Non-Small Cell Lung Cancer Market
Non-Small Cell Lung Cancer Market
Non-Small Cell Lung Cancer - Market Insight, Epidemiology and Market Forecast -2032
  • Published Date : Jul 2023

  • Pages : 200

  • Delivery Time : 7-10 Business Days

  • Region : United States, EU5, Japan

Non-Small Cell Lung Cancer Market

  • Non-small Cell Lung Cancer market size has seen a revolutionary change in the last decade owing to the increase in incident cases of NSCLC, continuous uptake of approved therapies mainly immune checkpoint inhibitors, expected entry of potential premium price emerging therapies and increasing awareness of mutations like KRAS, BRAF, c-Met, and others.
  • The real-world treatment trend depicts a drastic shift towards targeted and immunotherapies (from only systemic therapies in the past), which is expected to contribute the most now.
  • The existing Non-small Cell Lung Cancer treatment is mainly dominated by targeted therapies for mutations such as EGFR-sensitizing mutations, EGFR exon 20 insertions, ALK fusions, ROS1 fusions, BRAFV600E mutation, MET exon 14 skipping mutations, RET fusions, and KRASG12C mutation.
  • Amgen’s LUMAKRAS monotherapy is approved in 2021 for NSCLC patients harboring KRASG12C mutation. It is expected to reach approximately USD 400 million in first-line setting (mono and combo with Keytruda/Tecentriq), and approximately USD 800 million in relapsed refractory setting in the United States.
  • Throwing some light on adjuvant and neo-adjuvant NSCLC market trends, the entry of immunotherapies such as TECENTRIQ and OPDIVO has been witnessed in the last 2-3 years
  • As far as EGFR-positive NSCLC market size is concerned, we expect third-generation EGFRs such as AstraZeneca’s TAGRISSO to dominate
  • As per DelveInsight’s analysis, the total incident cases of NSCLC in the 7MM were approximately 500,000 cases in the year 2022 which is expected to reach approximately 600,000 cases in the year 2032.
  • The most common alteration seen in Non–Small Cell Lung Cancer is EGFR mutation. This occurs in about 20–25% of patients, and EGFR mutations occur in exon 19—that's a deletion—as well as L858R exon 21. This makes up about 80–85% of all EGFR mutations.
  • Other emerging therapies include AbbVie’s Telisotuzumab Vedotin, Sanofi’s SAR408701, and AstraZeneca and Daiichi Sankyo’s Datopotamab deruxtecan, which have the potential to create a significant positive shift in the Non-small Cell Lung Cancer market size.

Request for unlocking the CAGR of Non-Small Cell Lung Cancer Market

DelveInsight's “Non-small Cell Lung Cancer – Market Insights, Epidemiology and Market Forecast – 2032” report delivers an in-depth understanding of top oncogenic drivers/biomarker in Non-small Cell Lung Cancer (such as EGFR, c-MET, ROS1, KRAS, ALK, BRAF, PD-1/PD-L1), historical and forecasted epidemiology as well as the Non-small Cell Lung Cancer market trends in the United States, EU4 (Germany, Spain, Italy, and France) and the United Kingdom, and Japan.

Non-small Cell Lung Cancer market report provides real-world prescription pattern analysis, emerging drugs, market share of individual therapies, and historical and forecasted 7MM Non-small Cell Lung Cancer market size from 2019 to 2032. The report also covers current Non-small Cell Lung Cancer treatment market practices/algorithms and Non-small Cell Lung Cancer unmet medical needs to curate the best opportunities and assess the market’s underlying potential.

Geography Covered

  • The United States
  • EU4 (Germany, France, Italy, and Spain) and the United Kingdom
  • Japan

Study Period: 2019–2032

Non-small Cell Lung Cancer Treatment Market: Algorithm

Non-small Cell Lung Cancer Overview and Diagnosis

Non-small Cell Lung Cancer is the most common type of lung cancer, accounting for 81% of all lung cancer diagnoses. Early diagnosis offers the best prognosis for Non–Small Cell Lung Cancer. But, Non–Small Cell Lung Cancer and other lung cancers can be difficult to diagnose because, often, these cancers have symptoms that are mistaken for common illnesses or the effects of long-term smoking. Because of this, 80 percent of people diagnosed with Non–Small Cell Lung Cancer have already progressed to advanced stages, making it more difficult to treat. If lung cancer is suspected, the physician will recommend imaging tests (CT, PET, or MRI scans) to identify abnormalities in and around your lungs. The physician may also take a sample of mucus for examination under the microscope.

If these initial tests identify cancer, a lung biopsy can be conducted. A bronchoscopy can also be recommended, which allows the physician to not only visualize but also remove tissue. If lung cancer is confirmed, genetic testing can be done on the lung tissue to identify details about the cancer that can help inform treatment.

Further details related to country-based variations in diagnosis are provided in the report

Non-small Cell Lung Cancer Treatment

Treatment options and recommendations depend on several factors, including the type and stage of cancer, possible side effects, and the patient’s preferences and overall health. The most common treatments for non-small cell lung cancer are:

  • surgery
  • radiotherapy
  • chemotherapy
  • chemotherapy with radiotherapy (chemoradiotherapy)
  • immunotherapy
  • targeted cancer drugs

Clinical and Registrational Updates in 2023

  • The US FDA approval of Merck’s KEYTRUDA (pembrolizumab) for adjuvant treatment following resection and platinum-based chemotherapy for stage IB (T2a ≥4 cm), II, or IIIA NSCLC.
  • NDA acceptance of repotrectinib, for the treatment of patients with ROS1-positive locally advanced or metastatic NSCLC. The FDA granted Priority Review and assigned a Prescription Drug User Fee Act (PDUFA) goal date of November 27, 2023.
  • In January 2023, Daiichi Sankyo initiated the TROPION-Lung07 Phase III trial to evaluate datopotamab deruxtecan in combination with pembrolizumab in patients with previously untreated metastatic non-small cell lung cancer.
  • In January 2023, the EMA validated the ENHERTU Type II variation application for the treatment of HER2 mutant metastatic non-small cell lung cancer.

American Society of Clinical Oncology (ASCO) 2023 Key Updates

  • Dizal Pharmaceuticals’ Sunvozertinib shines in a groundbreaking WU-KONG6 trial, unveiling remarkable antitumor effectiveness and exceptional safety in previously treated NSCLC with EGFR Exon20 insertions.
  • Updated TROPION-Lung02 results revealed Daiichi Sankyo and AstraZeneca's datopotamab deruxtecan continued success in triggering promising and persistent responses across diverse NSCLC cancer patients.
  • AstraZeneca’s rilvegostomig, a TIGIT and PD-1 bispecific, offers hope for advanced PD-L1+ NSCLC after prior treatment resistance.
  • Kelun Pharma’s TROP2-targeting ADC, SKB264 exhibited manageable safety and promising antitumor activity in advanced or metastatic NSCLC, with enhanced response in EGFR mutant subtype.
  • Amgen’s Sotorasib provides a consistent benefit over docetaxel in the majority of key prespecified molecularly defined subsets pretreated KRAS G12C–mutated NSCLC patients enrolled in the Phase III CodeBreaK 200 trial.
  • Combining pembrolizumab with pemetrexed and platinum-based chemotherapy showed a slight numerical improvement in progression-free survival and overall survival compared to chemotherapy plus placebo. However, this improvement did not reach statistical significance in patients with TKI-resistant, EGFR-mutated, metastatic nonsquamous non-small cell lung cancer.
  • In the Phase III ADAURA trial, adjuvant treatment with AstraZeneca’s osimertinib demonstrated a significant improvement in overall survival compared to placebo for patients with resected, EGFR-mutated, stage IB to IIIA non-small cell lung cancer.

