| 1 |
Pfizer’s TALA (talazoparib) in metastatic castration-resistant prostate cancer (mCRPC) |
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| 2 |
AstraZeneca and Merck’s Lynparza (olaparib) in Metastatic Castration-resistant Prostate Cancer (mCRPC) |
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| 3 |
Bayer Healthcare and Orion's Nubeqa (darolutamide) in Non-metastatic castration-resistant prostate cancer (nmCRPC) |
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| 4 |
Roche’s Ipatasertib (RG7440) in Metastatic Castration-resistant Prostate Cancer (mCRPC) |
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| 5 |
GSK has a strong say in ASCO 2020 as they are announcing key data on Cell Therapy and Next-generation Immuno-oncology |
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| 6 |
Can much awaited JAVELIN data give any surprise in ASCO 2020? |
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| 7 |
Another new combination approaches for front line multiple myeloma may bring a new option to patients |
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| 8 |
How effectively microsatellite instability-high/mismatch repair can be used for proper positioning in the Colorectal Cancer treatment landscape? |
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| 9 |
Another win for blockbuster Osimertinib (in an early stage of EGFR NSCLC) will further strengthen its potential in Lung Cancer |
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| 10 |
KEYNOTE-355: Randomized, double-blind, phase III study of pembrolizumab + chemotherapy versus placebo + chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative... |
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| 11 |
Alpelisib (ALP) + fulvestrant (FUL) in patients (pts) with PIK3CA-mutated (mut) hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–) advanced breast cancer (ABC)... |
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| 12 |
PARSIFAL: A randomized, multicenter, open-label, phase II trial to evaluate palbociclib in combination with fulvestrant or letrozole in endocrine-sensitive patients with estrogen receptor (ER)[+]/HER2... |
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| 13 |
Association of tumor mutational burden (TMB) and clinical outcomes with pembrolizumab (pembro) versus chemotherapy (chemo) in patients with metastatic triple-negative breast cancer (mTNBC) from KEYNOT... |
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| 14 |
Results of ENCORE 602 (TRIO025), a phase II, randomized, placebo-controlled, doubleblinded, multicenter study of atezolizumab with or without entinostat in patients with advanced triple-negative breas... |
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| 15 |
A phase Ib/II study of eribulin (ERI) plus pembrolizumab (PEMBRO) in metastatic triplenegative breast cancer (mTNBC) (ENHANCE 1). |
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| 16 |
Phase II trial of bicalutamide in combination with palbociclib for the treatment of androgen receptor (+) metastatic breast cancer. |
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| 17 |
A phase Ib study to evaluate the oral selective estrogen receptor degrader GDC-9545 alone or combined with palbociclib in metastatic ER-positive HER2-negative breast cancer. |
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| 18 |
SOPHIA analysis by chemotherapy (Ctx) choice: A phase III (P3) study of margetuximab (M) + Ctx versus trastuzumab (T) + Ctx in patients (pts) with pretreated HER2+ metastatic (met) breast cancer (MBC)... |
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| 19 |
Preliminary safety, efficacy and pharmacokinetics (PK) results of KN026, a HER2 bispecific antibody in patients (pts) with HER2-positive metastatic breast cancer. |
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| 20 |
A phase Ib study of abemaciclib in combination with pembrolizumab for patients with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) locally advanced or metas... |
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| 21 |
Phase Ib trial to evaluate safety and anti-tumor activity of the AKT inhibitor, ipatasertib, in combination with endocrine therapy and a CDK4/6 inhibitor for patients with hormone receptor positive (H... |
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| 22 |
Phase I/II study of SAR439859, an oral selective estrogen receptor degrader (SERD), in estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-) metastatic breast canc... |
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| 23 |
Dual anti-CTLA-4 and anti-PD-1 blockade in metaplastic carcinoma of the breast: (DART=Dual Anti-CTLA-4 & Anti-PD-1 blockade in Rare Tumors) (SWOG S1609, Cohort 36). |
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| 24 |
A phase Ib trial of the cyclin-dependent kinase inhibitor dinaciclib (dina) in combination with pembrolizumab (P) in patients with advanced triple-negative breast cancer (TNBC) and response correlatio... |
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| 25 |
A phase III study of trastuzumab emtansine (T-DM1) + pertuzumab versus trastuzumab + pertuzumab + taxane, after anthracyclines as adjuvant therapy for high-risk HER2-positive early breast cancer (EBC) |
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| 26 |
IMvigor130 results might support the usage of combination of atezolizumab +/- platinum/gemcitabine as an important new treatment option for patients with untreated mUC. |
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| 27 |
Another missed trial of the ASCO 2020 as Adjuvant treatment with the PD-L1 inhibitor did not significantly improve disease-free survival (DFS) in patients with muscle-invasive bladder cancer |
