveInsight estimates, the total diagnosed cases of NSCLC patients by stages in Germany were observed to be 9,546, 4,658, 7,346, 11,392, and 23,177 cases of stage I, stage II, stage IIIA, stage IIIB, and stage IV in the year 2017. These cases are expected to grow with a significant CAGR in the study period 2017–2030.
  • As per the DelveInsight estimates, the total NSCLC cases of patients by genetic mutation/biomarkers in the United States were observed to be 89,597, 37,370, 50,393, 8,449, 12,665, 8,979, 7,202, and 2,136 cases of PD-L1, EGFR, KRAS, ALK, PI3KCA, BRAF, MET, and ROS-1 in the year 2017. These cases are expected to grow with a significant CAGR in the study period 2017–2030. 


Country Wise- Non-Small Cell Lung Cancer Epidemiology 

The epidemiology segment also provides the Non-Small Cell Lung Cancer epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan. 


Non-Small Cell Lung Cancer Drug Chapters

Drug chapter segment of the Non-Small Cell Lung Cancer report encloses the detailed analysis of Non-Small Cell Lung Cancer marketed drugs and late stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Non-Small Cell Lung Cancer clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases.


Non-Small Cell Lung Cancer Approved Drug


1. Rozlytrek (Entrectinib): Hoffmann-La Roche (Genentech)


2. Imfinzi (Durvalumab): AstraZeneca


3. Opdivo (Nivolumab): Bristol-Myers Squibb


4. Tecentriq (Atezolizumab): Hoffmann-La Roche


5. Keytruda (Pembrolizumab): Merck


6. Tafinlar (Dabrafenib) in combination with Mekinist (Trametinib): Novartis


7. Tagrisso (Osimertinib): AstraZeneca


8. Lorbrena/Lorviqua (Lorlatinib): Pfizer


9. Vizimpro (Dacomitinib): Pfizer


10. Alunbrig (Brigatinib): Takeda Pharmaceuticals

 

11. Alecensa (Alectinib): Hoffmann-La Roche


12. Vitrakvi (Larotrectinib): Bayer Healthcare


13. Portrazza (Necitumumab): Eli Lilly and Company


Note: Detailed Current therapies assessment will be provided in the full report of NSCLC


Non-Small Cell Lung Cancer Emerging Drugs 


1. Nazartinib/EGF816: Novartis Pharmaceuticals


2. Capmatinib/INC280: Novartis Pharmaceuticals


3. Telisotuzumab Vedotin: AbbVie


4. JNJ-61186372/JNJ-6372: Janssen Pharmaceuticals


5. Ensartinib/X-396: Xcovery


6. Selpercatinib (LY3527723/LOXO-292): Eli Lilly and Company


7. SAR408701: Sanofi


8. Braftovi/encorafinib + Mektovi/binimetinib: Pfizer


9. PADCEV (enfortumab vedotin/ASG-22ME): Astellas Pharma/Seattle Genetics


10. TAK-788: Takeda Pharmaceuticals


11. Canakinumab/(ACZ885): Novartis


12. BAVENCIO (Avelumab): Merck/Pfizer


13. Veliparib: AbbVie


14. Sitravatinib (MGCD516): Mirati Therapeutics/Bristol-Myers Squibb/Beigene


15. M7824: Merck/GlaxoSmithKline


16. AMG 510: Amgen


17. INCMGA00012 (MGA012): Incyte Corporation


18. Romiplostim: Amgen


19. TEPMETKO (tepotinib): Merck


Note: Detailed emerging therapies assessment will be provided in the final report.


Non-Small Cell Lung Cancer Market Outlook

There are several treatment options available to treat this condition in the seven major markets. Typically, chemotherapy, targeted treatments, and immunotherapy—alone or in combination—are used to treat lung cancer. Besides, pharmacological treatment choices, surgery, and radiation are also frequently opted. When the patient is in the initial stages, the tumor is usually resectable. Most stage I and stage II NSCLC are treated with surgery to remove the tumor.


To recommend a treatment option to a patient of NSCLC, several key factors are taken into consideration, such as age of the patient, previous medical history, health status, and smoking history. Along with these, another essential factor to consider is the stage of cancer at the time of diagnosis. Staging is usually carried out twice: after clinical and radiological examinations; and after surgery, in the case of the surgically resected tumor. Furthermore, biological testing of the tumor is also crucial to understand the presence of specific mutations.


The main choice of treatment for cancer, before the discovery of targeted therapies was chemotherapy. Chemotherapy works by disrupting the way that cancer cells grow and divide. However, these drugs can also affect normal cells. Chemotherapy can be given before or after surgery for NSCLC. Some people have chemotherapy at the same time as radiotherapy this is called chemoradiotherapy. Chemotherapy may be given to try to cure cancer or to prolong life and control symptoms (palliative care).


One of the most exciting developments in lung cancer medicine is the introduction of targeted treatments. Unlike chemotherapy drugs, which cannot tell the difference between normal cells and cancer cells, targeted therapies are designed to attack cancer cells specifically by attaching to or blocking targets that appear on the surfaces of those cells. People who have advanced lung cancer with certain molecular biomarkers may receive treatment with a targeted drug alone or in combination with chemotherapy.


As several institutes and pharmacological companies indulged themselves in a more in-depth understanding of this disease, therapies for advanced NSCLC have developed significantly with a new awareness of histologic subtypes. It is an important factor in guiding treatment and the development of targeted agents for molecular subgroups harboring critical mutations that spur on cancer growth.


Key Findings

According to DelveInsight, Non-Small Cell Lung Cancer market in the 7MM is expected to change in the study period 2017–2030. The total therapeutic market of Non-Small Cell Lung Cancer in seven major markets was found to be USD 9,730 million in 2017 which is expected to increase during the study period (2017–2030).


The United States Market Outlook

In 2017, the total market size of Non-Small Cell Lung Cancer for five mutation therapies i.e. PD-L1, EGFR, ALK, BRAF, C-MET was estimated to be USD 5,562.6 million in the United States which is expected to increase in the study period (2017–2030).


EU-5 Countries: Market Outlook


Germany

In 2017, the total market size of Non-Small Cell Lung Cancer for five mutation therapies i.e. PD-L1, EGFR, ALK, BRAF, C-MET was estimated to be USD 772.8 million in Germany which is expected to increase in the study period (2017–2030).


France

In 2017, the total market size of Non-Small Cell Lung Cancer for five mutation therapies i.e. PD-L1, EGFR, ALK, BRAF, C-MET was estimated to be USD 577.4 million in France which is expected to increase in the study period (2017–2030).


Italy

In 2017, the total market size of Non-Small Cell Lung Cancer for five mutation therapies i.e. PD-L1, EGFR, ALK, BRAF, C-MET was estimated to be USD 506 million in Italy which is expected to increase in the study period (2017–2030).


Spain

In 2017, the total market size of Non-Small Cell Lung Cancer for five mutation therapies i.e. PD-L1, EGFR, ALK, BRAF, C-MET was estimated to be USD 360 million in Spain which is expected to increase in the study period (2017–2030).


The United Kingdom

In 2017, the total market size of Non-Small Cell Lung Cancer for five mutation therapies i.e. PD-L1, EGFR, ALK, BRAF, C-MET was estimated to be USD 590.5 million in the United Kingdom which is expected to increase in the study period (2017–2030).