Non-small Cell Lung Cancer Epidemiology

The Non-small Cell Lung Cancer epidemiology chapter in the report provides historical as well as forecasted epidemiology segmented by total incident cases of Non-small Cell Lung Cancer, total incident cases of Non-small Cell Lung Cancer by histology, total cases of Non-small Cell Lung Cancer by stages, total incident cases of Non-small Cell Lung Cancer by genetic mutation/biomarkers, total treated cases of Non-small Cell Lung Cancer by line of therapies in the 7MM covering the United States, EU4 countries (Germany, France, Italy, and Spain), United Kingdom, and Japan from 2019 to 2032.

  • In the US for 2023, there are approximately 200,000 new cases of lung cancer (117,550 in men and 120,790 in women). The society also reported that most lung cancer statistics include both small cell lung cancer and non-small cell lung cancer. About 10% to 15% of all lung cancers are SCLC, and about 80% to 85% are Non–Small Cell Lung Cancer.
  • The most frequent biomarkers are EGFR (64%), ALK (60%), PD-L1 (48%), ROS1 (46%), BRAF (40%), MET (35%), KRAS (29%), RET (22%), HER2 (21%), and PIK3CA (20%).
  • The three main histological subtypes of Non–Small Cell Lung Cancer are Adenocarcinoma, Squamous cell carcinoma, and Large cell (undifferentiated) carcinoma. About 40% of all lung cancers are adenocarcinomas. About 25-30% of all lung cancers are Squamous cell carcinoma. Large cell (undifferentiated) carcinoma makes up around 10-15% of all lung cancers.


Non-small Cell Lung Cancer Drug Chapters

The drug chapter segment of the Non-small Cell Lung Cancer report encloses a detailed analysis of Non-small Cell Lung Cancer marketed drugs and late-stage (Phase III and Phase II) Non-Small Cell Lung Cancer Pipeline Drugs. It also deep dives into the pivotal Non-small Cell Lung Cancer clinical trials details, recent and expected market approvals, patent details, the latest news, and recent deals and collaborations.

Non-small Cell Lung Cancer Marketed Drugs

KEYTRUDA (pembrolizumab): Merck

KEYTRUDA is an anti-programmed death receptor-1 (PD-1) therapy that works by increasing the ability of the body’s immune system to help detect and fight tumor cells. FDA’s approval in January 2023, marked the fifth indication for KEYTRUDA in non-small cell lung cancer and the first indication for KEYTRUDA in patients with resected stage IB (T2a ≥4 cm), II, or IIIA disease following adjuvant chemotherapy. With this approval, KEYTRUDA is the only immunotherapy with an approved option for Non–Small Cell Lung Cancer regardless of PD-L1 expression in both the adjuvant and metastatic settings. Six years ago, KEYTRUDA was the first anti-PD-1 therapy approved for the first-line treatment of metastatic non-small cell lung cancer and has changed the way metastatic disease is treated. The approval of KEYTRUDA is unfavorable for TECENTRIQ, which was the first immunotherapy to receive approval in the adjuvant setting for non-small cell lung cancer patients who underwent surgery in October 2021. KEYTRUDA's approval is more extensive compared to TECENTRIQ's approval, as it encompasses a wider range of cancer stages and PD-L1 statuses. TECENTRIQ has specifically approved for PD-L1-positive patients with stages 2 to 3A lung cancer, whereas KEYTRUDA's approval covers a broader range.

LIBTAYO (cemiplimab-rwlc): Regeneron Pharmaceuticals

LIBTAYO is a fully human monoclonal antibody targeting the immune checkpoint receptor PD-1 on T-cells and was invented using Regeneron's proprietary VelocImmune technology. In November 2022, Regeneron Pharmaceuticals announced that the US FDA has approved the PD-1 inhibitor LIBTAYO in combination with platinum-based chemotherapy for the first-line treatment of adult patients with advanced non-small cell lung cancer with no EGFR, ALK, or ROS1 aberrations. This second FDA approval for cemiplimab-rwlc in advanced non-small cell lung cancer greatly broadens the scope in which a cemiplimab-rwlc-based regimen can be prescribed to encompass a wide range of patients, either as a single agent in those with PD-L1 ≥50% or now in combination with chemotherapy irrespective of PD-L1 expression or tumor histology. LIBTAYO, alongside KEYTRUDA, is the only other PD-1/L1 inhibitor that can be used in combination with chemotherapy for first-line treatment of non-small cell lung cancer in the United States, irrespective of PD-L1 levels or histology. This approval complements the previous approval of LIBTAYO as a monotherapy for patients with high expression of PD-L1. However, having a similar indication to KEYTRUDA does not automatically imply that LIBTAYO will divide the market equally with the leading PD-1 inhibitor from Merck.

Note: Detailed current therapies assessment will be provided in the full report of Non-small Cell Lung Cancer

Non-small Cell Lung Cancer Emerging Drugs

Telisotuzumab Vedotin (Teliso-V): AbbVie

Teliso-V is an investigational antibody-drug conjugate targeting c-Met, a receptor tyrosine kinase that is overexpressed in tumors including Non-small Cell Lung Cancer. Teliso-V has the potential to become an important new treatment option in non-small cell lung cancer; with an anticipated approval in 2L+ Non–Small Cell Lung Cancer in 2024. In January 2022, AbbVie announced that the FDA granted Breakthrough Therapy Designation to investigational telisotuzumab vedotin for the treatment of patients with advanced/ metastatic epidermal growth factor receptor wild type, nonsquamous non-small cell lung cancer with high levels of c-Met overexpression whose disease has progressed on or after platinum-based therapy. In May 2022, AbbVie initiated a Phase III clinical trial to evaluate Teliso-V versus docetaxel for the treatment of patients with previously treated c-Met overexpressing, epidermal growth factor receptor wild type, advanced/metastatic non-squamous non-small cell lung cancer.