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| 28 |
Promising results from IMbrave150 TRIAL of Atezolizumab + Bevacizumab may shift the treatment paradigsm for advanced HCC |
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| 29 |
Good clinical response for dual immune checkpoint inhibitors (Tremelimumab + Durvalumab) in second line HCC however, tough fight ahead in first line setting from much promising Atezolizumab + Bevacizu... |
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| 30 |
Long term follow up of Lifileucel treatment in a heavily pretreated metastatic melanoma patients who progressed on multiple prior therapies, including anti-PD1 and BRAF/MEK inhibitors |
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| 31 |
Future directions for Head and Neck treatment based on TMB studies |
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| 32 |
Long term follow up study of the use of pembrolizumab and its combination as first line treatment for recurrent/metastatic head and neck cancer |
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| 33 |
Encorafenib plus cetuximab with or without binimetinib for BRAF V600E metastatic colorectal cancer: Updated survival results from a randomized, three-arm, phase III study versus choice of either irino... |
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| 34 |
Pembrolizumab monotherapy for patients with advanced MSI-H colorectal cancer: Longerterm follow-up of the phase II, KEYNOTE-164 study. |
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| 35 |
Nivolumab (NIVO) + low-dose ipilimumab (IPI) as first-line (1L) therapy in microsatellite instability-high/mismatch repair-deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC): Two-year clinical... |
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| 36 |
A Phase II, multicenter, open-label study of trastuzumab deruxtecan in patients with HER2-expressing metastatic colorectal cancer |
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| 37 |
Interim analysis of ZUMA-5: A phase II study of axi-cel in pts with R/R iNHL |
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| 38 |
Lisocabtagene maraleucel (liso-cel) for treatment of 2L TNE R/R aggressive large B-cell NHL |
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| 39 |
Effect of enasidenib plus azacitidine (AZA) on Complete and overall response versus AZA monotherapy in mutant-IDH2 newly diagnosed AML |
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| 40 |
Tolerability and efficacy of anti-CD47 antibody magrolimab combined with azacitidine in MDS and AML: Phase Ib results |
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| 41 |
Glasdegib plus low-dose cytarabine in AML or MDS: BRIGHT AML 1003 final report and four-year OS follow-up |
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| 42 |
Five year results of a phase III study of CPX-351 versus 7+3 in older adults with newly diagnosed high-risk/secondary AML |
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| 43 |
6 month update: Phase III study of venetoclax plus low-dose cytarabine in previously untreated older patients with AML (VIALE-C) |
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| 44 |
Long-term survivors and gilteritinib safety post 1 year in FLT3-mutated R/R AML: ADMIRAL trial |
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| 45 |
Glasdegib in combination with azacitidine in patients with untreated higher-risk MDS, AML and CMML: Effects on marrow recovery and transfusion independence |
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| 46 |
CC-486 is safe and well-tolerated as maintenance therapy in patients >75 years with AML in first remission following induction chemotherapy: Phase III QUAZAR AML-001 trial |
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| 47 |
HRQoL in the phase III QUAZAR-AML-001 trial of CC-486 as maintenance therapy for patients with AML in first remission following induction chemotherapy |
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| 48 |
Venetoclax + intensive chemo with CLIA achieves high rates of durable complete remission with low rates of MRD in pts with newly diagnosed AML |
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| 49 |
Phase II study of lower-dose pracinostat plus azacitidine safety and efficacy in patients with high/very high-risk MDS |
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| 50 |
Phase I study of teclistamab, a dual-targeting immunotherapeutic, in relapse/refractory Multiple Myeloma |
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| 51 |
Initial results from phase III BOSTON study, comparing weekly selinexor + Vd versus twice weekly Vd in patients with R/R multiple myeloma |
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| 52 |
Initial KarMMa results : bb2121, a BCMA-targeted CAR T-cell therapy, in R/R multiple myeloma patients |
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| 53 |
Phase 1/2 update from EVOLVE study : orva-cel, a BCMA- directed CAR T cell therapy for patients with R/R multiple myeloma |
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| 54 |
Efficacy of SCRI-CAR19x22 T cell product in B-ALL and persistence of antiCD22 activity |
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| 55 |
Safety and efficacy results of GC027: The first-in-human, universal CART cell therapy for adult r/r T-ALL |
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| 56 |
Update of CARTITUDE-1: A phase Ib/II study of JNJ-4528, a BCMA-directed CAR-T-cell therapy, in R/R multiple myeloma |
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| 57 |
Primary analysis of phase II trial of VRd with/without elotuzumab for newly diagnosed multiple myeloma (SWOG-1211). |
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| 58 |
