DelveInsight’s, “Toll-Like Receptor 4 (TLR-4) Agonist - Pipeline Insight, 2022,” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Toll-Like Receptor 4 (TLR-4) Agonist pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
Toll-Like Receptor 4 (TLR-4) Agonist: Overview
The activation of toll-like receptor 4 (TLR4) has been proposed to have a major influence on the inflammatory signalling pathways of the intestinal tract. Inhibition of TLR4 has been postulated as an effective way to treat intestinal inflammation. However, there are a limited number of studies looking into the potential of TLR4 antagonism as a therapeutic approach for intestinal inflammation.
Toll-like receptors (TLRs) are type 1 transmembrane proteins belonging to the wider family of pattern recognition receptors, and are responsible for the recognition of a variety of molecular signals, including endogenous damage and pathogen-associated signals, damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs), respectively. TLR4 is an intra- and extracellular receptor expressed on endosomes and cytoplasmic membranes, which recognizes PAMPs (flagellin and LPS) and DAMPS (calprotectin, S100A8/9 HMGB1 and HSP70) through its co-receptors MD2 and CD14.
Targeting TLR4 could represent a potential approach to regulate immune responses and treat inflammation. However, any potential therapeutic agent must be able to block the harmful effects of TLR4 activation without negatively affecting the host’s defense functions. Anti-TLR4 therapies present a promising alternative for future innovative treatments for both inflammatory bowel disease and intestinal mucositis.
The companies and academics are working to assess challenges and seek opportunities that could influence Toll-Like Receptor 4 (TLR-4) Agonist R&D. The therapies under development are focused on novel approaches for Toll-Like Receptor 4 (TLR-4) Agonist.
This segment of the Toll-Like Receptor 4 (TLR-4) Agonist report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
Toll-Like Receptor 4 (TLR-4) Agonist Emerging Drugs
E-5564: Eisai
E-5564 (Eritoran) is a TLR (Toll-Like Receptor) 4 antagonist created with natural product organic synthesis technology. It is a structural analogue of Lipid A which is an activator of endotoxins of bacteria. It is expected to suppress inflammation and increasing in severity caused by COVID-19 by inhibiting the activation of TLR4, which is found in the most upstream position of various cytokine gene expression signaling that causes the cytokine-storm. Development is in collaboration with GCAR (Global Coalition for Adaptive Research).
It is currently in Phase III stage of development and is being developed by Eisai.
TAK-242: Akaza Bioscience
TAK-242 acts as inhibitor of Toll-like receptor 4. Akaza Bioscience is preparing to run a Phase II study of TAK-242, a novel immunological therapy. This pan-European study aims to investigate the safety and efficacy of TAK-242, as measured by changes in key biomarkers and 28-day survival rates. The trial will be a randomised, double-blind, placebo-controlled study in patients with Grade 1 or 2 ACLF.
It is currently in Phase II stage of development and is being developed by Akaza Bioscience.
Further product details are provided in the report……..
This segment of the report provides insights about the different Toll-Like Receptor 4 (TLR-4) Agonist drugs segregated based on following parameters that define the scope of the report, such as:
There are approx. 10+ key companies which are developing the Toll-Like Receptor 4 (TLR-4) Agonist. The companies which have their Toll-Like Receptor 4 (TLR-4) Agonist drug candidates in the most advanced stage, i.e. Phase III include, Eisai.
DelveInsight’s report covers around 10+ products under different phases of clinical development like
Toll-Like Receptor 4 (TLR-4) Agonist pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Products have been categorized under various Molecule types such as
Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.
The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Toll-Like Receptor 4 (TLR-4) Agonist therapeutic drugs key players involved in developing key drugs.
Pipeline Development Activities
The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Toll-Like Receptor 4 (TLR-4) Agonist drugs.
Current Scenario and Emerging Therapies:
Introduction
Executive Summary
Toll-Like Receptor 4 (TLR-4) Agonist: Overview
Pipeline Therapeutics
Therapeutic Assessment
Toll-Like Receptor 4 (TLR-4) Agonist– DelveInsight’s Analytical Perspective
In-depth Commercial Assessment
Toll-Like Receptor 4 (TLR-4) Agonist Collaboration Deals
Late Stage Products (Phase III)
E5564: Eisai
Drug profiles in the detailed report…..
Mid Stage Products (Phase II)
TAK-242: Akaza Bioscience
Drug profiles in the detailed report…..
Early Stage Products (Phase I)
OX125: Orexo
Drug profiles in the detailed report…..
Preclinical and Discovery Stage Products
Drug Name: Company Name
Drug profiles in the detailed report…..
Inactive Products
Toll-Like Receptor 4 (TLR-4) Agonist Key Companies
Toll-Like Receptor 4 (TLR-4) Agonist Key Products
Toll-Like Receptor 4 (TLR-4) Agonist- Unmet Needs
Toll-Like Receptor 4 (TLR-4) Agonist- Market Drivers and Barriers
Toll-Like Receptor 4 (TLR-4) Agonist- Future Perspectives and Conclusion
Toll-Like Receptor 4 (TLR-4) Agonist Analyst Views
Toll-Like Receptor 4 (TLR-4) Agonist Key Companies
Appendix
List of Table
Table 1: Total Products for Toll-Like Receptor 4 (TLR-4) Agonist
Table 2: Late Stage Products
Table 3: Mid Stage Products
Table 4: Early Stage Products
Table 5: Pre-clinical & Discovery Stage Products
Table 6: Assessment by Product Type
Table 7: Assessment by Stage and Product Type
Table 8: Assessment by Route of Administration
Table 9: Assessment by Stage and Route of Administration
Table 10: Assessment by Molecule Type
Table 11: Assessment by Stage and Molecule Type
Table 12: Inactive Products
List of Figures
Figure 1: Total Products for Toll-Like Receptor 4 (TLR-4) Agonist
Figure 2: Late Stage Products
Figure 3: Mid Stage Products
Figure 4: Early Stage Products
Figure 5: Preclinical and Discovery Stage Products
Figure 6: Assessment by Product Type
Figure 7: Assessment by Stage and Product Type
Figure 8: Assessment by Route of Administration
Figure 9: Assessment by Stage and Route of Administration
Figure 10: Assessment by Molecule Type
Figure 11: Assessment by Stage and Molecule Type
Figure 12: Inactive Products
• Eisai
• Akaza Bioscience
• OPNT-003
• GeNeuro
• MN-166 (ibudilast)
• Orexo