Datopotamab deruxtecan (Dato-DXd): AstraZeneca and Daiichi Sankyo

Datopotamab deruxtecan (Dato-DXd) is an investigational TROP2-directed ADC. Designed using Daiichi Sankyo’s proprietary DXd ADC technology, datopotamab deruxtecan is one of the most advanced programs in AstraZeneca’s ADC scientific platform and one of the three leading ADCs in the oncology pipeline of Daiichi Sankyo. In January 2023, a Phase III clinical trial in combination with immune checkpoint inhibitors for the first-line treatment for Non–Small Cell Lung Cancer without actionable genomic alterations, PD-L1 < 50% (trial name: TROPION-Lung07) was initiated. No TROP2-directed therapies are currently approved for the treatment of patients with Non–Small Cell Lung Cancer. AstraZeneca and Daiichi Sankyo are interrogating Dato-DXd in 1L non-driver mutation patients with TROPION-Lung08 (trying to knock off the Keynote-024 regimen) and with TROPION-Lung07 (trying to dethrone Keynote-189 regimen, the most important indication for Merck’s KEYRTUDA), as well as covering all comer 2L and 3L patients in with TROPION-Lung01.

Note: Detailed emerging therapies assessment will be provided in the final report.

Drug Class Insights

The existing Non-small Cell Lung Cancer treatment is mainly dominated by targeted therapies for mutations such as EGFR-sensitizing mutations, EGFR exon 20 insertions, ALK fusions, ROS1 fusions, BRAFV600E mutation, MET exon 14 skipping mutations, RET fusions, and KRASG12C mutation.

Epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are well-known genetic abnormalities that drive the development of Non-small Cell Lung Cancer. The use of tyrosine kinase inhibitors (TKIs) as a treatment approach has shown better results in terms of patient outcomes when compared to chemotherapy.

EGFR mutations are frequently observed, EGFR exon 19 deletions and EGFR exon 21 L858R mutations. The FDA has approved various tyrosine kinase inhibitors (TKIs) to treat these mutations, with TAGRISSO (osimertinib) considered the standard treatment. GILOTRIF (afatinib) is approved for patients with other EGFR sensitivity mutations like S768I, L861Q, and G719X. However, approximately 8% to 10% of EGFR mutations involve exon 20 insertions, which do not respond to treatments targeting exon 19 or 21 alterations, including osimertinib. Currently, two targeted therapies, RYBREVANT (amivantamab) and EXKIVITY (mobocertinib) are approved for this particular mutation but only as a second-line option following platinum-based chemotherapy. These mutations represent an area of Non-small Cell Lung Cancer unmet needs. While treatment with EGFR TKIs effectively eliminates the majority of cancer cells, a small population of drug-tolerant cells may persist. These cells can remain inactive and undetectable for extended periods but eventually resume growth and spread to other parts of the body.

Moving onto ALK rearrangements, which are present in around 5% of Non-Small-Cell Lung Cancer cases, primarily in adenocarcinomas, and represent a distinct molecular subtype of lung cancer. The first ALK inhibitor approved for treatment was crizotinib, and subsequently, several other ALK inhibitors have received approval, including ceritinib, alectinib, brigatinib, and lorlatinib. A direct comparison among all the ALK TKIs is still lacking, but researchers are actively developing new ALK TKIs to overcome resistance to the currently available ones. This suggests the possibility of a sequential treatment strategy involving different ALK TKIs in this specific disease.

While tumors with ROS1 rearrangements, known as ROS1-positive tumors, are not common, the similarities between ROS1 and ALK receptors, as well as the similarities between ROS1-positive and ALK-positive Non-small Cell Lung Cancer, have led to the repurposing of ALK inhibitors for the treatment of ROS1-positive disease. XALKORI (crizotinib), which is already approved for treating patients with ALK fusions, became the first drug specifically indicated for patients with ROS1-positive Non-small Cell Lung Cancer in 2016.

In the treatment of patients with BRAF V600E mutations, the combination of dabrafenib and trametinib is approved. However, it is worth noting that BRAF mutations are relatively uncommon in Non-small Cell Lung Cancer compared to other cancers such as melanoma.

Even though numerous MET inhibitors with different mechanisms of action have failed to demonstrate significant effectiveness in clinical trials, the FDA has approved MET inhibitors like TABRECTA (capmatinib) and TEPMETKO (tepotinib) for treating patients with advanced Non-small Cell Lung Cancer that have MET exon 14 skipping mutations.

When treating RET alterations, Pralsetinib, and selpercatinib have received approval for the same. It's important to note that RET fusions, also referred to as RET gene rearrangements, are distinct from RET mutations as they do not involve changes in the gene itself.

Currently, TRK inhibitors have demonstrated promising effectiveness and good tolerability in patients with solid tumors carrying NTRK fusions, regardless of the tumor's histology. The first-generation TRK inhibitors, such as larotrectinib and entrectinib, are recommended as the initial treatment for patients with locally advanced or metastatic Non-Small Cell Lung Cancer who have confirmed NTRK fusion. However, resistance to TRK inhibitors can eventually emerge due to various mechanisms, either directly targeting the TRK protein or through other indirect means. Interestingly, NTRK fusion has been identified as a potential resistance mechanism to EGFR-TKIs, suggesting that combining EGFR-TKIs with TRK inhibitors could be a potential treatment option for patients experiencing EGFR-TKI resistance mediated by NTRK fusion.

Considering that HER2 has emerged as a notable targetable oncogenic driver and lung cancer is of particular interest due to the significant occurrence of mutations in the tyrosine kinase domain of the HER2 gene. In August 2022, ENHERTU (fam-trastuzumab deruxtecan-nxki) received approval for the treatment of Non-Small Cell Lung Cancer patients with an activating HER2 mutation.

Targeting KRAS represents a significant advancement in the field of oncology in recent times. KRAS is the most frequently mutated oncogene in human cancer, with the highest occurrence in non-small-cell lung cancer, colorectal cancer, and pancreatic cancer. In lung cancer, the most prevalent KRAS mutation is G12C. In the past, KRAS was considered "undruggable" due to the absence of conventional drug-binding sites. However, the approval of KRAS G12C inhibitors, such as sotorasib and adagrasib, for the treatment of locally advanced or metastatic Non-Small Cell Lung Cancer, has revolutionized the approach to treating cancers with KRAS G12C mutations. Currently, numerous other KRAS players such as Gritstone Bio and Elicio Therapeutics, both are evaluating their respective Pan-KRAS Vaccines in Phase I/II along with Immuneering Corporation with its KRASG12S in early stage trial.

Targeted therapies targeting NRG1 alterations have also entered early clinical studies. Currently, there are no approved treatments specifically targeting NRG1-positive cancer. However, zenocutuzumab presents promising potential as a new standard of care. Below is a glimpse of US FDA-approved therapies for NSCLC:

The US FDA-Approved Targeted Therapies for Advanced Stage Non–Small Cell Lung Cancer

Target

Approved drugs

EGFR-senstizing mutation

Osimertinib

Erlotinib

Afatinib

Gefitinib

Dacomitinib

ALK

Crizotinib

Alectinib

Ceritinib

Brigatinib

Lorlatinib

ROS1

Ceritinib

Lorlatinib

Entrectinib

BRAF V600E

Dabrafenib and trametinib

MET exon 14

Capmatinib

Tepotinib

NTRK

Larotrectinib

Entrectinib

KRAS G12C

Sotorasib

Adagrasib

RET

Selpercatinib

Pralsetinib

EGFR exon 20 insertion

Amivantamab

Mobocertinib

Note: The list is not exhaustive.