Depth of response to isatuximab + KRd (Isa-KRd) in front-line treatment of multiple myeloma: Interim analysis of the GMMG-CONCEPT trial |
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| 59 |
Updates from BELLINI, a phase III study of venetoclax or placebo in combination with Vd in R/R multiple myeloma |
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| 60 |
Selinexor, daratumumab, and dexamethasone in patients with R/R multiple myeloma |
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| 61 |
VRd superiority to lenalidomide, adriamycin, and dexamethasone (RAd) prior to risk-adapted transplant in newly diagnosed myeloma |
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| 62 |
Phase III TOURMALINE-MM4 : Ixazomib vs placebo maintenance for newly diagnosed multiple myeloma patients not undergoing ASCT |
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| 63 |
DREAMM-2 study: Single-agent belantamab mafodotin (GSK2857916) in patients with R/R multiple myeloma refractory to PI, IMiD, and anti-CD38 mAb |
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| 64 |
BELLINI study : Evaluation of MRD in R/R multiple myeloma patients treated with venetoclax or placebo with Vd |
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| 65 |
DREAMM-6: Safety and tolerability of belantamab mafodotin in combination with Vd in R/R multiple myeloma |
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| 66 |
First-in-human data of ALLO-501 and ALLO-647 in R/R LBCL/FL: ALPHA study |
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| 67 |
Comparison of efficacy and safety with obinutuzumab plus chemo vs. rituximab plus chemo in patients with previously untreated FL: Updates from phase III Gallium Study |
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| 68 |
First-line immunochemotherapy for FL in the GALLIUM study: Prognostic value of PET-CT status after long-term follow-up |
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| 69 |
Bosutinib for CP-CML after imatinib failure: 8-year update |
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| 70 |
Independent review: Arterial occlusive events due to ponatinib in PACE trial Ph+ CML |
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| 71 |
Bosutinib in patients with chronic phase chronic myeloid leukemia intolerant to prior tyrosine kinase inhibitors: Analyses from the BYOND study |
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| 72 |
KEYNOTE-204: Phase III study of Pembrolizumab vs Brentuximab vedotin in relapsed or refractory classic Hodgkin lymphoma |
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| 73 |
HALO Trial: Brentuximab vedotin and bendamustine as first-line treatment of Hodgkin lymphoma in the elderly |
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| 74 |
Frontline brentuximab vedotin as monotherapy or in combination for older Hodgkin lymphoma patients. |
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| 75 |
Gls-010 in Chinese patients with relapsed or refractory classical Hodgkin lymphoma: Impressive Phase II Results |
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| 76 |
Long-term follow-up of anti-CD19 CAR T-cell therapy for B-cell NHL and CLL |
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| 77 |
Safety and efficacy of optimized tandem CD19/CD20 CAR-engineered T cells in patients with R/R NHL |
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| 78 |
Phase I/II study of avadomide (CC-122) in combination with R-CHOP for newly diagnosed DLBCL |
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| 79 |
Phase I study of AUTO3 with pembrolizumab in patients with r/r DLBCL |
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| 80 |
Epcoritamab (GEN3013) to induce CR in pts with R/R B-NHL: Complete dose escalation data and efficacy results from a phase I/II trial |
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| 81 |
Retreatment of pts with refractory DLBCL with axi-cel in ZUMA-1 |
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| 82 |
Final results of Lenalidomide plus R-GDP (R2-GDP) - GOTEL in relapsed/refractory diffuse large B-cell lymphoma |
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| 83 |
RE-MIND study: A propensity score-based 1:1 matched comparison of tafasitamab + lenalidomide (L-MIND) versus lenalidomide monotherapy in transplant-ineligible pts with R/R DLBCL |
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| 84 |
Outpatient treatment with liso-cel across a variety of clinical sites from three ongoing clinical studies in R/R LBCL. |
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| 85 |
Atezolizumab + obinutuzumab + venetoclax in patients with R/R DLBCL: Primary analysis of a phase II trial from LYSA |
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| 86 |
Finally Opdivo in combination with Yervoy has got success in much awaited lucrative first line NSCLC patients whose tumors express PD-L1≥1% and approval is further supported by long term data |
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| 87 |
Wthin a space of 11 days, Opdivo-Yervoy with chemo bagged another approval in first line NSCLC irrespective of PD-L1 expression |
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| 88 |
Frontline durvalumab and tremelimumab combo misses overal survival endpoint in metastatic NSCLC |
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| 89 |
Another new combination of tiragolumab and atezolizumab has shown efficacy signals in lucrative first line NSCLC |
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| 90 |
Novartis unveils more capmatinib data from GEOMETRY mono-1 study |
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| 91 |
Osimertinib trial results in NSCLC patients with EGFR exon 20 insertions from ECOG-ACRIN 5162 trial |