Japan Market Outlook 

In 2017, the total market size of Non-Small Cell Lung Cancer for five mutation therapies i.e. PD-L1, EGFR, ALK, BRAF, C-MET was estimated to be USD 1,360.4 million in Japan which is expected to increase in the study period (2017–2030).


Non-Small Cell Lung Cancer Drugs Uptake

According to the current scenario of NSCLC and our analysis majority of patients fall into two mutations i.e. PD-L1 and EGFR with major percentage share in the market.

  • The highest revenue is expected to be generated by Keytruda (pembrolizumab) by 2030.
  • The second-highest revenue is expected to be taken by Opdivo (nivolumab) because most of the companies are focused on targeting first line setting and also early stage, so due to its dominancy in second-line line setting it is expected to generate second-highest revenue in the overall market of PD-L1 NSCLC.
  • Imfinzi is expected to enjoy the monopoly in the market due to no visibility of the competitors till 2023.
  • Keytruda with physicians familiarities and established clinical profile expected to take more share compared to canakinumab.
  • Tagrisso is expected to be dominate the market because of it selectively inhibits EGFR-TKI-sensitizing and EGFR T790M resistance mutations, also its use as first-line therapy in NSCLC does not lead to T790M mutations.


Other therapies like JNJ-6372 and TAK-788 which are mainly targeting EGFR exon 20 insertion mutations are expected to generate good revenue in the coming years. 


Non-Small Cell Lung Cancer Pipeline Development Activities 

The drugs which are in pipeline include:

1. Nazartinib/EGF816: Novartis Pharmaceuticals

2. Capmatinib/INC280: Novartis Pharmaceuticals

3. Telisotuzumab Vedotin: AbbVie

4. JNJ-61186372/JNJ-6372: Janssen Pharmaceuticals

5. Ensartinib/X-396: Xcovery

6. Selpercatinib (LY3527723/LOXO-292): Eli Lilly and Company

7. SAR408701: Sanofi

8. Braftovi/encorafinib + Mektovi/binimetinib: Pfizer

9. PADCEV (enfortumab vedotin/ASG-22ME): Astellas Pharma/Seattle Genetics

10. TAK-788: Takeda Pharmaceuticals

11. Canakinumab/(ACZ885): Novartis

12. BAVENCIO (Avelumab): Merck/Pfizer

13. Veliparib: AbbVie

14. Sitravatinib (MGCD516): Mirati Therapeutics/Bristol-Myers Squibb/Beigene

15. M7824: Merck/GlaxoSmithKline

16. AMG 510: Amgen

17. INCMGA00012 (MGA012): Incyte Corporation

18. Romiplostim: Amgen

19. TEPMETKO (tepotinib): Merck

Note: Detailed emerging therapies assessment will be provided in the final report.



Reimbursement Scenario in Non-Small Cell Lung Cancer

The current scenario of therapeutics for NSCLC is mainly based on the use of targeted therapies and immunotherapy’s. Especially the current paradigm is mainly associated with treatment specific to mutations that occur in NSCLC. NSCLC is characterized by the availability of a high number of branded therapies such as Keytruda, Opdivo, Tecentriq, Tagrisso, and others. Due to the high costs, some of the therapies are not able to show their cost-effectiveness and are unable to get a recommendation by assessment agencies. So, the access and reimbursement scenario of drugs for NSCLC is not easy as cost-effectiveness is a major barrier for therapies in NSCLC.

The recommendation of some drugs by NICE which are approved for NSCLC are Opdivo (Nivolumab), Tagrisso (osimertinib), Alunbrig (brigatinib), Keytruda (pembrolizumab), Nintedanib in combination with docetaxel, Durvalumab, Atezolizumab with carboplatin and nab-paclitaxel, among others.


KOL- Views 

To keep up with current market trends, we take KOLs and SME's opinion working in Non-Small Cell Lung Cancer domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps to understand and validate current and emerging therapies treatment patterns or Non-Small Cell Lung Cancer market trend. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the market and the unmet needs. 


Competitive Intelligence Analysis 

We perform Competitive and Market Intelligence analysis of the Non-Small Cell Lung Cancer Market by using various Competitive Intelligence tools that include - SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies etc. The inclusion of the analysis entirely depends upon the data availability.


Scope of the Report

  • The report covers the descriptive overview of Non-Small Cell Lung Cancer, explaining its causes, signs and symptoms, pathophysiology, diagnosis and currently available therapies
  • Comprehensive insight has been provided into the Non-Small Cell Lung Cancer epidemiology and treatment in the 7MM
  • Additionally, an all-inclusive account of both the current and emerging therapies for Non-Small Cell Lung Cancer are provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape
  • A detailed review of Non-Small Cell Lung Cancer market; historical and forecasted is included in the report, covering drug outreach in the 7MM
  • The report provides an edge while developing business strategies, by understanding trends shaping and driving the global Non-Small Cell Lung Cancer market


Report Highlights

  • In the coming years, Non-Small Cell Lung Cancer market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market
  • The companies and academics are working to assess challenges and seek opportunities that could influence Non-Small Cell Lung Cancer R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition       
  • Major players are involved in developing therapies for Non-Small Cell Lung Cancer. Launch of emerging therapies will significantly impact the Non-Small Cell Lung Cancer market
  • A better understanding of disease pathogenesis will also contribute to the development of novel therapeutics for Non-Small Cell Lung Cancer
  • Our in-depth analysis of the pipeline assets across different stages of development (Phase III and Phase II), different emerging trends and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities


Non-Small Cell Lung Cancer Report Insights

  • Patient Population
  • Therapeutic Approaches
  • Non-Small Cell Lung Cancer Pipeline Analysis
  • Non-Small Cell Lung Cancer Market Size and Trends
  • Market Opportunities
  • Impact of upcoming Therapies


Non-Small Cell Lung Cancer Report Key Strengths

  • 11 Years Forecast
  • 7MM Coverage 
  • Non-Small Cell Lung Cancer Epidemiology Segmentation
  • Key Cross Competition 
  • Highly Analyzed Market
  • Drugs Uptake


Non-Small Cell Lung Cancer Report Assessment

  • Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • Market Drivers and Barriers


Key Questions

Market Insights:

  • What was the Non-Small Cell Lung Cancer share (%) distribution in 2017 and how it would look like in 2030?
  • What would be the Non-Small Cell Lung Cancer total market size as well as market size by therapies across the 7MM during the study period (2017–2030)?
  • What are the key findings pertaining to the market across the 7MM and which country will have the largest Non-Small Cell Lung Cancer market size during the study period (2017–2030)?
  • At what CAGR, the Non-Small Cell Lung Cancer market is expected to grow in the 7MM during the study period (2017–2030)?
  • What would be the Non-Small Cell Lung Cancer market outlook across the 7MM during the study period (2017–2030)?
  • What would be the Non-Small Cell Lung Cancer market growth till 2030 and what will be the resultant market size in the year 2030?
  • How would the market drivers, barriers and future opportunities affect the market dynamics and a subsequent analysis of the associated trends?
  • Non-Small Cell Lung Cancer patient types/pool where unmet need is more and whether emerging therapies will be able to address the residual unmet need?
  • How emerging therapies are performing on the parameters like efficacy, safety, route of administration (RoA), treatment duration and frequencies on the basis of their clinical trial results?
  • Among the emerging therapies, what are the potential therapies which are expected to disrupt the Non-Small Cell Lung Cancer market? And how the development of immunotherapy will impact the therapeutic market of Non-Small Cell Lung Cancer ?