Non–Small Cell Lung Cancer Market Outlook

As more targetable mutations are discovered and new targeted drugs are developed, patients and oncologists will have an expanding array of treatment options. Given the rapid pace of drug approvals, it is important to pause and ensure that there is sufficient data supporting the use of specific agents in the appropriate treatment settings, including adjuvant, consolidation, first-line, or subsequent therapy.

Previously, molecular-based treatments were limited to advanced-stage Non-small Cell Lung Cancer. However, recent findings have demonstrated their efficacy in early-stage and locally advanced disease as well. New studies have explored therapies that target a wider range of oncogenes, aiming to overcome drug resistance and provide treatment options for patients who were previously excluded from Non-small Cell Lung Cancer clinical trials for advanced-stage lung cancer. The emerging data from these ongoing trials are expected to influence future treatment guidelines and foster the adoption of personalized medicine. As a result, a continuous evolution of the treatment landscape is anticipated, ultimately leading to improved survival rates and enhanced quality of life for lung cancer patients.

Non–Small Cell Lung Cancer Companies such as AstraZeneca, Bristol-Myers-Squibb, AbbVie, Roche, Merck, Novartis, Pfizer, Takeda, Eli Lilly, Immutep, Sanofi, GlaxoSmithKline, and others are evaluating their lead candidates in different stages of clinical development, respectively. They aim to investigate their products for the treatment of Non–Small Cell Lung Cancer.

Non–Small Cell Lung Cancer Drugs Uptake

This section focuses on the uptake rate of potential Non-Small Cell Lung Cancer Drugs expected to be launched in the market during 2019–2032, which depends on the competitive landscape, safety, efficacy data along with order of entry. It is important to understand that the companies evaluating their novel therapies in the pivotal and confirmatory trials should remain vigilant when selecting appropriate comparators to stand the greatest chance of a positive opinion from regulatory bodies, leading to approval, smooth launch, and rapid uptake.

Further detailed analysis of emerging therapies drug uptake in the report…

Non–Small Cell Lung Cancer Activities

The report provides insights into different therapeutic candidates in Phase III and Phase II stages. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers information on collaborations, acquisitions and mergers, licensing, and patent details for Non–Small Cell Lung Cancer emerging therapies.

KOL Views

To keep up with the real world scenario in current and emerging market trends, we take opinions from Key Industry leaders working in the domain through primary research to fill the data gaps and validate our secondary research. Industry Experts contacted for insights on evolving treatment landscape, patient reliance on conventional therapies, patient’s therapy switching acceptability, and drug uptake along with challenges related to accessibility, including Medical/scientific writers, Medical Oncologists, Pulmonologists and Professors, Chief of the Thoracic Service at the Memorial Sloan Kettering Cancer Center, and Others.

Delveinsight’s analysts connected with 40+ KOLs to gather insights; however, interviews were conducted with 18+ KOLs in the 7MM. Centers such as MD Anderson Cancer Center, Texas, UT Southwestern Medical Center in Dallas, Cancer Research UK Barts Centre in London, LUNGevity Foundation, etc., were contacted. Their opinion helps understand and validate current and emerging therapy treatment patterns or Non–Small Cell Lung Cancer market trends.

Region

KOL Views

United States

“The known driver mutations in oncogenes have been most successful, such as EGFR, ALK, ROS1, and RET. There are approved targeted therapies for these alterations that are effective enough to be used as frontline therapy for patients with NSCLC, making broad genetic testing important for patients with advanced disease. I think as we go forward, [it will] be interesting to see how TROP…is predictive of benefit to TROP2 inhibitors, and also CEACAM5, because there are novel therapies aimed toward that as well.”

Switzerland

“Over the past few years, we have seen how agents targeting KRAS G12C mutations are revolutionizing the way we treat patients with NSCLC harboring this molecular alteration.”

Spain

“The shift of immune checkpoint inhibitors to first-line therapy has left an unmet need for effective second-line therapies We must now wait for the results of ongoing phase III trials, such as SAPPHIRE with sitravatinib plus nivolumab, Pragmatica-Lung with ramucirumab plus pembrolizumab, and LEAP-008 with pembrolizumab plus lenvatinib, to establish whether we can expand second-line treatment options for our patients.”

Japan

“Osimertinib was first approved in Japan over 6 years ago and it has since played a critical role in our treatment of patients with lung cancer, particularly given the high prevalence of EGFR mutations among Japanese patients.”

Qualitative Analysis

We perform Qualitative and market Intelligence analysis using various approaches, such as SWOT analysis and Conjoint Analysis. In SWOT analysis, strengths, weaknesses, opportunities, and threats in terms of gaps in disease diagnosis, patient awareness, physician acceptability, competitive landscape, cost-effectiveness, and geographical accessibility of therapies are provided.

Conjoint Analysis analyzes multiple approved and emerging therapies based on relevant attributes such as safety, efficacy, frequency of administration, route of administration, and order of entry. Scoring is given based on these parameters to analyze the effectiveness of therapy.

In efficacy, the trial’s primary and secondary outcome measures are evaluated; for instance, in event-free survival, one of the most important primary outcome measures is event-free survival and overall survival.

Further, the therapies’ safety is evaluated wherein the acceptability, tolerability, and adverse events are majorly observed, and it sets a clear understanding of the side effects posed by the drug in the trials. In addition, the scoring is also based on the probability of success, and the addressable patient pool for each therapy. According to these parameters, the final weightage score and the ranking of the emerging therapies are decided.

Non-small Cell Lung Cancer Market Access and Reimbursement

The cost of treating Non–Small Cell Lung Cancer has shown significant increases over time, irrespective of the stage of the disease. This is particularly true for younger patients treated in the outpatient setting, according to real-world findings. Although first‐generation epidermal growth factor receptor tyrosine kinase inhibitors were reimbursed and available in all countries, for other registered therapies—even for ALK inhibitors and checkpoint inhibitors in first‐line—there were apparent gaps in availability and/or reimbursement.

The report further provides detailed insights on the country-wise accessibility and reimbursement scenarios, cost-effectiveness scenario of approved therapies, programs making accessibility easier and out-of-pocket costs more affordable, insights on patients insured under federal or state government prescription drug programs, etc.

Non-small Cell Lung Cancer Market Report Scope

  • The report covers a segment of key events, an executive summary, descriptive overview of Non–Small Cell Lung Cancer, explaining its causes, signs and symptoms, pathogenesis, and currently available therapies.
  • Comprehensive insight has been provided into the epidemiology segments and forecasts, the future growth potential of diagnosis rate, disease progression along with treatment guidelines.
  • Additionally, an all-inclusive account of both the current and emerging therapies, along with the elaborative profiles of late-stage and prominent therapies, will have an impact on the current treatment landscape.
  • A detailed review of the Non–Small Cell Lung Cancer market, historical and forecasted market size, market share by therapies, detailed assumptions, and rationale behind our approach is included in the report, covering the 7MM drug outreach.
  • The patient-based Non-small Cell Lung Cancer market forecasting report provides an edge while developing business strategies, by understanding trends, through SWOT analysis and expert insights/KOL views, patient journey, and treatment preferences that help in shaping and driving the 7MM Non–Small Cell Lung Cancer market.

