DelveInsight’s, “Proto oncogene protein c-myc inhibitors - Pipeline Insight, 2022,” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Proto oncogene protein c-myc inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Proto oncogene protein c-myc inhibitors: Overview
cMyc is a 62 kDa protein (439 amino acids) and belongs to the basic helix-loop-helix zipper (bHLHZip) class of transcription factors. cMyc has been implicated in multiple cellular processes, including proliferation, differentiation, apoptosis and metabolism. The four-helix structure of cMyc and MAX binds to DNA sequences, such as E-box motifs (5’-CACGTG -3’), to control transcription of specific genes. These genes have been reported to be involved in chromatin modification, DNA replication, and ribosome and mitochondrial biogenesis. A large number of proofs of principle experiments suggest that targeting cMyc may have considerable therapeutic benefit in human tumors. cMyc binds to the MAX protein and forms dimers, which are necessary for the biological activation of cMyc. Strategies have emerged to inhibit cMyc expression, to interrupt cMyc-Max dimerization, to inhibit cMyc-Max DNA binding, to interfere with key cMyc target genes, and to inhibit cMyc in cancer stem cells (CSCs).
The companies and academics are working to assess challenges and seek opportunities that could influence Proto oncogene protein c-myc inhibitors R&D. The therapies under development are focused on novel approaches for Proto oncogene protein c-myc inhibitors.
This segment of the Proto oncogene protein c-myc inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Proto oncogene protein c-myc inhibitors Emerging Drugs
RRx-001: EpicentRx Inc.
RRx-001 is a next generation, small molecule anticancer immunotherapeutic that downregulates the CD47/SIRPα axis and repolarizes TAMs and other immunosuppressive cells in the tumor microenvironment to an immunostimulatory phenotype. RRx-001 is designed to be used either as a monotherapy or in combination with chemotherapy, radiation therapy or immunotherapy. RRx-001 has Orphan Drug designation from FDA for SCLC, neuroendocrine cancer and glioblastoma, and from EMA for SCLC.
WP1066: Moleculin Biotech
WP1066 is the company’s flagship Immune/Transcription Modulator. It has been the subject of over 50 peer-reviewed articles and its activity against p-STAT3 has now been validated in independent laboratories around the globe. WP1066 and other congeners (molecules similar in structure) in this portfolio have demonstrated in animal models the ability of this new class of agents to increase the natural immune response to tumor activity.
Further product details are provided in the report……..
This segment of the report provides insights about the different Proto oncogene protein c-myc inhibitors drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 15+ key companies which are developing the Proto oncogene protein c-myc inhibitors. The companies which have their Proto oncogene protein c-myc inhibitors drug candidates in the most advanced stage, i.e. Phase III include, EpicentRx.
DelveInsight’s report covers around 15+ products under different phases of clinical development like
Proto oncogene protein c-myc inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Proto oncogene protein c-myc inhibitors therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Proto oncogene protein c-myc inhibitors drugs.
Current Scenario and Emerging Therapies:
Introduction
Executive Summary
Proto oncogene protein c-myc inhibitors: Overview
Pipeline Therapeutics
Therapeutic Assessment
Proto oncogene protein c-myc inhibitors – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
RRx-001: EpicentRx Inc.
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
C41443: Teva Pharmaceutical Industries
Drug profiles in the detailed report…..
Early Stage Products (Phase I and I/II)
WP1066: Moleculin Biotech
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
ES-4000: Escend Pharmaceuticals
Drug profiles in the detailed report…..
Inactive Products
Proto oncogene protein c-myc inhibitors Key Companies
Proto oncogene protein c-myc inhibitors Key Products
Proto oncogene protein c-myc inhibitors- Unmet Needs
Proto oncogene protein c-myc inhibitors- Market Drivers and Barriers
Proto oncogene protein c-myc inhibitors- Future Perspectives and Conclusion
Proto oncogene protein c-myc inhibitors Analyst Views
Proto oncogene protein c-myc inhibitors Key Companies
Appendix
List of Table
Table 1: Total Products for Proto Oncogene Protein c-myc Inhibitors
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Proto Oncogene Protein c-myc Inhibitors
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• EpicentRx Inc.
• Moleculin Biotech
• Peptomyc
• Teva Pharmaceutical Industries
• Plexxikon
• CURACLE
• Aptose Biosciences
• Kintor Pharmaceutical
• Escend Pharmaceuticals
• Hillstream BioPharma
