Anemia In Chronic Kidney Disease Pipeline Insight

DelveInsight’s, “Anemia in Chronic Kidney Disease – Pipeline Insights, 2021,” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Anemia in Chronic Kidney Disease pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. 

Geography Covered

  • Global coverage

Anemia in Chronic Kidney Disease Understanding

Anemia in Chronic Kidney Disease: Overview

Anemia is a frequent complication of Chronic Kidney Disease. The major cause of anemia in patients with CKD is the decreased ability of kidneys to produce erythropoietin (EPO). Decreased erythrocyte counts leads to insufficient oxygen supply in organs and decreases mobility and activities in daily life, which ultimately leads to a poor quality of life. Anemia might begin in early stages of CKD and usually gets worse as CKD gets progress. Anemia in CKD is typically normocytic, normochromic, and hypoproliferative.

Symptoms

The symptoms of Anemia in Chronic Kidney Disease include:

  • weakness
  • fatigue, or feeling tired
  • headaches
  • problems with concentration
  • paleness
  • dizziness
  • difficulty breathing or shortness of breath
  • chest pain

Diagnosis

A diagnosis of Anemia in Chronic Kidney Disease is based upon a thorough clinical evaluation and a detailed patient history. The laboratory tests including RBC indices, Peripheral blood smear, Reticulocyte count Test are vital in the evaluation of anemia of chronic illness or chronic kidney disease. Diagnosis of anemia of renal disease is based on demonstration of renal insufficiency, normocytic anemia, and peripheral reticulocytopenia.

Treatment

Pateints with anemia with chronic kidney disease can be treated on an outpatient basis. Depending on the cause, treatments options include Iron Supplements, Erythropoiesis-stimulating agents (ESAs), Red Blood Cell Transfusions, and Vitamin B12 and Folic Acid Supplements.

Anemia in Chronic Kidney Disease Emerging Drugs Chapters

This segment of the Anemia in Chronic Kidney Disease report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Anemia in Chronic Kidney Disease Emerging Drugs

  • BCD-066: Biocad

Erythropoietin-based therapy represents the primary treatment and prevention option for anemia in chronic kidney disease. BCD-066 is under Phase III equivalence studies to determine the efficacy and safety of BCD-066 and Aranesp® in treatment of anemia in end-stage chronic kidney disease patients on dialysis.


  • SSS17: Shenyang Sunshine Pharmaceutical

SSS17 is a selective small molecule inhibitor to hypoxia inducible factor proline hydroxylase. It is under Phase 1 development as an oral treatment for anemic patients with chronic kidney diseases. HIF-PH is a hypoxia inducible factor proline hydroxylase, a molecule which can improve the stability and half-life of hypoxia inducible factor α (HIFα), so as to motivate the secretion of erythropoietin, or EPO.

Further product details are provided in the report……..

Anemia in Chronic Kidney Disease: Therapeutic Assessment

This segment of the report provides insights about the different Anemia in Chronic Kidney Disease drugs segregated based on following parameters that define the scope of the report, such as:


  • Major Players in Anemia in Chronic Kidney Disease

There are approx. 10+ key companies which are developing the therapies for Anemia in Chronic Kidney Disease. The companies which have their Anemia in Chronic Kidney Disease drug candidates in the most advanced stage, i.e. phase III include, Biocad.


  • Phases

DelveInsight’s report covers around 10+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration


Anemia in Chronic Kidney Disease pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Oral
  • Parenteral
  • intravitreal
  • Subretinal
  • Topical.
  • Molecule Type


Products have been categorized under various Molecule types such as

  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.


Anemia in Chronic Kidney Disease: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Anemia in Chronic Kidney Disease therapeutic drugs key players involved in developing key drugs.


Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Anemia in Chronic Kidney Disease drugs.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Anemia in Chronic Kidney Disease R&D. The therapies under development are focused on novel approaches to treat/improve Anemia in Chronic Kidney Disease.