Epidemiology Insights:

  • What is the historical Non-Small Cell Lung Cancer patient pool in the 7MM covering the United States, EU5 (Germany, Spain, France, Italy, the United Kingdom) and Japan?
  • What would be the forecasted patient pool of Non-Small Cell Lung Cancer in the 7MM covering the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan?
  • What will be the growth opportunities in the 7MM with respect to the patient population pertaining to Non-Small Cell Lung Cancer?
  • Out of all the 7MM countries, which country would have the highest incident population of Non-Small Cell Lung Cancer during the study period (2017–2030)?
  • At what CAGR the population is expected to grow in the 7MM during the study period (2017–2030)?
  • What are the various recent and upcoming events which are expected to improve the diagnosis of Non-Small Cell Lung Cancer?
  • What are the different types of specific segment cases (Stages, Histology, Genetic mutations/Biomarkers) in Non-Small Cell Lung Cancer ? And among them, which are more prominent in Non-Small Cell Lung Cancer patients?

Current Treatment Scenario, Marketed Drugs and Emerging Therapies:

  • What are the current options for the Non-Small Cell Lung Cancer treatment, along with the approved therapy?
  • What are the current treatment guidelines for the treatment of Non-Small Cell Lung Cancer in the USA, Europe, and Japan?
  • What are the Non-Small Cell Lung Cancer marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety and efficacy, etc.?
  • How many companies are developing therapies for the treatment of Non-Small Cell Lung Cancer?
  • How many therapies are developed by each company for Non-Small Cell Lung Cancer treatment?
  • How many are emerging therapies in mid-stage, and late stage of development for Non-Small Cell Lung Cancer treatment?
  • What are the key collaborations (Industry - Industry, Industry - Academia), Mergers and acquisitions, licensing activities related to the Non-Small Cell Lung Cancer therapies? 
  • What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies? 
  • What are the clinical studies going on for Non-Small Cell Lung Cancer and their status?
  • What are the key designations that have been granted for the emerging therapies for Non-Small Cell Lung Cancer?
  • What are the global historical and forecasted market of Non-Small Cell Lung Cancer?


Reasons to buy

  • The report will help in developing business strategies by understanding trends shaping and driving the Non-Small Cell Lung Cancer market
  • To understand the future market competition in the Non-Small Cell Lung Cancer market and Insightful review of the key market drivers and barriers
  • Organize sales and marketing efforts by identifying the best opportunities for Non-Small Cell Lung Cancer in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan
  • Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors
  • Organize sales and marketing efforts by identifying the best opportunities for Non-Small Cell Lung Cancer market
  • To understand the future market competition in the Non-Small Cell Lung Cancer market