Non–Small Cell Lung Cancer Report Insights

  • Patient-based Non-small Cell Lung Cancer Market Forecasting
  • Therapeutic Approaches
  • Non–Small Cell Lung Cancer Pipeline Analysis
  • Non–Small Cell Lung Cancer Market Size and Trends
  • Existing and future Market Opportunity

Non–Small Cell Lung Cancer Report Key Strengths

  • 10 Years Non-Small Cell Lung Cancer Market Forecast
  • 7MM Coverage
  • Non–Small Cell Lung Cancer Epidemiology Segmentation
  • Key Cross Competition
  • Conjoint analysis
  • Drugs Uptake and Key Market Forecast Assumptions

Non–Small Cell Lung Cancer Report Assessment

  • Current Non–Small Cell Lung Cancer Treatment Market Practices
  • Non-small Cell Lung Cancer Unmet Needs
  • Non-small Cell Lung Cancer Pipeline Drugs Profiles
  • Non-small Cell Lung Cancer Market Attractiveness
  • Qualitative Analysis (SWOT and Conjoint Analysis)

FAQs

  • What is the historical and forecasted Non–Small Cell Lung Cancer patient pool in the United States, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan?
  • What was the total Non–Small Cell Lung Cancer market size, the market size by therapies, market share (%) distribution in 2019, and what would it look like in 2032? What are the contributing factors for this growth?
  • How will KRAS as a target class affect the treatment paradigm of Non–Small Cell Lung Cancer?
  • What will be the impact of KEYTRUDA’s expected patent expiry in 2028?
  • How will KEYTRUDA compete with LIBTAYO in the first- and second lines?
  • Which class is going to be the largest contributor in 2032?
  • What are the pricing variations among different geographies for approved and off-label therapies?
  • How would the market drivers, barriers, and future opportunities affect the market dynamics and subsequent analysis of the associated trends?
  • Although multiple expert guidelines recommend testing for targetable mutations prior to therapy initiation, why do barriers to testing remain high?
  • What are the current and emerging options for the treatment of Non–Small Cell Lung Cancer?
  • How many companies are developing therapies for the treatment of Non–Small Cell Lung Cancer?
  • What are the recent novel therapies, targets, mechanisms of action, and technologies developed to overcome the limitation of existing therapies?
  • Patient acceptability in terms of preferred treatment options as per real-world scenarios?
  • What are the country-specific accessibility issues of expensive, recently approved therapies?

Reasons to buy

  • The patient-based Non–Small Cell Lung Cancer market forecasting report will help in developing business strategies by understanding the latest trends and changing treatment dynamics driving the Non–Small Cell Lung Cancer Market.
  • Insights on patient burden/disease prevalence, evolution in diagnosis, and factors contributing to the change in the epidemiology of the disease during the forecast years
  • Understand the existing market opportunity in varying geographies and the growth potential over the coming years.
  • Distribution of historical and current patient share based on real-world prescription data along with reported sales of approved products in the US, EU4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan.
  • Identifying strong upcoming players in the market will help devise strategies to help get ahead of competitors.
  • Detailed analysis and ranking of class-wise potential current and emerging therapies under the Conjoint analysis section to provide visibility around leading classes.
  • Highlights of access and reimbursement policies of approved therapies, barriers to accessibility of expensive off-label therapies, and patient assistance programs.
  • To understand Key Opinion Leaders’ perspectives around the accessibility, acceptability, and compliance-related challenges of existing treatment to overcome barriers in the future.
  • Detailed insights on the Non-small Cell Lung Cancer unmet needs of the existing market so that the upcoming players can strengthen their development and launch strategy.