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| 92 |
Roche presented long term data of alectinib from ALEX study in frontline advanced ALK+ NSCLC |
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| 93 |
Another MET inhibitor expected to make their way in METex14+ mutated NSCLC |
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| 94 |
Novartis presented the data from GEOMETRY mono-1 study to support the capmatinib usage in second line setting |
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| 95 |
Takeda published brigatinib data from J-ALTA study to supprt its approval in Japanese patients |
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| 96 |
Heat Biologics's allogeneic cellular vaccine in combination with nivolumab shown efficacy signals in phase I/II data |
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| 97 |
Pembrolizumab usage along with radiothreapy associated with better efficacy outcomes |
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| 98 |
Merck presented the data from VISION study to support its FDA approval in patients with NSCLC with METex14 skipping |
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| 99 |
Two year follow up data of bintrafusp alfa presented by Merck with encouraging efficacy signals |
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| 100 |
CheckMate 568 Part 2 data will further support the approval of nivolumab plus ipilimumab with two cycles of chemotherapy combo in firstline NSCLC setting |
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| 101 |
Pegilodecakin did not show any improvement in efficacy when added to pembrolizumab in first line NSCLC |
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| 102 |
Data from exploratory RELAY+ study of ramucirumab plus gefitinib supports its usage in first line EGFR mutated NSCLC |
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| 103 |
Phase II study of venetoclax plus dose-adjusted R-EPOCH for Richter’s syndrome |
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| 104 |
Good interim data from phase 2 trial of first-line pembrolizumab and vorinostat in patients with metastatic NSCLC |
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| 105 |
Initial results of MRD driven time limited therapy with zanubrutinib, obinutuzumab, and venetoclax |
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| 106 |
Novartis presented Phase II data of one more promising irreversible 3rd-generation EGFR TKI |
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| 107 |
TAK-788 vs real-world data outcomes in refractory non-small cell lung cancer (NSCLC) with EGFR exon 20 insertions |
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| 108 |
Acalabrutinib versus idelalisib plus rituximab or bendamustine plus rituximab in R/R CLL: ASCEND final results |
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| 109 |
Final data of KEYNOTE-189 study in patients with newly diagnosed metastatic nonsquamous NSCLC |
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| 110 |
Updated overall survival (OS) and genomic analysis from a single-arm phase II study of dabrafenib + trametinib in patients with BRAF V600E mutant metastatic NSCLC |
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| 111 |
Patient-reported outcomes (PROs) in the randomized, phase III IMpower110 study of atezolizumab (atezo) vs chemotherapy in 1L metastatic NSCLC |
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| 112 |
Effect of adding ublituximab to ibrutinib on efficacy in previously treated high-risk CLL: GENUINE phase III study |
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| 113 |
Some supporting data of Lorlatinib; irreversible 3rd-generation EGFR TKI in patients with ALK-positive NSCLC |
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| 114 |
Mute response of Durvalumab trial as Durvalumab plus tremelimumab fails to show the clinical activity in patients with acquired resistance to PD-1 checkpoint inhibitors |
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| 115 |
Acalabrutinib in treatment-naïve CLL: Mature results from Ph II study demonstrating durable remissions and longterm tolerability |
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| 116 |
Fixed-duration venetoclax-obinutuzumab for previously untreated pts with CLL: Follow-up results from phase III CLL14 trial |
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| 117 |
Supportive data from Nivolumab trial for its use as monotherapy or in combination with cisplatin/carboplatin and etoposide as frontline therapy for extensive-stage small cell lung cancer (ES-SCLC) |
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| 118 |
Phase III MURANO study results: Impact of premature venetoclax discontinuation/interruption on outcomes in R/R CLL |
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| 119 |
Consistent result of tazemetostat in terms of Efficacy, safety, and immune priming effect in patients with epithelioid sarcoma. |
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| 120 |
Eribulin and pembrolizumab disappointed with its efficacy results in Uterine leiomyosarcoma (LMS) |
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| 121 |
Role of CDK4/6 inhibitors in treating advanced Soft Tissue Sarcoma (STS) |
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| 122 |
Highest reported efficacy of doxorubicin + pembrolizumab till date in a preliminary advanced STS trial |
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| 123 |
AKT inhibition by Ipatasertib in mCRPC: The A.MARTIN Randomized Phase II trial |
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| 124 |
Updated results from ARAMIS phase III trial showed darolutamide improves overall survival (OS) over placebo in nmCRPC patients |