1.   Key Insights

2.   Executive Summary of NSCLC

3.   SWOT Analysis of NSCLC

4.   NSCLC: Market Overview at a Glance

4.1.  Total Market Share (%) Distribution of NSCLC in 2017: By Country

4.2.  Total Market Share (%) Distribution of NSCLC in 2030: By Country

4.3.  Total Market Share (%) Distribution of NSCLC in 2017: By Mutations/ biomarkers

4.4.  Total Market Share (%) Distribution of NSCLC in 2030: By Mutations/ biomarkers

4.5.  NSCLC Revenue Summary by Mutations/ biomarkers

5.   Non-small Cell Lung Cancer (NSCLC): Disease Background and Overview

5.1.  Introduction

5.1.1. Cellular Classification of NSCLC

5.1.2. Signs and Symptoms of NSCLC

5.1.3. Risk Factors of Lung Cancer

5.1.4. Causes of NSCLC

5.1.5. Disease Biology: NSCLC

6.   Diagnosis of NSCLC

6.1.  Diagnostic Algorithm for NSCLC

6.2.  Stages of NSCLC

6.3.  Staging System

7.   Epidemiology and Patient Population

7.1.  Epidemiology Key Findings

7.2.  Assumptions and Rationale: 7MM

7.3.  Epidemiology Scenario: 7MM

7.3.1. Total Incident cases of NSCLC patients in the 7MM

7.3.2. Total Incident cases of NSCLC patients by Histology in the 7MM

7.3.3. Total Diagnosed cases of NSCLC patients by Stages in the 7MM

7.4. The United States Epidemiology

7.4.1. Total Incident cases of NSCLC patients in the United States

7.4.2. Total Incident cases of NSCLC patients by Histology in the United States

7.4.3. Total Diagnosed cases of NSCLC patients by Stages in the United States

7.4.4. Total NSCLC cases of patients by Genetic mutation/Biomarkers in the United States

8.   EU-5 Epidemiology

8.1.  Germany

8.1.1. Total Incident cases of NSCLC patients in Germany

8.1.2. Total Incident cases of NSCLC patients by Histology in Germany

8.1.3. Total Diagnosed cases of NSCLC patients by Stages in Germany

8.1.4. Total NSCLC cases of patients by Genetic mutation/Biomarkers in Germany

8.2.  France

8.2.1. Total Incident cases of NSCLC patients in France

8.2.2. Total Incident cases of NSCLC patients by Histology in France

8.2.3. Total Diagnosed cases of NSCLC patients by Stages in France

8.2.4. Total NSCLC cases of patients by Genetic mutation/Biomarkers in France

8.3.  Italy

8.3.1. Total Incident cases of NSCLC patients in Italy

8.3.2. Total Incident cases of NSCLC patients by Histology in Italy

8.3.3. Total Diagnosed cases of NSCLC patients by Stages in Italy

8.3.4. Total NSCLC cases of patients by Genetic mutation/Biomarkers in Italy

8.4.  Spain

8.4.1. Total Incident cases of NSCLC patients in Spain

8.4.2. Total Incident cases of NSCLC patients by Histology in Spain

8.4.3. Total Diagnosed cases of NSCLC patients by Stages in Spain

8.4.4. Total NSCLC cases of patients by Genetic mutation/Biomarkers in Spain

8.5.  The United Kingdom

8.5.1. Total Incident cases of NSCLC patients in the United Kingdom

8.5.2. Total Incident cases of NSCLC patients by Histology in the United Kingdom

8.5.3. Total Diagnosed cases of NSCLC patients by Stages in the United Kingdom

8.5.4. Total NSCLC cases of patients by Genetic mutation/Biomarkers in the United Kingdom

9.   Japan Epidemiology

9.1.  Japan

9.1.1. Total Incident cases of NSCLC patients in Japan

9.1.2. Total Incident cases of NSCLC patients by Histology in Japan

9.1.3. Total Diagnosed cases of NSCLC patients by Stages in Japan

9.1.4. Total NSCLC cases of patients by Genetic mutation/Biomarkers in Japan

10. Current Treatment Practices: NSCLC

10.1.  Advanced/Metastatic NSCLC Treatment Algorithm

10.2.  Chemotherapy

10.3.  Targeted Therapy

10.4.  Immunotherapy

10.5.  Surgery

10.6.  Radiation Therapy

10.7.  Stage-wise Treatment Options of NSCLC

11. Guideline of NSCLC

11.1.  The National Comprehensive Cancer Network (NCCN) Clinical Guidelines: 2020

11.2.  The European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for Diagnosis, Treatment, and Follow-up

11.3.  The Spanish Society of Medical Oncology (SEOM) Clinical Guidelines: 2018

11.4.  The Japanese Lung Cancer Society Guideline for NSCLC, Stage IV: 2018

12. Unmet Needs of NSCLC

13. Key Endpoints in NSCLC Clinical Trials

14. Marketed Therapies

14.1. Key Cross

14.2. Rozlytrek (Entrectinib): Hoffmann-La Roche (Genentech)

14.2.1. Product Description

14.2.2. Regulatory Milestones

14.2.3. Other Developmental Activities

14.2.4. Pivotal Clinical Trials

14.2.5. Ongoing Current Pipeline Activity

14.3. Imfinzi (Durvalumab): AstraZeneca

14.3.1. Product Description

14.3.2. Regulatory Milestones

14.3.3. Other Developmental Activities

14.3.4. Pivotal Clinical Trials

14.3.5. Ongoing Current Pipeline Activity

14.3.6. Safety and Efficacy of Ongoing Clinical Trials

14.4. Opdivo (Nivolumab): Bristol-Myers Squibb

14.4.1. Product Description

14.4.2. Regulatory Milestones

14.4.3. Other Developmental Activities

14.4.4. Pivotal Clinical Trials

14.4.5. Ongoing Current Pipeline Activity

14.5. Tecentriq (Atezolizumab): Genentech/Hoffmann-La Roche

14.5.1. Product Description

14.5.2. Regulatory Milestones

14.5.3. Other Developmental Activities

14.5.4. Pivotal Clinical Trials

14.5.5. Ongoing Current Pipeline Activity

14.6. Keytruda (Pembrolizumab): Merck

14.6.1. Product Description

14.6.2. Regulatory Milestones

14.6.3. Other Developmental Activities

14.6.4. Pivotal Clinical Trials

14.6.5. Ongoing Current Pipeline Activity

14.7. Tafinlar(Dabrafenib)in Combination with Mekinist(Trametinib): Novartis

14.7.1. Product Description

14.7.2. Regulatory Milestones

14.7.3. Other Developmental Activities

14.7.4. Pivotal Clinical Trials

14.8. Tagrisso(Osimertinib): AstraZeneca

14.8.1. Product Description

14.8.2. Regulatory Milestones

14.8.3. Other Developmental Activities

14.8.4. Pivotal Clinical Trials

14.8.5. Ongoing Current Pipeline Activity

14.9. Lorbrena/Lorviqua (Lorlatinib): Pfizer

14.9.1. Product Description

14.9.2. Regulatory Milestones

14.9.3. Other Developmental Activities

14.9.4. Pivotal Clinical Trials

14.9.5. Ongoing Current Pipeline Activity

14.10. Vizimpro(Dacomitinib): Pfizer

14.10.1. Product Description

14.10.2. Regulatory Milestones

14.10.3. Other Developmental Activities

14.10.4. Pivotal Clinical Trials

14.10.5. Ongoing Current Pipeline Activity

14.11. Alunbrig (Brigatinib): Takeda Pharmaceuticals

14.11.1. Product Description

14.11.2. Regulatory Milestones

14.11.3. Pivotal Clinical Trials

14.11.4. Ongoing Current Pipeline Activity

14.11.5. Safety and Efficacy of Ongoing Clinical Trials

14.12. Alecensa (Alectinib): Hoffmann-La Roche

14.12.1. Product Description

14.12.2. Regulatory Milestones

14.12.3. Other Developmental Activities

14.12.4. Pivotal Clinical Trials

14.12.5. Ongoing Current Pipeline Activity

14.13. Vitrakvi (Larotrectinib): Bayer Healthcare

14.13.1. Product Description

14.13.2. Regulatory Milestones

14.13.3. Other Developmental Activities

14.13.4. Pivotal Clinical Trials

14.13.5. Safety and Efficacy

14.14. Portrazza (Necitumumab): Eli Lilly

14.14.1. Product Description

14.14.2. Regulatory Milestones

14.14.3. Other Developmental Activities

14.14.4.  Pivotal Clinical Trials

14.14.5.  Ongoing Current Pipeline Activity

15. Emerging Therapies

15.1. Nazartinib (EGF816): Novartis Pharmaceuticals

15.1.1. Product Description

15.1.2. Clinical Development

15.1.3. Safety and Efficacy

15.2. Capmatinib (INC280): Novartis Pharmaceuticals

15.2.1. Product Description

15.2.2. Other Development Activities

15.2.3. Clinical Development

15.2.4. Safety and Efficacy

15.3. Tepmetko (tepotinib): Merck KGaA

15.3.1. Product Description

15.3.2. Other Development Activities

15.3.3. Clinical Development

15.3.4. Safety and Efficacy

15.4. Merestinib: Eli Lilly and Company

15.4.1. Product Description

15.4.2. Clinical Development

15.4.3. Telisotuzumab Vedotin: AbbVie

15.4.4. Product Description

15.4.5. Clinical Development

15.4.6. Safety and Efficacy

15.5. JNJ-61186372 (JNJ-6372): Janssen Research & Development

15.5.1. Product Description

15.5.2. Other Development Activity

15.5.3. Clinical Development

15.5.4. Safety and Efficacy

15.6. Lazertinib: Yuhan Corporation/ Janssen Research & Development

