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Prostate Cancer Pipeline Insight

DelveInsight’s, “Prostate Cancer - Pipeline Insight, 2021,” report provides comprehensive insights about 200+ companies and 200+ pipeline drugs in Prostate Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

Geography Covered

  • Global coverage

Prostate Cancer Understanding

Prostate Cancer: Overview

The prostate is a small walnut shaped gland in the pelvis of men. It is located next to the bladder and can be examined by getting a digital rectal exam. Prostate Cancer is a form of cancer that develops in the prostate gland. It is the second-leading cause of cancer deaths for men in the U.S. About 1 in 9 men will be diagnosed with Prostate Cancer in their lifetime. This year, nearly 250,000 men will be diagnosed with Prostate Cancer. Prostate Cancer cells can spread by breaking away from a prostate tumor. They can travel through blood vessels or lymph nodes to reach other parts of the body. After spreading, cancer cells may attach to other tissues and grow to form new tumors, causing damage where they land.


"Prostate Cancer - Pipeline Insight, 2021" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Prostate Cancer pipeline landscape is provided which includes the disease overview and Prostate Cancer treatment guidelines. The assessment part of the report embraces, in depth Prostate Cancer commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Prostate Cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Prostate Cancer R&D. The therapies under development are focused on novel approaches to treat/improve Prostate Cancer.

Prostate Cancer Emerging Drugs Chapters

This segment of the Prostate Cancer report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.


Prostate Cancer Emerging Drugs


Pembrolizumab: Merck & Co

Keytruda (pembrolizumab) is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. Binding of the PD-1 ligands, PD-L1 and PD-L2, to the PD-1 receptor found on T cells, inhibits T cell proliferation and cytokine production. Upregulation of PD-1 ligands occurs in some tumors and signaling through this pathway can contribute to inhibition of active T-cell immune surveillance of tumors. Pembrolizumab is a monoclonal antibody that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2, releasing PD-1 pathway-mediated inhibition of the immune response, including the anti-tumor immune response. Currently, it is in phase 3 stage of development to treat Prostate Cancer.


Talazoparib: Pfizer

Talazoparib is an inhibitor of PARP enzymes, which play a role in DNA repair. Preclinical studies suggest that talazoparib may work by blocking PARP enzyme activity and trapping PARP at the site of DNA damage, leading to decreased cancer cell growth and cancer cell death. Talazoparib anti-tumor activity also was observed in mouse models of human breast cancer that expressed mutated or non-mutated BRCA1/2.


ODM-208: Orion

ODM 208, an orally bioavailable, non-steroid selective inhibitor of CYP11A1 (cholesterol side-chain cleavage enzyme), is being developed by Orion. Steroid hormones stimulate the growth of hormonally regulated cancers, such as most prostate and breast cancers. Hormonal treatments are highly effective, but drug resistance will often eventually emerge and cancer will start growing again. The molecule (ODM-208) has shown antitumor activity. It has potential efficacy also for those cancers that have become resistant to the standard hormonal treatments. Currently, it is in phase 2 stage of development to treat Prostate Cancer.


ZEN 3694: Zenith Epigenetics

The company’s lead product, ZEN-3694, a BET inhibitor, in combination with enzalutamide, is in a Phase 2 randomized clinical trial for treatment of metastatic castration resistant Prostate Cancer (mCRPC) in patients that have progressed on an androgen receptor signaling inhibitor.


EPI-7386: ESSA Pharma

EPI-7386 is an investigational, highly-selective, oral, small molecule inhibitor of the N-terminal domain of the androgen receptor. EPI-7386 is currently being studied in a Phase 1 clinical trial (NCT04421222) in men with metastatic castration-resistant Prostate Cancer (""mCRPC"") whose tumors have progressed on current standard-of-care therapies. The Phase I clinical trial of EPI-7386 began in Q3 of 2020 following FDA allowance of the IND and Health Canada acceptance. The U.S. FDA has granted Fast Track designation to EPI-7386 for the treatment of adult male patients with mCRPC resistant to standard-of-care treatment. ESSA retains all rights to EPI-7386 worldwide.

Further product details are provided in the report……..

Prostate Cancer: Therapeutic Assessment

This segment of the report provides insights about the different Prostate Cancer drugs segregated based on following parameters that define the scope of the report, such as:

  • Major Players in Prostate Cancer

There are approx. 200+ key companies which are developing the therapies for Prostate Cancer. The companies which have their Prostate Cancer drug candidates in the most advanced stage, i.e. phase III include, Merck & Co.

Phases

DelveInsight’s report covers around 200+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration


Prostate Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Oral
  • Parenteral
  • Intravenous
  • Subcutaneous
  • Topical.
  • Molecule Type


Products have been categorized under various Molecule types such as

  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Prostate Cancer: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Prostate Cancer therapeutic drugs key players involved in developing key drugs.


Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Prostate Cancer drugs.

Prostate Cancer Report Insights

  • Prostate Cancer Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Prostate Cancer Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Prostate Cancer drugs?
  • How many Prostate Cancer drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Prostate Cancer?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Prostate Cancer therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Prostate Cancer and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

Prostate Cancer: Overview

  • Causes
  • Mechanism of Action
  • Signs and Symptoms
  • Diagnosis
  • Disease Management

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Late Stage Products (Phase III)

  • Comparative Analysis

Pembrolizumab: Merck & Co

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report….

Mid Stage Products (Phase II)

  • Comparative Analysis

ODM-208: Orion Pharma

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report….

Early Stage Products (Phase I)

  • Comparative Analysis

EPI 7386: ESSA Pharma

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report….

Preclinical and Discovery Products

  • Comparative Analysis

Drug name: Company name

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…

Inactive Products

  • Comparative Analysis

Prostate Cancer Key Companies

Prostate Cancer Key Products

Prostate Cancer- Unmet Needs

Prostate Cancer- Market Drivers and Barriers

Prostate Cancer- Future Perspectives and Conclusion

Prostate Cancer Analyst Views

Prostate Cancer Key Companies

Appendix

List of Table

Table 1: Total Products for Prostate Cancer 

Table 2: Late Stage Products                                                      

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for Prostate Cancer

Figure 2: Late Stage Products                              

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Products    

• Merck & Co

• Pfizer

• Orion

• Zenith Epigenetics

• ESSA Pharma

• RhoVac

• AstraZeneca

• Blue Earth Diagnostics

• Advaxis, Inc.

• Emtora Biosciences

• Tracon Pharmaceuticals Inc.

• Bristol-Myers Squibb

• Laekna Limited

• Bracco Diagnostics, Inc

• Arvinas Inc

• Epizyme

• Harpoon Therapeutics

• Plexxikon

• Regeneron Pharmaceuticals

• Veru Inc.

• Jiangsu Hengrui Medicine Co.

• Eli Lilly and Company

• Exelixis

• Luye Pharma Group

• Amgen

• Innocrin Pharmaceutical

• Genovax

• Cancer Targeted Technology

• Bayer

• Nymox Pharmaceutical

• Matrix Biomed

• Tavanta Therapeutics

• Fortis Therapeutics, Inc.

• Janssen Research & Development, LLC

• Clarity Pharmaceuticals

• Leap Therapeutics

• Hinova pharmaceuticals

• Allife Medical Science and Technology

• Vaccitech

• Cardiff Oncology

• Suzhou Kintor Pharmaceuticals

• Teneobio, Inc.

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