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| 125 |
Updated overall survival results from PROSPER: A phase III, randomized, double-blind, placebo controlled study of enzalutamide (ENZA) in men with nmCRPC |
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| 126 |
Apalutamide Plus ADT Leads to Significantly Improved Outcomes in Nonmetastatic CRPC: Results from the phase III SPARTAN trial |
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| 127 |
Novel AKT inhibitor fails to demonstrate a difference in the primary outcome of PFS: Results from phase II ProCAID trial |
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| 128 |
Pembrolizumab plus enzalutamide in patients with abiraterone acetate pretreated mCRPC: KEYNOTE-365 cohort C efficacy, safety, and biomarker results |
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| 129 |
HERO phase III trial: Results comparing relugolix, an oral GnRH receptor antagonist, versus leuprolide acetate for advanced prostate cancer |
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| 130 |
Impact of Olaparib vs Physician’s Choice of New Hormonal Agent On Burden of Pain in mCRPC: Results from PROfound |
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| 131 |
AstraZeneca presented the Health-related quality of life (HRQoL) data for olaparib versus enzalutamide or abiraterone in mCRPC with HRR gene alterations |
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| 132 |
Exelixis reports data from Phase 1b COSMIC-021 Trial of Cabozantinib in Combination With Atezolizumab in Patients With mCRPC |
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| 133 |
Pfizer has presented the positive interim data of PARP inhibitor from the TALAPRO-1 phase II trial |
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| 134 |
Data from CARD study Confirm Benefit of Cabazitaxel Over Abiraterone or Enzalutamide in mCRPC |
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| 135 |
Much awaited result of Trastuzumab + trimodality treatment for HER2+ esophageal adenocarcinoma brought disappointment with its failure in reaching the primary end point |
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| 136 |
No significant survival benefit of pembrolizumab over 2L paclitaxel in previusly treated PD-L1+ advanced gastric or gastroesophageal junction cancer |
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| 137 |
Tumor mutational burden (TMB) demonstrates a positive association with clinical outcomes with pembrolizumab in gastric cancer |
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| 138 |
Another PD-1 inhibitor (Sintilimab) jointly developed by Innovent and Eli Lilly has met its primary endpoint of overall survival in the second-line treatment of patients with metastatic esophageal squ... |
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| 139 |
In gastric cancer no treatment till date has shown such a strong data, Definately Enhetru will be positioned much ahead of Kadcyla |
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| 140 |
A rare failure of Olaparib brought a lot of disappointment for ovarian cancer patient community |
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| 141 |
Role of DOCK8, EP 400, and PDX1 mutations as prognostic biomarkers & its association with longer survival in patients treated with Selinexor. |
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| 142 |
Role of MDNA55 (Interleukin-4 Receptor) in a difficult to treat population (de novo GBM, IDH wild-type, not eligible for surgery at recurrence) & its benefit for patient resistant to temozolomide. |
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| 143 |
Another novel combination approach (INO-5401 + INO-9012 with Cemiplimab) for newly diagnosed GBM patients |
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| 144 |
Not so encouraging results for Atezolizumab in comination of Temozolomide for newly diagnosed GBM |
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| 145 |
Savolitinib can be a better treatment choice than sunitinib due to its improved efficacy and safety profile |
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| 146 |
Results from TIVO-3 supports use of Tivozanib for highly treatment refractory RCC patients |
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| 147 |
Not very promising but Cabozantinib is an effective treatment option for the patients with advanced refractory RCC |
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| 148 |
The result from KEYNOTE-426 warrants the use of pembrolizumab and axitinib as a standard of care for patients with previously untreated RCC |
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| 149 |
Lenvatinib plus Pembrolizumab shows strong data for mccRCC with disease progression following prior PD-1/PDL-1 therapy |
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| 150 |
Tumor Mutation Burden (TMB): One Size fits for all? Not really! |
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| 151 |
Lilly overthrows Pfizer in Early HR+/HER2- Breast Cancer, what Next? |
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| 152 |
ESMO 2020 – Major trials in focus and Our View Points |
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| 153 |
Triumphs and Troubles for Combination Therapies in Melanoma: COMBI-I Trial Failure Story |
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| 154 |
Will ADC’s be in focus in ESMO 2020 too? |
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| 155 |
BMS/Exelixis face-off with Merck’s Keytruda in front-line renal cancer |
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| 156 |
Gilead's ASCENT into Oncology: Sacituzumab results at ESMO 2020 |
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