1. Key Insights

2. Executive Summary of Non–Small Cell Lung Cancer

3. SWOT Analysis of Non–Small Cell Lung Cancer

4. Non–Small Cell Lung Cancer: Market Overview at a Glance

4.1. Total Market Share (%) Distribution of Non–Small Cell Lung Cancer in 2019: By Country

4.2. Total Market Share (%) Distribution of Non–Small Cell Lung Cancer in 2032: By Country

4.3. Total Market Share (%) Distribution of Non–Small Cell Lung Cancer in 2019: By Mutations/ biomarkers

4.4. Total Market Share (%) Distribution of Non–Small Cell Lung Cancer in 2032: By Mutations/ biomarkers

4.5. Non–Small Cell Lung Cancer Revenue Summary by Mutations/Biomarkers

5. Non-small Cell Lung Cancer: Disease Background and Overview

5.1. Introduction

5.1.1. Cellular Classification of Non–Small Cell Lung Cancer

5.1.2. Signs and Symptoms of Non–Small Cell Lung Cancer

5.1.3. Risk Factors of Lung Cancer

5.1.4. Causes of Non–Small Cell Lung Cancer

5.1.5. Disease Biology: Non–Small Cell Lung Cancer

6. Diagnosis of Non–Small Cell Lung Cancer

6.1. Diagnostic Algorithm for Non–Small Cell Lung Cancer

6.2. Stages of Non–Small Cell Lung Cancer

6.3. Staging System

7. Epidemiology and Patient Population

7.1. Epidemiology Key Findings

7.2. Assumptions and Rationale: 7MM

7.3. Epidemiology Scenario: 7MM

7.3.1. Total Incident cases of Non–Small Cell Lung Cancer patients in the 7MM

7.3.2. Total Incident Cases of Non–Small Cell Lung Cancer Patients by Histology in the 7MM

7.3.3. Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in the 7MM

7.3.4. Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in the 7MM

7.3.5. Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in the 7MM

7.4. The United States Epidemiology

7.4.1. Total Incident cases of Non–Small Cell Lung Cancer patients in the United States

7.4.2. Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in the United States

7.4.3. Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in the United States

7.4.4. Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in the United States

7.4.5. Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in the 7MM

7.5. EU 4 and the United Kingdom Epidemiology

7.5.1. Total Incident cases of Non–Small Cell Lung Cancer patients in EU4 and the UK

7.5.2. Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in EU4 and the UK

7.5.3. Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in EU4 and the UK

7.5.4. Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in EU4 and the UK

7.5.5. Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in EU4 and the UK

7.6. Japan Epidemiology

7.6.1. Total Incident cases of Non–Small Cell Lung Cancer patients in Japan

7.6.2. Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in Japan

7.6.3. Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in Japan

7.6.4. Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in Japan

7.6.5. Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in Japan

8. Current Treatment Practices: Non–Small Cell Lung Cancer

8.1. Advanced/Metastatic Non–Small Cell Lung Cancer Treatment Algorithm

8.2. Chemotherapy

8.3. Targeted Therapy

8.4. Immunotherapy

8.5. Surgery

8.6. Radiation Therapy

8.7. Stage-wise Treatment Options of Non–Small Cell Lung Cancer

9. Guideline of Non–Small Cell Lung Cancer

9.1. The National Comprehensive Cancer Network (NCCN) Clinical Guidelines

9.2. The European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for Diagnosis, Treatment, and Follow-up

9.3. The Spanish Society of Medical Oncology (SEOM) Clinical Guidelines

9.4. The Japanese Lung Cancer Society Guideline for Non–Small Cell Lung Cancer, Stage IV

10. Unmet Needs of Non–Small Cell Lung Cancer

11. Key Endpoints in Non–Small Cell Lung Cancer Clinical Trials

12. Marketed Therapies

12.1. Key Cross

12.2. Rozlytrek (Entrectinib): Hoffmann-La Roche (Genentech)

12.2.1. Product Description

12.2.2. Regulatory Milestones

12.2.3. Other Developmental Activities

12.2.4. Pivotal Clinical Trials

12.2.5. Ongoing Current Pipeline Activity

12.3. Imfinzi (Durvalumab): AstraZeneca

12.3.1. Product Description

12.3.2. Regulatory Milestones

12.3.3. Other Developmental Activities

12.3.4. Pivotal Clinical Trials

12.3.5. Ongoing Current Pipeline Activity

12.3.6. Safety and Efficacy of Ongoing Clinical Trials

12.4. Opdivo (Nivolumab): Bristol-Myers Squibb

12.4.1. Product Description

12.4.2. Regulatory Milestones

12.4.3. Other Developmental Activities

12.4.4. Pivotal Clinical Trials

12.4.5. Ongoing Current Pipeline Activity

12.5. Portrazza (Necitumumab): Eli Lilly

12.5.1. Product Description

12.5.2. Regulatory Milestones

12.5.3. Other Developmental Activities

12.5.4. Pivotal Clinical Trials

12.5.5. Ongoing Current Pipeline Activity

12.6. Pralsetinib (BLU-667): Blueprint Medicines Corporation

12.6.1. Product Description

12.6.2. Regulatory Milestones

12.6.3. Other Developmental Activities

12.6.4. Pivotal Clinical Trials

12.6.5. Ongoing Current Pipeline Activity

List to be Continued.

13. Emerging Therapies

13.1. Telisotuzumab Vedotin: Abbvie

13.1.1. Product Description

13.1.2. Other Development Activities

13.1.3. Clinical Development

13.1.4. Safety and Efficacy

13.2. Ensartinib/X-396: Xcovery

13.2.1. Product Description

13.2.2. Other Development Activities

13.2.3. Clinical Development

13.2.4. Safety and Efficacy

13.3. SAR408701: Sanofi

13.3.1. Product Description

13.3.2. Other Development Activities

13.3.3. Clinical Development

13.3.4. Safety and Efficacy

13.4. Relatlimab and nivolumab: Bristol-Myers Squibb

13.4.1. Product Description

13.4.2. Other Development Activities

13.4.3. Clinical Development

13.4.4. Safety and Efficacy

13.5. Avelumab (Bavencio: Merck KGaA and Pfizer

13.5.1. Product Description

13.5.2. Other Development Activities

13.5.3. Clinical Development

13.5.4. Safety and Efficacy

13.6. Sitravatinib: Mirati Therapeutics

13.6.1. Product Description

13.6.2. Other Development Activity

13.6.3. Clinical Development

13.6.4. Safety and Efficacy

13.7. Eftilagimod alpha and pembrolizumab: Immutep and Merck Sharp & Dohme

13.7.1. Product Description

13.7.2. Other Development Activity

13.7.3. Clinical Development

13.7.4. Safety and Efficacy

List to be Continued

14. Non-small Cell Lung Cancer: Seven Major Market Analysis

14.1. Key Findings

14.2. Market Outlook: 7MM

15. PD-L1—Market Size

15.1. Total Market Size of PD-L1 Non–Small Cell Lung Cancer in the 7MM

15.1.1. Market Size of PD-L1 Non–Small Cell Lung Cancer by Therapeutic Class in the 7MM

15.2. Total Market Size of PD-L1 Non–Small Cell Lung Cancer in the US

15.2.1. Market Size of PD-L1 Non–Small Cell Lung Cancer by Therapeutic Class in the US

15.3. Total Market Size of PD-L1 Non–Small Cell Lung Cancer in EU4 and the UK

15.3.1. Market Size of PD-L1 Non–Small Cell Lung Cancer by Therapeutic Class in EU4 and the UK

15.4. Japan Market Size

15.4.1. Total Market size of PD-L1 Non–Small Cell Lung Cancer in Japan

16. BRAF Mutation—Market Size

16.1. Total Market Size of BRAF Non–Small Cell Lung Cancer in the 7MM

16.2. Market Size of BRAF-Non–Small Cell Lung Cancer by Therapeutic Class in the 7MM

16.3. United States Market Size

16.3.1. Total Market size of BRAF Non–Small Cell Lung Cancer in the United States

16.4. EU4 and the UK Market Size

16.4.1. Total Market size of BRAF Non–Small Cell Lung Cancer in EU4 and the UK

16.5. Japan Market Size

16.5.1. Total Market size of BRAF Non–Small Cell Lung Cancer in Japan

17. c-MET Mutation—Market Size

17.1. Total Market Size of c-MET Non–Small Cell Lung Cancer in the 7MM

17.2. Market Size of c-MET Non–Small Cell Lung Cancer by Therapeutic Class in the 7MM

17.3. United States Market Size

17.3.1. Total Market size of c-MET Non–Small Cell Lung Cancer in the United States

17.4. EU4 and the UK Market Size

17.4.1. Total Market size of c-MET Non–Small Cell Lung Cancer in EU4 and the UK

17.5. Japan Market Size

17.5.1. Total Market size of c-MET Non–Small Cell Lung Cancer in Japan

18. EGFR Mutation—Market Size

18.1. Total Market Size of EGFR-positive Non–Small Cell Lung Cancer in the 7MM

18.2. Market Size of EGFR-positive Non–Small Cell Lung Cancer by Therapeutic Class in the 7MM

18.3. United States Market Size

18.3.1. Total Market size of EGFR Non–Small Cell Lung Cancer in the United States

18.4. EU 4 and the UK Market Size

18.4.1. Total Market size of EGFR Non–Small Cell Lung Cancer in EU 4 and the UK

18.5. Japan Market Size

18.5.1. Total Market size of Non–Small Cell Lung Cancer in Japan

19. ALK-Mutation—Market Size

19.1. Total Market Size of ALK Non–Small Cell Lung Cancer in the 7MM

19.2. Market Size of ALK Non–Small Cell Lung Cancer by Therapeutic Class in the 7MM

19.3. United States Market Size

19.3.1. Total Market size of ALK Non–Small Cell Lung Cancer in the United States

19.4. EU4 and the UK Market Size

19.4.1. Total Market size of ALK Non–Small Cell Lung Cancer in EU4 and the UK

19.5. Japan Market Size

19.5.1. Total Market size of Non–Small Cell Lung Cancer in Japan

20. Market Access and Reimbursement of Non–Small Cell Lung Cancer Therapies

21. Appendix

21.1. Bibliography

21.2. Acronyms and Abbreviations

21.3. Report Methodology

22. DelveInsight Capabilities

23. Disclaimer

24. About DelveInsight

List of Tables:

