DelveInsight’s, “TIE-2 Receptor Agonists - Pipeline Insight, 2022,” report provides comprehensive insights about 4+ companies and 6+ pipeline drugs in TIE-2 Receptor Agonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
TIE-2 Receptor Agonists: Overview
The tie receptors form another family of receptor tyrosine kinases. They are important for the regulation of angiogenesis together with the ligands of the tie-2 receptor, the Angiopoietins. The tie tyrosine kinase receptors, like the VEGF receptors, form the only receptor families that are predominantly expressed on endothelial cells. Most studies have focused on Ang-1 and Ang-2 which bind the Tie2 receptor and have the best characterized roles in angiogenesis. The roles of Ang-1 and Ang-2 signaling are complex and context dependent. Ang-1 binds and directly activates the Tie2 receptor, and this can have pro-angiogenic roles, stimulating EC sprouting and vessel growth as well as being correlated with vessel density in a variety of tumors.
The companies and academics are working to assess challenges and seek opportunities that could influence TIE-2 Receptor Agonists R&D. The therapies under development are focused on novel approaches for TIE-2 Receptor Agonists.
This segment of the TIE-2 Receptor Agonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
TIE-2 Receptor Agonists Emerging Drugs
AV-001: Vasomune Therapeutics
AV-001, a synthetic Angiopoietin 1 mimetic, activates the Tie2 receptor which is highly expressed on the surface of endothelial cells located within the vasculature.. AV-001 is designed to interact with the Tie2 receptor on a binding domain distinct from the natural ligands Angiopoietin 1 and Angiopoietin 2. Activation of Tie2 broadly promotes barrier defense against vascular leak and counteracts vascular inflammation by decreasing the activity of multiple pro-inflammatory factors. AV-001 represents a novel multifactorial approach that acts at the cellular and tissue-level. This approach is in contrast to the traditional highly specific lock and key therapies aimed at killing the pathogen or individual targets within the inflammatory response pathway. There are no clinically available medications to treat vascular leak.
Razuprotafib: Aadi Biosciences
Razuprotafib binds to and inhibits vascular endothelial protein tyrosine phosphatase (VE-PTP), an important negative regulator of Tie2. Decreased Tie2 activity contributes to vascular instability in many diseases including diabetes and more recently has been shown to contribute to the development of increased IOP and glaucoma. Razuprotafib activates the Tie2 receptor irrespective of extracellular levels of its binding ligands, angiopoietin-1 (agonist) or angiopoietin-2 (antagonist) and we believe that it may be the most efficient pharmacologic approach to maintain normal Tie2 activation. Aerpio is studying a topical ocular formulation of razuprotafib in open angle glaucoma and exploring the utility of subcutaneous razuprotafib for diabetic complications, including diabetic nephropathy. In addition, a subcutaneous formulation of razuprotafib is being explored for its therapeutic potential in treating or preventing ARDS associated with COVID-19.
Further product details are provided in the report……..
This segment of the report provides insights about the different TIE-2 Receptor Agonists drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 4+ key companies which are developing the TIE-2 Receptor Agonists. The companies which have their TIE-2 Receptor Agonists drug candidates in the most advanced stage, i.e. Phase II include, Aadi Biosciences.
DelveInsight’s report covers around 6+ products under different phases of clinical development like
TIE-2 Receptor Agonists pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses TIE-2 Receptor Agonists therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging TIE-2 Receptor Agonists drugs.
Current Scenario and Emerging Therapies:
Introduction
Executive Summary
TIE-2 Receptor Agonists: Overview
Pipeline Therapeutics
Therapeutic Assessment
TIE-2 Receptor Agonists – DelveInsight’s Analytical Perspective
Late Stage Products (Phase III)
Drug name: Company name
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
Razuprotafib: Aadi Biosciences
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
AV 001: Vasomune Therapeutics
Drug profiles in the detailed report…..
Pre-clinical and Discovery Stage Products
PMC 403: PharmAbcine
Drug profiles in the detailed report…..
Inactive Products
TIE-2 Receptor Agonists Key Companies
TIE-2 Receptor Agonists Key Products
TIE-2 Receptor Agonists- Unmet Needs
TIE-2 Receptor Agonists- Market Drivers and Barriers
TIE-2 Receptor Agonists- Future Perspectives and Conclusion
TIE-2 Receptor Agonists Analyst Views
TIE-2 Receptor Agonists Key Companies
Appendix
List of Table
Table 1: Total Products for TIE-2 Receptor Agonists
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for TIE-2 Receptor Agonists
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• Aadi Biosciences
• Vasomune Therapeutics
• AsclepiX Therapeutics
• Q BioMed
• PharmAbcine
• Mannin Research