15.6.1. Product Description

15.6.2. Clinical Development

15.6.3. Safety and Efficacy

15.7. Vemurafenib Plus Cobimetinib: Hoffmann-La Roche

15.7.1. Product Description

15.7.2. Clinical Development

15.7.3. Safety and Efficacy

15.8. X-396 (Ensartinib): Xcovery

15.8.1. Product Description

15.8.2. Clinical Development

15.8.3. Safety and Efficacy

15.9. Plinabulin: BeyondSpring Pharmaceuticals

15.9.1. Product Description

15.9.2. Clinical Development

15.9.3. Safety and Efficacy

15.10. (OSE2101): OSE Immunotherapeutics

15.10.1. Description

15.10.2. Development

15.10.3  Safety and Efficacy

15.11. Selpercatinib (LY3527723/ LOXO-292): Eli Lilly and Company

15.11.1. Product Description

15.11.2. Clinical Development

15.11.3. Safety and Efficacy

15.12. SAR408701: Sanofi

15.12.1. Product Description

15.12.2. Clinical Development

15.13. Braftovi (encorafinib) + Mektovi (binimetinib): Pfizer

15.13.1. Product Description

15.13.2. Clinical Development

15.14. PADCEV (enfortumab vedotin/ASG-22ME): Astellas Pharma/Seattle Genetics

15.14.1. Product Description

15.14.2. Clinical Development

15.15. Pralsetinib (BLU-667): Blueprint Medicines Corporation

15.15.1. Product Description

15.15.2. Clinical Development

15.15.3. Safety and Efficacy

15.16.TAK-788: Takeda

15.16.1. Product Description

15.16.2. Clinical Development

15.16.3. Safety and Efficacy

15.17. Canakinumab (ACZ885): Novartis Pharmaceuticals

15.17.1. Product Description

15.17.2. Clinical Development

15.18. Avelumab (Bavencio): Merck KGaA and Pfizer

15.18.1. Product Description

15.18.2. Clinical Development

15.18.3. Safety and Efficacy

15.19. Veliparib (ABT-888): AbbVie

15.19.1.Product Description

15.19.2.Clinical Development

15.19.3. Safety and Efficacy

15.20. Sitravatinib (MGCD516): Mirati Therapeutics/Bristol-Myers Squibb/Beigene

15.20.1. Product Description

15.20.2. Other Developmental Activities

15.20.3. Clinical Development

15.20.4. Safety and Efficacy

15.21. Tesevatinib: Kadmon Corporation

15.21.1. Product Description

15.21.2. Clinical Development

15.21.3. Safety and Efficacy

15.22. Romiplostim: Amgen

15.22.1. Product Description

15.22.2. Clinical Development

15.23. Cabozantinib: Exelixis/Ipsen/Takeda

15.23.1. Product Description

15.23.2. Other Development Activities

15.23.3. Clinical Development

15.23.4. Safety and Efficacy

15.24. Sym015: Symphogen

15.24.1. Product Description

15.24.2. Clinical Development

15.24.3. Safety and Efficacy

15.25. AMG 510: Amgen

15.25.1. Product Description

15.25.2. Clinical Development

15.25.3. Safety and Efficacy

15.26. INCMGA00012 (MGA012): Incyte Corporation/ Zai Lab Limited

15.26.1. Product Description

15.26.2. Clinical Development

15.27. Libtayo (Cemiplimab): Regeneron Pharmaceuticals

15.27.1. Product Description

15.27.2. Clinical Development

15.27.3. Safety and Efficacy

15.28. Bavituximab: Peregrine Pharmaceuticals/ Avid Bioservices, Inc

15.28.1. Product Description

15.28.2. Clinical Development

15.28.3. Safety and Efficacy

15.29. M7824 (Bintrafusp alfa): GlaxoSmithKline/Merck KGaA

15.29.1. Product Description

15.29.2. Clinical Development

15.29.3. Safety and Efficacy

16. Non-Small Cell Lung Cancer (NSCLC): Seven Major Market Analysis

16.1. Key Findings

16.2. Market Outlook: 7MM

17. PD-L1—Market Size

17.1. Total Market Size of PD-L1 NSCLC in the 7MM

17.2. Market Size of PD-L1 NSCLC by Therapeutic Class in the 7MM

17.3. United States Market Size

17.3.1. Total Market size of PD-L1 NSCLC in the United States

17.4. EU-5 Market Size

17.4.1. Germany Market Size

17.4.2. France Market Size

17.4.3. Italy Market Size

17.4.4. Spain Market Size

17.4.5. United Kingdom Market Size

17.5. Japan Market Size

17.5.1. Total Market size of PD-L1 NSCLC in Japan

18. BRAF Mutation—Market Size

18.1. Total Market Size of BRAF NSCLC in the 7MM

18.2. Market Size of BRAF-NSCLC by Therapeutic Class in the 7MM

18.3. United States Market Size

18.3.1. Total Market size of BRAF NSCLC in the United States

18.4. EU-5 Market Size

18.4.1. Germany Market Size

18.4.2. France Market Size

18.4.3. Italy Market Size

18.4.4. Spain Market Size

18.4.5. United Kingdom Market Size

18.5. Japan Market Size

18.5.1. Total Market size of BRAF NSCLC in Japan

19. c-MET Mutation—Market Size

19.1. Total Market Size of c-MET NSCLC in the 7MM

19.2. Market Size of c-MET NSCLC by Therapeutic Class in the 7MM

19.3. United States Market Size

19.3.1. Total Market size of c-MET NSCLC in the United States

19.4. EU-5 Market Size

19.4.1. Germany Market Size

19.4.2. France Market Size

19.4.3. Italy Market Size

19.4.4. Spain Market Size

19.4.5. United Kingdom Market Size

19.5. Japan Market Size

19.5.1. Total Market size of c-MET NSCLC in Japan

20. EGFR Mutation—Market Size

20.1. Total Market Size of EGFR-positive NSCLC in the 7MM

20.2. Market Size of EGFR-positive NSCLC by Therapeutic Class in the 7MM

20.3. United States Market Size

20.3.1. Total Market size of EGFR NSCLC in the United States

20.4. EU-5 Market Size

20.4.1. Germany Market Size

20.4.2. France Market Size

20.4.3. Italy Market Size

20.4.4. Spain Market Size

20.4.5. United Kingdom Market Size

20.5. Japan Market Size

20.5.1. Total Market size of NSCLC in Japan

21. ALK-Mutation—Market Size

21.1. Total Market Size of ALK NSCLC in the 7MM

21.2. Market Size of ALK NSCLC by Therapeutic Class in the 7MM

21.3. United States Market Size

21.3.1. Total Market size of ALK NSCLC in the United States

21.4. EU-5 Market Size

21.4.1. Germany Market Size

21.4.2. France Market Size

21.4.3. Italy Market Size

21.4.4. Spain Market Size

21.4.5. United Kingdom Market Size

21.5. Japan Market Size

21.5.1. Total Market size of NSCLC in Japan

22. Market Access and Reimbursement of NSCLC Therapies

23. Market Drivers of NSCLC

24. Market Barriers of NSCLC

25. Appendix

25.1. Bibliography

25.2. Report Methodology

26. DelveInsight Capabilities

27. Disclaimer

28. About DelveInsight

Table 1: Summary of Non-small-cell Lung Cancer (NSCLC) Market, Epidemiology, and Key Events (2017–2030)

Table 2: TNM Staging of NSCLC

Table 3: Total Incident cases of NSCLC patients in the 7MM (2017–2030)

Table 4: Total Incident cases of NSCLC patients by Histology in the 7MM (2017–2030)

Table 5: Total Diagnosed cases of NSCLC patients by Stages in the 7MM (2017–2030)

Table 6: Total Incident cases of NSCLC patients in the United States (2017–2030)

Table 7: Total Incident cases of NSCLC patients by Histology in the United States (2017–2030)

Table 8: Total Diagnosed cases of NSCLC patients by Stages in the United States (2017–2030)

Table 9: Total NSCLC cases of patients by Genetic mutation/Biomarkers in the United States (2017–2030)

Table 10: Total Incident cases of NSCLC patients in Germany (2017–2030)

Table 11: Total Incident cases of NSCLC patients by Histology in Germany (2017–2030)

Table 12: Total Diagnosed cases of NSCLC patients by Stages in Germany (2017–2030)

Table 13: Total NSCLC cases of patients by Genetic mutation/Biomarkers in Germany (2017–2030)

Table 14: Total Incident cases of NSCLC patients in France (2017–2030)

Table 15: Total Incident cases of NSCLC patients by Histology in France (2017–2030)

Table 16: Total Diagnosed cases of NSCLC patients by Stages in France (2017–2030)

Table 17: Total NSCLC cases of patients by Genetic mutation/Biomarkers in France (2017–2030)

Table 18: Total Incident cases of NSCLC patients in Italy (2017–2030)

Table 19: Total Incident cases of NSCLC patients by Histology in Italy (2017–2030)

Table 20: Total Diagnosed cases of NSCLC patients by Stages in Italy (2017–2030)

Table 21: Total NSCLC cases of patients by Genetic mutation/Biomarkers in Italy (2017–2030)

Table 22: Total Incident cases of NSCLC patients in Spain (2017–2030)

Table 23: Total Incident cases of NSCLC patients by Histology in Spain (2017–2030)

Table 24: Total Diagnosed cases of NSCLC patients by Stages in Spain (2017–2030)

Table 25: Total NSCLC cases of patients by Genetic mutation/Biomarkers in Spain (2017–2030)