  • Table 1: Summary of Non-small-cell Lung Cancer Market, Epidemiology, and Key Events (2019–2032)
  • Table 2: TNM Staging of Non–Small Cell Lung Cancer
  • Table 3: Total Incident cases of Non–Small Cell Lung Cancer patients in the 7MM (2019–2032)
  • Table 4: Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in the 7MM (2019–2032)
  • Table 5: Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in the 7MM (2019–2032)
  • Table 6: Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in the 7MM (2019–2032)
  • Table 7: Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in the 7MM (2019–2032)
  • Table 8: Total Incident cases of Non–Small Cell Lung Cancer patients in the United States (2019–2032)
  • Table 9: Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in the United States (2019–2032)
  • Table 10: Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in the United States (2019–2032)
  • Table 11: Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in the United States (2019–2032)
  • Table 12: Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in the United States (2019–2032)
  • Table 13: Total Incident cases of Non–Small Cell Lung Cancer patients in EU 4 and the UK (2019–2032)
  • Table 14: Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in EU4 and the UK (2019–2032)
  • Table 15: Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in EU 4 and the UK (2019–2032)
  • Table 16: Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in EU 4 and the UK (2019–2032)
  • Table 17: Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in EU 4 and the UK (2019–2032)
  • Table 18: Total Incident cases of Non–Small Cell Lung Cancer patients in Japan (2019–2032)
  • Table 19: Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in Japan (2019–2032)
  • Table 20: Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in Japan (2019–2032)
  • Table 21: Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in Japan (2019–2032)
  • Table 22: Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in Japan (2019–2032)
  • Table 23: Standard Treatment Options of Non–Small Cell Lung Cancer (Stage-wise)
  • Table 24: Summary of Recommendations (SEOM Clinical Guideline)
  • Table 25: Strength of Evidence
  • Table 26: Strength of Evidence
  • Table 27: Marketed Drugs Key Cross
  • Table 28: Rozlytrek (Entrectinib), Clinical Trial Description, 2023
  • Table 29: Imfinzi (Durvalumab), Clinical Trial Description, 2023
  • Table 30: Opdivo (Nivolumab), Clinical Trial Description, 2023
  • Table 31: Tecentriq (Atezolizumab), Clinical Trial Description, 2023
  • Table 32: Keytruda (Pembrolizumab), Clinical Trial Description, 2023
  • Table 33: Tagrisso (Osimertinib), Clinical Trial Description, 2023
  • Table 34: Lorbrena (Lorlatinib), Clinical Trial Description, 2023
  • Table 35: Vizimpro (Dacomitinib), Clinical Trial Description, 2023
  • Table 36: Alunbrig (Brigatinib), Clinical Trial Description, 2023
  • Table 37: Alecensa (Alectinib), Clinical Trial Description, 2023
  • Table 38: Portrazza (Necitumumab), Clinical Trial Description, 2023
  • Table 39: Telisotuzumab Vedotin (ABBV-399), Clinical Trial Description, 2023
  • Table 40: X-396 (Ensartinib), Clinical Trial Description, 2023
  • Table 41: SAR408701, Clinical Trial Description, 2023
  • Table 42: Avelumab, Clinical Trial Description, 2023
  • Table 43: Eftilagimod alpha, Clinical Trial Description, 2023
  • Table 44: Sitravatinib (MGCD516), Clinical Trial Description, 2023
  • Table 45: 7MM Market Size of PD-L1 Non–Small Cell Lung Cancer By Line of Therapy, in USD Million (2019–2032)
  • Table 46: 7MM Market Size ofPD-L1 Non–Small Cell Lung Cancer by therapies, in USD Million (2019–2032)
  • Table 47: United States Market Size of PD-L1 Non–Small Cell Lung Cancer By Line of Therapy, in USD Million (2019–2032)
  • Table 48: United States Market Size ofPD-L1 Non–Small Cell Lung Cancer by therapies, in USD Million (2019–2032)
  • Table 50: EU 4 and the UK Market Size of PD-L1 Non–Small Cell Lung Cancer By Line of Therapy, in USD Million (2019–2032)
  • Table 51: EU 4 and the UK Market Size of PD-L1 Non–Small Cell Lung Cancer by therapies, in USD Million (2019–2032)
  • Table 52: Japan Market Size of PD-L1 Non–Small Cell Lung Cancer By Line of Therapy, in USD Million (2019–2032)
  • Table 53: Japan Market Size ofPD-L1 Non–Small Cell Lung Cancer by therapies, in USD Million (2019–2032)
  • Table 54: 7MM Market Size of BRAF Non–Small Cell Lung Cancer By Line of Therapy, in USD Million (2019–2032)
  • Table 55: 7MM Market Size of BRAF Non–Small Cell Lung Cancer by therapies, in USD Million (2019–2032)
  • Table 56: United States Market Size of BRAF Non–Small Cell Lung Cancer By Line of Therapy, in USD Million (2019–2032)
  • Table 57: United States Market Size of BRAF Non–Small Cell Lung Cancer by Therapies, in USD Million (2019–2032)
  • Table 59: EU 4 and the UK Market Size of BRAF Non–Small Cell Lung Cancer By Line of Therapy, in USD Million (2019–2032)
  • Table 60: EU 4 and the UK Market Size of BRAF Non–Small Cell Lung Cancer by Therapies, in USD Million (2019–2032)
  • Table 61: Japan Market Size of BRAF Non–Small Cell Lung Cancer By Line of Therapy, in USD Million (2019–2032)
  • Table 62: Japan Market Size of BRAF Non–Small Cell Lung Cancer by Therapies, in USD Million (2019–2032)
  • Table 63: 7MM Market Size of c-MET Non–Small Cell Lung Cancer by Line of Therapy, in USD Million (2019–2032)
  • Table 64: 7MM Market Size of c-MET Non–Small Cell Lung Cancer by therapies, in USD Million (2019–2032)
  • Table 65: United States Market Size of c-MET Non–Small Cell Lung Cancer by Line of Therapy, in USD Million (2019–2032)
  • Table 66: United States Market Size of c-MET Non–Small Cell Lung Cancer by Therapies, in USD Million (2019–2032)
  • Table 68: EU 4 and the UK Market Size of c-MET Non–Small Cell Lung Cancer by Line of Therapy, in USD Million (2019–2032)
  • Table 69: EU 4 and the UK Market Size of c-MET Non–Small Cell Lung Cancer by Therapies, in USD Million (2019–2032)
  • Table 70: Japan Market Size of c-MET Non–Small Cell Lung Cancer by Line of Therapy, in USD Million (2019–2032)
  • Table 71: Japan Market Size of c-MET Non–Small Cell Lung Cancer by Therapies, in USD Million (2019–2032)
  • Table 72: 7MM Market Size of EGFR-positive Non–Small Cell Lung Cancer By Line of Therapy in USD Million (2019–2032)
  • Table 73: 7MM Market Size of EGFR-positive Non–Small Cell Lung Cancer by therapies in USD Million (2019–2032)
  • Table 74: United States Market Size of EGFR-positive Non–Small Cell Lung Cancer By Line of Therapy in USD Million (2019–2032)
  • Table 75: United States Market Size of EGFR-positive Non–Small Cell Lung Cancer by Therapies in USD Million (2019–2032)
  • Table 77: EU 4 and the UK Market Size of EGFR-positive Non–Small Cell Lung Cancer By Line of Therapy in USD Million (2019–2032)
  • Table 78: EU 4 and the UK Market Size of EGFR-positive Non–Small Cell Lung Cancer by Therapies in USD Million (2019–2032)
  • Table 79: Japan Market Size of EGFR-positive Non–Small Cell Lung Cancer By Line of Therapy in USD Million (2019–2032)
  • Table 80: Japan Market Size of EGFR-positive Non–Small Cell Lung Cancer by Therapies in USD Million (2019–2032)
  • Table 81: 7MM Market Size of ALK Non–Small Cell Lung Cancer By Line of Therapy, in USD Million (2019–2032)
  • Table 82: 7MM Market Size of ALK Non–Small Cell Lung Cancer by therapies, in USD Million (2019–2032)
  • Table 83: United States Market Size of ALK Non–Small Cell Lung Cancer by Line of Therapy, in USD Million (2019–2032)
  • Table 84: United States Market Size of ALK Non–Small Cell Lung Cancer by Therapies, in USD Million (2019–2032)
  • Table 85: EU 4 and the UK Market Size of ALK Non–Small Cell Lung Cancer by Line of Therapy, in USD Million (2019–2032)
  • Table 86: EU 4 and the UK Market Size of ALK Non–Small Cell Lung Cancer by Therapies, in USD Million (2019–2032)
  • Table 87: Japan Market Size of ALK Non–Small Cell Lung Cancer by Line of Therapy, in USD Million (2019–2032)
  • Table 88: Japan Market Size of ALK Non–Small Cell Lung Cancer by Therapies, in USD Million (2019–2032)