Anemia in Chronic Kidney Disease Report Insights

  • Anemia in Chronic Kidney Disease Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs


Anemia in Chronic Kidney Disease Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Anemia in Chronic Kidney Disease drugs?
  • How many Anemia in Chronic Kidney Disease drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Anemia in Chronic Kidney Disease?
  • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Anemia in Chronic Kidney Disease therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Anemia in Chronic Kidney Disease and their status?
  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • Pieris Pharmaceuticals
  • Jiangsu HengRui Medicine
  • Shenyang Sunshine Pharmaceutical
  • Biocad
  • Xenetic Biosciences
  • Chiasma
  • Liminal BioSciences
  • Acceleron Pharma
  • Celgene Corporation

Key Products

  • PRS-080
  • DDO-3055
  • SSS17
  • BCD-131
  • BCD-066
  • Erythropoietin polysialic
  • CHIP 2
  • PBI 1402
  • Sotatercept

 

Introduction

Executive Summary

Anemia in Chronic Kidney Disease: Overview

• Causes

• Mechanism of Action

• Signs and Symptoms

• Diagnosis

• Disease Management

Pipeline Therapeutics

• Comparative Analysis

Therapeutic Assessment

• Assessment by Product Type

• Assessment by Stage and Product Type

• Assessment by Route of Administration

• Assessment by Stage and Route of Administration

• Assessment by Molecule Type

• Assessment by Stage and Molecule Type

Anemia in Chronic Kidney Disease – DelveInsight’s Analytical Perspective

In-depth Commercial Assessment

• Anemia in Chronic Kidney Disease companies’ collaborations, Licensing, Acquisition -Deal Value Trends

Anemia in Chronic Kidney Disease Collaboration Deals

• Company-Company Collaborations (Licensing / Partnering) Analysis

• Company-University Collaborations (Licensing / Partnering) Analysis

Late Stage Products (Phase III)

• Comparative Analysis

Darbepoetin alfa biosimilar: Biocad

• Product Description

• Research and Development

• Product Development Activities

Mid Stage Products (Phase II)

• Comparative Analysis

BCD-131: Biocad

• Product Description

• Research and Development

• Product Development Activities

Drug profiles in the detailed report…..

Early Stage Products (Phase I)

• Comparative Analysis

DDO-3055: Jiangsu HengRui Medicine

• Product Description

• Research and Development

• Product Development Activities

Drug profiles in the detailed report…..

Inactive Products

• Comparative Analysis

Anemia in Chronic Kidney Disease Key Companies

Anemia in Chronic Kidney Disease Key Products

Anemia in Chronic Kidney Disease- Unmet Needs

Anemia in Chronic Kidney Disease- Market Drivers and Barriers

Anemia in Chronic Kidney Disease- Future Perspectives and Conclusion

Anemia in Chronic Kidney Disease Analyst Views

Anemia in Chronic Kidney Disease Key Companies

Appendix

List of Table

 Table 1 Total Products for Anemia in Chronic Kidney Disease

Table 2 Late Stage Products

Table 3 Mid Stage Products

Table 4 Early Stage Products

Table 5 Pre-clinical & Discovery Stage Products

Table 6 Assessment by Product Type

Table 7 Assessment by Stage and Product Type

Table 8 Assessment by Route of Administration

Table 9 Assessment by Stage and Route of Administration

Table 10 Assessment by Molecule Type

Table 11 Assessment by Stage and Molecule Type

Table 12 Inactive Products

List of Figures

 Figure 1 Total Products for Anemia in Chronic Kidney Disease

Figure 2 Late Stage Products

Figure 3 Mid Stage Products

Figure 4 Early Stage Products

Figure 5 Preclinical and Discovery Stage Products

Figure 6 Assessment by Product Type

Figure 7 Assessment by Stage and Product Type

Figure 8 Assessment by Route of Administration

Figure 9 Assessment by Stage and Route of Administration

Figure 10 Assessment by Molecule Type

Figure 11 Assessment by Stage and Molecule Type

Figure 12 Inactive Products

• Pieris Pharmaceuticals

• Jiangsu HengRui Medicine

• Shenyang Sunshine Pharmaceutical

• Biocad

• Xenetic Biosciences

• Chiasma

• Liminal BioSciences

• Acceleron Pharma

• Celgene Corporation

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