Table 26: Total Incident cases of NSCLC patients in the United Kingdom (2017–2030)

Table 27: Total Incident cases of NSCLC patients by Histology in the United Kingdom (2017–2030)

Table 28: Total Diagnosed cases of NSCLC patients by Stages in the United Kingdom (2017–2030)

Table 29: Total NSCLC cases of patients by Genetic mutation/Biomarkers in the United Kingdom (2017–2030)

Table 30: Total Incident cases of NSCLC patients in Japan (2017–2030)

Table 31: Total Incident cases of NSCLC patients by Histology in Japan (2017–2030)

Table 32: Total Diagnosed cases of NSCLC patients by Stages in Japan (2017–2030)

Table 33: Total NSCLC cases of patients by Genetic mutation/Biomarkers in Japan (2017–2030

Table 34: Standard Treatment Options of NSCLC (Stage-wise)

Table 35: Summary of Recommendations (SEOM Clinical Guideline)

Table 36: Strength of Evidence

Table 37: Strength of Evidence

Table 38: Marketed Drugs Key Cross

Table 39:Rozlytrek (Entrectinib), Clinical Trial Description, 2020

Table 40:Imfinzi (Durvalumab), Clinical Trial Description, 2020

Table 41:Opdivo (Nivolumab), Clinical Trial Description, 2020

Table 42:Tecentriq (Atezolizumab), Clinical Trial Description, 2020

Table 43:Keytruda (Pembrolizumab), Clinical Trial Description, 2020

Table 44:Tagrisso (Osimertinib), Clinical Trial Description, 2020

Table 45:Lorbrena (Lorlatinib), Clinical Trial Description, 2020

Table 46:Vizimpro (Dacomitinib), Clinical Trial Description, 2020Table 47:Alunbrig (Brigatinib), Clinical Trial Description, 2020

Table 48:Alecensa (Alectinib), Clinical Trial Description, 2020

Table 49:Portrazza (Necitumumab), Clinical Trial Description, 2020

Table 50: Nazartinib (EGF816), Clinical Trial Description, 2020

Table 51: Capmatinib (INC280), Clinical Trial Description, 2020

Table 52: Tepotinib, Clinical Trial Description, 2020

Table 53: Merestinib, Clinical Trial Description, 2020

Table 54: Telisotuzumab Vedotin (ABBV-399), Clinical Trial Description, 2020

Table 55: JNJ-61186372 (JNJ-6372), Clinical Trial Description, 2020

Table 56: Lazertinib (YH25448), Clinical Trial Description, 2020

Table 57: Vemurafenib Plus Cobimetinib, Clinical Trial Description, 2020

Table 58: X-396 (Ensartinib), Clinical Trial Description, 2020

Table 59: Plinabulin, Clinical Trial Description, 2020

Table 60: Tedopi (OSE2101), Clinical Trial Description, 2020

Table 61: Selpercatinib (LY3527723/ LOXO-292), Clinical Trial Description, 2020

Table 62: SAR408701, Clinical Trial Description, 2020

Table 63: Braftovi (encorafinib) + Mektovi (binimetinib), Clinical Trial Description, 2020

Table 64: Enfortumab vedotin, Clinical Trial Description, 2020

Table 65: Pralsetinib, Clinical Trial Description, 2020

Table 66: TAK-788, Clinical Trial Description, 2020

Table 67: Canakinumab (ACZ885), Clinical Trial Description, 2020

Table 68: Avelumab, Clinical Trial Description, 2020

Table 69: Veliparib (ABT-888), Clinical Trial Description, 2020

Table 70: Sitravatinib (MGCD516), Clinical Trial Description, 2020

Table 71: Tesevatinib, Clinical Trial Description, 2020

Table 72: Romiplostim, Clinical Trial Description, 2020

Table 73: Cabozantinib (XL184), Clinical Trial Description, 2020

Table 74: Sym015, Clinical Trial Description, 2020

Table 75: AMG 510, Clinical Trial Description, 2020

Table 76: Libtayo (cemiplimab) Clinical Trial Description, 2020

Table 77: AMG 510, Clinical Trial Description, 2020

Table 78: M7824 (Bintrafusp alfa), Clinical Trial Description, 2020

Table 79: 7MM Market Size of PD-L1 NSCLC, in USD Million (2017–2030)

Table 80: 7MM Market Size of PD-L1 NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 81: 7MM Market Size ofPD-L1 NSCLC by therapies, in USD Million (2017–2030)

Table 82: United States Market Size ofPD-L1 NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 83: United States Market Size ofPD-L1 NSCLC by therapies, in USD Million (2017–2030)

Table 84: Germany Market Size of PD-L1 NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 85: Germany Market Size of PD-L1 NSCLC by therapies, in USD Million (2017–2030)

Table 86: France Market Size ofPD-L1 NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 87: France Market Size ofPD-L1 NSCLC by therapies, in USD Million (2017–2030)

Table 88: Italy Market Size ofPD-L1 NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 89: Italy Market Size ofPD-L1 NSCLC by therapies, in USD Million (2017–2030)

Table 90: Spain Market Size ofPD-L1 NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 91: Spain Market Size of PD-L1 NSCLC by therapies, in USD Million (2017–2030)

Table 92: United Kingdom Market Size of PD-L1 NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 93: United Kingdom Market Size of PD-L1 NSCLC by therapies, in USD Million (2017–2030)

Table 94: Japan Market Size of PD-L1 NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 95: Japan Market Size ofPD-L1 NSCLC by therapies, in USD Million (2017–2030)

Table 96: 7MM Market Size of BRAF NSCLC in USD Million (2017–2030)

Table 97: 7MM Market Size of BRAF NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 98: 7MM Market Size of BRAF NSCLC by therapies, in USD Million (2017–2030)

Table 99: United States Market Size of BRAF NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 100: United States Market Size of BRAF NSCLC by Therapies, in USD Million (2017–2030)

Table 101: Germany Market Size of BRAF NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 102: Germany Market Size of BRAF NSCLC by Therapies, in USD Million (2017–2030)

Table 103: France Market Size of BRAF NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 104: France Market Size of BRAF NSCLC by Therapies, in USD Million (2017–2030)

Table 105: Italy Market Size of BRAF NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 106: Italy Market Size ofBRAF NSCLC by Therapies, in USD Million (2017–2030)

Table 107: Spain Market Size of BRAF NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 108: Spain Market Size of BRAF NSCLC by Therapies, in USD Million (2017–2030)

Table 109: United Kingdom Market Size of BRAF NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 110: United Kingdom Market Size of BRAF NSCLC by Therapies, in USD Million (2017–2030)

Table 111: Japan Market Size of BRAF NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 112: Japan Market Size of BRAF NSCLC by Therapies, in USD Million (2017–2030)

Table 113: 7MM Market Size of c-MET NSCLC, in USD Million (2017–2030)

Table 114: 7MM Market Size of c-MET NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 115: 7MM Market Size of c-MET NSCLC by therapies, in USD Million (2017–2030)

Table 116: United States Market Size of c-MET NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 117: United States Market Size of c-MET NSCLC by Therapies, in USD Million (2017–2030)

Table 118: Germany Market Size of c-MET NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 119: Germany Market Size of c-MET NSCLC by Therapies, in USD Million (2017–2030)

Table 120: France Market Size ofc-MET NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 121: France Market Size of c-MET NSCLC by Therapies, in USD Million (2017–2030)