List of Figures:

  • Figure 1: Non–Small Cell Lung Cancer SWOT Analysis
  • Figure 2: Major Types of Non–Small Cell Lung Cancer
  • Figure 3: Sign and Symptoms of Non–Small Cell Lung Cancer
  • Figure 4: Risks Factors of Non–Small Cell Lung Cancer
  • Figure 5: Alterations in Targetable Oncogenic Pathways in LUAD and LUSC
  • Figure 6: Schematic Illustration of the Non–Small Cell Lung Cancer Staging
  • Figure 7: Global Heat Map of Lung Cancer
  • Figure 8: Total Incident cases of Non–Small Cell Lung Cancer patients in the 7MM (2019–2032)
  • Figure 9: Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in the 7MM (2019–2032)
  • Figure 10: Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in the 7MM (2019–2032)
  • Figure 11: Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in the 7MM (2019–2032)
  • Figure 12: Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in the 7MM (2019–2032)
  • Figure 13: Total Incident cases of Non–Small Cell Lung Cancer patients in the United States (2019–2032)
  • Figure 14: Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in the United States (2019–2032)
  • Figure 15: Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in the United States (2019–2032)
  • Figure 16: Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in the United States (2019–2032)
  • Figure 17: Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in the United States (2019–2032)
  • Figure 18: Total Incident cases of Non–Small Cell Lung Cancer patients in EU4 and the UK (2019–2032)
  • Figure 19: Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in EU4 and the UK (2019–2032)
  • Figure 20: Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in EU4 and the UK (2019–2032)
  • Figure 21: Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in EU4 and the UK (2019–2032)
  • Figure 22: Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in EU4 and the UK (2019–2032)
  • Figure 23: Total Incident cases of Non–Small Cell Lung Cancer patients in Japan (2019–2032)
  • Figure 24: Total Incident cases of Non–Small Cell Lung Cancer patients by Histology in Japan (2019–2032)
  • Figure 25: Total Diagnosed cases of Non–Small Cell Lung Cancer patients by Stages in Japan (2019–2032)
  • Figure 26: Total Non–Small Cell Lung Cancer cases of patients by Genetic mutation/Biomarkers in Japan (2019–2032)
  • Figure 27: Total Treated cases of Non–Small Cell Lung Cancer patients by Line of Therapies in Japan (2019–2032)
  • Figure 28: Advanced/Metastatic Non–Small Cell Lung Cancer Treatment Algorithm
  • Figure 29: Market Size of PD-L1 Non–Small Cell Lung Cancer in the 7MM Countries, in USD Million (2019–2032)
  • Figure 30: Market Size of PD-L1 Non–Small Cell Lung Cancer in the United States by Therapies, in USD Million (2019–2032)
  • Figure 31: Market Size of PD-L1 Non–Small Cell Lung Cancer in EU4 and the UK by Therapies, in USD Millions (2019–2032)
  • Figure 32: Market Size of PD-L1 Non–Small Cell Lung Cancer in Japan, in USD Millions (2019–2032)
  • Figure 33: Market Size of BRAF Non–Small Cell Lung Cancer in the 7MM Countries in USD Million (2019–2032)
  • Figure 34: Market Size of BRAF Non–Small Cell Lung Cancer in the United States by Therapies, in USD Millions (2019–2032)
  • Figure 35: Market Size of BRAF Non–Small Cell Lung Cancer in EU4 and the UK by Therapies, in USD Millions (2019–2032)
  • Figure 36: Market Size of BRAF Non–Small Cell Lung Cancer by Therapies in Japan, in USD Millions (2019–2032)
  • Figure 37: Market Size of c-MET Non–Small Cell Lung Cancer in the 7MM Countries, in USD Million (2019–2032)
  • Figure 38: Market Size of c-MET Non–Small Cell Lung Cancer in the United States by Therapies, in USD Millions (2019–2032)
  • Figure 39: Market Size of c-MET Non–Small Cell Lung Cancer in EU4 and the UK , in USD Millions (2019–2032)
  • Figure 40: Market Size of c-MET Non–Small Cell Lung Cancer by therapies in Japan, in USD Millions (2019–2032)
  • Figure 41: Market Size of EGFR-positive Non–Small Cell Lung Cancer in the 7MM, in USD Million (2019–2032)
  • Figure 42: Market Size of EGFR-positive Non–Small Cell Lung Cancer in the US, USD Millions (2019–2032)
  • Figure 43: Market Size of EGFR-positive Non–Small Cell Lung Cancer in EU 4 and the UK, USD Millions (2019–2032)
  • Figure 44: Market Size of Non–Small Cell Lung Cancer in Japan, USD Millions (2019–2032)
  • Figure 45: Market Size of ALK Non–Small Cell Lung Cancer in the 7MM, in USD Million (2019–2032)
  • Figure 46: Market Size of ALK Non–Small Cell Lung Cancer in the United States by Therapies, in USD Millions (2019–2032)
  • Figure 47: Market Size of ALK Non–Small Cell Lung Cancer in EU 4 and the UK by Therapies, in USD Millions (2019–2032)
  • Figure 48: Market Size of ALK Non–Small Cell Lung Cancer in Japan by Therapies, in USD Millions (2019–2032)
  • *The list of figures is not exhaustive; the final content may vary

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