Trail Receptor 2 Agonists Pipeline Insight

DelveInsight’s, “TRAIL Receptor 2 Agonists - Pipeline Insight, 2022,” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in TRAIL Receptor 2 Agonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

TRAIL Receptor 2 Agonists Understanding

TRAIL Receptor 2 Agonists: Overview

TRAIL receptor 2 (TRAILR2), also known as Death receptor 5 (DR5), is a cell surface receptor of the TNF-receptor superfamily that binds TRAIL and mediates apoptosis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in neoplastic cells upon binding to its receptors TRAIL-R1 and TRAIL-R2. This biological principle has been adopted for the development of cancer-selective therapies. However, many tumor cells are resistant to TRAIL and moreover TRAIL-R1/R2 can activate pro-inflammatory pathways thereby promoting invasion, migration, and metastasis

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence TRAIL Receptor 2 Agonists R&D. The therapies under development are focused on novel approaches for TRAIL Receptor 2 Agonists.

TRAIL Receptor 2 Agonists Emerging Drugs Chapters

This segment of the TRAIL Receptor 2 Agonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

 

TRAIL Receptor 2 Agonists Emerging Drugs

 

INBRX-109: Inhibrx

INBRX-109 is a tetravalent DR5 agonistic antibody, is designed to exploit tumor-biased direct cell death induction by DR5 activation in numerous cancer types. With a valency of four, it has the ability to potently agonize DR5 through efficient receptor clustering, causing cell death, but by way of our sdAb platform, also eliminates recognition by pre-existing anti-drug antibodies (ADAs) to lessen the potential for hyper-clustering. In January 2021, the U.S. Food and Drug Administration (FDA) granted Fast Track designation to INBRX-109 for the treatment of patients with unresectable or metastatic conventional chondrosarcoma.

 

BI 905711: Travere Therapeutics

BI 905711 is a tetravalent bispecific antibody that cross-links the pro-apoptotic tumor necrosis factor (TNF)-related apoptosis-inducing ligand receptor 2 (TRAILR2) with the tumor cell anchor cadherin 17 (CDH17). CDH17-dependent clustering of TRAILR2 allows BI 905711 to induce selective apoptosis in CDH17-expressing tumor cells. BI 905711 is currently being investigated in patients with advanced gastrointestinal (GI) cancers.

Further product details are provided in the report……..

TRAIL Receptor 2 Agonists: Therapeutic Assessment

This segment of the report provides insights about the different TRAIL Receptor 2 Agonists drugs segregated based on following parameters that define the scope of the report, such as:

  • Major Players working on TRAIL Receptor 2 Agonists

There are approx. 5+ key companies which are developing the TRAIL Receptor 2 Agonists. The companies which have their TRAIL Receptor 2 Agonists drug candidates in the most advanced stage, i.e. Phase II include, Inhibrx.

Phases

DelveInsight’s report covers around 5+ products under different phases of clinical development like

  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

 

TRAIL Receptor 2 Agonists pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Molecule Type

 

Products have been categorized under various Molecule types such as

  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

TRAIL Receptor 2 Agonists: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses TRAIL Receptor 2 Agonists therapeutic drugs key players involved in developing key drugs.

 

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging TRAIL Receptor 2 Agonists drugs.

TRAIL Receptor 2 Agonists Report Insights

  • TRAIL Receptor 2 Agonists Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

TRAIL Receptor 2 Agonists Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

  • How many companies are developing TRAIL Receptor 2 Agonists drugs?
  • How many TRAIL Receptor 2 Agonists drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of TRAIL Receptor 2 Agonists?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the TRAIL Receptor 2 Agonists therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for TRAIL Receptor 2 Agonists and their status?
  • What are the key designations that have been granted to the emerging drugs?

Introduction

Executive Summary

TRAIL Receptor 2 Agonists: Overview

  • Structure
  • Mechanism of Action

Pipeline Therapeutics

  • Comparative Analysis

Therapeutic Assessment

  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

TRAIL Receptor 2 Agonists – DelveInsight’s Analytical Perspective

Late Stage Products (Phase III)

  • Comparative Analysis

Drug name: Company name

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Mid Stage Products (Phase II)

  • Comparative Analysis

INBRX-109: Inhibrx

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Early Stage Products (Phase I)

  • Comparative Analysis

BI 905711: Boehringer Ingelheim

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Pre-clinical and Discovery Stage Products

  • Comparative Analysis

TLY 012: Theraly Fibrosis

  • Product Description
  • Research and Development
  • Product Development Activities

Drug profiles in the detailed report…..

Inactive Products

  • Comparative Analysis

TRAIL Receptor 2 Agonists Key Companies

TRAIL Receptor 2 Agonists Key Products

TRAIL Receptor 2 Agonists- Unmet Needs

TRAIL Receptor 2 Agonists- Market Drivers and Barriers

TRAIL Receptor 2 Agonists- Future Perspectives and Conclusion

TRAIL Receptor 2 Agonists Analyst Views

TRAIL Receptor 2 Agonists Key Companies

Appendix

List of Table

Table 1: Total Products for TRAIL Receptor 2 Agonists

Table 2: Late Stage Products

Table 3: Mid Stage Products

Table 4: Early Stage Products

Table 5: Pre-clinical & Discovery Stage Products

Table 6: Assessment by Product Type

Table 7: Assessment by Stage and Product Type

Table 8: Assessment by Route of Administration

Table 9: Assessment by Stage and Route of Administration

Table 10: Assessment by Molecule Type

Table 11: Assessment by Stage and Molecule Type

Table 12: Inactive Products

List of Figures

Figure 1: Total Products for TRAIL Receptor 2 Agonists

Figure 2: Late Stage Products                             

Figure 3: Mid Stage Products

Figure 4: Early Stage Products

Figure 5: Preclinical and Discovery Stage Products

Figure 6: Assessment by Product Type                                                                       

Figure 7: Assessment by Stage and Product Type

Figure 8: Assessment by Route of Administration

Figure 9: Assessment by Stage and Route of Administration

Figure 10: Assessment by Molecule Type

Figure 11: Assessment by Stage and Molecule Type

Figure 12: Inactive Products

• Inhibrx
• Boehringer Ingelheim
• IGM Biosciences
• Amgen
• Genmab
• Theraly Fibrosis
• IGM Biosciences

 

Forward to Friend

Need A Quote