Table 122: Italy Market Size of c-MET NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 123: Italy Market Size of c-MET NSCLC by Therapies, in USD Million (2017–2030)

Table 124: Spain Market Size of c-MET NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 125: Spain Market Size of c-MET NSCLC by Therapies, in USD Million (2017–2030)

Table 126: United Kingdom Market Size of c-MET NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 127: United Kingdom Market Size of c-MET NSCLC by Therapies, in USD Million (2017–2030)

Table 128: Japan Market Size of c-MET NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 129: Japan Market Size ofc-MET NSCLC by Therapies, in USD Million (2017–2030)

Table 130: 7MM Market Size of EGFR-positive NSCLC, in USD Million (2017–2030)

Table 131: 7MM Market Size of EGFR-positive NSCLC By Line of Therapy in USD Million (2017–2030)

Table 132: 7MM Market Size of EGFR-positive NSCLC by therapies in USD Million (2017–2030)

Table 133: United States Market Size of EGFR-positive NSCLC By Line of Therapy in USD Million (2017–2030)

Table 134: United States Market Size of EGFR-positive NSCLC by Therapies in USD Million (2017–2030)

Table 135: Germany Market Size of EGFR-positive NSCLC By Line of Therapy in USD Million (2017–2030)

Table 136: Germany Market Size of EGFR-positive NSCLC by Therapies in USD Million (2017–2030)

Table 137: France Market Size of EGFR-positive NSCLC By Line of Therapy in USD Million (2017–2030)

Table 138: France Market Size of EGFR-positive NSCLC by Therapies in USD Million (2017–2030)

Table 139: Italy Market Size of EGFR-positive NSCLC By Line of Therapy in USD Million (2017–2030)

Table 140: Italy Market Size of EGFR-positive NSCLC by Therapies in USD Million (2017–2030)

Table 141: Spain Market Size of EGFR-positive NSCLC By Line of Therapy in USD Million (2017–2030)

Table 142: Spain Market Size of EGFR-positive NSCLC by Therapies in USD Million (2017–2030)

Table 143: United Kingdom Market Size of EGFR-positive NSCLC By Line of Therapy in USD Million (2017–2030)

Table 144: United Kingdom Market Size of EGFR-positive NSCLC by Therapies in USD Million (2017–2030)

Table 145: Japan Market Size of EGFR-positive NSCLC By Line of Therapy in USD Million (2017–2030)

Table 146: Japan Market Size of EGFR-positive NSCLC by Therapies in USD Million (2017–2030)

Table 147: 7MM Market Size of ALK NSCLC, in USD Million (2017–2030)

Table 148: 7MM Market Size of ALK NSCLC By Line of Therapy, in USD Million (2017–2030)

Table 149: 7MM Market Size of ALK NSCLC by therapies, in USD Million (2017–2030)

Table 150: United States Market Size of ALK NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 151: United States Market Size of ALK NSCLC by Therapies, in USD Million (2017–2030)

Table 152: Germany Market Size of ALK NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 153: Germany Market Size of ALK NSCLC by Therapies, in USD Million (2017–2030)

Table 154: France Market Size of ALK NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 155: France Market Size of ALK NSCLC by Therapies, in USD Million (2017–2030)

Table 156: Italy Market Size of ALK NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 157: Italy Market Size of ALK NSCLC by Therapies, in USD Million (2017–2030)

Table 158: Spain Market Size of ALK NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 159: Spain Market Size of ALK NSCLC by Therapies, in USD Million (2017–2030)

Table 160: United Kingdom Market Size of ALK NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 161: United Kingdom Market Size of ALK NSCLC by Therapies, in USD Million (2017–2030)

Table 162: Japan Market Size of ALK NSCLC by Line of Therapy, in USD Million (2017–2030)

Table 163: Japan Market Size of ALK NSCLC by Therapies, in USD Million (2017–2030)

Table 164: National Institute for Health and Care Excellence (NICE) Decisions for NSCLC Therapies

Table 165: IQWiG Decisions for NSCLC Therapies

Table 166: Haute Autorité de santé (HAS) Decisions for NSCLC Therapies

Figure 1: NSCLC SWOT Analysis

Figure 2: Major Types of NSCLC

Figure 3: Sign and Symptoms of NSCLC

Figure 4: Risks Factors of NSCLC

Figure 5: Alterations in Targetable Oncogenic Pathways in LUAD and LUSC

Figure 6: Schematic Illustration of the NSCLC Staging

Figure 7: Stage IA Lung Cancer

Figure 8: Stage IB Lung Cancer

Figure 9: Stage IIA Lung Cancer

Figure 10: Stage IIB Lung Cancer

Figure 11: Stage IIIA Lung Cancer

Figure 12: Stage IIIB Lung Cancer

Figure 13: Stage IVA Lung Cancer

Figure 14: Global Heat Map of Lung Cancer

Figure 15: Total Incident cases of NSCLC patients in the 7MM (2017–2030)

Figure 16: Total Incident cases of NSCLC patients by Histology in the 7MM (2017–2030)

Figure 17: Total Diagnosed cases of NSCLC patients by Stages in the 7MM (2017–2030)

Figure 18: Total Incident cases of NSCLC patients in the United States (2017–2030)

Figure 19: Total Incident cases of NSCLC patients by Histology in the United States (2017–2030)

Figure 20: Total Diagnosed cases of NSCLC patients by Stages in the United States (2017–2030)

Figure 21: Total NSCLC cases of patients by Genetic mutation/Biomarkers in the United States (2017–2030)

Figure 22: Total Incident cases of NSCLC patients in Germany (2017–2030)

Figure 23: Total Incident cases of NSCLC patients by Histology in Germany (2017–2030)

Figure 24: Total Diagnosed cases of NSCLC patients by Stages in Germany (2017–2030)

Figure 25: Total NSCLC cases of patients by Genetic mutation/Biomarkers in Germany (2017–2030)

Figure 26: Total Incident cases of NSCLC patients in France (2017–2030)

Figure 27: Total Incident cases of NSCLC patients by Histology in France (2017–2030)

Figure 28: Total Diagnosed cases of NSCLC patients by Stages in France (2017–2030)

Figure 29: Total NSCLC cases of patients by Genetic mutation/Biomarkers in France (2017–2030)

Figure 30: Total Incident cases of NSCLC patients in Italy (2017–2030)

Figure 31: Total Incident cases of NSCLC patients by Histology in Italy (2017–2030)

Figure 32: Total Diagnosed cases of NSCLC patients by Stages in Italy (2017–2030)

Figure 33: Total NSCLC cases of patients by Genetic mutation/Biomarkers in Italy (2017–2030)

Figure 34: Total Incident cases of NSCLC patients in Spain (2017–2030)

Figure 35: Total Incident cases of NSCLC patients by Histology in Spain (2017–2030)

Figure 36: Total Diagnosed cases of NSCLC patients by Stages in Spain (2017–2030)

Figure 37: Total NSCLC cases of patients by Genetic mutation/Biomarkers in Spain (2017–2030)

Figure 38: Total Incident cases of NSCLC patients in the United Kingdom (2017–2030)

Figure 39: Total Incident cases of NSCLC patients by Histology in the United Kingdom (2017–2030)

Figure 40: Total Diagnosed cases of NSCLC patients by Stages in the United Kingdom (2017–2030)

Figure 41: Total NSCLC cases of patients by Genetic mutation/Biomarkers in the United Kingdom (2017–2030)

Figure 42: Total Incident cases of NSCLC patients in Japan (2017–2030)

Figure 43: Total Incident cases of NSCLC patients by Histology in Japan (2017–2030)

Figure 44: Total Diagnosed cases of NSCLC patients by Stages in Japan (2017–2030)

Figure 45: Total NSCLC cases of patients by Genetic mutation/Biomarkers in Japan (2017–2030)

Figure 46: Advanced/Metastatic NSCLC Treatment Algorithm

Figure 47: Timeline Illustrating the Development of Targeted Therapies and Immunotherapies for the Treatment of NSCLC Over two decades

Figure 48: Immune Checkpoint Inhibitor

Figure 49: Unmet Needs

Figure 50: Market Size ofPD-L1 NSCLC in the 7MM Countries, in USD Million (2017–2030)

Figure 51: Market Size of PD-L1 NSCLC by Line of therapies in the 7MM, in USD Million (2017–2030)

Figure 52: Market Size ofPD-L1 NSCLC by Line of therapies in the 7MM, in USD Million (2017–2030)

Figure 53: Market Size ofPD-L1 NSCLC in the United States by Therapies, in USD Million (2017–2030)

Figure 54: Market Size ofPD-L1 NSCLC in Germany by Therapies, in USD Millions (2017–2030)

Figure 55: Market Size ofPD-L1 NSCLC in France by Therapies, in USD Millions (2017–2030)

Figure 56: Market Size ofPD-L1 NSCLC in Italy by Therapies, in USD Millions (2017–2030)

Figure 57: Market Size ofPD-L1 NSCLC in Spain by Therapies, in USD Millions (2017–2030)

Figure 58: Market Size of PD-L1 NSCLC in the United Kingdom by Therapies, in USD Millions (2017–2030)

Figure 59: Market Size of PD-L1 NSCLC in Japan, in USD Millions (2017–2030)

Figure 60: Market Size of BRAF NSCLC in the 7MM Countries in USD Million (2017–2030)

Figure 61: Market Size of BRAF NSCLC by Line of therapies in the 7MM, in USD Million (2017–2030)

Figure 62: Market Size of BRAF NSCLC by therapies in the 7MM, in USD Million (2017–2030)

Figure 63: Market Size of BRAF NSCLC in the United States by Therapies, in USD Millions (2017–2030)

Figure 64: Market Size of BRAF NSCLC in Germany by Therapies, in USD Millions (2017–2030)

Figure 65: Market Size of BRAF NSCLC in France by Therapies, in USD Millions (2017–2030)

Figure 66: Market Size of BRAF NSCLC in Italy by Therapies, in USD Millions (2017–2030)

Figure 67: Market Size of BRAF NSCLC in Spain by Therapies, in USD Millions (2017–2030)

Figure 68: Market Size of BRAF NSCLC in the United Kingdom by Therapies, in USD Millions (2017–2030)

Figure 69: Market Size of BRAF NSCLC by Therapies in Japan, in USD Millions (2017–2030)

Figure 70: Market Size of c-MET NSCLC in the 7MM Countries, in USD Million (2017–2030)

Figure 71: Market Size of c-MET NSCLC by Line of therapies in the 7MM, in USD Million (2017–2030)

Figure 72: Market Size of c-MET NSCLC by therapies by in the 7MM, in USD Million (2017–2030)

Figure 73: Market Size of c-MET NSCLC in the United States by Therapies, in USD Millions (2017–2030)

Figure 74: Market Size of c-MET NSCLC in France, in USD Millions (2017–2030)

Figure 75: Market Size of c-MET NSCLC by therapies in Italy, in USD Millions (2017–2030)

Figure 76: Market Size of c-MET NSCLC by therapies in Spain, in USD Millions (2017–2030)

Figure 77: Market Size of c-MET NSCLC by Therapies in the United Kingdom, in USD Millions (2017–2030)

Figure 78: Market Size of c-MET NSCLC by therapies in Japan, in USD Millions (2017–2030)

Figure 79: Market Size of EGFR-positive NSCLC in the 7MM, in USD Million (2017–2030)

Figure 80: Market Size of EGFR-positive NSCLC by Line of therapies in the 7MM, in USD Million (2017–2030)

Figure 81: Market Size of EGFR-positive NSCLC by therapies in the 7MM, in USD Million (2017–2030)

Figure 82: Market Size of EGFR-positive NSCLC in the US, USD Millions (2017–2030)

Figure 83: Market Size of EGFR-positive NSCLC in Germany, USD Millions (2017–2030)

Figure 84: Market Size of NSCLC in France, USD Millions (2017–2030)

Figure 85: Market Size of EGFR-positive NSCLC in Italy, USD Millions (2017–2030)

Figure 86: Market Size of EGFR-positive NSCLC in Spain, USD Millions (2017–2030)

Figure 87: Market Size of EGFR-positive NSCLC in the United Kingdom USD Millions (2017–2030)

Figure 88: Market Size of NSCLC in Japan, USD Millions (2017–2030)

Figure 89: Market Size of ALK NSCLC in the 7MM, in USD Million (2017–2030)

Figure 90: Market Size of ALK NSCLC by Line of therapies in the 7MM, in USD Million (2017–2030)

Figure 91: Market Size of ALK NSCLC by therapies by Line of therapies in the 7MM, in USD Million (2017–2030)

Figure 92: Market Size of ALK NSCLC in the United States by Therapies, in USD Millions (2017–2030)

Figure 93: Market Size of ALK NSCLC in Germany by Therapies, in USD Millions (2017–2030)

Figure 94: Market Size of ALK NSCLC in France by Therapies, in USD Millions (2017–2030)

Figure 95: Market Size of ALK NSCLC in Italy by Therapies, in USD Millions (2017–2030)

Figure 96: Market Size of ALK NSCLC in Spain by Therapies, in USD Millions (2017–2030)

Figure 97: Market Size of ALK NSCLC in the United Kingdom by Therapies, in USD Millions (2017–2030)

Figure 98: Market Size of ALK NSCLC in Japan by Therapies, in USD Millions (2017–2030)

Figure 99: Market Drivers

Figure 100: Market Barriers

1.     Nazartinib/EGF816: Novartis Pharmaceuticals

2.     Capmatinib/INC280: Novartis Pharmaceuticals

3.     Telisotuzumab Vedotin: AbbVie

4.     JNJ-61186372/JNJ-6372: Janssen Pharmaceuticals

5.     Ensartinib/X-396: Xcovery

6.     Selpercatinib (LY3527723/LOXO-292): Eli Lilly and Company

7.     SAR408701: Sanofi

8.     Braftovi/encorafinib + Mektovi/binimetinib: Pfizer

9.     PADCEV (enfortumab vedotin/ASG-22ME): Astellas Pharma/Seattle Genetics

10. TAK-788: Takeda Pharmaceuticals

11. Canakinumab/(ACZ885): Novartis

12. BAVENCIO (Avelumab): Merck/Pfizer

13. Veliparib: AbbVie

14. Sitravatinib (MGCD516): Mirati Therapeutics/Bristol-Myers Squibb/Beigene

15. M7824: Merck/GlaxoSmithKline

16. AMG 510: Amgen

17. INCMGA00012 (MGA012): Incyte Corporation

18. Romiplostim: Amgen

19. TEPMETKO (tepotinib): Merck

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